Angiotensin II type 2 receptor agonists: where should they be applied?

Bibliography

• de Lannoy LM, Danser AHJ, van Kats JP, Renin-angiotensin system components in the interstitial fluid of the isolated perfused rat heart. Local production of angiotensin I. Hypertension 1997;29:1240-51
   PubMed Web of Science ®Google Scholar
• Danser AHJ, van Kats JP, Admiraal PJ, Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis. Hypertension 1994;24:37-48
   PubMed Web of Science ®Google Scholar
• van Kats JP, van Meegen JR, Verdouw PD, Subcellular localization of angiotensin II in kidney and adrenal. J Hypertens 2001;19:583-9
   PubMed Web of Science ®Google Scholar
• van Esch JHM, Gembardt F, Sterner-Kock A, Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts. Cardiovasc Res 2010;86:401-9
   PubMed Web of Science ®Google Scholar
• Schuijt MP, Danser AHJ. Cardiac angiotensin II: an intracrine hormone? Am J Hypertens 2002;15:1109-16
   PubMed Web of Science ®Google Scholar
• Campbell DJ, Kladis A, Duncan AM. Nephrectomy, converting enzyme inhibition, and angiotensin peptides. Hypertension 1993;22:513-22
   PubMed Web of Science ®Google Scholar
• Katz SA, Opsahl JA, Lunzer MM, Effect of bilateral nephrectomy on active renin, angiotensinogen, and renin glycoforms in plasma and myocardium. Hypertension 1997;30:259-66
   PubMed Web of Science ®Google Scholar
• Kumar R, Singh VP, Baker KM. The intracellular renin-angiotensin system in the heart. Curr Hypertens Rep 2009;11:104-10
   PubMed Web of Science ®Google Scholar
• Saris JJ, van den Eijnden MM, Lamers JM, Prorenin-induced myocyte proliferation: no role for intracellular angiotensin II. Hypertension 2002;39:573-7
   PubMed Web of Science ®Google Scholar
• Chai W, Danser AHJ. Is angiotensin II made inside or outside of the cell? Curr Hypertens Rep 2005;7:124-7
   PubMed Web of Science ®Google Scholar
• Silver RB, Reid AC, Mackins CJ, Mast cells: a unique source of renin. Proc Natl Acad Sci USA 2004;101:13607-12
   PubMed Web of Science ®Google Scholar
• Krop M, van Veghel R, Garrelds IM, Cardiac Renin levels are not influenced by the amount of resident mast cells. Hypertension 2009;54:315-21
   PubMed Web of Science ®Google Scholar
• de Gasparo M, Catt KJ, Inagami T, International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000;52:415-72
   PubMed Web of Science ®Google Scholar
• Mehta PK, Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 2007;292:C82-97
   PubMed Web of Science ®Google Scholar
• van Kats JP, Duncker DJ, Haitsma DB, Angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade prevent cardiac remodeling in pigs after myocardial infarction: role of tissue angiotensin II. Circulation 2000;102:1556-63
   PubMed Web of Science ®Google Scholar
• Batenburg WW, Garrelds IM, Bernasconi CC, Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries. Circulation 2004;109:2296-301
   PubMed Web of Science ®Google Scholar
• van Esch JHM, Schuijt MP, Sayed J, AT(2) receptor-mediated vasodilation in the mouse heart depends on AT(1A) receptor activation. Br J Pharmacol 2006;148:452-8
   PubMed Web of Science ®Google Scholar
• Padia SH, Howell NL, Siragy HM, Carey RM. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. Hypertension 2006;47:537-44
   PubMed Web of Science ®Google Scholar
• Horiuchi M, Hayashida W, Kambe T, Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J Biol Chem 1997;272:19022-6
   PubMed Web of Science ®Google Scholar
• van Kesteren CAM, van Heugten HAA, Lamers JMJ, Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts. J Mol Cell Cardiol 1997;29:2147-57
   PubMed Web of Science ®Google Scholar
• Kurisu S, Ozono R, Oshima T, Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis. Hypertension 2003;41:99-107
   PubMed Web of Science ®Google Scholar
• Steckelings UM, Widdop RE, Paulis L, Unger T. The angiotensin AT2 receptor in left ventricular hypertrophy. J Hypertens 2010;28(Suppl 1):S50-5
   PubMed Web of Science ®Google Scholar
• Rompe F, Artuc M, Hallberg A, Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension 2010;55:924-31
   PubMed Web of Science ®Google Scholar
• Duke LM, Widdop RE, Kett MM, Evans RG. AT(2) receptors mediate tonic renal medullary vasoconstriction in renovascular hypertension. Br J Pharmacol 2005;144:486-92
   PubMed Web of Science ®Google Scholar
• Moltzer E, Verkuil AV, van Veghel R, Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat. Loss of angiotensin II type 2 receptor-mediated vasodilation. Hypertension 2010;55:516-22
   PubMed Web of Science ®Google Scholar
• You D, Loufrani L, Baron C, High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats. Circulation 2005;111:1006-11
   PubMed Web of Science ®Google Scholar
• Touyz RM, Endemann D, He G, Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR. Hypertension 1999;33:366-72
   PubMed Web of Science ®Google Scholar
• Ichihara S, Senbonmatsu T, Price E Jr, Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation 2001;104:346-51
   PubMed Web of Science ®Google Scholar
• Senbonmatsu T, Ichihara S, Price E Jr, Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest 2000;106:R25-9
   PubMed Web of Science ®Google Scholar
• Mukoyama M, Nakajima M, Horiuchi M, Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. J Biol Chem 1993;268:24539-42
   PubMed Web of Science ®Google Scholar
• Millan MA, Jacobowitz DM, Aguilera G, Catt KJ. Differential distribution of AT1 and AT2 angiotensin II receptor subtypes in the rat brain during development. Proc Natl Acad Sci USA 1991;88:11440-4
   PubMed Web of Science ®Google Scholar
• Tsutsumi K, Saavedra JM. Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain. Am J Physiol 1991;261:R209-16
   PubMed Web of Science ®Google Scholar
• Tsutsumi K, Saavedra JM. Characterization of AT2 angiotensin II receptors in rat anterior cerebral arteries. Am J Physiol 1991;261:H667-70
   PubMed Web of Science ®Google Scholar
• Sechi LA, Griffin CA, Grady EF, Characterization of angiotensin II receptor subtypes in rat heart. Circ Res 1992;71:1482-9
   PubMed Web of Science ®Google Scholar
• Zhuo J, Dean R, MacGregor D, Presence of angiotensin II AT2 receptor binding sites in the adventitia of human kidney vasculature. Clin Exp Pharmacol Physiol 1996;23(Suppl 3):S147-54
   PubMed Web of Science ®Google Scholar
• Shanmugam S, Lenkei ZG, Gasc JM, Ontogeny of angiotensin II type 2 (AT2) receptor mRNA in the rat. Kidney Int 1995;47:1095-100
   PubMed Web of Science ®Google Scholar
• Grady EF, Sechi LA, Griffin CA, Expression of AT2 receptors in the developing rat fetus. J Clin Invest 1991;88:921-33
   PubMed Web of Science ®Google Scholar
• Yu L, Zheng M, Wang W, Developmental changes in AT1 and AT2 receptor-protein expression in rats. J Renin Angiotensin Aldosterone Syst 2010;11:214-21
   PubMed Web of Science ®Google Scholar
• Bottari SP, de Gasparo M, Steckelings UM, Levens NR. Angiotensin II receptor subtypes: characterization, signalling mechanisms, and possible physiological implications. Front Neuroendocrinol 1993;14:123-71
   PubMed Web of Science ®Google Scholar
• Silva-Antonialli MM, Tostes RC, Fernandes L, A lower ratio of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive rats. Cardiovasc Res 2004;62:587-93
   PubMed Web of Science ®Google Scholar
• Sampson AK, Moritz KM, Jones ES, Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats. Hypertension 2008;52:666-71
   PubMed Web of Science ®Google Scholar
• Ichiki T, Labosky PA, Shiota C, Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 1995;377:748-50
   PubMed Web of Science ®Google Scholar
• Hein L, Barsh GS, Pratt RE, Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature 1995;377:744-7
   PubMed Web of Science ®Google Scholar
• Yamada H, Akishita M, Ito M, AT2 receptor and vascular smooth muscle cell differentiation in vascular development. Hypertension 1999;33:1414-19
   PubMed Web of Science ®Google Scholar
• Perlegas D, Xie H, Sinha S, ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development. Am J Physiol Heart Circ Physiol 2005;288:H96-102
   PubMed Web of Science ®Google Scholar
• Noda K, Feng YH, Liu XP, The active state of the AT1 angiotensin receptor is generated by angiotensin II induction. Biochemistry 1996;35:16435-42
   PubMed Web of Science ®Google Scholar
• Le MT, Vanderheyden PM, Szaszak M, Angiotensin IV is a potent agonist for constitutive active human AT1 receptors. Distinct roles of the N-and C-terminal residues of angiotensin II during AT1 receptor activation. J Biol Chem 2002;277:23107-10
   PubMed Web of Science ®Google Scholar
• Jones ES, Del Borgo MP, Kirsch JF, A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function. Hypertension 2011;57:570-6
   PubMed Web of Science ®Google Scholar
• Miura S, Karnik SS. Angiotensin II type 1 and type 2 receptors bind angiotensin II through different types of epitope recognition. J Hypertens 1999;17:397-404
   PubMed Web of Science ®Google Scholar
• Rosenstrom U, Skold C, Lindeberg G, Synthesis and AT2 receptor-binding properties of angiotensin II analogues. J Pept Res 2004;64:194-201
   PubMedGoogle Scholar
• Miura S, Karnik SS, Saku K. Constitutively active homo-oligomeric angiotensin II type 2 receptor induces cell signaling independent of receptor conformation and ligand stimulation. J Biol Chem 2005;280:18237-44
   Google Scholar
• Miura S, Karnik SS. Ligand-independent signals from angiotensin II type 2 receptor induce apoptosis. EMBO J 2000;19:4026-35
   Google Scholar
• Bosnyak S, Jones ES, Christopoulos A, Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond) 2011;121:297-303
   PubMed Web of Science ®Google Scholar
• Bouley R, Perodin J, Plante H, N- and C-terminal structure-activity study of angiotensin II on the angiotensin AT2 receptor. Eur J Pharmacol 1998;343:323-31
   PubMed Web of Science ®Google Scholar
• Hansen JL, Servant G, Baranski TJ, Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation. Circ Res 2000;87:753-9
   PubMed Web of Science ®Google Scholar
• Padia SH, Kemp BA, Howell NL, Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor mediated natriuresis in rats. Hypertension 2008;51:460-5
   PubMed Web of Science ®Google Scholar
• van Esch JHM, Oosterveer CR, Batenburg WW, Effects of angiotensin II and its metabolites in the rat coronary vascular bed: is angiotensin III the preferred ligand of the angiotensin AT(2) receptor? Eur J Pharmacol 2008;588:286-93
   PubMed Web of Science ®Google Scholar
• Yatabe J, Yoneda M, Yatabe MS, Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor. Endocrinology 2011;152:1582-8
   PubMed Web of Science ®Google Scholar
• Chiu AT, Herblin WF, McCall DE, Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun 1989;165:196-203
   PubMed Web of Science ®Google Scholar
• Zhang J, Pratt RE. The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus. J Biol Chem 1996;271:15026-33
   PubMed Web of Science ®Google Scholar
• AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U. The angiotensin II AT2 receptor is an AT1 receptor antagonist. J Biol Chem 2001;276:39721-6
   PubMed Web of Science ®Google Scholar
• Siragy HM, Carey RM. The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J Clin Invest 1997;100:264-9
   PubMed Web of Science ®Google Scholar
• Abadir PM, Carey RM, Siragy HM. Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice. Hypertension 2003;42:600-4
   PubMed Web of Science ®Google Scholar
• Cervenka L, Maly J, Karasova L, Angiotensin II-induced hypertension in bradykinin B2 receptor knockout mice. Hypertension 2001;37:967-73
   PubMed Web of Science ®Google Scholar
• Katada J, Majima M. AT(2) receptor-dependent vasodilation is mediated by activation of vascular kinin generation under flow conditions. Br J Pharmacol 2002;136:484-91
   PubMed Web of Science ®Google Scholar
• Tsutsumi Y, Matsubara H, Masaki H, Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J Clin Invest 1999;104:925-35
   PubMed Web of Science ®Google Scholar
• Ritter O, Schuh K, Brede M, AT2 receptor activation regulates myocardial eNOS expression via the calcineurin-NF-AT pathway. FASEB J 2003;17:283-5
   PubMed Web of Science ®Google Scholar
• Madrid MI, Garcia-Salom M, Tornel J, Effect of interactions between nitric oxide and angiotensin II on pressure diuresis and natriuresis. Am J Physiol 1997;273:R1676-82
   PubMed Web of Science ®Google Scholar
• Siragy HM, Inagami T, Carey RM. NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats. Am J Physiol Regul Integr Comp Physiol 2007;293:R1461-7
   PubMed Web of Science ®Google Scholar
• Horiuchi M, Akishita M, Dzau VJ. Molecular and cellular mechanism of angiotensin II-mediated apoptosis. Endocr Res 1998;24:307-14
   PubMed Web of Science ®Google Scholar
• Miyamoto N, Zhang N, Tanaka R, Neuroprotective role of angiotensin II type 2 receptor after transient focal ischemia in mice brain. Neurosci Res 2008;61:249-56
   PubMed Web of Science ®Google Scholar
• Horiuchi M, Hayashida W, Akishita M, Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk. Circ Res 1999;84:876-82
   Google Scholar
• Tani T, Ayuzawa R, Takagi T, Angiotensin II bi-directionally regulates cyclooxygenase-2 expression in intestinal epithelial cells. Mol Cell Biochem 2008;315:185-93
   PubMed Web of Science ®Google Scholar
• Wu L, Iwai M, Li Z, Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells. Mol Endocrinol 2004;18:666-78
   PubMed Web of Science ®Google Scholar
• Kohout TA, Rogers TB. Angiotensin II activates the Na+/HCO3- symport through a phosphoinositide-independent mechanism in cardiac cells. J Biol Chem 1995;270:20432-8
   PubMed Web of Science ®Google Scholar
• Lokuta AJ, Cooper C, Gaa ST, Angiotensin II stimulates the release of phospholipid-derived second messengers through multiple receptor subtypes in heart cells. J Biol Chem 1994;269:4832-8
   PubMed Web of Science ®Google Scholar
• Dulin NO, Alexander LD, Harwalkar S, Phospholipase A2-mediated activation of mitogen-activated protein kinase by angiotensin II. Proc Natl Acad Sci USA 1998;95:8098-102
   PubMed Web of Science ®Google Scholar
• Rompe F, Unger T, Steckelings UM. The angiotensin AT2 receptor in inflammation. Drug News Perspect 2010;23:104-11
   PubMed Web of Science ®Google Scholar
• Arima S, Endo Y, Yaoita H, Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole. J Clin Invest 1997;100:2816-23
   PubMed Web of Science ®Google Scholar
• Batenburg WW, Tom B, Schuijt MP, Danser AHJ. Angiotensin II type 2 receptor-mediated vasodilation. Focus on bradykinin, NO and endothelium-derived hyperpolarizing factor(s). Vascul Pharmacol 2005;42:109-18
   PubMed Web of Science ®Google Scholar
• Barna M, Hawe N, Niswander L, Pandolfi PP. Plzf regulates limb and axial skeletal patterning. Nat Genet 2000;25:166-72
   PubMed Web of Science ®Google Scholar
• Senbonmatsu T, Saito T, Landon EJ, A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. EMBO J 2003;22:6471-82
   PubMedGoogle Scholar
• Yeyati PL, Shaknovich R, Boterashvili S, Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Oncogene 1999;18:925-34
   PubMed Web of Science ®Google Scholar
• Seidel K, Kirsch S, Lucht K, The promyelocytic leukemia zinc finger (PLZF) protein exerts neuroprotective effects in neuronal cells and is dysregulated in experimental stroke. Brain Pathol 2011;21:31-43
   PubMed Web of Science ®Google Scholar
• Schefe JH, Unger T, Funke-Kaiser H. PLZF and the (pro)renin receptor. J Mol Med 2008;86:623-7
   PubMed Web of Science ®Google Scholar
• Widdop RE, Matrougui K, Levy BI, Henrion D. AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade. Hypertension 2002;40:516-20
   PubMed Web of Science ®Google Scholar
• Wruck CJ, Funke-Kaiser H, Pufe T, Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein. Arterioscler Thromb Vasc Biol 2005;25:57-64
   PubMed Web of Science ®Google Scholar
• Nouet S, Amzallag N, Li JM, Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. J Biol Chem 2004;279:28989-97
   PubMed Web of Science ®Google Scholar
• Di Benedetto M, Bieche I, Deshayes F, Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP. Gene 2006;380:127-36
   PubMed Web of Science ®Google Scholar
• Miura S, Matsuo Y, Kiya Y, Molecular mechanisms of the antagonistic action between AT1 and AT2 receptors. Biochem Biophys Res Commun 2010;391:85-90
   PubMed Web of Science ®Google Scholar
• Abadir PM, Periasamy A, Carey RM, Siragy HM. Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization. Hypertension 2006;48:316-22
   PubMed Web of Science ®Google Scholar
• McMullen JR, Gibson KJ, Lumbers ER, Interactions between AT1 and AT2 receptors in uterine arteries from pregnant ewes. Eur J Pharmacol 1999;378:195-202
   PubMed Web of Science ®Google Scholar
• Touyz RM, Endemann D, He G, Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR. Hypertension 1999;33:366-72
   PubMed Web of Science ®Google Scholar
• Nora EH, Munzenmaier DH, Hansen-Smith FM, Localization of the ANG II type 2 receptor in the microcirculation of skeletal muscle. Am J Physiol 1998;275:H1395-403
   PubMed Web of Science ®Google Scholar
• Matrougui K, Loufrani L, Heymes C, Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries. Hypertension 1999;34:659-65
   PubMed Web of Science ®Google Scholar
• Yayama K, Horii M, Hiyoshi H, Up-regulation of angiotensin II type 2 receptor in rat thoracic aorta by pressure-overload. J Pharmacol Exp Ther 2004;308:736-43
   PubMed Web of Science ®Google Scholar
• Suzuki J, Iwai M, Nakagami H, Role of angiotensin II-regulated apoptosis through distinct AT1 and AT2 receptors in neointimal formation. Circulation 2002;106:847-53
   PubMed Web of Science ®Google Scholar
• Schinzari F, Tesauro M, Rovella V, Coexistence of functional angiotensin II type 2 receptors mediating both vasoconstriction and vasodilation in humans. J Hypertens 2011;29:1743-8
   PubMed Web of Science ®Google Scholar
• Savoia C, Touyz RM, Volpe M, Schiffrin EL. Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients. Hypertension 2007;49:341-6
   PubMed Web of Science ®Google Scholar
• Sohn HY, Raff U, Hoffmann A, Differential role of angiotensin II receptor subtypes on endothelial superoxide formation. Br J Pharmacol 2000;131:667-72
   PubMed Web of Science ®Google Scholar
• Dimitropoulou C, White RE, Fuchs L, Angiotensin II relaxes microvessels via the AT(2) receptor and Ca(2+)-activated K(+) (BK(Ca)) channels. Hypertension 2001;37:301-7
   PubMed Web of Science ®Google Scholar
• Hunley TE, Tamura M, Stoneking BJ, The angiotensin type II receptor tonically inhibits angiotensin- converting enzyme in AT2 null mutant mice. Kidney Int 2000;57:570-7
   PubMed Web of Science ®Google Scholar
• Pinaud F, Bocquet A, Dumont O, Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats. Hypertension 2007;50:96-102
   PubMed Web of Science ®Google Scholar
• Cosentino F, Savoia C, De Paolis P, Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists. Am J Hypertens 2005;18:493-9
   PubMed Web of Science ®Google Scholar
• Nakajima M, Hutchinson HG, Fujinaga M, The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci USA 1995;92:10663-7
   PubMed Web of Science ®Google Scholar
• Akishita M, Iwai M, Wu L, Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice. Circulation 2000;102:1684-9
   PubMed Web of Science ®Google Scholar
• Wu L, Iwai M, Nakagami H, Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury. Circulation 2001;104:2716-21
   PubMed Web of Science ®Google Scholar
• Habashi JP, Doyle JJ, Holm TM, Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism. Science 2011;332:361-5
   PubMed Web of Science ®Google Scholar
• Matsubara H. Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ Res 1998;83:1182-91
   PubMed Web of Science ®Google Scholar
• Regitz-Zagrosek V, Friedel N, Heymann A, Regulation, chamber localization, and subtype distribution of angiotensin II receptors in human hearts. Circulation 1995;91:1461-71
   PubMed Web of Science ®Google Scholar
• Asano K, Dutcher DL, Port JD, Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium. Circulation 1997;95:1193-200
   PubMed Web of Science ®Google Scholar
• Haywood GA, Gullestad L, Katsuya T, AT1 and AT2 angiotensin receptor gene expression in human heart failure. Circulation 1997;95:1201-6
   PubMed Web of Science ®Google Scholar
• Tsutsumi Y, Matsubara H, Ohkubo N, Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression. Circ Res 1998;83:1035-46
   PubMed Web of Science ®Google Scholar
• Wharton J, Morgan K, Rutherford RA, Differential distribution of angiotensin AT2 receptors in the normal and failing human heart. J Pharmacol Exp Ther 1998;284:323-36
   PubMed Web of Science ®Google Scholar
• Lee S, Kramer CM, Mankad S, Combined angiotensin converting enzyme inhibition and angiotensin AT(1) receptor blockade up-regulates myocardial AT(2) receptors in remodeled myocardium post-infarction. Cardiovasc Res 2001;51:131-9
   PubMed Web of Science ®Google Scholar
• Masaki H, Kurihara T, Yamaki A, Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest 1998;101:527-35
   PubMed Web of Science ®Google Scholar
• Sasaoka T, Egi Y, Tawa M, Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts. J Cardiovasc Pharmacol 2008;52:176-83
   PubMed Web of Science ®Google Scholar
• Yang Z, Bove CM, French BA, Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction. Circulation 2002;106:106-11
   PubMed Web of Science ®Google Scholar
• Bove CM, Yang Z, Gilson WD, Nitric oxide mediates benefits of angiotensin II type 2 receptor overexpression during post-infarct remodeling. Hypertension 2004;43:680-5
   PubMed Web of Science ®Google Scholar
• Senbonmatsu T, Ichihara S, Price E Jr, Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest 2000;106:R25-9
   PubMed Web of Science ®Google Scholar
• Gross V, Schunck WH, Honeck H, Inhibition of pressure natriuresis in mice lacking the AT2 receptor. Kidney Int 2000;57:191-202
   PubMed Web of Science ®Google Scholar
• Padia SH, Kemp BA, Howell NL, Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats. Hypertension 2007;49:625-30
   PubMed Web of Science ®Google Scholar
• Padia SH, Kemp BA, Howell NL, Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats. Hypertension 2009;53:338-43
   PubMed Web of Science ®Google Scholar
• Padia SH, Howell NL, Kemp BA, Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis in spontaneously hypertensive rats. Hypertension 2010;55:474-80
   PubMed Web of Science ®Google Scholar
• Haithcock D, Jiao H, Cui XL, Renal proximal tubular AT2 receptor: signaling and transport. J Am Soc Nephrol 1999;10(Suppl 11):S69-74
   PubMed Web of Science ®Google Scholar
• Hakam AC, Hussain T. Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am J Physiol Renal Physiol 2006;290:F1430-6
   PubMed Web of Science ®Google Scholar
• Sakai N, Wada T, Matsushima K, The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes. J Hypertens 2008;26:780-90
   PubMed Web of Science ®Google Scholar
• Kaschina E, Unger T. Angiotensin AT1/AT2 receptors: regulation, signalling and function. Blood Press 2003;12:70-88
   PubMed Web of Science ®Google Scholar
• Pawlowski TL, Heringer-Walther S, Cheng CH, Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice. Genomics 2009;94:188-95
   PubMed Web of Science ®Google Scholar
• Li Z, Iwai M, Wu L, Role of AT2 receptor in the brain in regulation of blood pressure and water intake. Am J Physiol Heart Circ Physiol 2003;284:H116-21
   PubMed Web of Science ®Google Scholar
• Lenkei Z, Palkovits M, Corvol P, Llorens-Cortes C. Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review. Front Neuroendocrinol 1997;18:383-439
   PubMed Web of Science ®Google Scholar
• Vervoort VS, Beachem MA, Edwards PS, AGTR2 mutations in X-linked mental retardation. Science 2002;296:2401-3
   PubMed Web of Science ®Google Scholar
• AbdAlla S, Lother H, el Missiry A, Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease. J Biol Chem 2009;284:6554-65
   PubMed Web of Science ®Google Scholar
• AbdAlla S, Lother H, el Missiry A, Dominant negative AT2 receptor oligomers induce G-protein arrest and symptoms of neurodegeneration. J Biol Chem 2009;284:6566-74
   PubMed Web of Science ®Google Scholar
• Dahlof B, Devereux RB, Kjeldsen SE, Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002;359:995-1003
   PubMed Web of Science ®Google Scholar
• Lu Q, Zhu YZ, Wong PT. Angiotensin receptor gene expression in candesartan mediated neuroprotection. Neuroreport 2004;15:2643-6
   PubMed Web of Science ®Google Scholar
• Li J, Culman J, Hortnagl H, Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. Faseb J 2005;19:617-19
   PubMed Web of Science ®Google Scholar
• Lucius R, Gallinat S, Rosenstiel P, The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats. J Exp Med 1998;188:661-70
   PubMed Web of Science ®Google Scholar
• Iwai M, Liu HW, Chen R, Possible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation. Circulation 2004;110:843-8
   PubMed Web of Science ®Google Scholar
• Cote F, Laflamme L, Payet MD, Gallo-Payet N. Nitric oxide, a new second messenger involved in the action of angiotensin II on neuronal differentiation of NG108-15 cells. Endocr Res 1998;24:403-7
   PubMed Web of Science ®Google Scholar
• Cote F, Do TH, Laflamme L, Activation of the AT(2) receptor of angiotensin II induces neurite outgrowth and cell migration in microexplant cultures of the cerebellum. J Biol Chem 1999;274:31686-92
   PubMed Web of Science ®Google Scholar
• Ardaillou R, Chansel D. Synthesis and effects of active fragments of angiotensin II. Kidney Int 1997;52:1458-68
   PubMed Web of Science ®Google Scholar
• Loufrani L, Henrion D, Chansel D, Functional evidence for an angiotensin IV receptor in rat resistance arteries. J Pharmacol Exp Ther 1999;291:583-8
   PubMed Web of Science ®Google Scholar
• Vinh A, Widdop RE, Drummond GR, Gaspari TA. Chronic angiotensin IV treatment reverses endothelial dysfunction in ApoE-deficient mice. Cardiovasc Res 2008;77:178-87
   PubMed Web of Science ®Google Scholar
• Saraiva VB, de Souza Silva L, Ferreira-DaSilva CT, Impairment of the Plasmodium falciparum erythrocytic cycle induced by angiotensin peptides. PLoS One 2011;6:e17174
   PubMed Web of Science ®Google Scholar
• Tesanovic S, Vinh A, Gaspari TA, Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2010;30:1606-13
   PubMed Web of Science ®Google Scholar
• Stoll M, Steckelings UM, Paul M, The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 1995;95:651-7
   PubMed Web of Science ®Google Scholar
• Carey RM, Howell NL, Jin XH, Siragy HM. Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats. Hypertension 2001;38:1272-7
   PubMed Web of Science ®Google Scholar
• Barber MN, Sampey DB, Widdop RE. AT(2) receptor stimulation enhances antihypertensive effect of AT(1) receptor antagonist in hypertensive rats. Hypertension 1999;34:1112-16
   PubMed Web of Science ®Google Scholar
• Li XC, Widdop RE. AT2 receptor-mediated vasodilatation is unmasked by AT1 receptor blockade in conscious SHR. Br J Pharmacol 2004;142:821-30
   PubMed Web of Science ®Google Scholar
• Laflamme L, Gasparo M, Gallo JM, Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors. J Biol Chem 1996;271:22729-35
   PubMed Web of Science ®Google Scholar
• Meffert S, Stoll M, Steckelings UM, The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol Cell Endocrinol 1996;122:59-67
   PubMed Web of Science ®Google Scholar
• McCarthy CA, Vinh A, Callaway JK, Widdop RE. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke 2009;40:1482-9
   PubMed Web of Science ®Google Scholar
• Abadir PM, Walston JD, Carey RM, Siragy HM. Angiotensin II Type-2 receptors modulate inflammation through signal transducer and activator of transcription proteins 3 phosphorylation and TNFalpha production. J Interferon Cytokine Res 2011;31:471-4
   PubMed Web of Science ®Google Scholar
• Wan Y, Wallinder C, Plouffe B, Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 2004;47:5995-6008
   PubMed Web of Science ®Google Scholar
• Wan Y, Wallinder C, Johansson B, First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo. J Med Chem 2004;47:1536-46
   PubMed Web of Science ®Google Scholar
• Kivlighn SD, Huckle WR, Zingaro GJ, Discovery of L-162,313: a nonpeptide that mimics the biological actions of angiotensin II. Am J Physiol 1995;268:R820-3
   PubMed Web of Science ®Google Scholar
• Perlman S, Schambye HT, Rivero RA, Non-peptide angiotensin agonist. Functional and molecular interaction with the AT1 receptor. J Biol Chem 1995;270:1493-6
   PubMed Web of Science ®Google Scholar
• Bosnyak S, Welungoda IK, Hallberg A, Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. Br J Pharmacol 2010;159:709-16
   PubMed Web of Science ®Google Scholar
• Gelosa P, Pignieri A, Fandriks L, Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. J Hypertens 2009;27:2444-51
   PubMed Web of Science ®Google Scholar
• Matavelli LC, Huang J, Siragy HM. Angiotensin AT receptor stimulation inhibits early renal inflammation in renovascular hypertension. Hypertension 2011;57:308-13
   PubMed Web of Science ®Google Scholar
• Kaschina E, Grzesiak A, Li J, Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 2008;118:2523-32
   PubMed Web of Science ®Google Scholar
• Jehle AB, Xu Y, Dimaria JM, A non-peptide Angiotensin II type 2 receptor agonist does not attenuate post-myocardial infarction left ventricular remodeling in mice. J Cardiovasc Pharmacol 2011 [In press]
   Google Scholar
• Hilliard LM, Jones ES, Steckelings UM, Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension. Hypertension 2012;59:409-14
   PubMed Web of Science ®Google Scholar
• Rehman A, Leibowitz A, Yamamoto N, Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension 2012;59:291-9
   PubMed Web of Science ®Google Scholar
• Jing F, Mogi M, Sakata A, Direct stimulation of angiotensin II type 2 receptor enhances spatial memory. J Cereb Blood Flow Metab 2012;32:248-55
   PubMed Web of Science ®Google Scholar
• Hilliard LM, Nematbakhsh M, Kett MM, Gender differences in pressure-natriuresis and renal autoregulation: role of the Angiotensin type 2 receptor. Hypertension 2011;57:275-82
   PubMed Web of Science ®Google Scholar
• Moltzer E, Essers J, van Esch JHM, The role of the renin-angiotensin system in thoracic aortic aneurysms: clinical implications. Pharmacol Ther 2011;131:50-60
   PubMed Web of Science ®Google Scholar
• Steckelings UM, Paulis L, Unger T, Bader M. Emerging drugs which target the renin-angiotensin-aldosterone system. Expert Opin Emerg Drugs 2011;16:619-30
   PubMed Web of Science ®Google Scholar