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Expert Opinion on Pharmacotherapy Volume 7, 2006 - Issue 12
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Key Paper Evaluation

Natalizumab in multiple sclerosis: proceed with caution?

POLMAN CH, O’CONNOR PW, HAVRDOVA E et al.: A randomised, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 354:899-910, RUDICK RA, STUART WH, CALABRESI PA et al.: Natalizumab plus interferon-b1a for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 354:911-923, and YOUSRY TA, MAJOR EO, RYSCHKEWITSCH C et al.: Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N. Engl. J. Med. (2006) 354:924-933.

Sheila A Doggrell Senior Lecturer, School of Science, Charles Darwin University, PO Box 41246, Casuarina, Northern Territory, 0811 Australia. [email protected]
Pages 1675-1678 | Published online: 28 Jul 2006

Bibliography

  • MILLER DH, KHAN OA, SHEREMATA WA: A controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. (2003) 348:15-23.
  • POLMAN CH, O’CONNOR PW, HAVRDOVA E et al.: A randomised, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 354:899-910.
  • LANGER-GOULD A, ATLAS SW, GREEN AJ, BOLLEN AW, PELLETIER D: Progressive multifocal leukoencephalopathy in a patients treated with natalizumab. N. Engl. J. Med. (2005) 353:375-381.
  • KLEINSCHMIDT-DEMASTERS BK, TYLER KL: Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon-β1a for multiple sclerosis. N. Engl. J. Med. (2005) 353:369-374.
  • RUDICK RA, STUART WH. CALABRESI PA et al.: Natalizumab plus interferon-β1a for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 354:911-923.
  • VAN ASSCHE G, VAN RANST M, SCIOT R et al.: Progressive multifocal leukoencephalopathy after natalizumab therapy in Crohn’s disease. N. Engl. J. Med. (2005) 353:362-368.
  • YOUSRY TA, MAJOR EO. RYSCHKEWITSCH C et al.: Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N. Engl. J. Med. (2006) 354:924-933.
  • ROPPER AH: Selective treatment of multiple sclerosis. N. Engl. J. Med. (2006) 354:965-966.
  • CHAUDHURI A: Lessons for clinical trials from natalizumab in multiple sclerosis. Br. Med. J. (2006) 332:416-419.

Website

  • http://www.emedicine.com/emerg/ topic321.htm An informative article on MS.

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