306
Views
22
CrossRef citations to date
0
Altmetric
Reviews

AT1 antagonists: a patent review (2008 – 2012)

, &
Pages 1483-1494 | Published online: 23 Aug 2013

Bibliography

  • Dasgupta C, Zhang L. Angiotensin II receptors and drug discovery in cardiovascular disease. Drug Discov Today 2011;16:22-34
  • Lang CC, Struthers DA. Targeting the renin–angiotensin–aldosterone system in heart failure. Nat Rev Cardiol 2013;10:125-34
  • Pessôa BS, Van der Lubbe N, Verdonk K, et al. Key developments in renin-angiotensin aldosterone system. Nat Rev Nephrol 2013;9:26-36
  • Naik P, Murumkar P, Giridhar R, et al. Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists - a perspective. Bioorg Med Chem 2010;18:8418-56
  • Tsukamoto O, Kitakaze M. It is time to reconsider the cardiovascular protection afforded by RAAS blockade-overview of RAAS systems. Cardiovasc Drugs Ther 2013;27:133-8
  • Akazawa H, Yabumoto C, Yano M, et al. ARB and cardioprotection. Cardiovasc Drugs Ther 2013;27:155-60
  • Steckelings UM, Paulis L, Unger T, et al. Emerging drugs which target rennin-angiotensin-aldosterone system. Expert Opin Emerg Drugs 2011;16:619-30
  • Castan C, Guimberteau F, Meyrueix R, et al. Multimicroparticulate oral pharmaceutical form with modified release of angiotensin II receptor antagonists. US0311315; 2009
  • Kordikowski A, Saez Munoz C, Ventosa Rull C, et al. Method for preparing amorphous combinations of Angiotensin II receptor antagonists and diuretics. WO125028; 2009
  • Ruben Dario Sinisterra M, Robston Augusto Souza DS, Frederic Jean Georges F, et al. Preparation of formulations of Angiotensin II AT1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications. US0091541; 2011
  • Castan C, Guimberteau F, Meyrueix R, et al. Multimicroparticulate oral pharmaceutical form with modified release of angiotensin II receptor antagonists. US0311315; 2009
  • Ruben D, Sinistera M, Robson Augusto DS, et al. Preparation of formulations of angiotensin II AT1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications. US08293723; 2012
  • Allison M, Gatlin MR. Pharmaceutical compositions of an AT1-receptor antagonist and insulin secretion enhancer. US07687528; 2010
  • Madan S, Rathinasabarthy V, Arora VK. Orally disintegrating compositions comprising antihypertensive agents. WO146551; 2010
  • Claudel S, Gaudin C. Method for managing the risks associated with an increase in serum creatinine during dronedarone treatment. EP2116239; 2009
  • Bergmann A. Method for the identification of patients in need of therapy having minor cognitive disorders and the treatment of such patients. US0039343; 2011
  • Melani F, Giuliani S, Maggi Carlo A. Association of xanthine oxidase inhibitors and Angiotensin II receptor antagonists and use thereof. WO141431; 2011
  • Pershadsingh HA. Novel PRAP ligands that do not cause fluid retention, edema or congestive heart failure. US0094913; 2012
  • Bonnichsen R. Cosmetic and pharmaceutical compositions comprising ACE inhibitors and/or angiotensin II receptor antagonists. US0219514; 2012
  • Jensen BV, Bonnichsen R. Use of ACE inhibitors and/or angiotensin II receptor antagonists for the improving and/or maintaining the skin tone and for the treatment of skin ageing. US0143458; 2009
  • Staudinger HW, Khanskaya IV, Sadeh J. Methods of treating COPD. MX006089; 2010
  • Baum T, Daniel H, Showalter H. Compositions and methods for treating inflammation conditions of the bowel. WO017312; 2010
  • Cheng ZJ, Vapaatalo H, Mervaala E. Angiotensin II and vascular inflammation. Med Sci Monit 2005;11:194-205
  • Dandona P, Dhindsa S, Ghanim H, et al. Angiotensin II and inflammation:the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade. J Hum Hyp 2007;21:20-7
  • Worcel M, Sagbolinski ML. Compositions and methods related to heart failure. US0118294; 2009
  • Schlinger R, Avramoff A. Process for forming solid oral dosage forms of angiotensin II receptor antagonists. US0278909; 2010
  • Anderson G, Yusuf S, Hilbrich L. Pharmaceutical combination of angiotensin II antagonists and angiotensin I converting enzyme inhibitors. US 0114046; 2008
  • Iyer EK, Rasendra JHA-KJ, Jain GK, et al. Cardiovascular combinations using renin-angiotensin inhibitors. WO010008; 2008
  • Garvey DS, Xiong C, Chia-En L, et al. Organic nitric oxide enhancing salts of angiotensin II antagonists compositions and methods of use. US0215838; 2009
  • Garvey DS. Cardiovascular compounds comprising nitric oxide enhancing groups, compositions and methods of use. US0012057; 2009
  • Notelovitz M, Bennink HJTC, Boerrigter PJ. Treatment of prevention of unscheduled bleeding in women on progestogen containing medication. US0197843; 2009
  • Norbert B, Hertzel G, Salim Y. Use of angiotensin II type 1 receptor antagonists for the prevention of stroke, diabetes and/or congestive heart failure. EP2277519; 2011
  • Wu HH, City X. Lead compound of anti-hypertensive drug and method for screening the same. US0221617; 2009
  • Mahima P, Sarvesh P. In silico identification of novel lead compounds with AT1 receptor antagonist activity: successful application of chemical database screening protocol. Org Med Chem Lett. 2012.2(1):7
  • Matsoukas J, Gavras C, Vlachakos D, et al. Compounds. WO016515; 2009
  • Matsoukas J, Maragoudakis M, Vlachakos D, et al. 1,3,5-substituted imidazoles and their use in the treatment of hypertension and methods for their preparation. MX012755; 2009
  • Matsoukas J, Gavras C, Vlachakos D, et al. 1,3 and 1,3,5 substituted imidazoles as antihypertensives. US0216854; 2010
  • Matsoukas J, Maragoudakis M, Vlachakos D. Angiotensin II receptor antagonists based on 4(5) substituted imidazoles and transdermal delivery in the treatment of hypertension and cardiovascular diseases. GR0100312B; 2007
  • Roumelioti P, Resvani A, Durdagi S, et al. An efficient synthesis of a rationally design 1,5 disubstituted imidazole AT1 angiotensin receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies. J Comput Aided Mol Des 2010;24:749-58
  • Agelis G, Resvani A, Matsoukas A, et al. Towards non-peptide Ang II AT1 receptor antagonists based on urocanic acid: rational design, synthesis and biological evaluation. Aminoacids 2011;40:411-20
  • Agelis G, Resvani A, Durdagi S, et al. The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives. Eur J Med Chem 2012;55:358-74
  • Agelis G, Resvani A, Koukoulitsa C, et al. Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent angiotensin II receptor blockers. Eur J Med Chem 2013;62:352-70
  • Mavromoustakos T, Agelis G, Resvani A, et al. Interactions of the potent synthetic AT1 antagonist analog BV6 with membrane bilayers and mesoporous silicate matrices. Biochim Biophys Acta 2013;1828:1846-55
  • Brooks C, Cheung M, Goodman K, et al. TRPV4 antagonists. WO174340; 2012
  • Amjad A, Freehold NJ, Lo MM-C, et al. Angiotensin II receptor antagonists. US0238608; 2012
  • Amjad A, Freehold NJ, Lo MM-C, et al. Angiotensin II receptor antagonists. WO140111; 2009
  • Amjad A, Lo MM-C, Franklin CQ, et al. Angiotensin II receptor antagonists. US0201621; 2011
  • Amjad A, Franklin CQ, Lo MM-C, Whitehead BR. Angiotensin II receptor antagonists. WO094242; 2009
  • Amjad A, Lo MM-C, Franklin CQ, et al. Angiotensin II receptor antagonists. WO070241; 2009
  • Almirante N, Ferrario M, Stefanini S, et al. Angiotensin II receptor antagonists. WO150007; 2009
  • Schiesser CH, Hsin IP, Ziogas J, et al. Novel Biphenyl Sartans. WO134019; 2011
  • Tan NP, Taylor MK, Bottle SE, et al. Novel paramagnetic AT1 receptor antagonists. Chem Commun 2011;47:12083-5
  • Min LJ, Mogi M, Shudou M, et al. Peroxisome proliferator-activated receptor-g activation with angiotensin II type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice. Hypertension 2012;59:1079-88
  • Martin MC, Foster MC, Brunner HR, et al. A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists. Pharmacol Rev 2013;65:809-48
  • Benson CS, Pershadsingh HA, Ho CI, et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARγ-modulating activity. Hypertension 2004;43:993-1002
  • Schupp M, Janke J, Clasen R. Angiotensin type 1 receptor blockers induce peroxisome proliferator activated receptor-γ activity. Circulation 2004;109:2054-7
  • Miura T, Higashimurayama S, Tagashira J, et al. Novel 2-pyridone derivative and pharmaceutical product containing same. US0225896; 2012
  • Miura T, Higashimurayama S, Kazuhiro O, et al. Compound containing a novel 4-alkoxypyrimidine structure and medicine containing same. US0322819; 2012
  • Miura T, Higashimurayama S, Kazuhiro O, et al. Novel sulfonamide derivative and pharmaceutical product containing same. US0122906; 2012
  • Fatheree PR, Hudson R, Murray R, et al. Dual-acting oxazole antihypertensive agents. US8372984; 2013
  • Kim JH, Lee JH, Paik SH, et al. Fimasartan, a novel angiotensin II receptor antagonist. Arch Pharm Res 2012;35:1123-6
  • Burnier M. Angiotensin II type 1 receptor blockers. Circulation 2001;103:904-12
  • Cappelo B, Di Maio C, Iervolino M, Miro A. Improvement of solubility and stability of valsartan by hydroxypropyl-b-cyclodextrin. J Incl Phenom Macro 2006;54:289-94
  • Tzoupis H, Leonis G, Megariotis G, et al. Dual inhibitors for aspartic proteases HIV-1 PR and renin: advancements in AIDS-hypertension-diabetes linkage via molecular dynamics, inhibition assays, and binding free energy calculations. J Med Chem 2012;55:5784-96
  • Fotakis C, Megariotis G, Christodouleas D, et al. Comparative study of the AT1 receptor prodrug antagonist candesartan cilexetil with other sartans on the interactions with membrane bilayers. Biochim Biophys Acta 2012;1818:3107-20
  • Ntountaniotis D, Mali G, Grdadolnik SG, et al. Thermal, dynamic and structural properties of drug AT1 antagonist olmesartan in lipid bilayers. Biochim Biophys Acta 2011;808:2995-3006
  • Fotakis C, Christodouleas D, Zoumpoulakis P, et al. Comparative biophysical studies of sartan class drug molecules losartan and candesartan (CV-11974) with membrane bilayers. J Phys Chem B 2011;115:6180-92
  • Mavromoustakos T, Chatzigeorgiou P, Koukoulitsa C, et al. Partial interdigitation of lipid bilayers. Int J Quantum Chem 2011;6:1172-83
  • Potamitis C, Chatzigeorgiou P, Siapi E, et al. Interactions of the AT1 antagonist valsartan with dipalmitoyl-phosphatidylcholine bilayers. Biochim Biophys Acta 2011;1808:1753-63
  • Potamitis C, Zervou M, Katsiaras V, et al. Antihypertensive drug valsartan in solution and at the AT1 receptor: conformational analysis, dynamic NMR spectroscopy, in silico docking and molecular dynamics simulations. J Chem Inf Model 2009;49:726-39
  • Agelis D, Resvani A, Durdagi S, et al. The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: A concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives. Eur J Med Chem 2012;55:358-74
  • Politi A, Durdagi S, Moutevelis-Minakaki P, et al. Development of accurate binding affinity predictions of novel renin inhibitors through molecular docking studies. J Mole Graph & Model 2010;29:425-35
  • Politi A, Durdagi S, Moutevelis-Minakaki P, et al. Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases. Euro J Med Chem 2009;44:3703-11
  • Agelis G, Roumelioti P, Resvani A, et al. An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT(1) Angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies. J Comput Aided Mole Des 2010;49:726-39

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.