Section Reviews: Biologicals & Immunologicals: Sjögren's syndrome: Pathogenesis and prospects for therapy

References to Primarv Literature

• ROSE NR, BONA C: Defining criteria for autoimmune diseases (WitebsIcy's postulates revisited). Immunol. To-day (1993) 14:426–430.
   PubMedGoogle Scholar
• TAN EM: Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. (1989) 44:93–151.
   PubMed Web of Science ®Google Scholar
• LAFER EM, RAUCH J, ANDRZEJEWSKI C, Jr. et al.: Polyspe-cific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids. J. Exp. Med. (1981) 153:897–909.
   Google Scholar
• AVRAMEAS S, TERNYNCK T: The natural autoantibodiessystem: between hypotheses and facts. Mol. Immunol. (1993) 30:1133–1142.
   PubMed Web of Science ®Google Scholar
• LEHMANN PV, SERCARZ EE, FORSTHUBER T, DAYAN CM,GAMMON G: Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol. Today (1993) 14:203–208.
   PubMedGoogle Scholar
• FOX RI, SAITO I: Criteria for diagnosis of Sjögren's syndrome. Rheum. Dis. Clin. NA. (1994) 20:391–408.
   PubMed Web of Science ®Google Scholar
• vrrAu C, BOMBARDIERI S, MOUTSOPOULOS IIM et al.: Preliminary criteria for the classification of Sjögren's syndrome - results of a prospective concerted action supported by the European community. Arthritis Rheum. (1993) 36(3):340–347.
   PubMed Web of Science ®Google Scholar
• MAMULA MJ, UN J, JANEWAY C, HARDIN J: Breaking T-cell tolerance with foreign and self-co-inununogen: a study of autoimmune B-and T-cell epitopes of cytochrome. J. Immunol. (1992) 151:789–799.
   Google Scholar
• MAMULA MJ: The inability to process a self-peptideallows autoreactive T-cells to escape tolerance. J. Exp. Med. (1993) 177:567–571.
   PubMed Web of Science ®Google Scholar
• MILICH DR, MCLACHLAN A, RANEY AK et al.: Autoanti-body production in hepatitis B e antigen transgenic mice elicited with a self-T-cell peptide and inhibited with nonseff-peptides. Proc. Natl. Acad. Sci. USA (1991) 88:4348–4352.
   PubMed Web of Science ®Google Scholar
• MILICH DR, JONES JE, MCLACHLAN A et al.: Distinctionbetween krununogenicity and tolerogenicity among HBcAg T-cell determinants. J. Immunol. (1989) 143:3148–3156.
   PubMed Web of Science ®Google Scholar
• GAMMON G, SERCARZ EE, BENICHOU G: The dominant self and the cryptic self: shaping the autoreactive T-cell repertoire. Immunol. Today (1991) 12:193–195.
   PubMedGoogle Scholar
• UN RH, MAMULA MJ, HARDIN JA, JANE WAY CA, Jr.: Induc-tion of autoreactive B-cells allows priming of autoreac- tiveJ. Exp. Med. (1991) 173:1433–1439.
   Google Scholar
• MAMULA MJ, UN R-H, JANEWAY CA, Jr., HARDIN JA: Breaking T-cell tolerance with foreign and self co-im-munogens. A study of autoimmune B- and T-cell epi-topes of cytochrome c. J. Immunol. (1992) 149:789–795.
   Google Scholar
• FATENEJAD 5, MAMULA MJ, CRAFT J: Role of intermolecu-lar/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles. Proc. Natl. Acad. Sci. USA (1993) 90:12010–12014.
   PubMed Web of Science ®Google Scholar
• POSSELT AM, BARKER CF, FRIEDMAN AL, NAJI A: Prevention of autoimmune diabetes in the BB rat by in-trathymk islet transplantation at birth. Science (1992) 256:1321–1324.
   Google Scholar
• KOEVARY SB, BLOMBERG M: Prevention of diabetes inBB/Wor rats by intrathymic islet injection. J. Clin. Invest. (1992) 89:512–516.
   PubMed Web of Science ®Google Scholar
• GERLING IC, SERREZE DV, CHRISTIANSON SW, LEITER EH:Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice. Diabetes (1992) 41:1672–1676.
   PubMed Web of Science ®Google Scholar
• HEROLD KC, MONTAG AG, BUCKINGHAM F: Induction of tolerance to autoimune diabetes with islet antigens. J. Exp. Med. (1992) 176:1107–1114.
   PubMed Web of Science ®Google Scholar
• KAUFMAN DL, CLARE-SALZER M, TIAN J et al.: Spontane-ous loss of T-cell tolerance to glutamic acid decarboxy-lase in murine insulin-dependent diabetes. Nature (1993) 366:69–72.
   PubMed Web of Science ®Google Scholar
• TISCH R, YANG X-D, SINGER SM et al.: Immune response to glutamic acid dec,arboxylase correlates with insulitis in non-obese diabetic mice. Nature (1993) 366:72–75.
   PubMed Web of Science ®Google Scholar
• KHOURY SJ, SAYEGH MIL HANCOCK WW et al.: Acquired tolerance to experimental autoimmune encephalomye-litis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide. J. Exp. Med. (1993) 178:559–566.
   Google Scholar
• ALDERUCCIO F, TOT! B-H, TAN S-S, GLEESON PA, VAN DRIEL IR: An autoimmune disease with multiple molecu-lar targets abrogated by the transgenic expression of a single autoantigen in the thymus. J. Exp. Med. (1993) 178:419–426.
   PubMed Web of Science ®Google Scholar
• CLARK E, LEDBE ILER J: How B- and T-cells talk to eachother. Nature (1994) 367:425–428.
   PubMed Web of Science ®Google Scholar
• DANIELS TE, WHITCHER JP: Association of patterns oflabial salivary gland inflammation with keratoconjunc-tivitis sicca. Analysis of 618 patients with suspected Sjögren's syndrome. Arthritis Rheum. (1994) 37:869–877.
   PubMed Web of Science ®Google Scholar
• FISHLEDER A, TUBBS R, HESSE B, LEVIN H: Lmmuno-globulin-gene rearrangement in benign lymphoepi-thelial lesions. New Engl. J. Med. (1987) 316:1118–1121.
   PubMed Web of Science ®Google Scholar
• SCHMID U, HELBRON D, LENNERT K: Development of malignant lymphoma in myoepithelial sialadenitis (Sjögren's syndrome). Virchows Arch. (1982) 395:11–41.
   PubMed Web of Science ®Google Scholar
• ADAMSON TC, III, FOX RI, FRISMAN DM, HOWELL FV: Lmmunohistologic analysis of lymphoid infiltrates in primary Sjögren's syndrome using monoclonal anti-bodies. J. Immunol. (1983) 130:203–208.
   PubMed Web of Science ®Google Scholar
• FOX R, KANG H, SAITO I: Pathogenesis of Sjogren's syndrome. Rheum. Dis. Clin. North Am. (1993) 33:41–61.
   Google Scholar
• FOX RI, BUMOL T, FANTOZZI R, BONE R, SCHREIBER R:Expression of histocompatibility antigen HLA-DR by salivary gland epithelial cells in Sjögren's syndrome. Arthritis Rheum. (1986) 29:1105–1111.
   PubMed Web of Science ®Google Scholar
• LINDAHL G, HEDFORS E: Labial salivary gland lympho-cytic infiltration in Sjögren's syndrome [Letter]. Arthritis Rheum. (1991) 34:1070–1071.
   PubMed Web of Science ®Google Scholar
• ADAMSON TC, III, FOX RI, FRISMAN DM: Immunohis-tologic analysis of lymphoid infiltrates in primary Sjagren's syndrome using monoclonal antibodies. J. Immunol. (1983) 130:203.
   PubMed Web of Science ®Google Scholar
• MAMULA M, JANEWAY C: Do B-cells drive the diversifi-cation of immune responses? Immunol. Today (1993) 14:151–153.
   Google Scholar
• CARSON DA, CHEN PP, KIPPS TJ: New roles for rheuma-toid factor. J. Clin. Invest. (1991) 87:379–383.
   PubMed Web of Science ®Google Scholar
• SCHWARTZ RH: A cell culture model for T-lymphocyte clonal anergy. Science (1990) 248:1349–1356.
   PubMed Web of Science ®Google Scholar
• JANEWAY CA, Jr., BOTTOMLY K: Signals and signs for lymphocyte responses. Cell (1994) 76:275–285.
   PubMed Web of Science ®Google Scholar
• OHASHI PS, OEHEN S, BUERKI K et al.: Ablation of 'tolerance' and induction of diabetes by virus infection In viral antigen transgenic mice. Cell (1991) 65:305–317.
   PubMed Web of Science ®Google Scholar
• OLDSTONE MB, NERENBERG M, SOUTHERN P, PRICE J, LEWICKI H: Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response. Cell (1991) 65:319–332.
   PubMed Web of Science ®Google Scholar
• MORGAN DG, NIEDERMAN JC et al.: Site of Epstein-Barr virus replication lathe oropharynx. Lancet (1979) i:1154.
   Google Scholar
• PFLUGFELDER SC, GROUSE C, PEREIRA I, ATHERTON S: Amplification of Epstein-Barr virus genomic sequences In blood cells, lacrimal glands, and tears from primary Sjögren's syndrome patients. Ophthalmology (1990) 97:976–984.
   PubMed Web of Science ®Google Scholar
• PFLUGFELDER SC, TSENG S, PEPOSE JS et al.: Epstein-Barrvirus infection and immunologic dysfunction in pa-tients with aqueous tear deficiency. Ophthalmology (1990) 97:313–323.
   PubMed Web of Science ®Google Scholar
• FOX RI: Epstein-Barr virus and human autoirnmunediseases. J. Virol. Methods (1988) 21:19.
   PubMed Web of Science ®Google Scholar
• FOX RI, LUPPI M, KANG II-I, PISA P: Reactivation ofEpstein-Barr virus in Sjogren's syndrome. In: Springer Seminar in Immunopathology. Sixbey JW (Ed.), Springer-Verlag, Heidelberg (1991):217–231.
   Google Scholar
• KUDO I, SAITO I, MORO I: Detection of Epstein-Barrvirus DNA from lacrimal gland biopsies in Spigren's syndrome patients. Clin. Exp. Rheumatol. (1991) 9:337.
   Google Scholar
• FOX RI, PEARSON G, VAUGHAN JH: Detection of Epstein-Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjögren's syndrome. J. Immunol. (1986) 137:3162–3168.
   PubMed Web of Science ®Google Scholar
• STREILEIN JW: Unraveling immune privilege. Science (1995) 270:1189–1192.
   PubMed Web of Science ®Google Scholar
• TAYLOR AW, STREILEIN JW: Alpha melanocyte-stimulat-ing hormone suppresses antigen-driven T-cell produc-tion of interferon-gamma. Immunol. (1994) 153:1080.
   Google Scholar
• JAGER MJ, GREGERSON DS, STREILEIN JW: Regulators of immunological responses in the cornea and the ante-rior chamber of the eye. Eye (1995) 9(Pt. 2):241–246.
   PubMedGoogle Scholar
• GERY 1, STREILEINAutoiramunity in the eye and its regulation. Curr. Opin. Immunol. (1994) 6:938–945.
   PubMed Web of Science ®Google Scholar
• SPENCER SV, FABRE PV: Immunoprotection. Transplan-tation (1987) 44:141.
   PubMed Web of Science ®Google Scholar
• KONTTTNEN YT, HUKKANEN M, KEMPPINEN P, SEGER-BERG M: Peptide-containing nerves in labial salivary glands in SjOgren's syndrome. Arthritis Rheum. (1992) 35:815–820.
   PubMed Web of Science ®Google Scholar
• KONTINEN Y, SORSA T, KUKKANEN M, SERGENBERG M: Topology of innervation of labial salivary glands. J. Rheumatol. (1992) 19:30.
   PubMedGoogle Scholar
• DORNER T, HUCK() M, MAYET WJ et al.: Enhanced mem-brane expression of the 52 kDa Ro(SS-A) and La(SS-B) antigens by human keratinocytes induced by TNF al-pha. Ann. Rheum. Dis. (1995) 54:904–909.
   Google Scholar
• OXHOLM P, DANIELS TE, BENDTZEN K: Cytokine expres-sion in labial salivary glands from patients with pri-mary Sjögren's syndrome. Autoimmunity (1992) 12:185–191.
   PubMed Web of Science ®Google Scholar
• KOSKI H, KONTTINEN YT, GU XH, HIETANEN J, MAIN-STROM M: Transforming growth factor beta 2 in labial salivary glands in Sjögren's syndrome. Ann. Rheum. Dis. (1995) 54:744–747.
   PubMed Web of Science ®Google Scholar
• VAUX DL: Toward an understanding of the molecularmechanisms of physiological cell death. Proc. Natl. Acad. Sci. USA (1993) 90:786–789.
   PubMed Web of Science ®Google Scholar
• ZHIVOTOVSKY B, NICOTERA P, BELLOMO G, HANSON K,ORRENIUS S: Ca2* and endonuclease activation in radia-tion-induced lymphoid cell death. E. Cell Res. (1993) 207:163–170.
   PubMed Web of Science ®Google Scholar
• BISSONNETTE RP, ECHEVERRI F, MAHBOUBI A, GREEN DR: Apoptotic cell death induced by c-myc is inhibited by bc1-2. Nature (1992) 359:552–554.
   PubMed Web of Science ®Google Scholar
• ITOH N, NAGATA 5: A novel protein domain required for apoptosis. Mutational analysis of human fas anti-gen. J. Biol. Chem. (1993) 268:1093210937.
   Google Scholar
• BISSONEIth R, ECHEVEUI F, GREEN R: Apoptotic death Induced by c-myc is inhibited by bc1-2. Nature (1992) 359:552–554.
   PubMed Web of Science ®Google Scholar
• OSMOND DG, KIM N, MANOUKIAN R et al.: Dynamics and localko tion of early B-lymphocyte precursor cells (pro-B-cells) in the bone marrow of SC1D mice. Blood (1992) 79: 1695-1703.
   Google Scholar
• STRASSER A, HARRIS A, CORCORAN L, CORY S: Bc1-2 expression promotes B- but not T-lymphoid develop-ment in mice. Nature (1994) 368:457–463.
   PubMed Web of Science ®Google Scholar
• WATANABE-FUKUNAGA R, BRANNAN CI et al.: Lympho-proliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (1992) 3 56:314–317.
   Google Scholar
• ADACHI M, WATANABE-FUKUNAGA R, NAGATA S: Aber-rant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc. Natl. Acad. Sci. USA (1993) 90:1756–1760.
   PubMed Web of Science ®Google Scholar
• CHU JL, DRAPPA J, PARNASSA A, ELKON KB: The defectin Fas mRNA expression in MRL/ipr mice is associated with insertion of the retrotransposon, ETn. J. E7Cp. Med. (1993) 178:723–730.
   Web of Science ®Google Scholar
• WU J, ZHOU T, HE J, MOUNTZ JD: Autoinunune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene. J. Exp. Med. (1993) 178:461–468.
   PubMed Web of Science ®Google Scholar
• TAKAHASHI T, TANAKA M, BRANNAN CI et al.: General-ised lymphoproliferative disease in mice caused by a point mutation in the Fas ligand. Cell (1994) 76:969–976.
   PubMed Web of Science ®Google Scholar
• LYNCH DH, WATSON ML, ALDERSON MR et al.: The mouse Fas ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity (1994) 1:131–136.
   PubMed Web of Science ®Google Scholar
• KOTZIN BL, BABCOCK SK, HERRON LR: Deletion of po-tentially self-reactive T-cell receptor specificities in L3T4-, Lyt-2- T-cells of lpr mice. J. Exp. Med. (1988) 168:2221–2229.
   PubMed Web of Science ®Google Scholar
• SINGER PA, THEOFILOPOULOS AN: T-cell receptor V betarepertoire expression in murine models of SLE. Immu-nol. Rev. (1990) 118:103–127.
   PubMed Web of Science ®Google Scholar
• SINGER PA, BALDERAS RS, MCEVILLY RJ et al.: Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta+ and abnormal lpr and gkl cell populations. J. Exp. Med. (1989) 170:1869–1877.
   PubMed Web of Science ®Google Scholar
• HERRON LR, EISENBERG RA, ROPER E et al.: Selection of the T-cell receptor repertoire in lpr mice. J. Immunol. (1993) 15 1:3450–3 459.
   Google Scholar
• BOSSU P, SINGER GG, ANDRES P et al.: Mature CD44" T-lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J. Immunol. (1993) 15 1:7233–7 239.
   Google Scholar
• THEOFILOPOULOS AN, DIXON FJ: Murine models of systemic lupus erythematosus. Adv. Immunol. (1985) 37:269–390.
   PubMed Web of Science ®Google Scholar
• WU J, ZIIOU T, ZHANG J et al.: Correction of acceleratedautoimmune disease by early replacement of the mu-tated lpr gene with the normal Fas apoptosis gene in the T-cells of transgenic mRL-tprApr mice. Proc. Natl. Acad. Sci. USA (1994) 91:2344–2348.
   PubMed Web of Science ®Google Scholar
• MOUNTZ JD, TALAL N: Retroviruses, apoptosis and auto-genes. Immunol. Today (1993) 14:532–536.
   PubMedGoogle Scholar
• RIEUX-LAMOT F: Inborn mutations associated with lu-pus-like disease. Science (1995) 268:1347–1349.
   PubMedGoogle Scholar
• MYSLER E, BINI P, DRAPPA J el al.: The apoptosis-1/Fas protein in human systemic lupus erythematosus. J. Clin. Invest. (1994) 93:1029–1034.
   Google Scholar
• KNIPPING E, 'CRAMMER PH, ONEL KB et al.: Levels of soluble Fas/AP0-1/CD95 in systemic lupus erythemato-sus and juvenile rheumatoid arthritis. Arthritis Rheum. (1995) 38:1735–1737.
   Google Scholar
• GOEL N, ULRICH DT, ST.CLAIR EW et al.: Lack of correla-tion between serum soluble Fas/APO-1 levels and autokamune disease. Arthritis Rheum. (1995) 38:1738–1743.
   Google Scholar
• HOCKENBERY DM, OLTVAI ZN, YIN X-M, MILLIMAN CL, KORSMEYER Bc1-2 functions in an antioxidant path-way to prevent apoptosis. Cell (1993) 75:241–251.
   PubMed Web of Science ®Google Scholar
• BUTTKE TM, SANDSTROM PA: Oxidative stress as a me-diator of apoptosis. Immunol. Today (1994) 15:7–10.
   PubMedGoogle Scholar
• SENTMAN CL, SHUTTER JR, HOCKENBERY D, KANAGAWA O, KORSMEYER SJ: Bc1-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell (1991) 67:879–888.
   PubMed Web of Science ®Google Scholar
• STRASSER A, HARRIS AW, CORY S: Bc1-2 transgene inhib-its T-cell death and perturbs thymic self-censorship. Cell (1991) 67:889–899.
   PubMed Web of Science ®Google Scholar
• NISITANI S, TSUBATA T, MURAKAMI M, OKAMOTO M, HONJO T: The bc1-2 gene product inhibits clonal dele-tion of self-reactive B-lymphocytes in the periphery but not in the bone marrow. J. Exp. Med. (1993) 178:1247–1254.
   PubMed Web of Science ®Google Scholar
• STRASSER A, WHITTINGHAM S. VAUX DL et al.: Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA (1991) 88:8661–8665.
   Google Scholar
• MOUNTZ JD, STEINBERG AD, KLINMAN DM, SMITH HR, MUSHINSKI JF: Autoinununity and increased c-myb tran-scription. Science (1984) 266:1087–1090.
   Google Scholar
• CHENG J, ZHOU T, LIU C et al.: Protection from Fas-me-diated apoptosis by a soluble form of the Fas molecule. Science (1994) 263:17 59–1762.
   Google Scholar
• ALI3ERTINI Rj, O'NEILL JP, NICICLAS JA, HEINTZ N, KELLE-HER PC: Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes. Nature (1985) 316:369–371.
   PubMed Web of Science ®Google Scholar
• GMELIG-MEYLING F, DAWISHA S, STEINBERG AD: Assess-ment of in vivo frequency of mutated T-cells in patients with systemic lupus erythematosus. J. Exp. Med. (1992) 175:297–300.
   PubMed Web of Science ®Google Scholar
• DAWISHA SM, GMELIG-MEYLIG F, STEINBERG AD: Assess-ment of clinical parameters associated with increased frequency of mutant T-cells in patients with systemic lupus erythematosus. Arthritis Rheum, (1994) 37:270–277.
   PubMed Web of Science ®Google Scholar
• KONO DII, THEOFILOPOULOS AN: Genetic contribu-tions to SLE. J. Autoimmun. In Press,
   Google Scholar
• DAVIES JL, KAWAGUCHI Y, BENNETT ST et al.: A genome-wide search for human type 1 diabetes susceptibility genes. Nature (1994) 371:130–136.
   PubMed Web of Science ®Google Scholar
• HASHIMOTO L, HABITA C, BERESSI JP et al.: Genetic mapping of a susceptibility locus for insulin-dependent diabetes meMtus on chromosome 11q. Nature (1994) 371:161464.
   Google Scholar
• THEOFILOPOULOS AN: The basis of autoinununity: Part IL Genetic predisposition. Immunol. Today (1995) 16:150–158.
   PubMedGoogle Scholar
• DRAKE CG, BABCOCK SK, PALMER E, KOTZIN BL: Genetic analysis of the NZB contribution to lupus-like autoim-mune disease. Proc. Natl. Acad. Sci. USA (1994) 91:4062–4066.
   PubMed Web of Science ®Google Scholar
• MOREL L, RUDOFSKY LT11, LONGMATE JA, SCHIFEEN-BAUER J, WAKELAND EK: Polygenic control of suscepti-bility to murine systemic lupus erythematosus. Immunity (1994) 1:219–229.
   PubMed Web of Science ®Google Scholar
• KONO DH, BURLINGAME RW, OWENS DG et aL: Lupussusceptibility loci in New Zealand mice. Proc. Natl. Acad. Sci. USA (1994) 91:10168–10172.
   PubMed Web of Science ®Google Scholar
• REICHLIN S: Neuroendocrine-immune interactions. NewEngl. J. Med. (1994) 329:1246–1247.
   Web of Science ®Google Scholar
• INSEL PA: Adrenergic receptors - evolving concepts and clinical implications. New Engl.J. Med. (1996) 334:580–585.
   PubMed Web of Science ®Google Scholar
• WILDER RL: Neuroendocrine-im.mune system interac-tions and autoimmunity. Ann. Rev. Immunol. (1995) 13:307–338.
   PubMedGoogle Scholar
• CHOWDREY HS, LARSEN PJ, HARBUZ MS, LIGHTMAN SL, JESSOP DS: Endogenous substance P inhibits the expres-sion of corticotropin-releasing hormone during a chronic inflammatory stress. Life Sci. (1995) 57:2021–2029.
   PubMed Web of Science ®Google Scholar
• BOUDREAU N, SYMPSON CJ, WERB Z, BISSELL MJ: Sup-pression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science (1995) 267:891–893.
   PubMed Web of Science ®Google Scholar
• BEHRENDTSEN O, ALEXANDER CM, WERB Z: Metallopro-teinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths. Development (1992) 114:447–456.
   PubMed Web of Science ®Google Scholar
• SYMPSON CJ, TALHOUK RS, ALEXANDER CM et al.: Tar-geted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branch-ing morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expres-sion. J. Cell Biol. (1994) 125:681–693.
   PubMed Web of Science ®Google Scholar
• DAMSKY CH, WERB Z: Signal transduction by integrin receptors for extracellular matrix: Co-operative proc-essing of extracellular information. Cur-. Opin Cell. Biol. (1992) 4:772–781.
   PubMed Web of Science ®Google Scholar
• TOURNIER JM, POLETTE M, HINNRASKY J et aL: Expres-sion of gelatinase A, a mediator of extracellular matrix remodeling, by tracheal gland serous cells in culture and in vivo. J. Biol. Chem. (1994) 269:25454–25464.
   PubMed Web of Science ®Google Scholar
• BLANK M, KRAUSE I, BUSKILA D et al.: Bromocriptine immunomodulation of experimental SLE and primary antiphos pholipid syndrome via induction of non-spe-cific T-suppressor cells. Cell. Immunol. (1995) 162:114–122.
   PubMed Web of Science ®Google Scholar
• MUNOZ JA, GIL A, LOPEZ-DUPLA JM et al.: Sex hormones in chronic systemic lupus erythematosus. Correlation with clinical and biological parameters. Ann. Med. In-terne (Paris) (1994) 145:459–463.
   Google Scholar
• PAUZNER R, UROWITZ MB, GLADMAN DD, GOUGH JM: Prolactin In systemic lupus erythematosus. J. Rheumatol. (1994) 21:2064–2067.
   PubMed Web of Science ®Google Scholar
• MONCAYO R, MONCAYO HE: A new endocrinological and inununological syndrome in SLIE: elevation of hu-man chorionic gonadotropin and of antibodies di-rected against ovary and endometrium antigens. Lupus (1995) 4:39–45.
   PubMed Web of Science ®Google Scholar
• FREEMONT AJ, JONES CJP: Endothelial specialization of salivary gland vessels for accelerated lymphocyte trans-fer in Sjögren's syndrome. J. Rheumatol. (1983) 10:801.
   PubMed Web of Science ®Google Scholar
• ST. CLAIR EW, ANGELLELO JC, SINGER KH: Expression of cell-adhesion molecules in the salivary gland microen-vironment of Sjögren's syndrome. Arthritis Rheum. (1992) 35:62–66.
   PubMed Web of Science ®Google Scholar
• CYSTER J, HARTLEY S, GOODNOW C: Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature (1994) 371:389–392.
   PubMed Web of Science ®Google Scholar
• SATO K, MIYASAKA N, YAMAOKA K: Quantitative defect of CD4'2H4* cells in systemic lupus erythematosus and Sjögren's syndrome. Arthritis Rheum. (1987) 30:1407–1411.
   PubMed Web of Science ®Google Scholar
• HUMPHREYS-BEHER MG, HU Y, WANG PL, PU-RUSHOTHAM KR: Utilization of the non-obese diabetic (NOD) mouse as an animal model for the study of secondary Sjögren's syndrome. Adv. Exp. Med. Biol. (1994) 350:631–636.
   PubMedGoogle Scholar
• HU Y, NAKAGAWA Y, PURUSHOTHAM KR, HUMPIIREYS-BEHER MG: Functional changes in salivary glands of autoinunune disease-prone NOD mice. Am. J. Physiol. (1992) 263:E607–E614.
   PubMedGoogle Scholar
• FOX RI, HUGLI TE, LANIER LL, MORGAN EL, HOWELL F: Salivary gland lymphocytes in primary Sjogren's syn-drome lack lymphocyte subsets defined by Leu 7 and Leu 11 antigens. J. Immunol. (1985) 135:207.
   PubMed Web of Science ®Google Scholar
• CHEN R, IVENS KW, ALPERT S et al.: The use of granzyrne A as a marker of heart transplant rejection in cyclospor-ine or anti-CD4 monoclonal antibody-treated rats. Transplantation (1993) 55:146–153,
   PubMed Web of Science ®Google Scholar
• ALPERT S, RANG HI, WEISSMAN I, FOX RI: Granzyme expression in Sjagren's syndrome. Arthritis Rheum. (1994) 37:1048–1055.
   Web of Science ®Google Scholar
• KASSAN SS, THOMAS U, MOUTSOPOULOS HM et al.: Increased risk of lymphoma in sicca syndrome. Ann. Intern. Med. (1978) 89:888–892.
   PubMed Web of Science ®Google Scholar
• FOX RI, CARSTENS SA, FONG S et al.: Use of monoclonal antibodies to analyze peripheral blood and salivary gland lymphocyte subsets in Sjögren's syndrome. Ar-thritis Rheum. (1982) 25:419.
   PubMed Web of Science ®Google Scholar
• FOX RI, ADAMSON TC, III, FONG S et al.: Lymphocyte phenotype and function of pseudolymphomas associ-ated with Sjögren's syndrome. J. Clin. Invest. (1983) 72:52–62.
   PubMed Web of Science ®Google Scholar
• FOX RI, CHEN PP, CARSON DA, FONG S: Expression of a cross-reactive idiotype on rheumatoid factor in patients with Sjögren's syndrome. J. Immunol. (1986) 136:477–483.
   PubMed Web of Science ®Google Scholar
• FOX RI, CARSON DA, CHEN P, FONG S: Characterization of a cross-reactive idiotype in Sjögren's syndrome. Scand. J. Rheumatol. (1986) 561:83–88.
   Google Scholar
• FOX RI, FONG S, CHEN PP, KIPPS TJ: Autoantibody production in Sjögren's syndrome: a hypothesis re-garding defects in somatic diversification of germ line encoded genes. In Vivo (1988) 2:47–56.
   PubMedGoogle Scholar
• KIPPS TJ, TOMHAVE E, CHEN PP, FOX RI: Molecular characterization of a major autoantibody-associated cross-reactive idiotype in Sjögren's syndrome. J. Immu-nol. (1989) 142:4261–4268.
   PubMed Web of Science ®Google Scholar
• MAURY CPJ, TORNROTH T, TEPPO A-M: Arthropic gastri-tis in Sjögren's syndrome. Arthritis Rheum. (1985) 28:388.
   PubMedGoogle Scholar
• FREIMARK B, FANTOZZI R, BONE R, BORDIN G, FOX R: Detection of clonally expanded salivary gland lympho-cytes in Sjogren's syndrome. Arthritis Rheum, (1989) 32:859–869.
   PubMed Web of Science ®Google Scholar
• SKOPOULI FN, BOUMBA D, MOUTSOPOULOS HM: Cytok- Incexpression in the labial salivary gland tissuesfrom patients with primary Sjögren's syndrome. Chn. Rheumatol. (1993) 12:18.
   Google Scholar
• BODEUTSCH C, DE WILDE PC, KATER L: Monotypic plasma cells in labial salivary glands of patients with Sjögren's syndrome: prognosticator for systemic lym-phoproliferative disease. J. ain. Pathol. (1993) 46:123–128.
   Web of Science ®Google Scholar
• MOUTSOPOULOS HM, TZIOUFAS AG, BAT MK: Associa-tion of serum IgM kappa monoclonicity in patients with Sjögren's syndrome with an increased proportion of kappa positive plasma cells infiltrating the labial minor salivary gland. Ann. Rheum. Dis. (1990) 49:929–931.
   PubMed Web of Science ®Google Scholar
• PISA EK, PISA P, KANG HI, FOX RI: High frequency of t(14;18) translocation in salivary gland lymphomas from Sjogren's syndrome patients. J. E. Med. (1991) 174:1245–1250.
   PubMed Web of Science ®Google Scholar
• LEGRAS F, MARTIN T, KNAPP AM: Infiltrating T-cells from patients with primary Sjögren's syndrome express re-stricted or unrestricted T-cell receptor V beta regions depending on the stage of the disease. Eur. J. Immunol. (1994) 24:181–185.
   PubMed Web of Science ®Google Scholar
• SUMIDA T, YONAHA F, MAEDA T et al.: T-cell receptor repertoire in infiltrating T-cells in lips of Sjögren's syndrome patients.]. Clin. Invest. (1992) 89:681.
   PubMed Web of Science ®Google Scholar
• SMITH M, LAMOUR A, BOYLSTON A: Selective expression of Vb families by T-cells in the blood and salivary gland Infiltrate of patients with primary Sjogren's syndrome. J. Rheumatol. (1994) 21:1832–1837.
   PubMed Web of Science ®Google Scholar
• BRENNAN F, PLATER-ZYBERK C, MAINI RN: Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and pri-mary Sjogren's syndrome. Glin. Exp. Immunol. (1989) 77:175–178.
   Web of Science ®Google Scholar
• ICHI1CAWA Y, SHIMIZU H, YOSHIDA M: T-cells bearing gamma/delta T-cell receptor and their expression of activation antigen in peripheral blood from patients with Sjögren's syndrome. Urn. Exp. Rheumatol. (1991) 9:603–609.
   PubMed Web of Science ®Google Scholar
• FOX RI, THEOFILOPOLTLOS AN, ALTMAN A: Production of interleukin-2 (IL-2) by salivary gland lymphocytes in Sjogren's syndrome. Detection of reactive cells by using antibody directed to synthetic peptides of IL-2. J. Immu-no/. (1985) 135:3109–3115.
   Google Scholar
• FOX RI, KANG HI: Pathogenesis of Sjögren's syndrome. In: Clinics of North America. Fox RI (Ed.), WB Saunders (1992):517–538.
   Google Scholar
• FOX RI, KANG HI, ANDO D, ABRAHAMS J: Cytokine transcription in salivary gland biopsies of Sjögren's syndrome. J. Immunol. (1994) 1511132–142,
   Google Scholar
• FOX RI, ADAMSON TC, III: Human lymphocyte cell sur-face antigens defined by monoclonal antibodies. In: Advances in Laboratory Methods, Volume 4. Nakamura R (Ed.), Masson Publishing, USA (1983).
   Google Scholar
• FOX RI, CHAN EK, KANG H: Laboratory evaluation of patients with Sjögren's syndrome. Clin. Biochem. (1992) 25:213–222.
   PubMed Web of Science ®Google Scholar
• BEN-CHETRIT E: The molecular basis of the SSA/Ro antigens and the clinical significance of their autoanti-bodies. Br.]. Rheumatol. (1993) 32:396–402.
   PubMedGoogle Scholar
• CHAN E, ANDRADE L: Antinuclear antibodies in Sjögren's syndrome. Rheum. Clin. North Am. (1992) 18:561–567.
   Google Scholar
• FRANK MB, MCCUBBIN VR, HELDERMON C: Expression and DNA binding of the human 52 ItDa Ro/SSA autoan-tigen. Biochem. J. (1995) 305:359–362.
   PubMed Web of Science ®Google Scholar
• MANLEY G, WONG E, DALMAU J et at: Sera from some patients with antibody-associated paraneoplastic en-cephalomyelitis/sensory neuronopathy recognise the Ro-52K antigen.]. Neurooncol. (1994) 19:104–112.
   Google Scholar
• LIN-MARQ N, CLARKSON SG: A yeast RNA binding protein that resembles the human autoantigen La. J. Mol. Biol. (1995) 245:81–85.
   PubMed Web of Science ®Google Scholar
• TROSTER H, METZGER TE, SCHWEMMLE M e al.: One gene, two transcripts: isolation of an alternative tran-script encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögren's syn-drome. J. Exp. Med. (1994) 180:2059–2067.
   Google Scholar
• PEEK R, WESTPHAL J, PRUJIN G, VAN DER KEMP A, VAN ROOJ W: Adenovirus infection induces loss of HIA class I and CD3 antigens but doesn't induce cell surface presentation of the SS-B autoantigen. Clin . Exp. Immunol. (1994) 180:2059–2067.
   Google Scholar
• BEN-CHETRIT E, FOX RI, TAN EM: Dissociation of im-mune responses to the SS-A (Ro) 52-kd and 60-kd polypeptides in systemic lupus erythe:matosus and Sjögren's syndrome. Arthritis Rheum. (1990) 33:349–355.
   PubMed Web of Science ®Google Scholar
• ST. CLAIR W, BURCH J, SAITTA M: Specificity of autoan-tibodles for recombinant 60-kd and 52-kd Ro autoan-tigens. Arthritis Rheum. (1994) 37:1373–1379.
   PubMed Web of Science ®Google Scholar
• REVEILLE JD, MACLEOD MJ, WHFITINGTON K, ARNETr EC: Specific amino acid residues in the second hypervari-able region of HLA-DQB1 chain genes promote the Ro (SS-A)/La (SS-B) autoantibody responses. J. Immunol. (1991) 146:3871–3876.
   PubMed Web of Science ®Google Scholar
• HARLEY JB, SESTALK AL, WILLIA LG et al.: A model for disease heterogeneity in systemic lupus erythematosus. Arthritis Rheum. (1989) 32:826–836.
   PubMed Web of Science ®Google Scholar
• KANG H-I, FEI HM, SAITO I et al.: Comparison of H1A class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjogren's syndrome.]. immutz0/ (1993) 150:3615–3623.
   Google Scholar
• FEI HM, KANG H-I, SCHARF S et al.: Specific HLA-DQA and ILIA-DRB1 alleles confer susceptibility to Sjögren's syn-drome and autoantibody SS-B production. J Clin. Lab. Anal. (1991) 5:382–391.
   PubMed Web of Science ®Google Scholar
• KANG HF, ERLICH H, FOX R: Comparison of genetic factors in Chinese, Japanese and Caucasoid patients with Sjogren's syndrome. J. Immunol. (1994) 150,3615–3635.
   Web of Science ®Google Scholar
• FOX RI: Epidemiology, pathogenesis, animal models, and treatment of Sjögren's syndrome. Curr. Opin. Rheu-matol. (1994) 6:501–508.
   PubMedGoogle Scholar
• WALCOTT B, CAMERON RH, BRINK PR: The anatomy and Innervation of lacrimal glands. In: Lacrimal Gland, Tear Film, and Thy Eye Syndromes. Sullivan DA (Ed.), Plenum Press, New York (1994):11.
   Google Scholar
• SIBONY PA, WALCOTT' B, MCKEON C, JAKOBIEC FA: Vasoactive intestinal polypeptide and the innervation of the human lacrimal gland. Arch. Ophthalmol. (1988) 106:1085–1088.
   PubMed Web of Science ®Google Scholar
• CHROUSOS GP: The hypothalamic-pituitary-adrenal axis and immune-mediated Inflammation. New Engl. J. Med. (1995) 332:353–360.
   Google Scholar
• BONAFEDE RP, DOWNEY DC, BENNETT RM: An associa-tion of fibromyalgia with primary Sjögren's syndrome: a prospective study of 72 patients. J. Rheumatol. (1995) 22:133–136.
   PubMed Web of Science ®Google Scholar
• CALABRESE LH, DAVIS ME, WILKE WS: Chronic fatigue syndrome and a disorder resembling Sjögren's syn-drome: preliminary report. din. Infect. Dis. (1994) 18\(Suppl. 1):528–531.
   Google Scholar
• OLDSTONE MB: Molecular mimicry and autoinamune disease. Cell (1987) 50:819–820.
   PubMed Web of Science ®Google Scholar
• DYRBERG T: Antigenic mimicry. In: The Molecular Pathol-ogy of AutoirrimuneDiseases. Bona C, Siminovitch KA, Zanetti M, Theofilopoulous AN (Eds.), Harwood Academic Publish-ers, Langhome, PA (1993):257–261.
   Google Scholar
• CUNNINGHAM M: Bacterial antigen mimicry. In: The Molecular Pathology of Autoimmune Diseases. Bona C, Simi-novitch KA, Zanetti M, Theofilopoulos AN (Eds.). Harwood Academic Publishers, Langhome, PA (1993):245–256.
   Google Scholar
• WUCHERPFENNIG KW, STOMINGER JL: Molecular mim-icry in T-cell-mediated autoimmunity: Viral peptides activate human T-cell clones specific for myelin basic protein. Cell (1995) 80:695–705.
   PubMed Web of Science ®Google Scholar
• MAUDSLEY DJ, POUND J: Modulation of MHC antigen expression by viruses and oncogenes. Immunol. Today (1991) 12:429–431.
   PubMedGoogle Scholar
• BABOONIAN C, VENABLES PJW, BOOTH P at al.: Virus Infection induces redistribution and membrane local-ization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity. Clin. Exp. Immunol. (1989) 78:454–459.
   Google Scholar
• MOSKOPHIDIS D, LECHNER F, PIRCHER H, ZINKERNAGEL RM: Virus persistence in acutely infected immunocom-petent mice by exhaustion of antiviral cytotoxic effec-tor T-cells. Nature (1993) 362:758–761.
   PubMed Web of Science ®Google Scholar
• SAITO I, SERVENIUS B, COMPTON T, FOX RI: Detection of Epstein-Barr virus DNA by polymerase chain reac-tion in blood and tissue biopsies from patients with Sjögren's syndrome. J. Exp. Med. (1989) 169:2191–2198.
   PubMed Web of Science ®Google Scholar
• GORGOULIS V, GIATROMANOLAKI A, ILIOPOULOS A et al.: EGF and EGF-r hmanmoexpression in Sjögren's syndrome secondary to rheumatoid arthritis. Correla-tion with EBV expression? Clin. Exp. Rheumatol. (1993) 11:623–627.
   PubMed Web of Science ®Google Scholar
• SKOPOULI FN, FOX PC, GALANOPOULOU V, MOUT-SOPOULOS H: T-cell subpopulations in the labial minor salivary gland histopathologic lesion of Sjögren's syn-drome. J. Rheumatol. (1991) 18:44–49.
   PubMedGoogle Scholar
• TATEISHI M, SAITO I, YAMAMOTO K, MIYASAKA N: Spon-taneous production of Epstein-Barr virus by B-Iym-phoblastoid cell lines obtained from patients with Sjögren's syndrome-possible involvement of a novel strain of Epstein-Barr virus in disease pathogenesis. Arthritis Rheum, (1993) 36:827–835
   PubMed Web of Science ®Google Scholar
• OOSTERVEER MA, MARKUSSE HM, LENNETTE ET et al.: Characterization of Epstein-Barr virus strains in parotid gland saliva and peripheral blood of patients with primary Sj?igren's syndrome and healthy EBV carriers. J. Med. Virol. (1993) 41:261–269.
   PubMed Web of Science ®Google Scholar
• MISKO L, SCHMIDT C, HONEYMAN M: Failure of 03V-spe-cific cytotoxic T-lymphocytes to lyse B-cells trans-formed with B 95-8 strain is mapped to an epitope that associates with the 111A-138 antigen. Clin. Exp. Immunol. (1992) 87:65–70.
   PubMed Web of Science ®Google Scholar
• LEVY JA, FERRO F, GREENSPAN D, LENNETETE ET: Fre-quent isolation of HHV-6 from saliva and high seropre-valence of the virus in the population. Lancet (1990) 335:1047–1050.
   PubMed Web of Science ®Google Scholar
• JOSEPHS SF, ABLASHI DV, SALAHUDDIN SZ, FOX R: Mo-lecular studies of HHV-6. J. Virol. Methods (1988) 21:179–190.
   PubMed Web of Science ®Google Scholar
• CLARK DA, ALEXANDER FE, MCKINNEY PA et al.: The seropidemiology of human herpesvirus-6 (HHV-6) from a case-control study of leukaemia and lymphoma. Intl. Cancer (1990) 45:829–833.
   PubMed Web of Science ®Google Scholar
• AUBIN J, COLLANDRE II, CANDOTTI D: Several groups among human herpes virus 6 can be distinguished by Southern blotting and polymerase chain reaction. J. Clin. Micro biol. (1991) 29:367–372.
   PubMed Web of Science ®Google Scholar
• ABLASHI DV, SALAHUDDIN SZ, JOSEPHS SF et al.: HTLV (or HHV-6) in human cell lines. Nature (1987) 329:207.
   PubMed Web of Science ®Google Scholar
• TORELLI G, MARASCA R, LUPPI M et al.: Human herpes virus-6 in human lymphomas: Identification of specific sequences in Hodgkin's lymphomas by polymerase chain reaction. Blood (1991) 77:2251–2258.
   PubMed Web of Science ®Google Scholar
• FOX RI, LUPP1 M, KANG HI, ABLASHIK D, JOSEPHS S: Detection of human herpes virus-6 DNA in a lymphoma arising in a patient with Sjögren's syndrome. J. Rheuma-tol. (1993) 20:764–765.
   PubMed Web of Science ®Google Scholar
• MARIE I IF. X, AGBALIKA F, DANIEL MT et al.: Detection of human T lymphotropic virus type I tax gene in salivary gland epithelium from two patients with Sjögren's syndrome. Arthritis Rheum. (1993) 36:1423–1428.
   Google Scholar
• MARIE I IE X, ZERBIB M, JACCARD A, SCIIENMETZLER C, DANON F: Hepatitis-C virus and Sjogren's syndrome. Arthritis Rheum. (1993) 36:280–281.
   PubMed Web of Science ®Google Scholar
• MARIEIIE X, ZERBIB M, JACCARD A et al.: Hepatitis C virus and Sjeogren's syndrome. Arthritis Rheum. (1993) 36:280–281.
   PubMed Web of Science ®Google Scholar
• ACETI A, TALIANI G, SORICE M, AMENDOLEA MA: HCV and Sjögren's syndrome [Letter; comment]. Lancet (1992) 339:1425–1426.
   PubMed Web of Science ®Google Scholar
• MARSON P, OSTUNI PA, VICARIOTO M, ONGARO G, GAMBARI PF: Anti-hepatitis C virus serology in primary Sjögren's syndrome: no evidence of cross-reactivity between rheumatoid factor and specific viral proteins [Letter]. Clin. Exp. Rheumatol. (1991) 9:661–662.
   PubMed Web of Science ®Google Scholar
• ALMASIO P, PROVENZANO G, SCIMEMI M et al.: Hepatitis C virus and Sjogren's syndrome [Letter] (see com-ments). Lancet (1992) 339:989–990.
   PubMed Web of Science ®Google Scholar
• VITALI C, SCIUTO M, NERI R, GRECO F: Anti-hepatitis C virus antibodies in primary Sjögren's syndrome: false-positive results are related to hypergammaglobulinae-nuts [Letter]. Clin. Exp. Rheumatol. (1992) 10:103–104.
   PubMed Web of Science ®Google Scholar
• PAWLOTSKY JM, BEN YAHIA M, ANDRE C et al.: Inmiu-nological disorders in C virus chronic active hepatitis: a prospective case-control study. Hepatology (1994) 19:841–848.
   PubMed Web of Science ®Google Scholar
• GOREVIC P, KASSAB H, MELZER M, FRANKLIN E: Mixed cryoglobulinemia: clinical aspects and long-term fol-low-up of 40 patients. Am. J. Med. (1980) 69:287–308.
   PubMed Web of Science ®Google Scholar
• FERRI C, GRECO F, LOMGOMBARDO G et al.: Antibodies to hepatitis C virus in patients with mixed cryoglobu-linemia. Arthritis Rheum. (1994) 34:1606–1609.
   Google Scholar
• SUMIDA T, YONAHA F, MAEDA T et al.: Expression of sequences homologous to HTLV-1 tax gene in the labial salivary glands of Japanese patients with Sjagren's syndrome. Arthritis Rheum. (1994) 37:545–550.
   PubMed Web of Science ®Google Scholar
• GARRY R: New evidence for involvement of retroviruses In Sjögren's syndrome and other autoimmune diseases [Editorial]. Arthritis Rheum. (1994) 37:465–469.
   PubMed Web of Science ®Google Scholar
• ITESCU S, BRANCATO LJ, BUXBAUM J et al.: A diffuse infiltrative CD8 lymphocytosis syndrome in human im.munodeficiency virus (HIV) infection: a host im-mune response associated with HLA-DRS. Ann. Intern. Med. (1990) 112:3–10.
   Google Scholar
• SUZUKI K, MAKINO M, OKADA Y et al.: Exocrinopathy resembling Sjetgren's syndrome induced by a murine retrovirus. Lab. Invest. (1993) 69:430–435.
   PubMed Web of Science ®Google Scholar
• ATKINSON JC, SCHIODT M, ROBATAILLE S et al.: Salivary autoantibodies in HIV-associated salivary gland disease. J. Oral Pathol. Med. (1993) 22:203–206.
   PubMed Web of Science ®Google Scholar
• SCHIODT M, DODD CL, GREENSPAN D et al.: Natural history of HIV-associated salivary gland disease. Oral Slog. Oral Med. Oral Pathol. (1992) 74:326–331.
   PubMed Web of Science ®Google Scholar
• LAMEY PJ, FELIX D, NOLAN A: Sialectasis and HIV infec-tion. Dentomarillofac. Radio!. (1993) 22:159–160.
   PubMedGoogle Scholar
• SCHUVAL SJ, BONAGURA VR, ILOWITE NT: Rheuma-tologic manifestations of pediatric human immunode-ficiency virus infection. J. Rheumatol. (1993) 20:1578–1582.
   PubMed Web of Science ®Google Scholar
• TALAL N, DAUPHINEE M, DANG H et al.: Detection of serum antibodies to retroviral proteins in patients with primary Sjogren's syndrome. Arthritis Rheum. (1990) 33:774–781.
   PubMed Web of Science ®Google Scholar
• CATTANEO R, TOSONI C, FRANZINI M et al.: Antibodies to retroviral proteins in Sjögren's syndrome [Letter]. Ann. Rheum. Dis. (1993) 52:621.
   PubMed Web of Science ®Google Scholar
• KRIEG AM, STEINBERG AD: Analysis of thymic endo-genous retroviral expression in murine lupus. Genetic and immune studies. J. Gun. Invest. (1990) 86:809–816.
   Google Scholar
• KRIEG AM, GOURLEY ME, PERL A: Endogenous retroviruses: potential etiologic agents in autoinunu-nity. LASES J. (1992) 6:2537–2544.
   Google Scholar
• DIXON FJ: Animal models of autoirnmune disease. Sprin-ger Semin. Immunopathol. (1992) 14:103–104.
   PubMed Web of Science ®Google Scholar
• SINAFI A, LOZPE M, mcpwrrr H: Autoinunune diseases: the failure of self tolerance. Science (1990) 248:1380–1390.
   PubMed Web of Science ®Google Scholar
• PFLUGFELDER SC, WILHELMUS KR, OSATO MS et al.: The autoimmune nature of aqueous tear deficiency. Ophthal-mology(1986) 93:1513–1517.
   PubMed Web of Science ®Google Scholar
• VAN DER REIJDEN WA, VAN DER KWAAK II, VISSINK A, VEERMAN ECI, NIEW AMERONGEN AV: Treatment of xerostomia with polymer-based saliva substitutes in patients with Sjögren's syndrome. Arthritis Rheum. (1996) 39:57–63.
   PubMed Web of Science ®Google Scholar
• DANIELS T, FOX P: Salivary and oral components of Sjiigren's syndrome. Rheum. Dis. din. North Am. (1992) 18:571–589.
   PubMed Web of Science ®Google Scholar
• FOX P: Systemic therapy of salivary gland hypofunc-don. J. Am, Dent. Assoc. (1987) 115:581–588.
   PubMed Web of Science ®Google Scholar
• FOX P, ATKINSON JC, MACYNSKI AA: Pilocarpine treat-ment of salivary gland hypofunction and dry mouth. Arch. Intern. Med. (1991) 151:1149–1152.
   PubMed Web of Science ®Google Scholar
• FOX RI, RANG HI: Mechanism of action of hydroxychlo-roquine as an antirheumatic drug. Semin. Arthritis Rheum. (1993) 23:82–91.
   PubMed Web of Science ®Google Scholar
• IZUI S, MERINO R, FOSSATI L, IWAMOTO M: The role of the Yaa gene in lupus syndrome. Int. Rev. Immunol. (1994) 11:211–230.
   PubMedGoogle Scholar