Advanced search
Publication Cover
Expert Opinion on Therapeutic Patents Volume 26, 2016 - Issue 2
Submit an article Journal homepage
1,538
Views
108
CrossRef citations to date
0
Altmetric
Reviews

Topical drug delivery systems: a patent review

Deepinder Singh MalikDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India
,
Neeraj MitalDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India
&
Gurpreet KaurDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, IndiaCorrespondence[email protected]
Pages 213-228 | Received 22 Jun 2015, Accepted 09 Dec 2015, Published online: 08 Jan 2016

References

  • Papers of special note have been highlighted as
  • • of interest
  • •• of considerable interest
  • Chen HY, Fang JY. Therapeutic patents for topical and transdermal drug delivery systems. Expert Opin Ther Pat. 2000;10:1035–1043.
  • Tripathi KD. Essentials of medical pharmacology. New Delhi: JP Medical Ltd; 2013.
  • Mycek MJ, Harvey RA, Champe RC. Lippincott’s illustrated reviews pharmacology. Philadelphia (PA): Lippincott-Raven; 2009.
  • TorinHuzil J, Sivaloganathan S, Kohandel M, et al. Drug delivery through the skin: molecular simulations of barrier lipids to design more effective noninvasive dermal and transdermal delivery systems for small molecules, biologics, and cosmetics. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011;3:449–462.
  • Joshi M, Butola BS, Saha K. Advances in topical drug delivery system: micro to nanofibrous structures. J Nanosci Nanotechnol. 2014;14:853–867.
  • Brown MB, Martin GP, Jones SA, et al. Dermal and transdermal drug delivery systems: current and future prospects. Drug Delivery. 2006;13:175–187.
  • Wong TW, Dhanawat M, Rathbone MJ. Vaginal drug delivery: strategies and concerns in polymeric nanoparticle development. Expert Opin Drug Delivery. 2014;11:1419–1434.
  • Pham J, Nayel A, Hoang C, et al. Enhanced effectiveness of tocotrienol-based nano-emulsified system for topical delivery against skin carcinomas. Drug Delivery. 2014;1–11. DOI:10.3109/10717544.2014.966925.
  • Chen M, Kumar S, Anselmo AC, et al. Topical delivery of Cyclosporine A into the skin using SPACE-peptide. J Controlled Release. 2015;199:190–197.
  • Cosco D, Paolino D, Maiuolo J, et al. Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery. Int J Pharm. 2015;489:1–10.
  • Zhang YT, Shen LN, Zhao JH, et al. Evaluation of psoralenethosomes for topical delivery in rats by using in vivo microdialysis. Int J Nanomed. 2014;9:669.
  • Bikkad ML, Nathani AH, Mandlik SK, et al. Halobetasol propionate-loaded solid lipid nanoparticles (SLN) for skin targeting by topical delivery. J Liposome Res. 2014;24:113–123.
  • Frederiksen K, Guy RH, Petersson K. Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin. Eur J Pharm Biopharm. 2015;91:9–15.
  • Lathiyare KB, Jain V. Development and characterization of karanj oil based proniosomal gel for topical delivery. Res J Pharm Technol. 2014;7:959–962.
  • Mohammed NN, Pandey P, Khan NS, et al. Clotrimazole-cyclodextrin-based approach for the management and treatment of Candidiasis-a formulation and chemistry-based evaluation. Pharm Dev Technol. 2015;1–11. DOI:10.3109/10837450.2015.1041041.
  • Baffoe CS, Nguyen N, Boyd P, et al. Disulfiram‐loaded immediate and extended release vaginal tablets for the localised treatment of cervical cancer. J Pharm Pharmacol. 2015;67:189–198.
  • Singh VK, Anis A, Banerjee I, et al. Preparation and characterization of novel carbopol based bigels for topical delivery of metronidazole for the treatment of bacterial vaginosis. Mater Sci Eng C. 2014;44:151–158.
  • Mbah C, Builders P, Nzekwe I, et al. Formulation and in vitro evaluation of pH-responsive ethosomes for vaginal delivery of metronidazole. J Drug Delivery Sci Technol. 2014;24:565–571.
  • Elosaily GH, Salem HA, Hassan AM, et al. Formulation, In vitro and In vivo evaluation of nystatin topical gel. J Am Sci. 2014;10:75–85.
  • Boyd P, Major I, Wang W, et al. Development of disulfiram-loaded vaginal rings for the localised treatment of cervical cancer. Eur J Pharm Biopharm. 2014;88:945–953.
  • Asasutjarit R, Theerachayanan T, Kewsuwan P, et al. Development and evaluation of diclofenac sodium loaded-n-trimethyl chitosan nanoparticles for ophthalmic use. AAPS Pharm Sci Tech. 2015;16:1013–1024.
  • Lidich N, Wachtel EJ, Aserin A, et al. Water-dilutable microemulsions for transepithelial ocular delivery of riboflavin phosphate. J Colloid Interface Sci. 2015. DOI:10.1016/j.jcis.2015.02.011.
  • Dong Y, Dong P, Huang D, et al. Fabrication and characterization of silk fibroin-coated liposomes for ocular drug delivery. Eur J Pharm Biopharm. 2015;91:82–90.
  • Mahajan HS, Deshmukh SR. Development and evaluation of gel-forming ocular films based on xyloglucan. Carbohydr Polym. 2015;122:243–247.
  • Jaiswal M, Kumar M, Pathak K. Zero order delivery of itraconazole via polymeric micelles incorporated in situ ocular gel for the management of fungal keratitis. Colloids Surf B Biointerfaces. 2015;130:23–30.
  • Garapati C, Clarke B, Zadora S, et al. Development and characterization of erythrosine nanoparticles with potential for treating sinusitis using photodynamic therapy. Photodiagnosis Photodyn Ther. 2015;12:9–18.
  • Maiti S, Chakravorty A, Chowdhury M. Gellan co-polysaccharide micellar solution of budesonide for allergic anti-rhinitis: an in vitro appraisal. Int J Biol Macromol. 2014;68:241–246.
  • Xu X, Shen Y, Wang W, et al. Preparation and in vitro characterization of thermosensitive and mucoadhesive hydrogels for nasal delivery of phenylephrine hydrochloride. Eur J Pharm Biopharm. 2014;88:998–04.
  • Waugh A, Grant A. Anatomy and physiology in health and illness. Ross & Wilson: Elsevier Health Sciences; 2014.
  • Gupta M, Agrawal U, Vyas SP. Nanocarrier-based topical drug delivery for the treatment of skin diseases. Expert Opin Drug Delivery. 2012;9:783–784.
  • Bruno BJ, Miller GD, Lim CS. Basics and recent advances in peptide and protein drug delivery. Ther Delivery. 2013;4:1443–1467.
  • Fleischer AB, Feldman SR, Rapp SR. The magnitude of skin disease in the United States. Dermatol Clin. 2000;18:15–21.

•• This review summarizes the common skin infection, their prevalence and available treatment options.

  • Dawson AL, Dellavalle RP, Elston DM. Infectious skin diseases: a review and needs assessment. Dermatol Clin. 2012;30:141–151.
  • Prausnitz MR, Elias PM, Franz TJ, et al. Skin barrier and transdermal drug delivery. Dermatology. Philadelphia (PA): Elsevier Saunders; 2012.
  • Epikinetics Pharma LLC. Waterborne topical compositions for the delivery of active ingredients such as azelaic acid. US8729108 B2. 2014.
  • Draelos ZD. Cosmetic dermatology: products and procedures. West Sussex: John Wiley & Sons; 2011.
  • Habif TP, Chapman MS, Campbell JL Jr, et al. Skin disease: diagnosis and treatment. Philadelphia (PA): Elsevier Health Sciences; 2011.
  • Swansea University. Topical drug patch including microsphere. WO 2015/025119A1. 2015.
  • Emisphere Technologies, Inc. Topical administration of acyclovir. US 8771712B2. 2014.
  • Iqbal MA, Md S, Sahni JK. Nanostructured lipid carriers system: recent advances in drug delivery. J Drug Targeting. 2012;20:813–830.

• This review highlights the recent innovations in drug delivery.

  • Florida Agricultural and Mechanical University, Tallahassee, FL (US). Nanoparticle formulations for skin delivery. US8715736B2. 2014.
  • Rathinamoorthy R. Nanofiber for drug delivery system–principle and application. Pak Text J. 2012;61:45–48.
  • Conifer Living Formulas PTE Ltd, Clearbridge Nanomedics PTE Ltd. Topical treatment delivery system. WO2014098764A1. 2014.
  • The National University of Singapore. A composite, method of producing the composite and uses of the same. WO2006036130A1. 2006.
  • Alpha And Omega Semiconductor Limited. Semi-conductor package having a bridged plate interconnection. WO2009045342A1. 2009.
  • Hyosung Corp. Method for preparing a cosmetic web and a cosmetic web prepared thereby electrospinning. KR20110077792. 2011.
  • Notus Laboratories, Inc. Drug delivery compositions and methods using nanofiber webs. US20110229551A1. 2011.
  • Cheung K, Das DB. Microneedles for drug delivery: trends and progress. Drug Delivery. 2015. DOI:10.3109/10717544.2014.986309.
  • 3M Innovation Properties Company. Microneedle devices and methods. US 20140066843 A1. 2014.
  • Vermani K, Garg S. The scope and potential of vaginal drug delivery. Pharm Sci Technol Today. 2000;3:359–364.

•• Comprehensive review demonstrates the potential of vagina as an alternative route for the drug delivery.

  • Bassi P, Kaur G. Innovations in bioadhesive vaginal drug delivery system. Expert Opin Ther Pat. 2012;22:1019–1032.
  • Srikrishna S, Cardozo L. The vagina as a route for drug delivery: a review. Int Urogynecol J. 2013;24:537–543.
  • Frank LA, Sandri G, D’Autilia F, et al. Chitosan gel containing polymeric nanocapsules: a new formulation for vaginal drug delivery. Int J Nanomed. 2014;9:3151.
  • Caramella CM, Rossi S, Ferrari F, et al. Mucoadhesive and thermogelling systems for vaginal drug delivery. Adv Drug Delivery Rev. 2015. DOI:10.1016/j.addr.2015.02.001.
  • Hiorth M, Nilsen S, Tho I. Bioadhesive mini-tablets for vaginal drug delivery. Pharmaceutics. 2014;6:494–511.
  • Ashok V, Kumar RM, Murali D, et al. A review on vaginal route as a systemic drug delivery. Crit Rev Sci Res. 2012;1:1–19.
  • University of Utah Research Foundation. Glycol chitin based thermosensitive hydrogel for vaginal delivery of progesterone. WO2015/073066A1. 2015.
  • Li Z, Guan J. Thermosensitive hydrogels for drug delivery. Expert Opin Drug Delivery. 2011;8:991–1007.
  • Creighton University. Polymeric nanoparticles in a thermosensitive gel for coital-independent vaginal prophylaxis of HIV. US 20150190398. 2015.
  • Castelo-Branco C, Cancelo MJ, Villero J, et al. Management of post-menopausal vaginal atrophy and atrophic vaginitis. Maturitas. 2005;52:46–52.
  • Medlite A/S. Formulation for treatment of vaginal dryness. US9005597B2. 2015.
  • AptalisPharmatech, Inc. Rapid dissolve tablet compositions for vaginal administration. US20140134246A1. 2014.
  • Tan HS, Pfister WR. Pressure-sensitive adhesives for transdermal drug delivery systems. Pharm Sci Technol Today. 1999;2:60–69.
  • Agile Therapeutics, Inc. Transdermal contraceptive delivery system and process. US7045145B1. 2006.
  • Agile Therapeutics, Inc. Skin permeation enhancement composition for transdermal hormone delivery system. US7384650B2. 2008.
  • Cygnus Inc. Solid matrix system for transdermal drug delivery. US5770219A. 1998.
  • Agile Therapeutics, Inc. Transdermal hormone delivery system: compositions and methods. US8221785B2. 2012.
  • Noven Pharmaceuticals, Inc. Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol WO2014106014A1. 2014.
  • Reich G. Formulation and physical properties of soft capsules. London: Pharmaceutical Press; 2004.
  • Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositons and methods. WO2015/073177A1. 2015.
  • Universidad De Chile, Laboratories Andromaco S.A. Vaginal ring comprising DHEA or DHEA sulfate and optionally a release-modulating agent of the active principle, useful to increase the ovarian reserve in women and to relieve symptoms associated with menopause. US20150004214A1. 2015.
  • Davies NM. Biopharmaceutical considerations in topical ocular drug delivery. Clin Exp Pharmacol Physiol. 2000;27:558–562.

•• This review article summarizes the important considerations before formulating topical ocular drug delivery.

  • Geroski DH, Edelhauser HF. Drug delivery for posterior segment eye disease. Invest Ophthalmol Visual Sci. 2000;41:961–964.
  • Mittal N, Kaur G. In situ gelling ophthalmic drug delivery system: formulation and evaluation. J Appl Polym Sci. 2014;131:1–9.
  • Ribeiro F, Veiga D, Santos JJ, et al. Bioinspired imprinted PHEMA-hydrogels for ocular delivery of carbonic anhydrase inhibitor drugs. Biomacromolecules. 2011;12:701–709.
  • Nagai N, Yoshioka C, Mano Y, et al. A nanoparticle formulation of disulfiram prolongs corneal residence time of the drug and reduces intraocular pressure. Exp Eye Res. 2015;132:115–123.
  • Khandan O, Kahook MY, Rao MP. Fenestrated microneedles for ocular drug delivery. Sens Actuators B. 2016;223:15–23.
  • GNT, LLC. Ophthalmic lipophilic and hydrophilic drug delivery vehicle formulations. WO 2014/204791A1. 2014.
  • Eye CRO, LLC. Microemulsion topical delivery platform. US 8968775B2. 2015.
  • Fialho SL, Silva‐Cunha D. New vehicle based on a microemulsion for topical ocular administration of dexamethasone. Clin Experiment Ophthalmol. 2004;32:626–632.
  • Trivedi R, Kompella UB. Nanomicellar formulations for sustained drug delivery: strategies and underlying principles. Nanomedicine. 2010;5:485–05.
  • Aurinia Pharmaceuticals, Inc. Topical drug delivery systems for ophthalmic use. US 9017725B2. 2015.
  • Auburn University, Auburn. Contact drug delivery system. US 2012/0087971A1. 2012.
  • Rosenthal P, Cotter JM, Baum J. Treatment of persistent corneal epithelial defect with extended wear of a fluid-ventilated gas-permeable scleral contact lens. Am J Ophthalmol. 2000;130:33–41.
  • Jade Therapeutics, LLC. Ocular drug delivery system. US 2014/0107025A1. 2014.
  • Ugwoke MI, Agu RU, Verbeke N, et al. Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives. Adv Drug Deliv Rev. 2005;57:1640–1665.
  • Brar V, Kaur G. Biopolymers as carriers for nasal drug delivery. Polym–Plast Technol Eng. 2014;53:1518–1531.
  • Arora P, Sharma S, Garg S. Permeability issues in nasal drug delivery. Drug Discov Today. 2002;7:967–975.
  • Elliott KA, Stringer SP. Evidence-based recommendations for antimicrobial nasal washes in chronic rhinosinusitis. Am J Rhinol. 2006;20:1–6.
  • Ugwoke MI, Verbeke N, Kinget R. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J Pharm Pharmacol. 2001;53:3–21.

• This article provides an insight into the delivery of drugs to nasal mucosa.

  • Kleinstreuer C, Zhang Z, Donohue JF. Targeted drug-aerosol delivery in the human respiratory system. Annu Rev Biomed Eng. 2008;10:195–20.
  • Alfadhel M, Puapermpoonsiri U, Ford SJ, et al. Lyophilized inserts for nasal administration harboring bacteriophage selective for Staphylococcus aureus: in vitro evaluation. Int J Pharm. 2011;416:280–287.
  • Demirhan H, Aksoy F, Ozturan O, et al. Medical treatment of adenoid hypertrophy with fluticasone propionate nasal drops. Int J Pediatr Otorhinolaryngol. 2010;74:773–776.
  • Lee LA, Sterling R, Maspero J, et al. Growth velocity reduced with once-daily fluticasone furoate nasal spray in prepubescent children with perennial allergic rhinitis. J Allergy Clin Immunol Pract. 2014;2:421–427.
  • El-Gizawy SA, Osman MA, El-Hagaar SM, et al. Nasal drug delivery of a mucoadhesive oxybutynin chloride gel: in vitro evaluation and in vivo in situ study in experimental rats. J Drug Delivery Sci Technol. 2014;23:569–575.
  • Scherließ R, Monckedieck M, Young K, et al. First in vivo evaluation of particulate nasal dry powder vaccine formulations containing ovalbumin in mice. Int J Pharm. 2015;479:408–415.
  • Shan Z, Tan Y, Qin L, et al. Formulation and evaluation of novel reverse microemulsions containing salmon calcitonin in hydrofluoroalkane propellants. Int J Pharm. 2014;466:390–399.
  • Lost Creek Consulting, LLC. Honey nasal rinse. US 2014/0199266A1. 2014.
  • MedInvent, LLC. Method for nasal irrigation and drug delivery. US 8146587B2. 2012.
  • The Foundry, LLC. Methods and systems for toxin delivery to the nasal cavity. US 2014/0114233A1. 2014.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.