Bibliography
- Zhu H, Lo HW. The human glioma-associated oncogene homolog 1 (Gli1) family of transcription factors in gene regulation and diseases. Curr Genomics 2010;11:238-45
- Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell 2008;15:801-12
- Banerjee U, Hadden MK. Recent advances in the design of hedgehog pathway inhibitors for the treatment of malignancies. Exp Opin Drug Discov 2014;9:751-71
- Amakye D, Jagani Z, Dorsch M. Unraveling the therapeutic potential of the hedgehog pathway in cancer. Nat Med 2013;19:1410-22
- Saran A. Basal cell carcinoma and the carcinogenic role of aberrant hedgehog signaling. Future Oncol 2010;6:1003-14
- Archer TC, Weeraratne SD, Pomeroy SL. Hedgehog-GLI pathway in medulloblastoma. J Clin Oncol 2012;30:2154-6
- Yauch RL, Dijkgraaf GJ, Alicke B, et al. Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science 2009;326:572-4
- Chang AL, Oro AE. Initial assessment of tumor regrowth after vismodegib in advanced basal cell carcinoma. Arch Dermatol 2012;148:1324-5
- Buonamici S, Williams J, Morrissey M, et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med 2010;2:51ra70
- Lee MJ, Hatton BA, Villavicencio EH, et al. Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. Proc Natl Acad Sci USA 2012;109:7859-64
- Brugières L, Remenieras A, Pierron G, et al. High frequenct of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age. J Clin Oncol 2012;30:2087-93
- Yue D, Li H, Che J, et al. Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas. J Exp Clin Cancer Res 2014;33:34
- Stecca B, Mas C, Clement V. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and RAS-MEK/AKT pathways. Proc Natl Acad Sci USA 2007;104:5895-900
- Santini R, Vinci MC, Pandolfi S, et al. Hedgehog-Gli singlaing drives self-renewal and tumorigenicity of human melanoma-initiating cells. Stem Cells 2012;30:1808-18
- Hosoya T, Arai MA, Koyano T, et al. Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription. ChemBioChem 2008;9:1082-92
- Arai MA, Tateno C, Koyano T, et al. New hedgehog/GLI-signaling inhibitors from Adenium obesum. Org Biomol Chem 2011;9:1133-9
- Infante P, Mori M, Alfonsi R, et al. Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. EMBO J 2015;34:200-17
- Arai MA, Uchida K, Sadhu SK, et al. Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1-DNA-complex formation. Beilstein J Org Chem 2014;10:134-40
- Arai MA, Fujimatsu T, Uchida K, et al. Hh signaling inhibitors from Vitex negundo; naturally occurring inhibitors of the GLI1-DNA complex. Mol BioSyst 2013;9:1012-18
- The Regents Of The University Of California. Targeting gli proteins in human cancer by small molecules. WO116651;2014
- The Regents Of The University Of California. Targeting gli proteins in human cancer by small molecules. WO067814;2007