Integrase-defective lentiviral-vector-based vaccine: a new vector for induction of T cell immunity

Bibliography

• Vidor E. Evaluation of the persistence of vaccine-induced protection with human vaccines. J Comp Pathol 2010;142(Suppl 1):96-101
   Web of Science ®Google Scholar
• Coffman RL, Sher A, Seder RA. Vaccine adjuvants: putting innate immunity to work. Immunity 2010;33:492-503
   PubMed Web of Science ®Google Scholar
• Walker LM, Burton DR. Rational antibody-based HIV-1 vaccine design: current approaches and future directions. Curr Opin Immunol 2010;22:358-66
   PubMed Web of Science ®Google Scholar
• Liu M, Acres B, Balloul JM, Gene-based vaccines and immunotherapeutics. Proc Natl Acad Sci USA 2004;101:14567-71
   PubMed Web of Science ®Google Scholar
• Relph K, Harrington K, Pandha H. Recent developments and current status of gene therapy using viral vectors in the United Kingdom. BMJ 2004;329:839-42
   PubMed Web of Science ®Google Scholar
• Tatsis N, Ertl HCJ. Adenoviruses as vaccine vectors. Mol Ther 2004;10:616-29
   PubMed Web of Science ®Google Scholar
• Truckenmiller ME, Norbury CC. Viral vectors for inducing CD8+ T cell responses. Expert Opin Biol Ther 2004;4:861-8
   PubMed Web of Science ®Google Scholar
• Voltan R, Robert-Guroff M. Live recombinant vectors for AIDS vaccine development. Curr Mol Med 2003;3:273-84
   PubMed Web of Science ®Google Scholar
• Beignon AS, Mollier K, Liard C, Lentiviral vector-based prime/boost vaccination against AIDS: pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques. J Virol 2009;83:10963-74
   PubMed Web of Science ®Google Scholar
• Arya SK, Cho JE, Chang SH. HIV-2 vectors. Methods Mol Biol 2003;229:219-31
   PubMedGoogle Scholar
• Naldini L, Blomer U, Gallay P, In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996;272:263-7
   PubMed Web of Science ®Google Scholar
• Negre D, Cosset FL. Vectors derived from simian immunodeficiency virus (SIV). Biochimie 2002;84:1161-71
   PubMed Web of Science ®Google Scholar
• Barraza RA, Poeschla EM. Human gene therapy vectors derived from feline lentiviruses. Vet Immunol Immunopathol 2008;123:23-31
   PubMed Web of Science ®Google Scholar
• Molina RP, Matukonis M, Paszkiet B, Mapping of the bovine immunodeficiency virus packaging signal and RRE and incorporation into a minimal gene transfer vector. Virology 2002;304:10-23
   PubMed Web of Science ®Google Scholar
• Mitrophanous K, Yoon S, Rohll J, Stable gene transfer to the nervous system using a non-primate lentiviral vector. Gene Ther 1999;6:1808-18
   PubMed Web of Science ®Google Scholar
• Mselli-Lakhal L, Guiguen F, Greenland T, Gene transfer system derived from the caprine arthritis-encephalitis lentivirus. J Virol Methods 2006;136:177-84
   PubMed Web of Science ®Google Scholar
• Metharom P, Takyar S, Xia HH, Novel bovine lentiviral vectors based on Jembrana disease virus. J Gene Med 2000;2:176-85
   PubMed Web of Science ®Google Scholar
• Berkowitz RD, Ilves H, Plavec I, Gene transfer systems derived from Visna virus: analysis of virus production and infectivity. Virology 2001;279:116-29
   PubMed Web of Science ®Google Scholar
• Cronin J, Zhang XY, Reiser J. Altering the tropism of lentiviral vectors through pseudotyping. Curr Gene Ther 2005;5:387-98
   PubMed Web of Science ®Google Scholar
• Watson DJ, Kobinger GP, Passini MA, Targeted transduction patterns in the mouse brain by lentivirus vectors pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV envelope proteins. Mol Ther 2002;5:528-37
   PubMed Web of Science ®Google Scholar
• Miyoshi H, Takahashi M, Gage FH, Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci USA 1997;94:10319-23
   PubMed Web of Science ®Google Scholar
• Kafri T, Blomer U, Peterson DA, Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet 1997;17:314-17
   PubMed Web of Science ®Google Scholar
• Chang AH, Sadelain M. The genetic engineering of hematopoietic stem cells: the rise of lentiviral vectors, the conundrum of the LTR, and the promise of lineage-restricted vectors. Mol Ther 2007;15:445-56
   PubMed Web of Science ®Google Scholar
• Arce F, Rowe HM, Chain B, Lentiviral vectors transducer proliferating dendritic cell precursor leading to persistent antigen presentation and immunization. Mol Ther 2009;17:1643-50
   PubMed Web of Science ®Google Scholar
• Schroers R, Sinha I, Segall H, Transduction of human PBMC-derived dendritic cells and macrophages by an HIV-1-based lentiviral vector system. Mol Ther 2000;1:171-9
   PubMed Web of Science ®Google Scholar
• Hematti P, Hong BK, Ferguson C, Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol 2004;2(12):e423
   PubMed Web of Science ®Google Scholar
• Mitchell RS, Beitzel BF, Schroder AR, Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS Biol 2004;2(8):e234
   PubMed Web of Science ®Google Scholar
• Couzin J, Kaiser J. Gene Therapy. As Gelsinger case ends, gene therapy suffers another blow. Science 2005;307:1028
   PubMed Web of Science ®Google Scholar
• Hacein-Bey-Abina S, Von Kalle C, Schmidt M, LMO2- associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 2003;302:415-19
   PubMed Web of Science ®Google Scholar
• Cattoglio C, Facchini G, Sartori D, Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood 2007;110:1770-8
   PubMed Web of Science ®Google Scholar
• Montini E, Cesana D, Schmidt M, Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol 2006;24:687-96
   PubMed Web of Science ®Google Scholar
• Emery DW. The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors. Hum Gene Ther 2011: published online 19 January 2011, doi:10.1089/hum.2010.233
   Google Scholar
• Hu B, Tai A, Wang P. Immunization delivered by lentiviral vectors for cancer and infectious diseases. Immunol Rev 2011;239:45-61
   PubMed Web of Science ®Google Scholar
• Gene Therapy Clinical Trials Worldwide. Hoboken, NJ: John Wiley and Sons, 2007. Available from: http://www.wiley.co.uk/genmed/clinical/Updated Jun 2010 [Last accessed 10March 2011]
   Google Scholar
• Butler SL, Hansen MS, Bushman FD. A quantitative assay for HIV DNA integration in vivo. Nat Med 2001;7:631-4
   PubMed Web of Science ®Google Scholar
• Cara A, Reitz MS Jr. New insight on the role of extrachromosomal retroviral DNA. Leukemia 1997;11:1395-9
   PubMed Web of Science ®Google Scholar
• Cara A, Klotman ME. Retroviral E-DNA: persistence and gene expression in nondividing immune cells. J Leukoc Biol 2006;80:1013-17
   PubMed Web of Science ®Google Scholar
• Wanisch K, Yanez-Munoz RJ. Integration-deficient lentiviral vectors: a slow coming of age. Mol Ther 2009;17:1316-32
   PubMed Web of Science ®Google Scholar
• Vargas J Jr, Gusella GL, Najfeld V, Novel integrase-defective lentiviral episomal vectors for gene transfer. Hum Gene Ther 2004;15:361-72
   PubMed Web of Science ®Google Scholar
• Lu R, Nakajima N, Hofmann W, Simian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophages. J Virol 2004;78:658-68
   PubMed Web of Science ®Google Scholar
• Daelemans D, Lu R, De Clercq E, Characterization of a replication-competent, integrase-defective human immunodeficiency virus (HIV)/simian virus 40 chimera as a powerful tool for the discovery and validation of HIV integrase inhibitors. J Virol 2007;81:4381-5
   PubMed Web of Science ®Google Scholar
• Vargas J Jr, Klotman ME, Cara A. Conditionally replicating lentiviral-hybrid episomal vectors for suicide gene therapy. Antivir Res 2008;80:288-94
   PubMed Web of Science ®Google Scholar
• Yanez-Munoz RJ, Balaggan KS, MacNeil A, Effective gene therapy with nonintegrating lentiviral vectors. Nat Med 2006;12:348-53
   PubMed Web of Science ®Google Scholar
• Apolonia L, Waddington SN, Fernandes C, Stable gene transfer to muscle using non-integrating lentiviral vectors. Mol Ther 2007;15:1947-54
   PubMed Web of Science ®Google Scholar
• Bayer M, Kantor B, Cockrell A, A large U3 deletion causes increased in vivo expression from a nonintegrating lentiviral vector. Mol Ther 2008;16:1968-76
   PubMed Web of Science ®Google Scholar
• Saenz DT, Loewen N, Peretz M, Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants. J Virol 2004;78:2906-20
   PubMed Web of Science ®Google Scholar
• Philippe S, Sarkis C, Barkats M, Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo. Proc Natl Acad Sci USA 2006;103:17684-9
   PubMed Web of Science ®Google Scholar
• Rahim AA, Wong A, Howe SJ, Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors. Gene Ther 2009;16:509-20
   PubMed Web of Science ®Google Scholar
• Negri DR, Michelini Z, Cara A. Toward integrase defective lentiviral vectors for genetic immunization. Curr HIV Res 2010;8:274-81
   PubMed Web of Science ®Google Scholar
• Coutant F, Frenkiel MP, Despres P, Protective antiviral immunity conferred by a nonintegrative lentiviral vector based vaccine. PLoS One 2008;3:e3973
   PubMed Web of Science ®Google Scholar
• Karwacz K, Mukherjee S, Apolonia L, Nonintegrating lentivector vaccines stimulate prolonged T-cell and antibody responses and are effective in tumor therapy. J Virol 2009;83:3094-103
   PubMed Web of Science ®Google Scholar
• Negri DR, Michelini Z, Baroncelli S, Successful immunization with a single injection of non-integrating lentiviral vector. Mol Ther 2007;15:1716-23
   PubMed Web of Science ®Google Scholar
• Hu B, Yang H, Dai B, Nonintegrating lentiviral vectors can effectively deliver ovalbumin antigen for induction of antitumor immunity. Hum Gene Ther 2009;20:1652-64
   PubMed Web of Science ®Google Scholar
• Michelini Z, Negri DR, Baroncelli S, Development and use of SIV-based Integrase defective lentiviral vector for immunization. Vaccine 2009;27:4622-9
   PubMed Web of Science ®Google Scholar
• Hu B, Dai B, Wang P. Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity. Vaccine 2010;28:6675-83
   PubMed Web of Science ®Google Scholar
• Negri DR, Michelini Z, Baroncelli S, Nonintegrating lentiviral vector-based vaccine efficiently induces functional and persistent CD8+ T cell responses in mice. J Biomed Biotechnol 2010;534501: published online 19 May2010, doi: 10.1155/2010/534501
   Google Scholar
• Negri DR, Bona R, Michelini Z, Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8+ T cells. Hum Gene Ther 2010;21:1029-35
   PubMed Web of Science ®Google Scholar
• Poon B, Chen IS. Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA. J Virol 2003;77:3962-72
   PubMed Web of Science ®Google Scholar
• Grandchamp N, Henriot D, Philippe S, Influence of insulators on transgene expression from integrating and non-integrating lentiviral vectors. Genet Vaccin Ther 2011;9:1
   PubMedGoogle Scholar
• Froelich S, Tai A, Wang P. Lentiviral vectors for immune cells targeting. Immunopharmacol Immunotoxicol 2010;32:208-18
   PubMed Web of Science ®Google Scholar
• Berger G, Goujon C, Darlix JL, SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors. Gene Ther 2009;16:159-63
   PubMed Web of Science ®Google Scholar
• Goujon C, Riviere L, Jarrosson-Wuilleme L, SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells. Retrovirology 2007;4:2
   PubMed Web of Science ®Google Scholar
• Neutra MR, Kozlowski PA. Mucosal vaccines: the promise and the challenge. Nat Rev Immunol 2006;6:148-58
   PubMed Web of Science ®Google Scholar
• Haase AT. Targeting early infection to prevent HIV-1 mucosal transmission. Nature 2010;464:217-23
   PubMed Web of Science ®Google Scholar
• Holmgren J, Czerkinsky C. Mucosal immunity and vaccines. Nat Med 2005;11(Suppl 4):S45-53
   PubMed Web of Science ®Google Scholar
• Armstrong ME, Lavelle EC, Loscher CE, Proinflammatory responses in the murine brain after intranasal delivery of cholera toxin: implications for the use of AB toxins as adjuvants in intranasal vaccines. J Infect Dis 2005;192:1628-33
   PubMed Web of Science ®Google Scholar
• Lemiale F, Kong WP, Akyurek LM, Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system. J Virol 2003;77:10078-87
   PubMed Web of Science ®Google Scholar
• Mutsch M, Zhou W, Rhodes P, N Engl J Med 2004;350:896-903
   PubMed Web of Science ®Google Scholar
• Lewis DJ, Huo Z, Barnett S, Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS One 2009;4(9):e6999
   PubMed Web of Science ®Google Scholar
• Zhu Q, Thomson CW, Rosenthal KL, Immunization with adenovirus at the large intestinal mucosa as an effective vaccination strategy against sexually transmitted viral infection. Mucosal Immunol 2008;1:78-88
   Google Scholar
• Durham SR. Sublingual immunotherapy: what have we learnt from the ’big trials‘?. Curr Opin Allergy Clin Immunol 2008;8:577-84
   PubMed Web of Science ®Google Scholar
• Song JH, Nguyen HH, Cuburu N, Sublingual vaccination with influenza virus protects mice against lethal viral infection. Proc Natl Acad Sci USA 2008;105:1644-9
   PubMed Web of Science ®Google Scholar
• Cuburu N, Kweon MN, Song JK, Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. Vaccine 2007;25:8598-610
   PubMed Web of Science ®Google Scholar
• Negri DR, Riccomi A, Pinto D, Persistence of mucosal and systemic immune responses following sublingual immunization. Vaccine 2010;28:4175-80
   Google Scholar
• Sinn PL, Arias AC, Brogden KA, Lentivirus vector can be readministered to nasal epithelia without blocking immune responses. J Virol 2008;82:10684-92
   PubMed Web of Science ®Google Scholar
• Kremer KL, Dunning KR, Parson DW, Gene delivery to airway epithelial cells in vivo: a direct comparison of apical and basolateral transduction strategies using pseudotyped lentivirus vectors. J Gene Med 2007;9:362-8
   PubMed Web of Science ®Google Scholar
• Copreni E, Penzo M, Carrabino S, Lentivirus-mediated gene transfer to the respiratory epithelium: a promising approach to gene therapy of cystic fibrosis.Gene Ther 2004;11(Suppl 1):S67-75
   PubMed Web of Science ®Google Scholar
• Hashimoto D, Nagata T, Uchijima M, Intratracheal administration of third-generation lentivirus vector encoding MPT51 from Mycobacterium tuberculosis induces specific CD8+ T-cell responses in the lung. Vaccine 2008;26:5095-100
   PubMed Web of Science ®Google Scholar
• Sinn PL, Burnight ER, Hickey MA, Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer. J Virol 2005;79:12818-27
   PubMed Web of Science ®Google Scholar
• Rowe HM, Lopes L, Brown N, Expression of vFLIP in a lentiviral vaccine vector activates NF-kappaB, matures dendritic cells, and increases CD8+ T-cell responses. J Virol 2009;83:1555-62
   PubMed Web of Science ®Google Scholar
• Pluymers W, De Clercq E, Debyser Z. HIV-1 integration as a target for antiretroviral therapy: a review. Curr Drug Targets Infect Disord 2001;1:133-49
   PubMedGoogle Scholar
• Summa V, Petrocchi A, Bonelli F, Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem 2008;51:5843-55
   PubMed Web of Science ®Google Scholar
• Klibanov OM. Elvitegravir, an oral HIV integrase inhibitor, for the potential treatment of HIV infection. Curr Opin Investig Drugs 2009;10:190-200
   PubMed Web of Science ®Google Scholar
• Ojwang JO, Buckheit RW, Pommier Y, T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1. Antimicrob Agents Chemother 1995;39:2426-35
   PubMed Web of Science ®Google Scholar
• Hazuda D J, Felock P, Witmer M, Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000;287:646-50
   PubMed Web of Science ®Google Scholar
• Vandegraaff N, Kumar R, Hocking H, Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase. Antimicrob Agents Chemother 2001;45:2510-16
   PubMed Web of Science ®Google Scholar
• Nair V. HIV integrase as a target for antiviral chemotherapy. Rev Med Virol 2002;12:179-93
   PubMed Web of Science ®Google Scholar
• Svarovskaia E S, Barr R, Zhang X, Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-longterminal-repeat-circle junctions. J Virol 2004;78:3210-22
   PubMed Web of Science ®Google Scholar
• Bona R, Andreotti M, Buffa V, Development of a human immunodeficiency virus vector-based, single-cycle assay for evaluation of anti-integrase compounds. Antimicrob Agents Chemother 2006;50:3407-17
   PubMed Web of Science ®Google Scholar
• Michelini Z, Galluzzo CM, Negri DR, Evaluation of HIV-1 integrase inhibitors on human primary macrophages using a luciferase-based single-cycle phenotypic assay. J Virol Methods 2010;168:272-6
   PubMed Web of Science ®Google Scholar
• Wu Y, Marsh JW. Early transcription from nonintegrated DNA in human immunodeficiency virus infection. J Virol 2003;77:10376-82
   PubMed Web of Science ®Google Scholar
• Gillim-Ross L, Cara A, Klotman ME. HIV-1 extrachromosomal 2-LTR circular DNA is long-lived in human macrophages. Viral Immunol 2005;18:190-6
   PubMed Web of Science ®Google Scholar
• Zheng Y, Ourmanov I, Hirsch VM. Persistent transcription of a nonintegrating mutant of simian immunodeficiency virus in rhesus macrophages. Virology 2008;372:291-9
   PubMed Web of Science ®Google Scholar
• Kelly J, Beddall MH, Yu D, Human macrophages support persistent transcription from unintegrated HIV-1 DNA. Virology 2008;372:300-12
   PubMed Web of Science ®Google Scholar
• Gillim-Ross L, Cara A, Klotman ME. Nef expressed from human immunodeficiency virus type 1 extrachromosomal DNA downregulates CD4 on primary CD4+ T lymphocytes: implications for integrase inhibitors. J Gen Virol 2005;86:765-71
   PubMed Web of Science ®Google Scholar
• Poon B, Chang MA, Chen IS. Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA. J Virol 2007;81:10515-23
   PubMed Web of Science ®Google Scholar
• Sloan RD, Donahue DA, Kuhl BD, Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes. Retrovirology 2010;7:44
   PubMed Web of Science ®Google Scholar
• Kantor B, Ma H, Webster-Cyriaque J, Epigenetic activation of unintegrated HIV-1 genomes by gut-associated short chain fatty acids and its implication for HIV infection. Proc Natl Acad Sci USA 2009;106:18786-91
   PubMed Web of Science ®Google Scholar