Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections

Bibliography

• WHO. Antimicrobial resistance global report on surveillance 2014. WHO; Switzerland: 2014
   Google Scholar
• CDC. Antibiotic resistance threats in the United States, 2013. CDC; Atlanta, Georgia: 2013
   Google Scholar
• DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet 2010;375:1557-68
   PubMed Web of Science ®Google Scholar
• Lowy FD. Staphylococcus aureus infections. N Engl J Med 1998;339:520-32
   PubMed Web of Science ®Google Scholar
• Rooijakkers SH, van Kessel KP, van Strijp JA. Staphylococcal innate immune evasion. Trends Microbiol 2005;13:596-601
   PubMed Web of Science ®Google Scholar
• Foster TJ, Hook M. Surface protein adhesins of Staphylococcus aureus. Trends Microbiol 1998;6:484-8
   PubMed Web of Science ®Google Scholar
• Otto M. Staphylococcus aureus toxins. Curr Opin Microbiol 2014;17:32-7
   PubMed Web of Science ®Google Scholar
• Schlievert PM. Role of superantigens in human disease. J Infect Dis 1993;167:997-1002
   PubMed Web of Science ®Google Scholar
• Wang R, Braughton KR, Kretschmer D, et al. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 2007;13:1510-14
   PubMed Web of Science ®Google Scholar
• Surewaard BG, de Haas CJ, Vervoort F, et al. Staphylococcal alpha-phenol soluble modulins contribute to neutrophil lysis after phagocytosis. Cell Microbiol 2013;15:1427-37
   PubMed Web of Science ®Google Scholar
• Otto M. Bacterial evasion of antimicrobial peptides by biofilm formation. Curr Top Microbiol Immunol 2006;306:251-8
   PubMed Web of Science ®Google Scholar
• Otto M. Staphylococcal biofilms. Curr Top Microbiol Immunol 2008;322:207-28
   PubMed Web of Science ®Google Scholar
• Nealson KH, Hastings JW. Bacterial bioluminescence: its control and ecological significance. Microbiol Rev 1979;43:496-518
   PubMedGoogle Scholar
• Passador L, Cook JM, Gambello MJ, et al. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science 1993;260:1127-30
   PubMed Web of Science ®Google Scholar
• Recsei P, Kreiswirth B, O’Reilly M, et al. Regulation of exoprotein gene expression in Staphylococcus aureus by agr. Mol Gen Genet 1986;202:58-61
   PubMedGoogle Scholar
• Cassat J, Dunman PM, Murphy E, et al. Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390. Microbiology 2006;152:3075-90
   PubMed Web of Science ®Google Scholar
• Yao Y, Vuong C, Kocianova S, et al. Characterization of the Staphylococcus epidermidis accessory-gene regulator response: quorum-sensing regulation of resistance to human innate host defense. J Infect Dis 2006;193:841-8
   PubMed Web of Science ®Google Scholar
• Zhang L, Lin J, Ji G. Membrane anchoring of the AgrD N-terminal amphipathic region is required for its processing to produce a quorum-sensing pheromone in Staphylococcus aureus. J Biol Chem 2004;279:19448-56
   PubMed Web of Science ®Google Scholar
• Thoendel M, Kavanaugh JS, Flack CE, Horswill AR. Peptide signaling in the staphylococci. Chem Rev 2011;111:117-51
   PubMed Web of Science ®Google Scholar
• Ji G, Beavis RC, Novick RP. Cell density control of staphylococcal virulence mediated by an octapeptide pheromone. Proc Natl Acad Sci U S A 1995;92:12055-9
   PubMed Web of Science ®Google Scholar
• Otto M, Sussmuth R, Jung G, Gotz F. Structure of the pheromone peptide of the Staphylococcus epidermidis agr system. FEBS Lett 1998;424:89-94
   PubMed Web of Science ®Google Scholar
• Kavanaugh JS, Thoendel M, Horswill AR. A role for type I signal peptidase in Staphylococcus aureus quorum sensing. Mol Microbiol 2007;65:780-98
   PubMed Web of Science ®Google Scholar
• Lina G, Jarraud S, Ji G, et al. Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus. Mol Microbiol 1998;28:655-62
   PubMed Web of Science ®Google Scholar
• Lyon GJ, Mayville P, Muir TW, Novick RP. Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase. AgrC. Proc Natl Acad Sci U S A 2000;97:13330-5
   PubMed Web of Science ®Google Scholar
• George Cisar EA, Geisinger E, Muir TW, Novick RP. Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC. Mol Microbiol 2009;74:44-57
   PubMed Web of Science ®Google Scholar
• Koenig RL, Ray JL, Maleki SJ, et al. Staphylococcus aureus AgrA binding to the RNAIII-agr regulatory region. J Bacteriol 2004;186:7549-55
   PubMed Web of Science ®Google Scholar
• Novick RP. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol 2003;48:1429-49
   PubMed Web of Science ®Google Scholar
• Jarraud S, Lyon GJ, Figueiredo AM, et al. Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. J Bacteriol 2000;182:6517-22
   PubMed Web of Science ®Google Scholar
• Ji G, Beavis R, Novick RP. Bacterial interference caused by autoinducing peptide variants. Science 1997;276:2027-30
   PubMed Web of Science ®Google Scholar
• Geisinger E, Chen J, Novick RP. Allele-dependent differences in quorum-sensing dynamics result in variant expression of virulence genes in Staphylococcus aureus. J Bacteriol 2012;194:2854-64
   PubMed Web of Science ®Google Scholar
• Cheung AL, Nishina KA, Trotonda MP, Tamber S. The SarA protein family of Staphylococcus aureus. Int J Biochem Cell Biol 2008;40:355-61
   PubMed Web of Science ®Google Scholar
• Lauderdale KJ, Boles BR, Cheung AL, Horswill AR. Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation. Infect Immun 2009;77:1623-35
   PubMed Web of Science ®Google Scholar
• Shaw LN, Aish J, Davenport JE, et al. Investigations into sigmaB-modulated regulatory pathways governing extracellular virulence determinant production in Staphylococcus aureus. J Bacteriol 2006;188:6070-80
   PubMed Web of Science ®Google Scholar
• Sun F, Liang H, Kong X, et al. Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc Natl Acad Sci U S A 2012;109:9095-100
   PubMed Web of Science ®Google Scholar
• Fournier B, Klier A, Rapoport G. The two-component system ArlS-ArlR is a regulator of virulence gene expression in Staphylococcus aureus. Mol Microbiol 2001;41:247-61
   PubMed Web of Science ®Google Scholar
• Giraudo AT, Calzolari A, Cataldi AA, et al. The sae locus of Staphylococcus aureus encodes a two-component regulatory system. FEMS Microbiol Lett 1999;177:15-22
   PubMed Web of Science ®Google Scholar
• Giraudo AT, Cheung AL, Nagel R. The sae locus of Staphylococcus aureus controls exoprotein synthesis at the transcriptional level. Arch Microbiol 1997;168:53-8
   PubMed Web of Science ®Google Scholar
• Throup JP, Zappacosta F, Lunsford RD, et al. The srhSR gene pair from Staphylococcus aureus: genomic and proteomic approaches to the identification and characterization of gene function. Biochemistry 2001;40:10392-401
   PubMed Web of Science ®Google Scholar
• Yarwood JM, McCormick JK, Schlievert PM. Identification of a novel two-component regulatory system that acts in global regulation of virulence factors of Staphylococcus aureus. J Bacteriol 2001;183:1113-23
   PubMed Web of Science ®Google Scholar
• Queck SY, Jameson-Lee M, Villaruz AE, et al. RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell 2008;32:150-8
   PubMed Web of Science ®Google Scholar
• Cheung AL, Bayer AS, Zhang G, et al. Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus. FEMS Immunol Med Microbiol 2004;40:1-9
   PubMedGoogle Scholar
• Novick RP, Ross HF, Projan SJ, et al. Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. Embo J 1993;12:3967-75
   PubMed Web of Science ®Google Scholar
• Peschel A, Otto M. Phenol-soluble modulins and staphylococcal infection. Nat Rev Microbiol 2013;11:667-73
   PubMed Web of Science ®Google Scholar
• Cheung GY, Rigby K, Wang R, et al. Staphylococcus epidermidis strategies to avoid killing by human neutrophils. PLoS Pathog 2010;6:e1001133
   PubMedGoogle Scholar
• Cheung GY, Wang R, Khan BA, et al. Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. Infect Immun 2011;79:1927-35
   PubMed Web of Science ®Google Scholar
• Boisset S, Geissmann T, Huntzinger E, et al. Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism. Genes Dev 2007;21:1353-66
   PubMed Web of Science ®Google Scholar
• McNamara PJ, Milligan-Monroe KC, Khalili S, Proctor RA. Identification, cloning, and initial characterization of rot, a locus encoding a regulator of virulence factor expression in Staphylococcus aureus. J Bacteriol 2000;182:3197-203
   PubMed Web of Science ®Google Scholar
• Said-Salim B, Dunman PM, McAleese FM, et al. Global regulation of Staphylococcus aureus genes by Rot. J Bacteriol 2003;185:610-19
   PubMed Web of Science ®Google Scholar
• Periasamy S, Joo HS, Duong AC, et al. How Staphylococcus aureus biofilms develop their characteristic structure. Proc Natl Acad Sci U S A 2012;109:1281-6
   PubMed Web of Science ®Google Scholar
• Vuong C, Gerke C, Somerville GA, et al. Quorum-sensing control of biofilm factors in Staphylococcus epidermidis. J Infect Dis 2003;188:706-18
   PubMed Web of Science ®Google Scholar
• Wang R, Khan BA, Cheung GY, et al. Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. J Clin Invest 2011;121:238-48
   PubMed Web of Science ®Google Scholar
• Vuong C, Kocianova S, Yao Y, et al. Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo. J Infect Dis 2004;190:1498-505
   PubMed Web of Science ®Google Scholar
• Vuong C, Saenz HL, Gotz F, Otto M. Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus. J Infect Dis 2000;182:1688-93
   PubMed Web of Science ®Google Scholar
• Li M, Villaruz AE, Vadyvaloo V, et al. AI-2-dependent gene regulation in Staphylococcus epidermidis. BMC Microbiol 2008;8:4
   PubMed Web of Science ®Google Scholar
• Kennedy AD, Bubeck Wardenburg J, Gardner DJ, et al. Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model. J Infect Dis 2010;202:1050-8
   PubMed Web of Science ®Google Scholar
• Montgomery CP, Boyle-Vavra S, Daum RS. Importance of the global regulators Agr and SaeRS in the pathogenesis of CA-MRSA USA300 infection. PLoS ONE 2010;5:e15177
   PubMed Web of Science ®Google Scholar
• Bubeck Wardenburg J, Patel RJ, Schneewind O. Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia. Infect Immun 2007;75:1040-4
   PubMed Web of Science ®Google Scholar
• Heyer G, Saba S, Adamo R, et al. Staphylococcus aureus agr and sarA functions are required for invasive infection but not inflammatory responses in the lung. Infect Immun 2002;70:127-33
   PubMed Web of Science ®Google Scholar
• Cheung AL, Eberhardt KJ, Chung E, et al. Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. J Clin Invest 1994;94:1815-22
   PubMed Web of Science ®Google Scholar
• Painter KL, Krishna A, Wigneshweraraj S, Edwards AM. What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia? Trends Microbiol 2014;22:676-85
   PubMed Web of Science ®Google Scholar
• Peterson MM, Mack JL, Hall PR, et al. Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection. Cell Host Microbe 2008;4:555-66
   PubMed Web of Science ®Google Scholar
• Kernbauer E, Maurer K, Torres VJ, et al. Gastrointestinal dissemination and transmission of Staphylococcus aureus following bacteremia. Infect Immun 2014;83(1):372-8
   PubMed Web of Science ®Google Scholar
• Periasamy S, Joo HS, Duong AC, et al. How Staphylococcus aureus biofilms develop their characteristic structure. Proc Natl Acad Sci USA 2012;109:1281-6
   PubMed Web of Science ®Google Scholar
• Somerville GA, Beres SB, Fitzgerald JR, et al. In vitro serial passage of Staphylococcus aureus: changes in physiology, virulence factor production, and agr nucleotide sequence. J Bacteriol 2002;184:1430-7
   PubMed Web of Science ®Google Scholar
• Shopsin B, Drlica-Wagner A, Mathema B, et al. Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains. J Infect Dis 2008;198:1171-4
   Google Scholar
• Gagnaire J, Dauwalder O, Boisset S, et al. Detection of Staphylococcus aureus delta-toxin production by whole-cell MALDI-TOF mass spectrometry. PLoS One 2012;7:e40660
   PubMed Web of Science ®Google Scholar
• Fowler VGJr, Sakoulas G, McIntyre LMet al. Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein. J Infect Dis 2004;190:1140-9
   PubMed Web of Science ®Google Scholar
• Abdelnour A, Arvidson S, Bremell T, et al. The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect Immun 1993;61:3879-85
   PubMed Web of Science ®Google Scholar
• Shopsin B, Eaton C, Wasserman GA, et al. Mutations in agr do not persist in natural populations of methicillin-resistant Staphylococcus aureus. J Infect Dis 2010;202:1593-9
   PubMed Web of Science ®Google Scholar
• McDowell P, Affas Z, Reynolds C, et al. Structure, activity and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus. Mol Microbiol 2001;41:503-12
   PubMed Web of Science ®Google Scholar
• Lyon GJ, Wright JS, Muir TW, Novick RP. Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry 2002;41:10095-104
   PubMed Web of Science ®Google Scholar
• Scott RJ, Lian LY, Muharram SH, et al. Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system. Bioorg Med Chem Lett 2003;13:2449-53
   PubMed Web of Science ®Google Scholar
• Wright JS3rd, Jin R, Novick RP. Transient interference with staphylococcal quorum sensing blocks abscess formation. Proc Natl Acad Sci U S A 2005;102:1691-6
   PubMed Web of Science ®Google Scholar
• Fowler SA, Stacy DM, Blackwell HE. Design and synthesis of macrocyclic peptomers as mimics of a quorum sensing signal from Staphylococcus aureus. Org Lett 2008;10:2329-32
   PubMed Web of Science ®Google Scholar
• Mayville P, Ji G, Beavis R, et al. Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proc Natl Acad Sci U S A 1999;96:1218-23
   PubMed Web of Science ®Google Scholar
• Novick RP, Geisinger E. Quorum sensing in staphylococci. Annu Rev Genet 2008;42:541-64
   PubMed Web of Science ®Google Scholar
• George EA, Novick RP, Muir TW. Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis. J Am Chem Soc 2008;130:4914-24
   PubMed Web of Science ®Google Scholar
• Tal-Gan Y, Stacy DM, Blackwell HE. N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus. Chem Commun (Camb) 2014;50:3000-3
   PubMed Web of Science ®Google Scholar
• Tal-Gan Y, Stacy DM, Foegen MK, et al. Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide. J Am Chem Soc 2013;135:7869-82
   PubMed Web of Science ®Google Scholar
• Broderick AH, Stacy DM, Tal-Gan Y, et al. Surface coatings that promote rapid release of peptide-based AgrC inhibitors for attenuation of quorum sensing in Staphylococcus aureus. Adv Healthc Mater 2014;3:97-105
   Web of Science ®Google Scholar
• Melamed Yerushalmi S, Buck ME, Lynn DM, et al. Multivalent alteration of quorum sensing in Staphylococcus aureus. Chem Commun (Camb) 2013;49:5177-9
   PubMed Web of Science ®Google Scholar
• Dufour P, Jarraud S, Vandenesch F, et al. High genetic variability of the agr locus in Staphylococcus species. J Bacteriol 2002;184:1180-6
   PubMed Web of Science ®Google Scholar
• Olson ME, Todd DA, Schaeffer CR, et al. Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization. J Bacteriol 2014;196:3482-93
   PubMed Web of Science ®Google Scholar
• Otto M, Sussmuth R, Vuong C, et al. Inhibition of virulence factor expression in Staphylococcus aureus by the Staphylococcus epidermidis agr pheromone and derivatives. FEBS Lett 1999;450:257-62
   PubMed Web of Science ®Google Scholar
• Otto M, Echner H, Voelter W, Gotz F. Pheromone cross-inhibition between Staphylococcus aureus and Staphylococcus epidermidis. Infect Immun 2001;69:1957-60
   PubMed Web of Science ®Google Scholar
• Ji G, Pei W, Zhang L, et al. Staphylococcus intermedius produces a functional agr autoinducing peptide containing a cyclic lactone. J Bacteriol 2005;187:3139-50
   PubMed Web of Science ®Google Scholar
• Lyczak JB, Cannon CL, Pier GB. Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect 2000;2:1051-60
   PubMed Web of Science ®Google Scholar
• Winson MK, Camara M, Latifi A, et al. Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 1995;92:9427-31
   PubMed Web of Science ®Google Scholar
• Pearson JP, Gray KM, Passador L, et al. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci U S A 1994;91:197-201
   PubMed Web of Science ®Google Scholar
• Qazi S, Middleton B, Muharram SH, et al. N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus. Infect Immun 2006;74:910-19
   PubMed Web of Science ®Google Scholar
• Murray EJ, Crowley RC, Truman A, et al. Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. J Med Chem 2014;57:2813-19
   PubMed Web of Science ®Google Scholar
• Holden MT, Ram Chhabra S, de Nys R, et al. Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria. Mol Microbiol 1999;33:1254-66
   PubMed Web of Science ®Google Scholar
• Park DK, Lee KE, Baek CH, et al. Cyclo(Phe-Pro) modulates the expression of ompU in Vibrio spp. J Bacteriol 2006;188:2214-21
   PubMed Web of Science ®Google Scholar
• Degrassi G, Aguilar C, Bosco M, et al. Plant growth-promoting Pseudomonas putida WCS358 produces and secretes four cyclic dipeptides: cross-talk with quorum sensing bacterial sensors. Curr Microbiol 2002;45:250-4
   PubMed Web of Science ®Google Scholar
• Li J, Wang W, Xu SX, et al. Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci. Proc Natl Acad Sci U S A 2011;108:3360-5
   PubMed Web of Science ®Google Scholar
• Mansson M, Nielsen A, Kjaerulff L, et al. Inhibition of virulence gene expression in Staphylococcus aureus by novel depsipeptides from a marine photobacterium. Mar Drugs 2011;9:2537-52
   PubMed Web of Science ®Google Scholar
• Nielsen A, Mansson M, Bojer MS, et al. Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils. PLoS One 2014;9:e84992
   PubMed Web of Science ®Google Scholar
• Nakayama J, Uemura Y, Nishiguchi K, et al. Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in gram-positive bacteria. Antimicrob Agents Chemother 2009;53:580-6
   PubMed Web of Science ®Google Scholar
• Figueroa M, Jarmusch AK, Raja HA, et al. Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry. J Nat Prod 2014;77:1351-8
   Google Scholar
• Desouky SE, Nishiguchi K, Zendo T, et al. High-throughput screening of inhibitors targeting Agr/Fsr quorum sensing in Staphylococcus aureus and Enterococcus faecalis. Biosci Biotechnol Biochem 2013;77:923-7
   PubMed Web of Science ®Google Scholar
• Moran A, Gutierrez S, Martinez-Blanco H, et al. Non-toxic plant metabolites regulate Staphylococcus viability and biofilm formation: a natural therapeutic strategy useful in the treatment and prevention of skin infections. Biofouling 2014;30:1175-82
   PubMed Web of Science ®Google Scholar
• Qiu J, Jiang Y, Xia L, et al. Subinhibitory concentrations of licochalcone A decrease alpha-toxin production in both methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates. Lett Appl Microbiol 2010;50:223-9
   PubMed Web of Science ®Google Scholar
• Qiu J, Wang D, Xiang H, et al. Subinhibitory concentrations of thymol reduce enterotoxins A and B and alpha-hemolysin production in Staphylococcus aureus isolates. PLoS One 2010;5:e9736
   PubMed Web of Science ®Google Scholar
• Qiu J, Li H, Meng H, et al. Impact of luteolin on the production of alpha-toxin by Staphylococcus aureus. Lett Appl Microbiol 2011;53:238-43
   PubMed Web of Science ®Google Scholar
• Luo M, Qiu J. Zhang Y, et al. alpha-cyperone alleviates lung cell injury caused by Staphylococcus aureus via attenuation of alpha-hemolysin expression. J Microbiol Biotechnol 2012;22:1170-6
   PubMed Web of Science ®Google Scholar
• Rudkin JK, Edwards AM, Bowden MG, et al. Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system. J Infect Dis 2012;205:798-806
   PubMed Web of Science ®Google Scholar
• Park J, Jagasia R, Kaufmann GF, et al. Infection control by antibody disruption of bacterial quorum sensing signaling. Chem Biol 2007;14:1119-27
   PubMed Web of Science ®Google Scholar
• O’Rourke JP, Daly SM, Triplett KD, et al. Development of a Mimotope Vaccine Targeting the Staphylococcus aureus Quorum Sensing Pathway. PLoS One 2014;9:e111198
   Google Scholar
• Kirchdoerfer RN, Garner AL, Flack CE, et al. Structural basis for ligand recognition and discrimination of a quorum-quenching antibody. J Biol Chem 2011;286:17351-8
   PubMed Web of Science ®Google Scholar
• Khodaverdian V, Pesho M, Truitt B, et al. Discovery of antivirulence agents against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2013;57:3645-52
   PubMed Web of Science ®Google Scholar
• Leonard PG, Bezar IF, Sidote DJ, Stock AM. Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding. Biochemistry 2012;51:10035-43
   PubMed Web of Science ®Google Scholar
• Sully EK, Malachowa N, Elmore BO, et al. Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog 2014;10:e1004174
   PubMed Web of Science ®Google Scholar
• de Nys R, Steinber PD, Willemsen P, et al. Broad spectrum effects of secondary metabolites from the red alga Delisea pulchra in antifouling assays. Biofouling 1995;8:259-71
   Web of Science ®Google Scholar
• Hentzer M, Givskov M. Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. J Clin Invest 2003;112:1300-7
   PubMed Web of Science ®Google Scholar
• Kim C, Kim J, Park HY, et al. Furanone derivatives as quorum-sensing antagonists of Pseudomonas aeruginosa. Appl Microbiol Biotechnol 2008;80:37-47
   PubMed Web of Science ®Google Scholar
• Janssens JC, Steenackers H, Robijns S, et al. Brominated furanones inhibit biofilm formation by Salmonella enterica serovar Typhimurium. Appl Environ Microbiol 2008;74:6639-48
   PubMed Web of Science ®Google Scholar
• Ren D, Sims JJ, Wood TK. Inhibition of biofilm formation and swarming of Escherichia coli by (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone. Environ Microbiol 2001;3:731-6
   PubMed Web of Science ®Google Scholar
• Jones MB, Jani R, Ren D, et al. Inhibition of Bacillus anthracis growth and virulence-gene expression by inhibitors of quorum-sensing. J Infect Dis 2005;191:1881-8
   PubMed Web of Science ®Google Scholar
• Lonn-Stensrud J, Petersen FC, Benneche T, Scheie AA. Synthetic bromated furanone inhibits autoinducer-2-mediated communication and biofilm formation in oral streptococci. Oral Microbiol Immunol 2007;22:340-6
   PubMedGoogle Scholar
• He Z, Wang Q, Hu Y, et al. Use of the quorum sensing inhibitor furanone C-30 to interfere with biofilm formation by Streptococcus mutans and its luxS mutant strain. Int J Antimicrob Agents 2012;40:30-5
   PubMed Web of Science ®Google Scholar
• Ren D, Sims JJ, Wood TK. Inhibition of biofilm formation and swarming of Bacillus subtilis by (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone. Lett Appl Microbiol 2002;34:293-9
   PubMed Web of Science ®Google Scholar
• Lonn-Stensrud J, Naemi AO, Benneche T, et al. Thiophenones inhibit Staphylococcus epidermidis biofilm formation at nontoxic concentrations. FEMS Immunol Med Microbiol 2012;65:326-34
   PubMed Web of Science ®Google Scholar
• Lonn-Stensrud J, Landin MA, Benneche T, et al. Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections? J Antimicrob Chemother 2009;63:309-16
   PubMed Web of Science ®Google Scholar
• Kuehl R, Al-Bataineh S, Gordon O, et al. Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression. Antimicrob Agents Chemother 2009;53:4159-66
   PubMed Web of Science ®Google Scholar
• Yujie L, Geng X, Huang YC, et al. The effect of brominated furanones on the formation of Staphylococcus aureus biofilm on PVC. Cell Biochem Biophys 2013;67:1501-5
   PubMed Web of Science ®Google Scholar
• Maeda T, Garcia-Contreras R, Pu M, et al. Quorum quenching quandary: resistance to antivirulence compounds. ISME J 2012;6:493-501
   PubMed Web of Science ®Google Scholar
• Balaban N, Novick RP. Autocrine regulation of toxin synthesis by Staphylococcus aureus. Proc Natl Acad Sci U S A 1995;92:1619-23
   PubMed Web of Science ®Google Scholar
• Novick RP, Ross HF, Figueiredo AMS, et al. Activation and Inhibition of the Staphylococcal AGR System. Science 2000;287:391
   Google Scholar
• Cirioni O, Giacometti A, Ghiselli R, et al. RNAIII-inhibiting peptide significantly reduces bacterial load and enhances the effect of antibiotics in the treatment of central venous catheter-associated Staphylococcus aureus infections. J Infect Dis 2006;193:180-6
   PubMed Web of Science ®Google Scholar
• Balaban N, Cirioni O, Giacometti A, et al. Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP. Antimicrob Agents Chemother 2007;51:2226-9
   PubMed Web of Science ®Google Scholar
• Naik S, Bouladoux N, Wilhelm C, et al. Compartmentalized control of skin immunity by resident commensals. Science 2012;337:1115-19
   PubMed Web of Science ®Google Scholar
• Otto M. Staphylococcus epidermidis–the ’accidental’ pathogen. Nat Rev Microbiol 2009;7:555-67
   PubMed Web of Science ®Google Scholar
• Cheung GY, Kretschmer D, Duong AC, et al. Production of an attenuated phenol-soluble modulin variant unique to the MRSA clonal complex 30 increases severity of bloodstream infection. PLoS Pathog 2014;10:e1004298
   PubMed Web of Science ®Google Scholar
• Kjaerulff L, Nielsen A, Mansson M, et al. Identification of four new agr quorum sensing-interfering cyclodepsipeptides from a marine Photobacterium. Mar Drugs 2013;11:5051-62
   PubMed Web of Science ®Google Scholar