Bibliography
- BERNARD C: Leçons sur les propriétés physiologiques et les altérations pathologiques des liquides de l’organisme. Ballière JB (Ed.), Paris, France (1859).
- SERHAN CN, SAVILL J: Resolution of inflammation: the beginning programs the end. Nat. Immunol. (2005) 6(12):1191-1197.
- SERHAN CN, HAMBERG M, SAMUELSSON B: Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. Biochem. Biophys. Res. Commun. (1984) 118(3):943-949.
- SERHAN CN: Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side. Arch. Immunol. Ther. Exp. (2001) 49(3):177-188.
- SERHAN CN, HAMBERG M, SAMUELSSON B: Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc. Natl. Acad. Sci. USA (1984) 81(17):5335-5339.
- PUUSTINEN T, WEBBER SE, NICOLAOU KC et al.: Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase. FEBS Lett. (1986) 207(1):127-132.
- SERHAN CN, SHEPPARD KA, FIORE S: Lipoxin formation: evaluation of the role and actions of leukotriene A4. Adv. Prostaglandin Thromboxane Leukot. Res. (1990) 20:54-62.
- ROMANO M, CHEN XS, TAKAHASHI Y et al.: Lipoxin synthase activity of human platelet 12-lipoxygenase. Biochem. J. (1993) 296(Pt 1):127-133.
- TORNHAMRE S, ELMQVIST A, LINDGREN JÅ: 15-Lipoxygenation of leukotriene A4. Studies of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation. Biochim. Biophys. Acta (2000) 1484(2-3):298-306.
- EDENIUS C, STENKE L, TORNHAMRE S et al.: Metabolism of granulocyte-derived leukotriene A4 in human platelets and respiratory tissue: transcellular formation of lipoxins and leukotrienes. Adv. Exp. Med. Biol. (1991) 314:281-288.
- SERHAN CN: Lipoxin biosynthesis and its impact in inflammatory and vascular events. Biochim. Biophys. Acta (1994) 1212(1):1-25.
- SERHAN CN: Lipoxins and aspirin-triggered 15-epi-lipoxins. In: Inflammation: Basic Principles and Clinical Correlates. Gallin JI et al. (Eds), Lippincott Williams & Wilkins, Philadelphia (1999):373-385.
- MARCUS AJ: Transcellular metabolism of eicosanoids. Prog. Hemost. Thromb. (1986) 8:127-142.
- FOLCO G, MURPHY RC: Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol. Rev. (2006) 58(3):375-388.
- SERHAN CN: Cell-cell interactions in the generation of eicosanoids: charting the routes and products of transcellular biosynthesis. J. Lab. Clin. Med. (1993) 121(3):372-374.
- SERHAN CN, HAMBERG M, RAMSTEDT U, SAMUELSSON B: Lipoxins: stereochemistry, biosynthesis and biological activities. Adv. Prostaglandin Thromboxane Leukot. Res. (1986) 16:83-97.
- Special Issue of Prostaglandins, Leukotrienes and Essential Fatty Acids on Lipoxins (2005) 73(3-4):139-321.
- FIORE S, RYEOM SW, WELLER PF, SERHAN CN: Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils. J. Biol. Chem. (1992) 267(23):16168-16176.
- CHIANG N, SERHAN CN, DAHLéN SE et al.: The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol. Rev. (2006) 58(3):463-487.
- LEE TH, HORTON CE, KYAN-AUNG U et al.: Lipoxin A4 and lipoxin B4 inhibit chemotactic responses of human neutrophils stimulated by leukotriene B4 and N-formyl-l-methionyl-l-leucyl-l-phenylalanine. Clin. Sci. (Lond) (1989) 77(2):195-203.
- COLGAN SP: Lipid mediators in epithelial cell-cell interactions. Cell. Mol. Life Sci. (2002) 59(5):754-760.
- GEWIRTZ AT, FOKIN VV, PETASIS NA, SERHAN CN, MADARA JL: LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation. Am. J. Physiol. (1999) 276(4 Pt 1):C988-C994.
- FILEP JG, KHREISS T, JOZSEF L: Lipoxins and aspirin-triggered lipoxins in neutrophil adhesion and signal transduction. Prostaglandins Leukot. Essent. Fatty Acids (2005) 73(3-4):257-262.
- RAMSTEDT U, SERHAN CN, NICOLAOU KC et al.: Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action. J. Immunol. (1987) 138(1):266-270.
- MACHADO FS, JOHNDROW JE, ESPER L et al.: Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nat. Med. (2006) 12(3):330-334.
- BANDEIRA-MELO C, BOZZA PT, DIAZ BL et al.: Cutting edge: lipoxin (LX) A4 and aspirin-triggered 15-epi-LXA4 block allergen-induced eosinophil trafficking. J. Immunol. (2000) 164(5):2267-2271.
- MADDOX JF, SERHAN CN: Lipoxin A4and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. J. Exp. Med. (1996) 183(1):137-146.
- GODSON C, MITCHELL S, HARVEY K et al.: Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. J. Immunol. (2000) 164(4):1663-1667.
- ARIEL A, CHIANG N, ARITA M, PETASIS NA, SERHAN CN: Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-α secretion from human T cells. J. Immunol. (2003) 170(12):6266-6272.
- ALIBERTI J, HIENY S, REIS E, SOUSA C,SERHAN CN, SHER A: Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nat. Immunol. (2002) 3(1):76-82.
- GRONERT K, GEWIRTZ A, MADARA JL, SERHAN CN: Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. J. Exp. Med. (1998) 187(8):1285-1294.
- CONTI P, REALE M, BARBACANE RC, BONGRAZIO M, PANARA MR: Lipoxins A4 and B4 inhibit leukotriene B4generation from human neutrophil leukocyte suspensions. Immunol. Lett. (1990) 24(4):237-242.
- BREZINSKI ME, GIMBRONE MA JR, NICOLAOU KC, SERHAN CN: Lipoxins stimulate prostacyclin generation by human endothelial cells. FEBS Lett. (1989) 245(1-2):167-172.
- MEINI S, EVANGELISTA S, GEPPETTI P et al.: Pharmacologic and neurochemical evidence for the activation of capsaicin-sensitive sensory nerves by lipoxin A4 in guinea pig bronchus. Am. Rev. Respir. Dis. (1992) 146(4):930-934.
- TAMAOKI J, TAGAYA E, YAMAWAKI I, KONNO K: Lipoxin A4 inhibits cholinergic neurotransmission through nitric oxide generation in the rabbit trachea. Eur. J. Pharmacol. (1995) 287(3):233-238.
- SVENSSON CI, ZATTONI M, SERHAN CN: Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. J. Exp. Med. (2007) 204(2):245-252.
- SERHAN CN: Endogenous chemical mediators in anti-inflammation and pro-resolution. Curr. Med. Chem. (2002) 1:177-192.
- KATOH T, TAKAHASHI K, DEBOER DK, SERHAN CN, BADR KF: Renal hemodynamic actions of lipoxins in rats: a comparative physiological study. Am. J. Physiol. (1992) 263(3 Pt 2):F436-F442.
- ROMANO M, MADDOX JF, SERHAN CN: Activation of human monocytes and the acute monocytic leukemia cell line (THP-1) by lipoxins involves unique signaling pathways for lipoxin A4 versus lipoxin B4: evidence for differential Ca2+ mobilization. J. Immunol. (1996) 157(5):2149-2154.
- FIORE S, MADDOX JF, PEREZ HD, SERHAN CN: Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J. Exp. Med. (1994) 180(1):253-260.
- SHEARMAN MS, NAOR Z, SEKIGUCHI K, KISHIMOTO A, NISHIZUKA Y: Selective activation of the gamma-subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites. FEBS Lett. (1989) 243(2):177-182.
- SCHALDACH CM, RIBY J, BJELDANES LF: Lipoxin A4: a new class of ligand for the Ah receptor. Biochemistry (1999) 38(23):7594-7600.
- GRONERT K, MARTINSSON-NISKANEN T, RAVASI S, CHIANG N, SERHAN CN: Selectivity of recombinant human leukotriene D4, leukotriene B4, and lipoxin A4 receptors with aspirin-triggered 15-epi-LXA4 and regulation of vascular and inflammatory responses. Am. J. Pathol. (2001) 158(1):3-9.
- VAUGHN MW, PROSKE RJ, HAVILAND DL: Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene. J. Immunol. (2002) 169(6):3363-3369.
- VANE JR, BOTTING RM: The mechanism of action of aspirin. Thromb. Res. (2003) 110(5-6):255-258.
- LECOMTE M, LANEUVILLE O, JI C, DEWITT DL, SMITH WL: Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. J. Biol. Chem. (1994) 269(18):13207-13215.
- CLÀRIA J, SERHAN CN: Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc. Natl. Acad. Sci. USA (1995) 92(21):9475-9479.
- CLÀRIA J, LEE MH, SERHAN CN: Aspirin-triggered lipoxins (15-epi-LX)are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. Mol. Med. (1996) 2(5):583-596.
- TAKANO T, FIORE S, MADDOX JF et al.: Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J. Exp. Med. (1997) 185(9):1693-1704.
- MADDOX JF, HACHICHA M, TAKANO T et al.: Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. J. Biol. Chem. (1997) 272(11):6972-6978.
- SERHAN CN, FIORE S, BREZINSKI DA, LYNCH S: Lipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: conversion to novel 15-oxo and dihydro products. Biochemistry (1993) 32(25):6313-6319.
- CLISH CB, LEVY BD, CHIANG N, TAI HH, SERHAN CN: Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation. J. Biol. Chem. (2000) 275(33):25372-25380.
- SERHAN CN, MADDOX JF, PETASIS NA et al.: Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry (1995) 34(44):14609-14615.
- MADDOX JF, COLGAN SP, CLISH CB et al.: Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity. FASEB J. (1998) 12(6):487-494.
- PALMBLAD J, GYLLENHAMMAR H, RINGERTZ B et al.: The effects of lipoxin A and lipoxin B on functional responses of human granulocytes. Biochem. Biophys. Res. Commun. (1987) 145(1):168-175.
- RAMSTEDT U, NG J, WIGZELL H, SERHAN CN, SAMUELSSON B: Action of novel eicosanoids lipoxin A and B on human natural killer cell cytotoxicity: effects on intracellular cAMP and target cell binding. J. Immunol. (1985) 135(5):3434-3438.
- SERHAN CN: In: Advances in Rheumatology and Inflammation. Hedqvist Pet al. (Eds), Eular, Basel (1991):141-153.
- FITZSIMMONS BJ, ADAMS J, EVANS JF, LEBLANC Y, ROKACH J: The lipoxins. Stereochemical identification and determination of their biosynthesis. J. Biol. Chem. (1985) 260(24):13008-13012.
- GUILFORD WJ, BAUMAN JG, SKUBALLA W et al.: Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo. J. Med. Chem. (2004) 47(8):2157-2165.
- SERHAN CN, HAMBERG M, SAMUELSSON B, MORRIS J, WISHKA DG: On the stereochemistry and biosynthesis of lipoxin B. Proc. Natl. Acad. Sci. USA (1986) 83(7):1983-1987.
- SERHAN CN, NICOLAOU KC, WEBBER SE et al.: Lipoxin A. Stereochemistry and biosynthesis. J. Biol. Chem. (1986) 261(35):16340-16345.
- CLISH CB, O’BRIEN JA, GRONERT K et al.: Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. Proc. Natl. Acad. Sci. USA (1999) 96(14):8247-8252.
- CHIANG N, GRONERT K, CLISH CB et al.: Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. J. Clin. Invest. (1999) 104(3):309-316.
- PAUL-CLARK MJ, VAN CAO T, MORADI-BIDHENDI N, COOPER D, GILROY DW: 15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation. J. Exp. Med. (2004) 200(1):69-78.
- POULIOT M, SERHAN CN: Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor-α-initiated neutrophil responses and trafficking: novel regulators of a cytokine-chemokine axis relevant to periodontal diseases. J. Periodontal Res. (1999) 34(7):370-373.
- GEWIRTZ AT, MCCORMICK B, NEISH AS et al.: Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs. J. Clin. Invest. (1998) 101(9):1860-1869.
- FIORUCCI S, DE LIMA OM JR, MENCARELLI A et al.: Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage. Gastroenterology (2002) 123(5):1598-1606.
- WALLACE JL: Recent advances in gastric ulcer therapeutics. Curr. Opin. Pharmacol. (2005) 5(6):573-577.
- FIORE S, ANTICO G, ALOMAN M, SODIN-SEMRL S: Lipoxin A4 biology in the human synovium. Role of the ALX signaling pathways in modulation of inflammatory arthritis. Prostaglandins Leukot. Essent. Fatty Acids (2005) 73(3-4):189-196.
- JOZSEF L, ZOUKI C, PETASIS NA, SERHAN CN, FILEP JG: Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes. Proc. Natl. Acad. Sci. USA (2002) 99(20):13266-13271.
- GUILFORD WJ, PARKINSON JF: Second-generation beta-oxidation resistant 3-oxa-lipoxin A4 analogs. Prostaglandins Leukot. Essent. Fatty Acids (2005) 73(3-4):245-250.
- BANNENBERG G, MOUSSIGNAC RL, GRONERT K et al.: Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration. Br. J. Pharmacol. (2004) 143(1):43-52.
- FIORUCCI S, WALLACE JL, MENCARELLI A et al.: A β-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction. Proc. Natl. Acad. Sci. USA (2004) 101(44):15736-15741.
- QIU FH, DEVCHAND PR, WADA K, SERHAN CN: Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. FASEB J. (2001) 15(14):2736-2738.
- SIMCHOWITZ L, FIORE S, SERHAN CN:Carrier-mediated transport of lipoxin A4 in human neutrophils. Am. J. Physiol. (1994) 267(6 Pt 1):C1525-C1534.
- DEVCHAND PR, ARITA M, HONG S et al.: Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense. FASEB J. (2003) 17(6):652-659.
- CANNY G, LEVY O, FURUTA GT et al.: Lipid mediator-induced expression of bactericidal/permeability-increasing protein (BPI) in human mucosal epithelia. Proc. Natl. Acad. Sci. USA (2002) 99(6):3902-3907.
- POULIOT M, CLISH CB, PETASIS NA, VAN DYKE TE, SERHAN CN: Lipoxin A4 analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Biochemistry (2000) 39(16):4761-4768.
- KANTARCI A, OYAIZU K, VAN DYKE TE: Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis. J. Periodontol. (2003) 74(1):66-75.
- HASTURK H, KANTARCI A, OHIRA T et al.: RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis. FASEB J. (2006) 20(2):401-403.
- GAMACHE DA, WEI ZY, WEIMER LK et al.: Corneal protection by the ocular mucin secretagogue 15(S)-HETE in a rabbit model of desiccation-induced corneal defect. J. Ocul. Pharmacol. Ther. (2002) 18(4):349-361.
- GRONERT K, MAHESHWARI N, KHAN N et al.: A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. J. Biol. Chem. (2005) 280(15):15267-15278.
- COTRAN PR, HSU C, SERHAN CN: Abstract; Meeting of the Association for Research in Vision and Ophthalmology (1995) 36(4):3812.
- WADA K, ARITA M, NAKAJIMA A et al.: Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation. FASEB J. (2006) 20(11):1785-1792.
- WU SH, WU XH, LU C, DONG L, CHEN ZQ: Lipoxin A4 inhibits proliferation of human lung fibroblasts induced by connective tissue growth factor. Am. J. Respir. Cell Mol. Biol. (2006) 34(1):65-72.
- MCMAHON B, MITCHELL D, SHATTOCK R et al.: Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. FASEB J. (2002) 16(13):1817-1819.
- FIERRO IM, KUTOK JL, SERHAN CN: Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A4 and lipoxin A4. J. Pharmacol. Exp. Ther. (2002) 300(2):385-392.
- MUNGER KA, MONTERO A, FUKUNAGA M et al.: Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis. Proc. Natl. Acad. Sci. USA (1999) 96(23):13375-13380.
- NASSAR GM, MORROW JD, ROBERTS LJ 2ND, LAKKIS FG, BADR KF: Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J. Biol. Chem. (1994) 269(44):27631-27634.
- PRAT C, BESTEBROER J, DE HAAS CJ, VAN STRIJP JA, VAN KESSEL KP: A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1. J. Immunol. (2006) 177(11):8017-8026.
- PERRETTI M, CHIANG N, LA M et al.: Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat. Med. (2002) 8(11):1296-1302.
- LE Y, OPPENHEIM JJ, WANG JM: Pleiotropic roles of formyl peptide receptors. Cytokine Growth Factor Rev. (2001) 12(1):91-105.
- CHIANG N, FIERRO IM, GRONERT K, SERHAN CN: Activation of lipoxin A4 receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation. J. Exp. Med. (2000) 191(7):1197-1208.
- NANAMORI M, CHENG X, MEI J et al.: A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol. Pharmacol. (2004) 66(5):1213-1222.
- BüRLI RW, XU H, ZOU X et al.: Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg. Med. Chem. Lett. (2006) 16(14):3713-3718.
- BREZINSKI ME, SERHAN CN: Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids. Proc. Natl. Acad. Sci. USA (1990) 87(16):6248-6252.
- GLORIAM DE, SCHIOTH HB, FREDRIKSSON R: Nine new human rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim. Biophys. Acta (2005) 1722(3):235-246.
- SERHAN CN, GOTLINGER K, HONG S, ARITA M: Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. Prostaglandins Other Lipid Mediat. (2004) 73(3-4):155-172.
- SERHAN CN: Resolution phases of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu. Rev. Immunol. (2006).
- BANNENBERG GL, CHIANG N, ARIEL A et al.: Molecular circuits of resolution: formation and actions of resolvins and protectins. J. Immunol. (2005) 174(7):4345-4355.
Patents
- SAMUELSSON B, SERHAN C, HAMBERG M: US4560514 (1985).
- THE UPJOHN COMPANY: US4576758 (1986).
- TEIJIN PHARMA: JP3227922 (1991).
- BRIGHAM & WOMEN's HOSPITAL: US5079261 (1992).
- BRIGHAM & WOMEN's HOSPITAL: WO9013292 (1990).
- BRIGHAM & WOMEN's HOSPITAL: WO9429262 (1994).
- BRIGHAM & WOMEN's HOSPITAL: US5441951 (1995).
- MADARA JL, SERHAN CN, COLGAN SP: US5650435 (1997).
- BRIGHAM & WOMEN's HOSPITAL: EP1163204 (2005).
- BRIGHAM & WOMEN's HOSPITAL: US6659282 (2003).
- BRIGHAM & WOMEN's HOSPITAL: US6433202 (2002).
- BRIGHAM & WOMEN's HOSPITAL: WO0054767 (2000).
- BRIGHAM & WOMEN's HOSPITAL: US6387953 (2002).
- SCHERING AKTIENGESELLSCHAFT: WO2003040080 (2003).
- SCHERING AKTIENGESELLSCHAFT: US6831186 (2004).
- PETASIS N: US20060270734 (2006).
- BRIGHAM & WOMEN's HOSPITAL: WO03039533 (2003).
- BRIGHAM & WOMEN's HOSPITAL: US20060079577 (2006).
- PETASIS NP, KARP CL: WO2004110426 (2004).
- KARP CL, PETASIS NP: US20050113443 (2005).
- BRIGHAM & WOMEN's HOSPITAL: WO03051350 (2003).
- SERHAN CN, COLGAN SP: US20030195248 (2003).
- TRUSTEES OF BOSTON UNIVERSITY, BRIGHAM & WOMEN's HOSPITAL, UNIVERSITY OF SOUTHERN CALIFORIA: WO0170664 (2001).
- VAN DYKE TE, PETASIS NA, SERHAN CN: US04019110 (2004).
- ALCON, INC.: US6645978 (2003).
- BRIGHAM & WOMEN's HOSPITAL: US6048897 (2000).
- BRIGHAM & WOMEN's HOSPITAL: US6627658 (2003).
- BRIGHAM & WOMEN's HOSPITAL: WO02070068 (2002).
- SERHAN CN: US060069158 (2006).
- EMORY UNIVERSITY: US5830453 (1998).
- UNITED STATES SECRETARY OF AGRICULTURE: US6177415 (2001).
- ACADIA PHARM, INC.: WO05047899 (2005).
- BRIGHAM & WOMEN's HOSPITAL: US5750354 (1998).
- BAYER HEALTHCARE AG: EP1266005 (2007).
- RAMAKRISHNAN S: US20020058259 (2002).
- BRIGHAM & WOMEN's HOSPITAL: US6670396 (2003).
- CADUS PHARMACEUTICAL CORP.: US20050059135 (2005).
- TAKEDA PHARM. COMPANY LTD.: EP1559721 (2005).
- WANG JM, OPPENHEIM JJ, SU S-B, GONG WH, GAO J-L, MURPHY PM: US050085629 (2005).