Section Review: Central & Peripheral Nervous Systems: Disorders of sexual response: Pioneering new pharmaceutical and therapeutic opportunities

References

• BRACKET NL, BLOCH WE, ABAE M: Neurological anatomy ••and physiology of sexual function. In: Sexual Dysfunction: A Newomedical Approach. Singer C, Weiner W3 (Eds.). Futura Pub. Co., Armonk, NY (1994):1–45. A recent review of sexual physiology and dysfunction from an internal medicine perspective.
   Google Scholar
• KAPLAN HS: The comprehensive evaluation of psy-chosexual disorders. In: The Evaluation of Sexual Disor-ders: Psychological and Medical Aspects. Kaplan HS (Ed.). Brunner Mazel, New York (1983):199–276. A landmark review with case histories of psychosexual disorders from a psychiatry perceptive.
   Google Scholar
• BANCROFT J: The biological basis of human sexuality.
   Google Scholar
• •••I= Human Sexuality and Its Problems (Second Edition).Bancroft J (Ed.). Churchill Livingstone, Edinburgh (1989):12–145. Comprehensive review of sexual physiology.
   Google Scholar
• SCHMIDT CW, SCHIAVI R, SCHOVERL, SEAGRAVES T, WISE •TN: Sexual and gender identity disorders. In: Diagnosticand Statistical Manual of Mental Disorders (Fourth Edition) - DSM-IV. Frances A, Pincus HA, First MB (Eds.). Am. Psychiatric Assoc., Washington (1994):493–538. The most current classification of psychosexual disorders by the Am. Psychiatric Assoc.
   Google Scholar
• FRANK E, ANDERSSON C, RUBENSTEIN D: Frequency of sexual dysfunction in normal couples. New Engl. J. Med. (1978) 299:111–115.
   PubMed Web of Science ®Google Scholar
• SCHEIN M, ZYZANSKI SJ, LEVINE S, MEDAUE JH, DICICMANRL, ALEMANGNO SA: The frequency of sexual problems among family practice patients. Family Practice Res. J. (1988) 7:122–134.
   PubMedGoogle Scholar
• BANCROFT J: Sexual Problems. In: Human Sexuality and •Its Problems (Second Edition). Bancroft J (Ed.). ChurchillLivingstone, Edinburgh, UK (1989):360–411. Review of epidemiology studies on sexual disorders.
   Google Scholar
• FELDMAN HA, GOLDSTEIN I, HATZICHRISTOU DG, KRANE RJ, MCKINLAY JB: Impotence and its medical and psy-chosocial correlates: Results of the Massachusetts male aging study. J. Urol. (1994) 151:54-61. Recent epidemiology study on the comorbid variables associated with erectile dysfunction.
   Google Scholar
• SCHMIDT CW: Common male sexual disorders: Impotence and ejaculation. In: Clinical Management of Sexual Disorders (Second Edition). Meyer JK, Schmidt CW Jr., Wise TN (Eds.). Am. Psychiatric Assoc., Washington (1986)173–187.
   Google Scholar
• MELMAN A, TIEFER L, PEDERSON R: Evaluation of first 406 patients in urology department based center for male sexual dysfunction. Urol. (1988) 32:6–12.
   PubMed Web of Science ®Google Scholar
• CARROLL JL, ELLIS DJ, BAGLEY DH: Age-related changes In hormones in impotent men. Urol. (1990) 36:42–46.
   PubMed Web of Science ®Google Scholar
• GALL H, BAHREN W, HOLZKI G, SCHERB W, SPARWASSER C, ZIEGLER U: Ergebnisse nach multidisziplinarer abk-larung bei patienten mit erektiler dysfunktion. Hautarzt (1990) 41:353–359.
   PubMedGoogle Scholar
• KINSEY AC, POMEROY WB, MARTIN CE (Eds.): Sexual behavior in the human male. Saunders, Philadelphia (1948).
   Google Scholar
• BANCROFT J: Sexuality and Aging. In: Human Sexualityand Its Problems (Second Edition). Bancroft J (Ed.). Churchill Livingstone, Edinburgh, UK (1989):360–411.
   Google Scholar
• VIRAG R, SHOU1CRY K, FLORESCO J, NOLLET F, GRECO E: Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J. Urol. (1991) 145:287–293.
   PubMed Web of Science ®Google Scholar
• ELLIS LR, NELLANS RE, KRAMER-LEVIEN DJ, STEWART KNOEPFLER G, KNOEPFLER P: Evaluation of the first 300 patients treated at an outpatient center for male sexual dysfunction. West. J. Med. (1985) 147:296–300.
   Google Scholar
• KAPLAN HS: Anxiety and Sexual Dysfunction. J. Clin.
   Google Scholar
• •Psychiat. (1988) 49\(Suppl. 10):21–25. Clinical evaluation of anxiety as a cause for sexual disorders.
   Google Scholar
• PATTERSON DG, O'GORMAN EC: Sexual anxiety in sexual dysfunction. Br. J. Psychiat. (1989) 155:374-378. Clinical evaluation of anxiety as a cause for sexual disorders.
   Google Scholar
• HOWELL JR, REYNOLDS CF, THASE ME, FRANK E, JEN- NINGS JR, HOUCK PR, BERMAN S, JACOBS E, KUPFER DJ: Assessment of sexual function, interest and activity in depressed men. (1987)J. Affective Dis. 13:61-66. Clinical evaluation of depression as a cause for sexual disorders.
   Google Scholar
• LEIF HI: Evaluation of inhibited sexual desire: Relation- ship aspects. In: Comprehensive Evaluation of Disorders of Sexual Desire. Kaplan HS (Ed.). Am. Psychiatric Assoc., Washington (1985):61–76. Original clinical description of HSD as a separate psychiatric disor-der.
   Google Scholar
• LEIBLUM SR, ROSEN RC: Introduction: Changing per- spectives on sexual desire. In: Sexual Desire Disorders. Leiblum SR, Rosen RC (Eds.). Guilford Press, New York (1988):1–20. Description of diagnostic changes following acceptance of HSD as a psychiatric disorder.
   Google Scholar
• SCHREINER-ENGEL P, SCHIAVI RC: Lifetime psychopathology in individuals with low sexual desire. J. Nero. Mental Dis. (1986) 174:646-651. Landmark study on the association between HSD and subsequent psychiatric disorders.
   Google Scholar
• •••
   Google Scholar
• ERNST C, FOLDENYI M, ANGST J: The Zurich study: X/CL Sexual dysfunctions and disturbances in young adults. Eur. Arch. Psychiat. Clin. Neurosci. (1993) 243:179–188.
   PubMed Web of Science ®Google Scholar
• SEGRAVES KB, SEGRAVES RT: Hypoactive sexual desire ••disorder: Prevalence and comorbidity in 906 subjects.
   Google Scholar
• J Sex Marital Ther. (1991) 17:55-59. Patient characterisation from a drug study on HSD.
   Google Scholar
• SEGRAVES RT, SEGRAVES KB: Categorical and mull-In/dal ••diagnosis of male erectile disorder. J. Sex Marital Ther. (1990)16:208-214. Patient characterisation from a drug study on erectile dysfunction.
   Google Scholar
• FOREMAN MM, DOHERTY PC: Experimental approaches ••for the development of pharmacological therapies for erectile dysfunction. In: Sexual Pharmacology. Riley AJ, Peet M, Wilson C (Eds.). Clarendon Press, Oxford (1993):87–113. Recent review on theoretical pharmaceutical approaches for erectile dysfunction.
   Google Scholar
• SACHS BD, MEISEL RL: The physiology of male sexual ..behavior. In: The Physiology of Reproduction, Volume 2. Knobil E, Neill JD, Ewing JD (Eds.). Karger, New York (1988):1393–1423. Comprehensive review of preclinical studies on sexual physiology.
   Google Scholar
• MIRAN D, HULL EM: Pharmacological analysis of male rat sexual behavior. Neurosci. Biobehav. Rev. (1987) 11:365–389.
   PubMed Web of Science ®Google Scholar
• PFAUSJ, GORZALKA B: Opioids and sexual behavior. Neurosci. Biobehav. Rev. (1987) 11:1–34.
   PubMed Web of Science ®Google Scholar
• BARBEAU A: L-DOPA therapy in Parkinson's disease: a critical review of nine years' experience. Can. Med. Assoc.J. (1969) 101:59–69.
   PubMedGoogle Scholar
• ANGRIST B, GERSHON S: Clinical effects of amphetamine and L-DOPA on sexuality and aggression. Comprehensive Psychiatry (1976) 17:715–722.
   PubMed Web of Science ®Google Scholar
• BENKERT 0, CROMBACH G, KOCKOTT G: Effect of L-DOPA on sexually impotent patients. Psychopharmacolo-gia (1972) 23:91–95.
   PubMedGoogle Scholar
• BROWN E, BROWN GM, KOFMAN 0, QUARRINGTON B: Sexual function and affect in Parkinsonian men treated with L-DOPA. Am. J. Psychiatry (1978) 135:1552–1555.
   PubMed Web of Science ®Google Scholar
• CLARK JT, SMITH ER, DAVIDSON JM: Evidence for modu-lation of sexual behavior by alpha adrenoceptors in male rats. Neuroendo. (1985) 41:36–43.
   PubMed Web of Science ®Google Scholar
• MORALES A, CONDRA M, OWEN J, FENEMORE J, HARRIS C: Is yohimbine effective in the treatment of impotence? Results of a controlled triaL J. Urol. (1987) 137:1168–1172.
   Web of Science ®Google Scholar
• RILEY AJ, GOODMAN RS, KELLETT JM, ORR R: Double blind trial of yohbnbine hydrochloride in the treatment of erection inadequacy. Sexual Marital Tber. (1989) 4:17–26.
   Google Scholar
• SUSSET J, TESSIER C, WINCZE J, BANSAL S, MALHOTRA C,SCI-PWACHA MG: Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J. Urol. (1989)141:1360–1363.
   PubMed Web of Science ®Google Scholar
• LINNANKOSKI I, GRONOSOOS M, CARLSON S, PER-TOVAARA A: Atizepamezoic, an alpha-2-adrenoreceptor increases sexual behavior in male monkeys. Soc. for Neurosci. (1991) 17:282.
   Google Scholar
• MACKINNON AC, KILPATRICK AT, KENNY BA, SPEDDING M, BROWN CM: PHI-RS-15385-197. A selective and high affinity radioligand of az-adrenoceptors: implications for receptor classification. Br. J. Pharmacol. (1992) 106:1011–1018.
   Google Scholar
• BROWN, CM, MACKINNON AC, REDFERN WS, HICKS PE,KILPATRICK AT, SMALL C, RAMCHARANM, CLAGUE RU, CLARKE CB, MACFARLANE CB, SPEDDING M: The phar-macology of RS-15385-197, a potent and selective az-ad-renoceptor antagonist. Br. J. Pharmacol. (1993) 108:516–525.
   PubMedGoogle Scholar
• MUNOZ M, BANCROFT J, TURNER M: Evaluating the effects of an alpha-2-adenoceptor antagonist on erectilefunction in the human male. 1. The erectile response to erotic stimuli in volunteers. Psychopbarmacol. (1994) 115:463-470. Pioneering effort to develop objective measurements of sexual responses in men.
   Google Scholar
• MUNOZ M, BANCROFT J, TURNER M: Evaluating the effects of an alpha-2-adenoceptor antagonist on erectile function in the human male. 2. The erectile response to erotic stimuli in men with erectile dysfunction, in relation to age and in comparison with normal volun-teers. Psychopbarmacol. (1994) 115:471–477.
   Google Scholar
• JACOBSEN FM: Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J. Clin. Psychiatry (1992) 53:119–122
   PubMed Web of Science ®Google Scholar
• DE LEO D, MAGNI G, PAVAN L: Modifications of libidoand sex drive during treatment of minor depression with viloxamine. Int.J. Clin. Pharmacol. Tber. Tax. (1983) 21:176–177.
   PubMed Web of Science ®Google Scholar
• DE LEO D, MAGNI G: Does viloxazine really improve sexdrive? A double-blind controlled study. Br. J. Psychiatr. (1986) 148:597–599.
   PubMed Web of Science ®Google Scholar
• FREED E: Increased sexual function with nomifensine. Med. J. Aust. (1983) 1:551.
   PubMed Web of Science ®Google Scholar
• CRENSHAW T, GOLDBERG J, STERN W: Pharsnacologic modification of psychosexual dysfunction. J. Sexual Marital Tber. (1987) 13, 239–250. Clinical research report on the effects of bupropion on sexual responses of patients with HSD.
   Google Scholar
• DEL BENE E, FANCIULLACCI M, POGGIONI M: Apomor- phine and other dopamine modifiers of human sexual and nociceptive tonus. In: Psychopharrnacology of Sexual Disorders. Segal M (Ed.). John Libbey, London (1989:145–153.
   Google Scholar
• UTTI RJ, TANNER CM, RAJPUTAH: Hypersexuality with antiparkinsonian therapy. Clin. Neuropbarm. (1989) 5:375–383.
   Google Scholar
• BRODERICK G, FOREMAN M: latrogenic sexual dysfunc-tion. Sexual Dysfunction: A Neuromedical Approach. Singer C, Weiner WJ (Eds.). Futura Publishing Co., Armonk, NY (1994):299–331. Recent review on side-effects of drugs on sexual responses.
   Google Scholar
• KLEIN KB, MENDELS J, LLEF H: Drug treatments in pa-tients with inhibited sexual desire: A controlled clinical trial. Soc. Sex Therapy. Res. Meetings, May 8, 1987.
   Google Scholar
• WALKER PW, COLE JO, GARDNER EA, HUGHESAR, JOHNSTON A, BATEY SR, LINEBERRY CG: Improvement In fluoxetine-associated sexual dysfunction in patients switched to bupropion. J. Clin. Psychiat. (1994) 54:459–465.
   Web of Science ®Google Scholar
• PAGLIETTI E, PELLEGRINI-QUARANTOTTI B, MERU G, GESSA G: Apomorphine and L-DOPA lower ejaculatory threshold in the male rat. Physiol. Bebav. 20:559–562.
   Google Scholar
• AHLENIUS S, ENGEL J, LARSSON K, SVENSSON L: Effects of pergolide and bromocriptine on male rat sexual behavior. J. Neural Trans. (1982) 54:165–170.
   PubMed Web of Science ®Google Scholar
• FOREMAN MM, HALL JL: Effects of D2-dopaminergIc receptor stimulation on male rat sexual behavior. J. Neural Trans. (1987) 68:153–170.
   PubMed Web of Science ®Google Scholar
• POMERANTZ SD: Quinelorane (LY163502), a D2 dopaminergic receptor agonist, acts centrally to facili-tate sexual behavior of rhesus monkeys. Pharmacol. Biochern. Behav. (1991) 39:123-128. First study reporting a rhesus monkey model for studying drug effects on sexual responses.
   Google Scholar
• HULL EM, WARNER RK, BAZZETT TJ, EATON RC, THOMPSON JT, SCALLETTA LL: D2/D1 ratio in the medial preoptic area affects copulation of male rats. J. Pharma-col. Exp. Therap. (1989) 251:422–427.
   PubMed Web of Science ®Google Scholar
• FOREMAN MM, GEHIERT DR, SCHAUS JM: Quinelorane, A potent and selective dopamine agonist for the 1:12-like' receptor family. Neurotransmissions (1995) 11:1–5.
   Google Scholar
• D'AQUILA PS, BRAIN P,WILLNER P: Effects of chronic mild stress on performance in behavioural tests rele-vant to anxiety and depression. Physiol. Behav. (1994) 56:861–868.
   PubMed Web of Science ®Google Scholar
• WILLNER P, MUSCAT R, PAPP M: Chronic mild stress-in-duced anhedonia: a realistic animal model of depres-sion. Neurosci. Biobebav. Rev. (1992) 16:525–534.
   PubMed Web of Science ®Google Scholar
• MAS M, RODRIGUEZ DEL CASTILLO A, GUERRA M, DAVID-SON JM, BATTNER E: Neuroc.hemical correlates of male sexual behavior. Physiol. Behav. (1987) 41:341–345.
   PubMed Web of Science ®Google Scholar
• PFAUS JG, DAMSMA G, NOMIKOS GG, WENKSTERN DG, BLAHA CD, PHILLIPS AG, FIBIGER HC: Sexual behavior enhances central dopaminergic transmission in the male rat. Brain Res. (1990) 530:345–348.
   PubMed Web of Science ®Google Scholar
• WILSON C: Pharmacological targets for the control of •male and female sexual behavior. In: Sexual Pharmacol-ogy. Riley AJ, Peet M, Wilson C (Eds.). Clarendon Press, Oxford (1993):1–59. Recent review of drug effects on sexual responses of the laboratory rat.
   Google Scholar
• PINDER RM, BROGEN, RN, SAWYER PR SPEIGHT TM, AVERY GS: Fenfluramine: a review of its pharmacologi-cal properties and efficacy in obesity. Drugs (1975) 10:241–323.
   PubMed Web of Science ®Google Scholar
• FOREMAN MM, FULLER RW, LEANDER JD, ZHANG L, BAR- RETT JE, WONG DT, NELSON DL, CALLIGARO DO, SWAN-SON SP, LUCOT JB, FLAUGH ME: Preclinical studies on LY228729: a potent and selective 5-11TIA agonist. J. Pharmacol. Exp. Therap. (1993) 268:58–71.
   Google Scholar
• FOREMAN MM, FULLER RW, LEANDER JD, BENVENGA MJ, •ZHANG L, BARRETT JE, RASMUSSEN K, WONG DT, NELSON DL, CALLIGARO DO, BOOHER RN, PAGET CJ, FLAUGH ME: Pharmacological characterization of LY293284: an ex-tremely potent and selective 5-HT1A agonist. J. Pharma-col. Exp. Ther. (1994) 270:1270-1281. Comparative effects of an extremely potent 5-HTiA agonist in models of anxiety, depression and sexual response.
   Google Scholar
• GLASER T, DOMPERT WU, SCHUURMAN T, SPENCER DG
   Google Scholar
• ••Jr., TRABER J: Differential pharmacology of the novel
   Google Scholar
• -HT1A receptor ligands 8-01I-DPAT, BAY R 1531 and ipsapirone. In: Brain 5-HTiA Receptors. Dourish CT, Ahlenius S, Hutson PT (Eds.). Ellis Harwood, New York (1987):106–119. Preclinical studies on the 5-HTiA agonist from Bayer for male sexual disorders.
   Google Scholar
• POMERANTZ SD: 5-HT2A agonists, 8-0H-DPAT and ipsapirone, lower the ejaculatory threshold of rhesus monkeys. Soc. for Neurosci. (1991) 17:149.
   Google Scholar
• ARNONE M, BARONI M, GAI J, GUZZI U, DESCLAUX MF, ••KEANE PE, LEFUR G, SOUBRIE P: Effect of SR59026A, A new 5-HTIA receptor agonist, on sexual activity in male rats. Behav. Pharmacol. (1995) 6:276-282. Preclinical studies on the 5-HT1A agonist from Sanofi for male sexual disorders.
   Google Scholar
• OTHMER E, OTHMER S: Effect of buspirone on sexual ••dysfunction in patients with generalized anxiety disor-der. Clin. Psychiatry (1987) 48:201-203. First clinical report of a beneficial effect of buspirone on sexual responses in men and women.
   Google Scholar
• JENIKE MA, BAER L, BUTTOLPH L: Buspirone augmenta-tion of fluoxetine in patients with obsessive compulsive disorder. J. Clin. Psychiat. (1991) 52:13–14.
   PubMed Web of Science ®Google Scholar
• SULLIVAN G: Increased libido in three men treated with trazodone. J. Clin. Psychiatry (1988) 49:202–203
   PubMed Web of Science ®Google Scholar
• LAL S, RIOS 0, THAVUNDAYIL pC: Treatment of impo-tence with trazodone: a case report. J. Urol. (1990) 143:819–820.
   PubMed Web of Science ®Google Scholar
• ADAIKAN PG, NG SC, CHAN C, RATNAM SS: Oral trazo-done in the treatment of total secondary impotence in a diabetic patient. Br. J. Urol. (1991) 68:212–213.
   PubMedGoogle Scholar
• KURT U, OZICARDES H, ALTUG U, GERMIYANOGLU C, eseGURDAL M, EROL D: The efficacy of antiserotonergicagents in the treatment of erectile dysfunction. J. Urol. (1994) 152:407-409. Recent clinical trial comparing different 5-HT2 antagonists in men with erectile dysfunction.
   Google Scholar
• FOREMAN MM, FULLER RW, NELSON DL, CALLIGARO DO, KURZ KD, MISNER JW, GARBRECHT WL, PARLI CJ: Preclini-cal studies on LY237733, a potent and selective seroton-ergic antagonist. J. Pharmacol. Exp. Therap. (1992) 260:51–57.
   PubMed Web of Science ®Google Scholar
• KLINT T, DAHLGREN IL, LARSSON K: The selective 5-HT2receptor antagonist amperozide attenuates 1-(2,5-di-methoxy-4-iodopheny1-2-aminopropane-induced inhi-bition of male rat sexual behaviour. Eur. J. Pharmacol. (1992) 212:241–246.
   PubMed Web of Science ®Google Scholar
• FORSTER P, KING J: Fluoxetine for premature ejacula-tion. Am. J. Psychiat. (1994) 151:1523.
   PubMed Web of Science ®Google Scholar
• FALASCHI P, ROCCO A, DE GIORGIO G, FRAJESE G, FRATTA W, GESSA GL: Brain dopamine and premature ejaculation: results of treatment with dopamine antago- nists.Apomotphine and Other Dopaminomimetics.Gessa GL, Corsini GU (Eds.). New York, Raven Press (1981):117–121.
   Google Scholar
• POWER-SMITH P: Beneficial sexual side-effects from fluoxetine. Brit. J. Psychiatry (1994) 164:249–250.
   PubMed Web of Science ®Google Scholar
• KAFKA MP, PRENTKY R: Fluoxetine treatment of non-paraphRic sexual addictions and paraphilias in men.]. din. Psychiat. (1992) 53:351–358.
   Google Scholar
• SKAGERBERG G, BJORKLUND A, LINDVALL 0, SCHMIDTRI-1: Origin and termination of the dlencephalo-spinal dopamine system in the rat. Brain Res. Bull. (1982) 9:237–244.
   PubMed Web of Science ®Google Scholar
• WAGNER,CK, CLEMENS LG: Projections of the paraven- tricular nucleus of the hypothalamus to the sexually dimorphic region of the spinal cord. Society for Neurosci. (1989) 15:1089.
   Google Scholar
• STANCAMPINO R, MELTS MR, ARGOLIS A: Penile erection •and yawning induced by 5-HTic receptor agonists in male rats: relationship with dopaminergic and oxyto-cinergic transmission. Eur.J. Pbarmacol. (1994) 261:149-155. Original research publication with references on the hypothalamic regulation of penile erection.
   Google Scholar
• MAEDA N, MATSUOKA N, YAMAGUCHI I: Role of the •dopaminergic, serotonergic and cholinergic link in theexpression of penile erection in rats. Jpn. J. PbarmacoL (1994) 66:59-66. Recent preclinical discoveries on hippocampal transmitters control-ling erection.
   Google Scholar
• MAEDA N, MATSUOKA N, YAMAZAKI M, ARAKAWA H, OHKUBO Y, YAMAGUCHI I: A screening concept based on a hypothesis led to the development of a putative cognitive enhancer that stimulates penile erection. Jpn.
   Google Scholar
• PharmacoL (1994) 64:147–153.
   Google Scholar
• MARSON L, MCKENNA K: The identification of a brain-stem site controlling spinal sexual reflexes. Brain Res. (1990) 515:303-308. First report of a brainstem area controlling descending inhibition of sexual reflexes.
   Google Scholar
• LOVICK TA: Projections from the diencephalon and mesencephalon to nucleus paragigantocellularis later-ails in the cat. Neurosci. (1985) 14:853–861.
   PubMed Web of Science ®Google Scholar
• ANDREZIK JA, CHAN-PALAY V, PALAY SL: The nucleusparagigantocellularis lateral's in the rat. Demonstra-tion of afferents by the retrograde transport of horse-radish peroxidase. Anat. Emb. (1981) 161:373–390.
   Google Scholar
• LOVICK TA: Tonic GABAergic and cholinergic influ-ences on pain control and cardiovascular control neu-rons in the nucleus paragigantocellularis lateral's of the rat. Pain (1987) 31:401–409.
   PubMed Web of Science ®Google Scholar
• GLAZER EJ, STEINBUSCH H, VERHOFSTAD A, BASBAUM Al: Serotonin neurons in the nucleus raphé dorsalis and paragigantocellularis of the cat contain enkephalin. J. Pbysiol. (1981) 77:241–245.
   Web of Science ®Google Scholar
• HANSEN S: Spinal control of sexual behavior: effects of intrathecal administration of lisuride. Neurosci. Letters (1982) 33:329–332.
   PubMed Web of Science ®Google Scholar
• JEANTY P, VAN DEN KERCHOVE M, LOWENTHAL A, DE-BRUYNE H: Pergolide therapy in Parkinson's disease. J. Neurol. (1984) 231:148–152.
   PubMed Web of Science ®Google Scholar
• DANJOU P, ALEXANDRE L, WAROT D, LACOMBLEZ L, •PUECH AJ: Assessment of erectogenic properties ofapomorphine and yohirnbine. Br. J. Clin. Pharm. (1989) 26:733-739. Pioneering clinical study on the acute effects of apomorphine and yohimbine in men.
   Google Scholar
• SEGRAVES RT, BARI M, SEGRAVES K, SPIRNAK P: Effect of apomorphine on penile tumescence in men with psy-chogenic impotence. J. Urol. (1991) 145:1174–1175.
   PubMed Web of Science ®Google Scholar
• LAL S, TESFAYE Y, THAVUNDAYIL J, THOMPSON TR, KIELY •• ME, NAIR NPV, GRASSINO A, DUBROVSICY B: Apo:mor-phine: Clinical studies on erectile impotence and yawn-ing. Prog. Neuropsychopharm. Biol. Psychiat. (1989) 13:329-339. First demonstration of a yawning-penile erection response to dopamine agonists in men.
   Google Scholar
• POMERANTZ SD: Apomorphine facilitates erection in •the rhesus monkey. Pharmacol. Biocb. Behav. (1990) 35:659–664. First full report on drug induced erections in the rhesus monkey.
   Google Scholar
• GOWER A, BERENDSEN H, PRINCEN M, BROEKKAMP CLE: The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity. Eur. J. Pharm. (1984) 103:81–9.
   PubMed Web of Science ®Google Scholar
• FERRARI F, PELLONI F, GIULIANI D: Behavioral evidencethat different neurochemical merhanbuns underlie stretching-yawning and penile erection induced in male rats by SND 919, a selective D2 dopaminergic receptor agonist Psychopharmacol. (1993) 113:172–176.
   Google Scholar
• DOHERTY PC, WISLER P, FOREMAN MM: Effects of quinelorane on yawning, penile erection and sexual behavior in the male rat. Soc. for Neurosci. (1991) 17:328.
   Google Scholar
• LAL S, KIELY ME, THAVUNDAYIL JX, STEWART JD, AS- SAL1AN P, ACKMAN CFD: Effects of bromocriptine in patients with apomorphine-responsive erectile impo-tence: An open study. J. Psychiat. Neurosci. (1991) 16:262-266. Recent clinical study on the effects of oral bromocriptine in men with impotence.
   Google Scholar
• DIEDERIC W, STLEF CG, LUE TF, TANAGHO EA: Sympa-thetic inhibition of papaverine induced erection. J. Urol. (1991) 146:195-198. Preclinical demonstration for sympathetic inhibition of erections induced by intrapenile injection.
   Google Scholar
• BERENDSEN HHG, JENCK F, BROEKKAMP CLE: involve-ment of 5-11Tic receptors in drug induced penile erec-tions in rats. Psychopharm. (1990) 101:57-61. First report of a 5-HT role in inducing erections in rats.
   Google Scholar
• SZELE FG, MURPHY DL, GARRICK NA: Fenfluramine, m-chlorophenylpiperazine and other serotonin reup- take agonists and antagonists on penile erections in non-human primates. Life Sciences (1988) 43:1297-1303. First report of a 5-HT role in inducing erections in rhesus monkeys.
   Google Scholar
• STEERS WD, DE GROAT WC: Effects of m-chloro-
   Google Scholar
• Ophenylpiperazine on penile and bladder function inrats. Am. J. Physiol. (1989) 257:R1441-1449. First neurophysiology report of mCPP induced erections.
   Google Scholar
• POWER-SMITH P: Beneficial sexual side-effects from fiuoxetine. Br. J. Psychiat. (1994) 164:249–250,
   PubMed Web of Science ®Google Scholar
• SMITH DM, LEVITTE SS: Association of fiuoxetine and return of sexual potency in three elderly men. J. Clin. Psychiatry (1993) 54:317–319.
   PubMed Web of Science ®Google Scholar
• PEROUTKA SJ: Molecular biology of serotonin receptors. Synapse (1994) 18:241–260.
   PubMed Web of Science ®Google Scholar
• ADA1KAN PG, NYG SC, CHAN C, RATNAM SS: Oral trazo-done in the treatment of total secondary impotence in the diabetic patient. Brit.J. Urol. (1991) 68:212–213.
   PubMedGoogle Scholar
• MURPHY MR: Endogenous opiates and the mechanisms of male sexual behavior. In: Psychopharmacology of Sex-ual Disorders. Segal M (Ed.). John Libbey, London (1988):51–62.
   Google Scholar
• DORNAN W, MALSBURY CW: Neuropeptides and male sexual behavior. Neurosci. Biobehav. Rev. (1989) 13:1–15.
   PubMed Web of Science ®Google Scholar
• FABBRI A, JANNINI A, GNESSI L, MORE1TI C, ULISSE S, FRANZESE A, LAZZARI R, FRAIOLI F, FRAJESE G, ISIDORI 84.
   Google Scholar
• A: Endorphins in male impotence: evidence for naltrex-one stimulation of erectile activity in patient therapy. Psychoneuroendo. (1989) 14:103411.
   Google Scholar
• CHARNEY DS, HENINGER GR: Alphaz-adrenergic and opiate receptor blockade. Arch. Gen. Psych:Wt. (1986) 43:1037–1041.
   PubMed Web of Science ®Google Scholar
• KLEIN DF: Repeated observations of yawning, clitoral engorgement, and orgasm associated with fluoxetine administration. J. Clin. Psychopharmacol. (1989) 9:384.
   PubMed Web of Science ®Google Scholar
• PESCATORI ES, ENGELMAN JC, DAVIS G, GOLDSTEIN I: Priapism of the clitoris: a case report following trazo-done use. J. Urol. (1993) 149:1557–1559.
   PubMed Web of Science ®Google Scholar
• BUN 0, SCHWERTSCHLAG US, SERRATRICE G: Painful clitoral tumescence during bromocriptine therapy. Lancet (1991) 337:1231–1232.
   PubMedGoogle Scholar
• ROSEN RC, ASHTON AK: Prosexual drugs: empirical status of the 'new aphrodisiacs'. Arch. Sex. Behav. (1993) 22:521–543.
   PubMed Web of Science ®Google Scholar
• MATSUI T, NAKAMURA Y, ISHIKAWA H, MATSUURA, KO-BAYASHI F: Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on strepto-zotocin-induced diabetic rats. Jpn. J. Pharmacol. (1994) 64:115–124.
   PubMedGoogle Scholar
• ANDERSSON K-E: Pharmacology of lower urinary tract ••• smooth muscle and penile erection. Pharmacol. Rev. (1993) 45:253-308. Recent comprehensive review of vascular phannacologic studies of the penile tissue.
   Google Scholar
• O'KEEFE M, HUNT D: Assessment and treatment of Impotence. Med. Clin. N. Am. (1995) 79:415–434.
   PubMed Web of Science ®Google Scholar
• RAYNER HC, MAY S, WALLS J: Penile erection due to nifedipine. Br. Med. J. (1988) 296:137.
   Web of Science ®Google Scholar
• Zonogen's Phentolamine Phase II clinical trials. Scrip (1995) 2001:26
   Google Scholar
• SAENZ DE, TEJADA I, WARE CJ, BLANCO R, PITTARD JT, NADIG PW, AZADZOI K, 1CRANE R, GOLDSTEIN I: Patho-physiology of prolonged penile erection associated with trazodone use. J. Urol. (1991)145:60–64.
   PubMedGoogle Scholar
• FORTES ZB, LEME JG, SCIVOLEFTO R: Vascular reactivity In diabetes: role of the endothelial cell. Br.J. Pharmacol. (1983) 79:771–781.
   PubMed Web of Science ®Google Scholar
• GERRAND JM, STUART MJ, RAO GHR, STEFFES MW, MALTER SM, BROWN DM, WHITE JG: Alterations in the balance of prostaglandin and thromboxane synthesis in dia-betic rats. J. Lab. Clin. Med. (1980) 95:950–958.
   PubMedGoogle Scholar
• SAENZ DE TEJADA I, GOLDSTEIN I, AZADZOI K, KRANE R, COHEN RA: Impaired neurogenic and endothelium- mediated relaxation of smooth muscle from diabetic men with impotence. New Engl. J. Med. (1990) 320:1025–1030.
   Web of Science ®Google Scholar
• MIKHALIDAS DP, JEREMY JY, SHOUKRY K, VIRAG R: Eicosanoids, impotence and pharmacologically in-duced erections. Prostaglandins, Leukotrienes andFssential Fatty Acids (1990) 40:239–242.
   PubMedGoogle Scholar
• HEDLUND H, ANDERSSON K-E, HOLMQUIST F, USKI T: Effects of the thromboxane receptor antagonist AH23848 on human isolated corpus cavernosutn. Int.J. Imp. Res. (1989) 1:19–25.
   Google Scholar
• KORENNIAN SG, VIOSCA SP: Treatment of vasculogenic sexual dysfunction with pentoxifylline. J. Am. Geriatr Soc. (1993) 41:363-366. Recent clinical trial on pentoxifylline in erectile dysfunction.
   Google Scholar
• GEORGMS WJ, MERENICH JA: Trial of pentoxifylline for diabetic impotence. Diabetes Care (1995) 18:345–352.
   PubMed Web of Science ®Google Scholar
• FRANCES A, PINCUS HA, FIRST MB: Introduction. Diag-nostic and Statistical Manual of Mental Disorders (Fourth Edition)-DSM-IV. Frances A, Pincus HA, First MB (Eds.). Am. Psychiatric Assoc., Washington (1994):xxi. Recent review from Am. Psychiat. Assoc. defining 'mental' disorders.
   Google Scholar
• ESCHALIER A, MESTRE C, DUBRAY C, ARDID D: Why are antidepressants effective as painrelieff CNS Drugs (1994) 2:261–267.
   Google Scholar
• BRESLAU N, MERIKANGAS K, BOWDEN CL: Comorbidity of migraine and major affective disorders. Neurol. (1994) 44:17–22.
   PubMed Web of Science ®Google Scholar
• TOLLEFSON GD, TOLLEFSON SL, PEDERSON M, LUXEN-BERG M, DUNSMORE G: Comorbid irritable bowel syn-drome in patients with generalized anxiety and major depression. Ann. Clin. Psychiat. (1991) 3:215–222.
   Google Scholar
• MACAULAY AJ, STERN RS, HOLMES DM, STANTON SL: Mkturition and the mind: psychological factors in the aetiology and treatment of urinary symptoms in women. Br. Med. J. (1987) 294:540–543.
   PubMed Web of Science ®Google Scholar
• MACAULAY AJ, STERN RS, STANTON SL: Psychological aspects of 211 female patients attending a urodynamic unit. J. Psychosom. Res. (1991) 35:1–10.
   PubMed Web of Science ®Google Scholar
• BRICKMAN AL, FINS Al: Psychological and cognitive aspects of chronic fatigue syndrome. In: Chronic fatigue and ?elated immune deficiency syndromes. PJ Goodnick, NG Klinas (Eds.). American Psychiatric Press, Washington (1993):67–94.
   Google Scholar