Search in:

Expert Opinion on Investigational Drugs Volume 18, 2009 - Issue 11

Submit an article Journal homepage

570

Views

CrossRef citations to date

Altmetric

Reviews

Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing

Simon Graham University of Leeds, School of Medicine, Leeds General Infirmary Teaching Hospitals NHS Trust, Academic Department of Trauma and Orthopaedics, Clarendon Wing A, Great George Street, Leeds LS1 3EX, UK +44 0 113 392 2621; +44 0 113 392 3290; [email protected]

, MBChB,

Andreas Leonidou University of Leeds, School of Medicine, Leeds General Infirmary Teaching Hospitals NHS Trust, Academic Department of Trauma and Orthopaedics, Clarendon Wing A, Great George Street, Leeds LS1 3EX, UK +44 0 113 392 2621; +44 0 113 392 3290; [email protected]

, MBChB MRCS,

Marie Lester University of Leeds, School of Medicine, Leeds General Infirmary Teaching Hospitals NHS Trust, Academic Department of Trauma and Orthopaedics, Clarendon Wing A, Great George Street, Leeds LS1 3EX, UK +44 0 113 392 2621; +44 0 113 392 3290; [email protected]

, MBChB,

Manolis Heliotis Reader (Chemical Engineering Department), Imperial College London, England, UK

, MSc FDS FRCS,

Athanasios Mantalaris Reader (Chemical Engineering Department), Imperial College London, England, UK

, PhD &

Eleftherios Tsiridis University of Leeds, School of Medicine, Leeds General Infirmary Teaching Hospitals NHS Trust, Academic Department of Trauma and Orthopaedics, Clarendon Wing A, Great George Street, Leeds LS1 3EX, UK +44 0 113 392 2621; +44 0 113 392 3290; [email protected]

, MD MSc PhD FRCS

Pages 1633-1654 | Published online: 13 Sep 2009

Cite this article
https://doi.org/10.1517/13543780903241607

Full Article
Figures & data
References
Citations
Metrics
Reprints & Permissions

Bibliography

Claesson-Welsh L, Heldin CH. Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors. Acta Oncol 1989;28(3):331-4
PubMed Web of Science ®Google Scholar
Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999;79(4):1283-316
PubMed Web of Science ®Google Scholar
Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008;22(10):1276-312
PubMed Web of Science ®Google Scholar
Andrew JG, Hoyland JA, Freemont AJ, Marsh DR. Platelet-derived growth factor expression in normally healing human fractures. Bone 1995;16(4):455-60
PubMed Web of Science ®Google Scholar
McCarthy HS, Williams JH, Davie MW, Marshall MJ. Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. J Cell Physiol 2009;218(2):350-4
PubMed Web of Science ®Google Scholar
Zhang L, Leeman E, Carnes DC, Graves DT. Human osteoblasts synthesize and respond to platelet-derived growth factor. Am J Physiol 1991;261(2 Pt 1):C348-54
PubMed Web of Science ®Google Scholar
Zhang Z, Chen J, Jin D. Platelet-derived growth factor (PDGF)-BB stimulates osteoclastic bone resorption directly: the role of receptor beta. Biochem Biophys Res Commun 1998;251(1):190-4
PubMed Web of Science ®Google Scholar
Howell TH, Fiorellini JP, Paquette DW, A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. J Periodontol 1997;68(12):1186-93
PubMed Web of Science ®Google Scholar
Nevins M, Giannobile WV, McGuire MK, Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. J Periodontol 2005;76(12):2205-15
PubMed Web of Science ®Google Scholar
Heldin CH, Eriksson U, Ostman A. New members of the platelet-derived growth factor family of mitogens. Arch Biochem Biophys 2002;398(2):284-90
PubMed Web of Science ®Google Scholar
Horner A, Bord S, Kemp P, Distribution of platelet-derived growth factor (PDGF) A chain mRNA, protein, and PDGF-alpha receptor in rapidly forming human bone. Bone 1996;19(4):353-62
PubMed Web of Science ®Google Scholar
Fujii H, Kitazawa R, Maeda S, Expression of platelet-derived growth factor proteins and their receptor alpha and beta mRNAs during fracture healing in the normal mouse. Histochem Cell Biol 1999;112(2):131-8
PubMed Web of Science ®Google Scholar
Barnes GL, Kostenuik PJ, Gerstenfeld LC, Einhorn TA. Growth factor regulation of fracture repair. J Bone Miner Res 1999;14(11):1805-15
PubMed Web of Science ®Google Scholar
Soriano P. The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 1997;124(14):2691-700
PubMed Web of Science ®Google Scholar
Mannaioni PF, Di Bello MG, Masini E. Platelets and inflammation: role of platelet-derived growth factor, adhesion molecules and histamine. Inflamm Res 1997;46(1):4-18
PubMed Web of Science ®Google Scholar
Slater M, Patava J, Kingham K, Mason RS. Involvement of platelets in stimulating osteogenic activity. J Orthop Res 1995;13(5):655-63
PubMed Web of Science ®Google Scholar
Tanaka H, Liang CT. Effect of platelet-derived growth factor on DNA synthesis and gene expression in bone marrow stromal cells derived from adult and old rats. J Cell Physiol 1995;164(2):367-75
PubMed Web of Science ®Google Scholar
Pfeilschifter J, Oechsner M, Naumann A, Stimulation of bone matrix apposition in vitro by local growth factors: a comparison between insulin-like growth factor I, platelet-derived growth factor, and transforming growth factor beta. Endocrinology 1990;127(1):69-75
PubMed Web of Science ®Google Scholar
Tsukamoto T, Matsui T, Fukase M, Fujita T. Platelet-derived growth factor B chain homodimer enhances chemotaxis and DNA synthesis in normal osteoblast-like cells (MC3T3-E1). Biochem Biophys Res Commun 1991;175(3):745-51
PubMed Web of Science ®Google Scholar
Centrella M, McCarthy TL, Kusmik WF, Canalis E. Relative binding and biochemical effects of heterodimeric and homodimeric isoforms of platelet-derived growth factor in osteoblast-enriched cultures from fetal rat bone. J Cell Physiol 1991;47(3):420-6
Google Scholar
Canalis E, McCarthy TL, Centrella M. Effects of platelet-derived growth factor on bone formation in vitro. J Cell Physiol 1989;140(3):530-7
PubMed Web of Science ®Google Scholar
Canalis E. Effect of platelet-derived growth factor on DNA and protein synthesis in cultured rat calvaria. Metabolism 1981;30(10):970-5
PubMed Web of Science ®Google Scholar
Herbertson A, Aubin JE. Dexamethasone alters the subpopulation make-up of rat bone marrow stromal cell cultures. J Bone Miner Res 1995;10(2):285-94
PubMed Web of Science ®Google Scholar
Tokunaga A, Oya T, Ishii Y, PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res 2008;23(9):1519-28
PubMed Web of Science ®Google Scholar
Hock JM, Canalis E. Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts. Endocrinology 1994;134(3):1423-8
PubMed Web of Science ®Google Scholar
Canalis E, Pash J, Gabbitas B, Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures. Endocrinology 1993;133(1):33-8
PubMed Web of Science ®Google Scholar
Kim HD, Valentini RF. Human osteoblast response in vitro to platelet-derived growth factor and transforming growth factor-beta delivered from controlled-release polymer rods. Biomaterials 1997;18(17):1175-84
PubMed Web of Science ®Google Scholar
Bateman J, Intini G, Margarone J, Platelet-derived growth factor enhancement of two alloplastic bone matrices. J Periodontol 2005;76(11):1833-41
PubMed Web of Science ®Google Scholar
Intini G, Andreana S, Margarone JEIII, Engineering a bioactive matrix by modifications of calcium sulfate. Tissue Eng 2002;8(6):997-1008
PubMedGoogle Scholar
Pittenger MF, Mackay AM, Beck SC, Multilineage potential of adult human mesenchymal stem cells. Science 1999;284(5411):143-7
PubMed Web of Science ®Google Scholar
Fiedler J, Roderer G, Gunther KP, Brenner RE. BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells. J Cell Biochem 2002;87(3):305-12
PubMed Web of Science ®Google Scholar
Yang D, Chen J, Jing Z, Jin D. Platelet-derived growth factor (PDGF)-AA: a self-imposed cytokine in the proliferation of human fetal osteoblasts. Cytokine 2000;12(8):1271-4
PubMed Web of Science ®Google Scholar
Chaudhary LR, Hofmeister AM, Hruska KA. Differential growth factor control of bone formation through osteoprogenitor differentiation. Bone 2004;34(3):402-11
PubMed Web of Science ®Google Scholar
Jilka RL, Hangoc G, Girasole G, Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 1992;257(5066):88-91
PubMed Web of Science ®Google Scholar
Franchimont N, Durant D, Rydziel S, Canalis E. Platelet-derived growth factor induces interleukin-6 transcription in osteoblasts through the activator protein-1 complex and activating transcription factor-2. J Biol Chem 1999;274(10):6783-9
PubMed Web of Science ®Google Scholar
van den Dolder J, Mooren R, Vloon AP, Platelet-rich plasma: quantification of growth factor levels and the effect on growth and differentiation of rat bone marrow cells. Tissue Eng 2006;12(11):3067-73
PubMedGoogle Scholar
Lucarelli E, Beccheroni A, Donati D, Platelet-derived growth factors enhance proliferation of human stromal stem cells. Biomaterials 2003;24(18):3095-100
PubMed Web of Science ®Google Scholar
Gruber R, Karreth F, Kandler B, Platelet-released supernatants increase migration and proliferation, and decrease osteogenic differentiation of bone marrow-derived mesenchymal progenitor cells under in vitro conditions. Platelets 2004;15(1):29-35
PubMed Web of Science ®Google Scholar
Arpornmaeklong P, Kochel M, Depprich R, Influence of platelet-rich plasma (PRP) on osteogenic differentiation of rat bone marrow stromal cells. An in vitro study. Int J Oral Maxillofac Surg 2004;33(1):60-70
PubMed Web of Science ®Google Scholar
Gruber R, Karreth F, Frommlet F, Platelets are mitogenic for periosteum-derived cells. J Orthop Res 2003;21(5):941-8
PubMed Web of Science ®Google Scholar
Humphrey EL, Williams JH, Davie MW, Marshall MJ. Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells. Bone 2006;38(5):652-61
PubMed Web of Science ®Google Scholar
Quinn JM, Horwood NJ, Elliott J, Fibroblastic stromal cells express receptor activator of NF-kappa B ligand and support osteoclast differentiation. J Bone Miner Res 2000;15(8):1459-66
PubMed Web of Science ®Google Scholar
Hofbauer LC, Heufelder AE. Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology. J Mol Med 2001;79(5-6):243-53
PubMed Web of Science ®Google Scholar
Cross SS, Yang Z, Brown NJ, Osteoprotegerin (OPG)–a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis? Int J Cancer 2006;118(8):1901-8
PubMed Web of Science ®Google Scholar
Tokuda H, Takai S, Hanai Y, Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts. J Bone Miner Metab 2008;26(4):335-41
PubMed Web of Science ®Google Scholar
Nicosia RF, Nicosia SV, Smith M. Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. Am J Pathol 1994;145(5):1023-9
PubMed Web of Science ®Google Scholar
Wilson RJ, Rhodes SA, Wood RL, Functional pharmacology of human prostanoid EP2 and EP4 receptors. Eur J Pharmacol 2004;501(1-3):49-58
PubMed Web of Science ®Google Scholar
Ke HZ, Shen VW, Qi H, Prostaglandin E2 increases bone strength in intact rats and in ovariectomized rats with established osteopenia. Bone 1998;23(3):249-55
PubMed Web of Science ®Google Scholar
Li XJ, Jee WS, Li YL, Patterson-Buckendahl P. Transient effects of subcutaneously administered prostaglandin E2 on cancellous and cortical bone in young adult dogs. Bone 1990;11(5):353-64
PubMed Web of Science ®Google Scholar
Dekel S, Lenthall G, Francis MJ. Release of prostaglandins from bone and muscle after tibial fracture. An experimental study in rabbits. J Bone Joint Surg Br 1981;63-B(2):185-9
PubMed Web of Science ®Google Scholar
Keller J, Bunger C, Andreassen TT, Bone repair inhibited by indomethacin. Effects on bone metabolism and strength of rabbit osteotomies. Acta Orthop Scand 1987;58(4):379-83
PubMedGoogle Scholar
Voegeli TL, Chapman MW. Utilization of prostaglandin in fracture healing. Trans Orthop Res Soc 1985;10:134 [abstract]
Google Scholar
Chen QR, Miyaura C, Higashi S, Activation of cytosolic phospholipase A2 by platelet-derived growth factor is essential for cyclooxygenase-2-dependent prostaglandin E2 synthesis in mouse osteoblasts cultured with interleukin-1. J Biol Chem 1997;272(9):5952-8
PubMed Web of Science ®Google Scholar
Rasubala L, Yoshikawa H, Nagata K, Platelet-derived growth factor and bone morphogenetic protein in the healing of mandibular fractures in rats. Br J Oral Maxillofac Surg 2003;41(3):173-8
PubMed Web of Science ®Google Scholar
Tyndall WA, Beam HA, Zarro C, Decreased platelet derived growth factor expression during fracture healing in diabetic animals. Clin Orthop Relat Res 2003;408:319-30
PubMedGoogle Scholar
Tanaka H, Wakisaka A, Ogasa H, Effect of IGF-I and PDGF administered in vivo on the expression of osteoblast-related genes in old rats. J Endocrinol 2002;174(1):63-70
PubMedGoogle Scholar
Street JT, Wang JH, Wu QD, The angiogenic response to skeletal injury is preserved in the elderly. J Orthop Res 2001;19(6):1057-66
PubMed Web of Science ®Google Scholar
Nash TJ, Howlett CR, Martin C, Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 1994;15(2):203-8
PubMed Web of Science ®Google Scholar
Arm DM, Tencer AF, Bain SD, Celino D. Effect of controlled release of platelet-derived growth factor from a porous hydroxyapatite implant on bone ingrowth. Biomaterials 1996;17(7):703-9
PubMed Web of Science ®Google Scholar
Lynch SE, de Castilla GR, Williams RC, The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing. J Periodontol 1991;62(7):458-67
PubMed Web of Science ®Google Scholar
Simion M, Rocchietta I, Kim D, Vertical ridge augmentation by means of deproteinized bovine bone block and recombinant human platelet-derived growth factor-BB: a histologic study in a dog model. Int J Periodontics Restorative Dent 2006;26(5):415-23
PubMed Web of Science ®Google Scholar
Hollinger JO, Onikepe AO, MacKrell J, Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-BB and an injectable beta-tricalcium phosphate/collagen matrix. J Orthop Res 2008;26(1):83-90
PubMed Web of Science ®Google Scholar
Mitlak BH, Finkelman RD, Hill EL, The effect of systemically administered PDGF-BB on the rodent skeleton. J Bone Miner Res 1996;11(2):238-47
PubMed Web of Science ®Google Scholar
Macey LR, Kana SM, Jingushi S, Defects of early fracture-healing in experimental diabetes. J Bone Joint Surg Am 1989;71(5):722-33
PubMedGoogle Scholar
Verhaeghe J, van Herck E, Visser WJ, Bone and mineral metabolism in BB rats with long-term diabetes. Decreased bone turnover and osteoporosis. Diabetes 1990;39(4):477-82
PubMed Web of Science ®Google Scholar
Kagel EM, Einhorn TA. Alterations of fracture healing in the diabetic condition. Iowa Orthop J 1996;16:147-52
PubMedGoogle Scholar
Loder RT. The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop Relat Res 1988;232:210-16
PubMed Web of Science ®Google Scholar
Ranly DM, McMillan J, Keller T, Platelet-derived growth factor inhibits demineralized bone matrix-induced intramuscular cartilage and bone formation. A study of immunocompromised mice. J Bone Joint Surg Am 2005;87(9):2052-64
PubMedGoogle Scholar
Roussy Y, Bertrand Duchesne MP, Gagnon G. Activation of human platelet-rich plasmas: effect on growth factors release, cell division and in vivo bone formation. Clin Oral Implants Res 2007;18(5):639-48
PubMed Web of Science ®Google Scholar
Libin BM, Ward HL, Fishman L. Decalcified, lyophilized bone allografts for use in human periodontal defects. J Periodontol 1975;46(1):51-6
PubMed Web of Science ®Google Scholar
Sarment DP, Cooke JW, Miller SE, Effect of rhPDGF-BB on bone turnover during periodontal repair. J Clin Periodontol 2006;33(2):135-40
PubMed Web of Science ®Google Scholar
McGuire MK, Kao RT, Nevins M, Lynch SE. rhPDGF-BB promotes healing of periodontal defects: 24-month clinical and radiographic observations. Int J Periodontics Restorative Dent 2006;26(3):223-31
PubMed Web of Science ®Google Scholar
Eastell R, Robins SP, Colwell T, Evaluation of bone turnover in type I osteoporosis using biochemical markers specific for both bone formation and bone resorption. Osteoporos Int 1993;3(5):255-60
PubMed Web of Science ®Google Scholar
Giannobile WV, Lynch SE, Denmark RG, Crevicular fluid osteocalcin and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. A pilot study in beagle dogs. J Clin Periodontol 1995;22(12):903-10
PubMed Web of Science ®Google Scholar
Sharp JD, White DL, Chiou XG, Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2. J Biol Chem 1991;266(23):14850-3
PubMed Web of Science ®Google Scholar
Hollinger JO, Hart CE, Hirsch SN, Recombinant human platelet-derived growth factor: biology and clinical applications. J Bone Joint Surg Am 2008;90(Suppl 1):48-54
PubMed Web of Science ®Google Scholar

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing

Bibliography

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing

Bibliography

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date