Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

Bibliography

• Pommier Y, Leo E, Zhang H, DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol 2010;17(9):421-33
   Google Scholar
• Pommier Y. Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer 2006;6(10):789-802
   PubMed Web of Science ®Google Scholar
• Marchand C, Antony S, Kohn KW, A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Mol Cancer Ther 2006;5(2):287-95
   PubMed Web of Science ®Google Scholar
• Teicher BA. Next generation topoisomerase I inhibitors: Rationale and biomarker strategies. Biochem Pharmacol 2008;75(6):1262-71
   PubMed Web of Science ®Google Scholar
• Pommier Y, Barcelo JM, Rao VA, Repair of topoisomerase I-mediated DNA damage. Prog Nucleic Acid Res Mol Biol 2006;81:179-229
   PubMed Web of Science ®Google Scholar
• Debethune L, Kohlhagen G, Grandas A, Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase. Nucleic Acids Res 2002;30(5):1198-204
   Google Scholar
• Interthal H, Champoux JJ. Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase (TDP1). Biochem J 2011;436(3):559-66
   Google Scholar
• Takashima H, Boerkoel CF, John J, Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy. Nat Genet 2002;32(2):267-72
   PubMed Web of Science ®Google Scholar
• El-Khamisy SF, Katyal S, Patel P, Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. DNA Repair (Amst) 2009;8(6):760-6
   Google Scholar
• Das BB, Antony S, Gupta S, Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. EMBO J 2009;28(23):3667-80
   PubMedGoogle Scholar
• Katyal S, el-Khamisy SF, Russell HR, TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J 2007;26(22):4720-31
   Google Scholar
• Hirano R, Interthal H, Huang C, Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation? EMBO J 2007;26(22):4732-43
   Google Scholar
• Barthelmes HU, Habermeyer M, Christensen MO, TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II. J Biol Chem 2004;279(53):55618-25
   PubMedGoogle Scholar
• Nivens MC, Felder T, Galloway AH, Engineered resistance to camptothecin and antifolates by retroviral coexpression of tyrosyl DNA phosphodiesterase-I and thymidylate synthase. Cancer Chemother Pharmacol 2004;53(2):107-15
   Google Scholar
• Pouliot JJ, Yao KC, Robertson CA, Yeast gene for a Tyr-DNA phosphodiesterase that repairs topo I covalent complexes. Science 1999;286:552-5
   PubMed Web of Science ®Google Scholar
• Pouliot JJ, Robertson CA, Nash HA. Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae. Genes Cells 2001;6(8):677-87
   Google Scholar
• Liu C, Pouliot JJ, Nash HA. Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1. Proc Natl Acad Sci USA 2002;99(23):14970-5
   Google Scholar
• Eng WK, Faucette L, Johnson RK, Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. Mol Pharmacol 1988;34:755-60
   PubMed Web of Science ®Google Scholar
• Vance JR, Wilson TE. Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases. Mol Cell Biol 2001;21(21):7191-8
   PubMedGoogle Scholar
• Vance JR, Wilson TE. Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage. Proc Natl Acad Sci USA 2002;99(21):13669-74
   Google Scholar
• Deng C, Brown JA, You D, Multiple Endonucleases Function to Repair Covalent Topoisomerase I Complexes in Saccharomyces cerevisiae. Genetics 2005;170:591-600
   PubMed Web of Science ®Google Scholar
• Sartori AA, Lukas C, Coates J, Human CtIP promotes DNA end resection. Nature 2007;450(7169):509-14
   PubMed Web of Science ®Google Scholar
• Nakamura K, Kogame T, Oshiumi H, Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair. PLoS Genet 2010;6(1):e1000828
   PubMed Web of Science ®Google Scholar
• Hartsuiker E, Neale MJ, Carr AM. Distinct Requirements for the Rad32(Mre11) Nuclease and Ctp1(CtIP) in the removal of covalently bound Topoisomerase I and II from DNA. Mol Cell 2009;33(1):117-23
   PubMed Web of Science ®Google Scholar
• Zhang YW, Regairaz M, Seiler JA, Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. Nucleic Acids Res 2011;39(9):3607-20
   Google Scholar
• Dexheimer TS, Antony S, Marchand C, Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy. Anticancer Agents Med Chem 2008;8(4):381-9
   Google Scholar
• Davies DR, Interthal H, Champoux JJ, Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures. J Mol Biol 2002;324(5):917-32
   Google Scholar
• Interthal H, Chen HJ, Champoux JJ. Human Tdp1 cleaves a broad spectrum of substrates, including \⊂\⊂phosphoamide linkages. J Biol Chem 2005;280(43):36518-28
   Google Scholar
• Dexheimer TS, Stephen AG, Fivash MJ, The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase. Nucleic Acids Res 2010;38(7):2444-52
   Google Scholar
• Davies DR, Interthal H, Champoux JJ, Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide. Chem Biol 2003;10(2):139-47
   Google Scholar
• Liao Z, Thibaut L, Jobson A, Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors. Mol Pharmacol 2006;70(1):366-72
   Google Scholar
• Pommier Y. inventors; The Government of the United States of America, assignee. Aminoglycosides and ribosome inhibitors as inhibitors of tyrosyl-DNA-phosphodiesterase. US60661306; 2005
   Google Scholar
• Antony S, Marchand C, Stephen AG, Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1. Nucleic Acids Res 2007;35(13):4474-84
   Google Scholar
• Pommier Y, Marchand C, Thibaut L., inventors; The Government of the United States of America, assignee. Diamidine derivatives as inhibitors of human tyrosyl-DNA-phosphodiesterase (Tdp1). US60786604; 2006
   Google Scholar
• Pommier Y, Cherfils J. Interfacial protein inhibition: a nature's paradigm for drug discovery. Trends Pharmacol Sci 2005;28:136-45
   Google Scholar
• Pommier Y, Marchand C, Thibaut L., inventors; The Government of the United States of America, assignee. Tetracyclines and derivatives as inhibitors of human tyrosyl-DNA-phosphodiesterase (Tdp1). US60786746; 2006
   Google Scholar
• Marchand C, Lea WA, Jadhav A, Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay. Mol Cancer Ther 2009;8(1):240-8
   PubMed Web of Science ®Google Scholar
• Pommier Y, Marchand C, Dexheimer T, , inventors; The Government of the United States of America, assignee. Protein-Tyrosine phosphatase inhibitors as inhibitors of TDP1 and methods of treating disorders. US61042706; 2008
   Google Scholar
• Dexheimer TS, Gediya LK, Stephen AG, 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. J Med Chem 2009;52(22):7122-31
   Google Scholar
• Liu C, Zhou S, Begum S, Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. Lung Cancer 2007;55(3):303-11
   Google Scholar
• Giannini G, Rinaldi C, Ristori E, Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Oncogene 2004;23(15):2640-7
   Web of Science ®Google Scholar
• Takemura H, Rao VA, Sordet O, Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem 2006;281(41):30814-23
   PubMed Web of Science ®Google Scholar
• Knez L, Sodja E, Kern I, Predictive value of multidrug resistance proteins, topoisomerases II and ERCC1 in small cell lung cancer: a systematic review. Lung Cancer 2011;72(3):271-9
   Google Scholar
• Zhou T, Akopiants K, Mohapatra S, Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks. DNA Repair (Amst) 2009;8(8):901-11
   Google Scholar
• Das BB, Dexheimer TS, Maddali K, Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria. Proc Natl Acad Sci USA 2010;107(46):19790-5
   Google Scholar
• Nitiss KC, Malik M, He X, Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage. Proc Natl Acad Sci USA 2006;103(24):8953-8
   Google Scholar
• Pommier Y, Cherfils J. Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery. Trends Pharmacol Sci 2005;26(3):138-45
   Google Scholar