Novel IκB kinase inhibitors for treatment of nuclear factor-κB-related diseases

Bibliography

• Ghosh S, Hayden MS. New regulators of NF-kappaB in inflammation. Nat Rev Immunol 2008;8:837-4
   PubMed Web of Science ®Google Scholar
• Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5:749-59
   PubMed Web of Science ®Google Scholar
• Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-kappaB activity. Annu Rev Immunol 2000;18:621-63
   PubMed Web of Science ®Google Scholar
• Bollrath J, Greten FR. IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep 2009;10:1314-19
   PubMed Web of Science ®Google Scholar
• Oeckinghaus A, Ghosh S. The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 2009;1:a000034
   PubMed Web of Science ®Google Scholar
• Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002;109:S81-96
   PubMed Web of Science ®Google Scholar
• Gerondakis S, Grossmann M, Nakamura Y, Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts. Oncogene 1999;18:6888-95
   PubMed Web of Science ®Google Scholar
• Caamano J, Hunter CA. NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions. Clin Microbiol Rev 2002;15:414-29
   PubMed Web of Science ®Google Scholar
• Onai Y, Suzuki J, Kakuta T, Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc Res 2004;63:51-9
   PubMed Web of Science ®Google Scholar
• Onai Y, Suzuki J, Maejima Y, Inhibition of NF-kappaB improves left ventricular remodeling and cardiac dysfunction after myocardial infarction. Am J Physiol Heart Circ Physiol 2007;292:H530-8
   PubMed Web of Science ®Google Scholar
• Wakatsuki S, Suzuki J, Ogawa M, A novel IKK inhibitor suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration. Expert Opin Ther Targets 2008;12:1469-76
   PubMed Web of Science ®Google Scholar
• Okazaki Y, Sawada T, Nagatani K, Effect of nuclear factor-kappaB inhibition on rheumatoid fibroblast-like synoviocytes and collagen induced arthritis. J Rheumatol 2005;32:1440-7
   PubMed Web of Science ®Google Scholar
• Burke JR, Pattoli MA, Gregor KR, BMS-345541 is a highly selective inhibitor of IkappaB kinase that binds at an allosteric site of the enzyme and blocks NF-kappaB-dependent transcription in mice. J Biol Chem 2003;278:1450-6
   PubMed Web of Science ®Google Scholar
• Hideshima T, Hayashi T, Chauhan D, Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines. Oncogene 2003;22:8797-801
   PubMed Web of Science ®Google Scholar
• Castro AC, Dang LC, Soucy F, Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett 2003;13:2419-22
   PubMed Web of Science ®Google Scholar
• Lam LT, Davis RE, Pierce J, Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. Clin Cancer Res 2005;12:28-40
   Google Scholar
• Kishore N, Sommers C, Mathialagan S, A selective IKK-2 inhibitor blocks NF-kappaB-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem 2003;278:32861-71
   PubMed Web of Science ®Google Scholar
• Murata T, Shimada M, Sakakibara S, Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1. Bioorg Med Chem Lett 2003;13:913-18
   PubMed Web of Science ®Google Scholar
• Murata T, Shimada M, Sakakibara S, Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: orally active anti-inflammatory agents. Bioorg Med Chem Lett 2004;14:4019-22
   PubMed Web of Science ®Google Scholar
• Ziegelbauer K, Gantner F, Lukacs NW, A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity. Br J Pharmacol 2005;145:178-92
   PubMed Web of Science ®Google Scholar
• Frelin C, Imbert V, Griessinger E, AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells. Oncogene 2003;22:8187-94
   PubMed Web of Science ®Google Scholar
• May MJ, D'Acquisto F, Madge LA, Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 2000;289:1550-4
   PubMed Web of Science ®Google Scholar
• Baima ET, Guzova JA, Mathialagan S, Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides. J Biol Chem 2010;285:13498-506
   PubMed Web of Science ®Google Scholar
• Pan MH, Lin-Shiau SY, Ho CT, Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages. Biochem Pharmacol 2000;59:357-67
   PubMed Web of Science ®Google Scholar
• Yang F, Oz HS, Barve S, The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappaB activation by inhibiting IkappaB kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol 2001;60:528-33
   PubMed Web of Science ®Google Scholar
• Morishita R, Sugimoto T, Aoki M, In vivo transfection of cis element ‘decoy’ against nuclear factor-kappaB binding site prevents myocardial infarction. Nat Med 1997;3:894-9
   PubMed Web of Science ®Google Scholar
• Townsend RM, Postelnek J, Susulic V, A highly selective inhibitor of IkappaB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection. Transplantation 2004;77:1090-4
   PubMed Web of Science ®Google Scholar
• Gomez AB, MacKenzie C, Paul A, Selective inhibition of inhibitory kappaB kinase-beta abrogates induction of nitric oxide synthase in lipopolysaccharide-stimulated rat aortic smooth muscle cells. Br J Pharmacol 2005;146:217-25
   PubMed Web of Science ®Google Scholar
• Kishore N, Sommers C, Mathialagan S, A selective IKK-2 inhibitor blocks NF-kappaB-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem 2003;278:32861-71
   PubMed Web of Science ®Google Scholar
• Moss NC, Stansfield WE, Willis MS, IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2007;293:H2248-53
   PubMed Web of Science ®Google Scholar
• Suzuki J, Ogawa M, Sagesaka YM, Tea catechins attenuate ventricular remodeling and graft arterial diseases in murine cardiac allografts. Cardiovasc Res 2006;69:272-9
   PubMed Web of Science ®Google Scholar
• Suzuki J, Ogawa M, Futamatsu H, Tea catechins improve left ventricular dysfunction, suppress myocardial inflammation, fibrosis, and alter cytokine expression in rat autoimmune myocarditis. Eur J Heart Fail 2007;9:152-9
   PubMed Web of Science ®Google Scholar
• Suzuki J, Ogawa M, Maejima Y, Tea catechins attenuate chronic ventricular remodeling after myocardial ischemia in rats. J Mol Cell Cardiol 2007;42:432-40
   PubMed Web of Science ®Google Scholar
• Suzuki J, Ogawa M, Izawa A, Dietary consumption of green tea catechins attenuate hyperlipidemia-induced atherosclerosis and systemic organ damage in mice. Acta Cardiologica 2005;60:271-6
   PubMed Web of Science ®Google Scholar
• Matsuda N, Hattori Y, Jesmin S, Nuclear factor-kappaB decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Mol Pharmacol 2005;67:1018-25
   PubMed Web of Science ®Google Scholar
• Inayama M, Nishioka Y, Azuma M, A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 2006;173:1016-22
   PubMed Web of Science ®Google Scholar
• Everhart MB, Han W, Sherrill TP, Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J Immunol 2006;176:4995-5005
   PubMed Web of Science ®Google Scholar
• Catley MC, Sukkar MB, Chung KF, Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol Pharmacol 2006;70:697-705
   PubMed Web of Science ®Google Scholar
• Newton R, Holden NS, Catley MC, Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J Pharmacol Exp Ther 2007;321:734-42
   PubMed Web of Science ®Google Scholar
• Chapoval SP, Al-Garawi A, Lora JM, Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. J Immunol 2007;179:7030-41
   PubMed Web of Science ®Google Scholar
• Tomita T, Takeuchi E, Tomita N, Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy. Arthritis Rheum 1999;42:2532-42
   PubMed Web of Science ®Google Scholar
• McIntyre KW, Shuster DJ, Gillooly KM, A highly selective inhibitor of IkappaB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum 2003;48:2652-9
   PubMed Web of Science ®Google Scholar
• Pattoli MA, MacMaster JF, Gregor KR, Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression. J Pharmacol Exp Ther 2005;315:382-8
   PubMed Web of Science ®Google Scholar
• Jimi E, Aoki K, Saito H, Selective inhibition of NF-kappaB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med 2004;10:617-24
   PubMed Web of Science ®Google Scholar
• Desmet C, Gosset P, Pajak B, Selective blockade of NF-kappaB activity in airway immune cells inhibits the effector phase of experimental asthma. J Immunol 2004;173:5766-75
   PubMed Web of Science ®Google Scholar
• Sugita A, Ogawa H, Azuma M, Antiallergic and anti-inflammatory effects of a novel IkappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation. Int Arch Allergy Immunol 2008;148:186-98
   PubMed Web of Science ®Google Scholar
• Keslacy S, Tliba O, Baidouri H, Inhibition of tumor necrosis factor-alpha-inducible inflammatory genes by interferon-gamma is associated with altered nuclear factor-kappaB transactivation and enhanced histone deacetylase activity. Mol Pharmacol 2007;71:609-18
   PubMed Web of Science ®Google Scholar
• Goto K, Chiba Y, Misawa M. IL-13 induces translocation of NF-kappaB in cultured human bronchial smooth muscle cells. Cytokine 2009;46:96-9
   PubMed Web of Science ®Google Scholar
• Ziegelbauer K, Gantner F, Lukacs NW, A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity. Br J Pharmacol 2005;145:178-92
   PubMed Web of Science ®Google Scholar
• Nakamura H, Aoki M, Tamai K, Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model. Gene Ther 2002;9:1221-9
   PubMed Web of Science ®Google Scholar
• Tanaka A, Muto S, Jung K, Topical application with a new NF-kappaB inhibitor improves atopic dermatitis in NC/NgaTnd mice. J Invest Dermatol 2007;127:855-63
   PubMed Web of Science ®Google Scholar
• di Meglio P, Ianaro A, Ghosh S. Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum 2005;52:951-8
   PubMed Web of Science ®Google Scholar
• Tanaka A, Muto S, Konno M, A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Res 2006;66:419-26
   PubMed Web of Science ®Google Scholar
• Tanaka A, Konno M, Muto S, A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Blood 2005;105:2324-31
   PubMed Web of Science ®Google Scholar
• Kawamura I, Morishita R, Tsujimoto S, Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. Gene Ther 2001;8:905-12
   PubMed Web of Science ®Google Scholar
• Yang J, Amiri KI, Burke JR, BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res 2006;12:950-60
   PubMed Web of Science ®Google Scholar
• Roue G, Perez-Galan P, Lopez-Guerra M, Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level. J Immunol 2007;178:1923-30
   PubMed Web of Science ®Google Scholar
• Ammann JU, Haag C, Kasperczyk H, Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-kappaB inhibition. Int J Cancer 2009;124:1301-11
   PubMed Web of Science ®Google Scholar
• Katdare M, Efimova EV, Labay E, Diverse TNFalpha-induced death pathways are enhanced by inhibition of NF-kappaB. Int J Oncol 2007;31:1519-28
   PubMed Web of Science ®Google Scholar
• Hideshima T, Chauhan D, Richardson P, NF-kappaB as a therapeutic target in multiple myeloma. J Biol Chem 2002;277:16639-47
   PubMed Web of Science ®Google Scholar
• Hideshima T, Hayashi T, Chauhan D, Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines. Oncogene 2003;22:8797-801
   PubMed Web of Science ®Google Scholar
• Akiyama M, Hideshima T, Hayashi T, Cytokines modulate telomerase activity in a human multiple myeloma cell line. Cancer Res 2002;62:3876-82
   PubMedGoogle Scholar
• Tai YT, Podar K, Mitsiades N, CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappaB signaling. Blood 2003;101:2762-9
   PubMed Web of Science ®Google Scholar
• Roychowdhury S, Baiocchi RA, Vourganti S, Selective efficacy of depsipeptide in a xenograft model of Epstein-Barr virus-positive lymphoproliferative disorder. J Natl Cancer Inst 2004;96:1447-57
   PubMed Web of Science ®Google Scholar
• Lam LT, Davis RE, Pierce J, Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. Clin Cancer Res 2005;11:28-40
   PubMed Web of Science ®Google Scholar
• Yemelyanov A, Gasparian A, Lindholm P, Effects of IKK inhibitor PS1145 on NF-kappaB function, proliferation, apoptosis and invasion activity in prostate carcinoma cells. Oncogene 2006;25:387-98
   PubMed Web of Science ®Google Scholar
• Domingo-Domenech J, Oliva C, Rovira A, Interleukin 6, a nuclear factor-kappaB target, predicts resistance to docetaxel in hormone-independent prostate cancer and nuclear factor-kappaB inhibition by PS-1145 enhances docetaxel antitumor activity. Clin Cancer Res 2006;12:5578-86
   PubMed Web of Science ®Google Scholar
• Khanbolooki S, Nawrocki ST, Arumugam T, Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells. Mol Cancer Ther 2006;5:2251-60
   PubMed Web of Science ®Google Scholar
• Singh S, Shi Q, Bailey ST, Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer. Mol Cancer Ther 2007;6:1973-82
   PubMed Web of Science ®Google Scholar
• Duncan EA, Goetz CA, Stein SJ, IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells. Mol Cancer Ther 2008;7:391-7
   PubMed Web of Science ®Google Scholar
• Lounnas N, Frelin C, Gonthier N, NF-kappaB inhibition triggers death of imatinib-sensitive and imatinib-resistant chronic myeloid leukemia cells including T315I Bcr-Abl mutants. Int J Cancer 2009;125:308-17
   PubMed Web of Science ®Google Scholar
• Choo MK, Sakurai H, Kim DH, A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells. Oncol Rep 2008;19:595-600
   PubMed Web of Science ®Google Scholar
• Sanda T, Iida S, Ogura H, Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor. Clin Cancer Res 2005;11:1974-82
   PubMed Web of Science ®Google Scholar
• Sanda T, Asamitsu K, Ogura H, Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. Leukemia 2006;20:590-8
   PubMed Web of Science ®Google Scholar
• Bednarski BK, Ding X, Coombe K, Active roles for inhibitory kappaB kinases alpha and beta in nuclear factor-kappaB-mediated chemoresistance to doxorubicin. Mol Cancer Ther 2008;7:1827-35
   PubMed Web of Science ®Google Scholar
• Ogushi I, Iimuro Y, Seki E, Nuclear factor kappaB decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model. Hepatology 2003;38:335-44
   PubMed Web of Science ®Google Scholar
• Beraza N, Malato Y, Vander Borght S, Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. Gut 2008;57:655-63
   PubMed Web of Science ®Google Scholar
• Dasgupta S, Jana M, Zhou Y, Antineuroinflammatory effect of NF-kappaB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis. J Immunol 2004;173:1344-54
   PubMed Web of Science ®Google Scholar
• Acharyya S, Villalta SA, Bakkar N, Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest 2007;117:889-901
   PubMed Web of Science ®Google Scholar
• Puel A, Picard C, Ku CL, Inherited disorders of NF-kappaB-mediated immunity in man. Curr Opin Immunol 2004;16:34-41
   PubMed Web of Science ®Google Scholar
• Maeda S, Kamata H, Luo JL, IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977-90
   PubMed Web of Science ®Google Scholar
• Chen LW, Egan L, Li ZW, The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 2003;9:575-81
   PubMed Web of Science ®Google Scholar
• Fukuda S, Horimai C, Harada K, Aldosterone-induced kidney injury is mediated by NF-kappaB activation. Clin Exp Nephrol. 2010. [Epub ahead of print]
   Google Scholar