Multifaceted roles of curcumin: two sides of a coin!

Bibliography

• Basnet P, Skalko-Basnet N. Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules 2011;16:4567-98
   PubMed Web of Science ®Google Scholar
• Kim DS, Park SY, Kim JK. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Neurosci Lett 2001;303:57-61
   PubMed Web of Science ®Google Scholar
• Verghese J. Isolation of curcumin from Curcuma longa L. rhizome. Flavour Fragrance J 1993;8:315-19
   Google Scholar
• Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol 2007;595:1-75
   PubMed Web of Science ®Google Scholar
• Mahady GB, Pendland SL, Yun G, Lu ZZ. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer Res 2002;22:4179-81
   PubMed Web of Science ®Google Scholar
• Haukvik T, Bruzell E, Kristensen S, Tonnesen HH. Photokilling of bacteria by curcumin in different aqueous preparations. Studies on curcumin and curcuminoids XXXVII. Pharmazie 2009;64:666-73
   PubMed Web of Science ®Google Scholar
• Kundu P, De R, Pal I, Curcumin alleviates matrix metalloproteinase-3 and -9 activities during eradication of Helicobacter pylori infection in cultured cells and mice. PLoS ONE 2011;6(11):e16306
   Google Scholar
• Han C, Wang L, Yu K, Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori. FEBS J 2006;273:4682-92
   PubMed Web of Science ®Google Scholar
• Koide T, Nose M, Ogihara Y, Leishmanicidal effect of curcumin in vitro. Biol Pharm Bull 2002;25:131-3
   PubMed Web of Science ®Google Scholar
• Moghaddam K, Iranshahi M, Yazdi M, Shahverdi A. The combination effect of curcumin with different antibiotics against Staphylococcus aureus. Int J Green Pharm 2009;3:141-3
   Google Scholar
• Liew FY, Li Y, Moss D, Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages. Eur J Immunol 1991;21:3009-14
   PubMed Web of Science ®Google Scholar
• Vazquez-Torres A, Jones-Carson J, Mastroeni P, Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro. J Exp Med 2000;192:227-36
   PubMed Web of Science ®Google Scholar
• De R, Kundu P, Swarnakar S, Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrob Agents Chemother 2009;53:1592-7
   PubMed Web of Science ®Google Scholar
• Foryst-Ludwig A, Neumann M, Schneider-Brachert W, Naumann M. Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells. Biochem Biophys Res Commun 2004;316:1065-72
   PubMed Web of Science ®Google Scholar
• Tomita M, Kawakami H, Uchihara JN, Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines. Leuk Res 2006;30:313-21
   PubMed Web of Science ®Google Scholar
• Churin Y, Al-Ghoul L, Kepp O, Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol 2003;161:249-55
   PubMed Web of Science ®Google Scholar
• Bergin PJ, Anders E, Sicheng W, Increased production of matrix metalloproteinases in Helicobacter pylori-associated human gastritis. Helicobacter 2004;9:201-10
   PubMed Web of Science ®Google Scholar
• Tomita M, Ando T, Minami M, Potential role for matrix metalloproteinase-3 in gastric ulcer healing. Digestion 2009;79:23-9
   PubMed Web of Science ®Google Scholar
• Parish T, Stoker NG. The common aromatic amino acid biosynthesis pathway is essential in Mycobacterium tuberculosis. Microbiology 2002;148:3069-77
   PubMed Web of Science ®Google Scholar
• Di Mario F, Cavallaro LG, Nouvenne A, A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure? Helicobacter 2007;12:238-43
   PubMed Web of Science ®Google Scholar
• Adapala N, Chan MM. Long-term use of an antiinflammatory, curcumin, suppressed type 1 immunity and exacerbated visceral leishmaniasis in a chronic experimental model. Lab Invest 2008;88:1329-39
   PubMed Web of Science ®Google Scholar
• Marathe SA, Ray S, Chakravortty D. Curcumin increases the pathogenicity of Salmonella enterica serovar Typhimurium in murine model. PLoS One 2010;5:e11511
   PubMed Web of Science ®Google Scholar
• Hansen-Wester I, Hensel M. Salmonella pathogenicity islands encoding type III secretion systems. Microbes Infect 2001;3:549-59
   PubMedGoogle Scholar
• Hassett DJ, Cohen MS. Bacterial adaptation to oxidative stress: implications for pathogenesis and interaction with phagocytic cells. FASEB J 1989;3:2574-82
   PubMed Web of Science ®Google Scholar
• Kehres DG, Janakiraman A, Slauch JM, Maguire ME. Regulation of Salmonella enterica serovar Typhimurium mntH transcription by H2O2, Fe2+, and Mn2+.. J Bacteriol 2002;184:3151-518
   PubMed Web of Science ®Google Scholar
• Gunn JS. The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more. Trends Microbiol 2008;16:284-90
   PubMed Web of Science ®Google Scholar
• Sabri M, Leveille S, Dozois CM. A SitABCD homologue from an avian pathogenic Escherichia coli strain mediates transport of iron and manganese and resistance to hydrogen peroxide. Microbiology 2006;152:745-58
   PubMed Web of Science ®Google Scholar
• Changtam C, Hongmanee P, Suksamrarn A. Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity. Eur J Med Chem 2010;45:4446-57
   PubMed Web of Science ®Google Scholar
• Amaral L, Martins M, Viveiros M. Enhanced killing of intracellular multidrug-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps. J Antimicrob Chemother 2007;59:1237-46
   PubMed Web of Science ®Google Scholar
• Shahverdi A, Moghaddam K, Yazdi M, Iranshahi M. The combination effect of curcumin with different antibiotics against Staphylococcus aureus. Int J Green Pharm 2009;3:141-3
   Google Scholar
• Rai D, Singh JK, Roy N, Panda D. Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity. Biochem J 2008;410:147-55
   PubMed Web of Science ®Google Scholar
• Oda Y. Inhibitory effect of curcumin on SOS functions induced by UV irradiation. Mutat Res 1995;348:67-73
   PubMed Web of Science ®Google Scholar
• Wessler S, Muenzner P, Meyer TF, Naumann M. The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection. Biol Chem 2005;386:481-90
   PubMed Web of Science ®Google Scholar
• Jazayeri SD, Mustafa S, Manap MY, Survival of bifidobacteria and other selected intestinal bacteria in TPY medium supplemented with curcumin as assessed in vitro. Int J Probiotics Prebiotics 2009;4:15-22
   Google Scholar
• Cerf-Bensussan N, Gaboriau-Routhiau V. The immune system and the gut microbiota: friends or foes? Nat Rev Immunol 2010;10:735-44
   PubMed Web of Science ®Google Scholar
• Chan MM, Adapala NS, Fong D. Curcumin overcomes the inhibitory effect of nitric oxide on Leishmania. Parasitol Res 2005;96:49-56
   PubMed Web of Science ®Google Scholar
• Saleheen D, Ali SA, Ashfaq K, Latent activity of curcumin against leishmaniasis in vitro. Biol Pharm Bull 2002;25:386-9
   PubMed Web of Science ®Google Scholar
• Das R, Roy A, Dutta N, Majumder HK. Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani. Apoptosis 2008;13:867-82
   PubMed Web of Science ®Google Scholar
• Perez-Arriaga L, Mendoza-Magana ML, Cortes-Zarate R, Cytotoxic effect of curcumin on Giardia lamblia trophozoites. Acta Trop 2006;98:152-61
   PubMed Web of Science ®Google Scholar
• Cui L, Miao J. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob Agents Chemother 2007;51:488-94
   PubMed Web of Science ®Google Scholar
• Ralph SA, Scherf A. The epigenetic control of antigenic variation in Plasmodium falciparum. Curr Opin Microbiol 2005;8:434-40
   PubMed Web of Science ®Google Scholar
• Singh N, Misra K. Computational screening of molecular targets in Plasmodium for novel non resistant anti-malarial drugs. Bioinformation 2009;3:255-62
   PubMedGoogle Scholar
• Nandakumar DN, Nagaraj VA, Vathsala PG, Curcumin-artemisinin combination therapy for malaria. Antimicrob Agents Chemother 2006;50:1859-60
   PubMed Web of Science ®Google Scholar
• Eckstein-Ludwig U, Webb RJ, Van Goethem ID, Artemisinins target the SERCA of Plasmodium falciparum. Nature 2003;424:957-61
   PubMed Web of Science ®Google Scholar
• Ji HF, Shen L. Interactions of curcumin with the PfATP6 model and the implications for its antimalarial mechanism. Bioorg Med Chem Lett 2009;19:2453-5
   PubMed Web of Science ®Google Scholar
• Martinelli A, Rodrigues LA, Cravo P. Plasmodium chabaudi: efficacy of artemisinin + curcumin combination treatment on a clone selected for artemisinin resistance in mice. Exp Parasitol 2008;119(2):304-7
   PubMed Web of Science ®Google Scholar
• Day N, Dondorp AM. The management of patients with severe malaria. Am J Trop Med Hyg 2007;77(6 Suppl):29-35
   PubMed Web of Science ®Google Scholar
• Mimche P, Taramelli D, Vivas L. The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria. Malar J 2011;10(Suppl 1):S10
   Google Scholar
• Changtam C, de Koning HP, Ibrahim H, Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. Eur J Med Chem 2010;45:941-56
   PubMed Web of Science ®Google Scholar
• Nose M, Koide T, Ogihara Y, Trypanocidal effects of curcumin in vitro. Biol Pharm Bull 1998;21:643-5
   PubMed Web of Science ®Google Scholar
• Zhang HS, Ruan Z, Sang WW. HDAC1/NFkappaB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation. J Cell Physiol 2011 February 22
   Web of Science ®Google Scholar
• Mazumder A, Raghavan K, Weinstein J, Inhibition of human immunodeficiency virus type-1 integrase by curcumin. Biochem Pharmacol 1995;49:1165-70
   PubMed Web of Science ®Google Scholar
• Kim K, Kim KH, Kim HY, Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway. FEBS Lett 2010;584:707-12
   PubMed Web of Science ®Google Scholar
• Rechtman MM, Har-Noy O, Bar-Yishay I, Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha. FEBS Lett 2010;584:2485-90
   PubMed Web of Science ®Google Scholar
• Bourne KZ, Bourne N, Reising SF, Stanberry LR. Plant products as topical microbicide candidates: assessment of in vitro and in vivo activity against herpes simplex virus type 2. Antiviral Res 1999;42:219-26
   PubMed Web of Science ®Google Scholar
• Prusty BK, Das BC. Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin. Int J Cancer 2005;113:951-60
   PubMed Web of Science ®Google Scholar
• Luo H, Zhang J, Cheung C, Proteasome inhibition reduces coxsackievirus B3 replication in murine cardiomyocytes. Am J Pathol 2003;163:381-5
   PubMed Web of Science ®Google Scholar
• Dutta K, Ghosh D, Basu A. Curcumin protects neuronal cells from Japanese encephalitis virus-mediated cell death and also inhibits infective viral particle formation by dysregulation of ubiquitin-proteasome system. J Neuroimmune Pharmacol 2009;4:328-37
   PubMed Web of Science ®Google Scholar
• Hanai H, Sugimoto K. Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr Pharm Des 2009;15:2087-94
   PubMed Web of Science ®Google Scholar
• Taylor RA, Leonard MC. Curcumin for inflammatory bowel disease: a review of human studies. Altern Med Rev 2011;16:152-6
   PubMedGoogle Scholar
• Binion DG, Heidemann J, Li MS, Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin. Am J Physiol Gastrointest Liver Physiol 2009;297:G259-68
   Web of Science ®Google Scholar
• Baugh MD, Perry MJ, Hollander AP, Matrix metalloproteinase levels are elevated in inflammatory bowel disease. Gastroenterology 1999;117:814-22
   PubMed Web of Science ®Google Scholar
• Epstein J, Docena G, MacDonald TT, Sanderson IR. Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Br J Nutr 2010;103:824-32
   PubMed Web of Science ®Google Scholar
• Larmonier CB, Midura-Kiela MT, Ramalingam R, Modulation of neutrophil motility by curcumin: implications for inflammatory bowel disease. Inflamm Bowel Dis 2011;17:503-15
   PubMed Web of Science ®Google Scholar
• Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci 2005;50:2191-3
   PubMed Web of Science ®Google Scholar
• Klein WL, Krafft GA, Finch CE. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends Neurosci 2001;24:219-24
   PubMed Web of Science ®Google Scholar
• Hamaguchi T, Ono K, Yamada M. Curcumin and Alzheimer's disease. CNS Neurosci Ther 2010;16:285-97
   PubMed Web of Science ®Google Scholar
• Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets 2011;12:332-47
   PubMed Web of Science ®Google Scholar
• Yanagisawa D, Taguchi H, Yamamoto A, Curcuminoid binds to amyloid-beta1-42 oligomer and fibril. J Alzheimers Dis 2011;24(Suppl 2):33-42
   PubMed Web of Science ®Google Scholar
• Narlawar R, Pickhardt M, Leuchtenberger S, Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease? ChemMedChem 2008;3:165-72
   PubMed Web of Science ®Google Scholar
• Lin MS, Hung KS, Chiu WT, Curcumin enhances neuronal survival in N-methyl-d-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:931-8
   PubMed Web of Science ®Google Scholar
• Daniel S, Limson JL, Dairam A, Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J Inorg Biochem 2004;98:266-75
   PubMed Web of Science ®Google Scholar
• Ahmed T, Gilani AH, Hosseinmardi N, Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices. Synapse 2011;65:572-82
   PubMed Web of Science ®Google Scholar
• Bharath S, Hsu M, Kaur D, Glutathione, iron and Parkinson's disease. Biochem Pharmacol 2002;64:1037-48
   PubMed Web of Science ®Google Scholar
• Jagatha B, Mythri RB, Vali S, Bharath MMS. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free Radic Biol Med 2008;44:907-17
   PubMed Web of Science ®Google Scholar
• Beal MF. Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease. Parkinsonism Relat Disord 2009;15(Suppl 3):S189-94
   Google Scholar
• Wang MS, Boddapati S, Emadi S, Sierks MR. Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. BMC Neurosci 2010;11:57
   PubMed Web of Science ®Google Scholar
• Ortiz-Ortiz MA, Moran JM, Ruiz-Mesa LM, Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells. Neurosci Lett 2010;468:120-4
   PubMed Web of Science ®Google Scholar
• Yu S, Zheng W, Xin N, Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway. Rejuvenation Res 2010;13:55-64
   PubMed Web of Science ®Google Scholar
• Thangapazham RL, Sharma A, Maheshwari RK. Beneficial role of curcumin in skin diseases. Adv Exp Med Biol 2007;595:343-57
   PubMed Web of Science ®Google Scholar
• Pol A, Bergers M, Schalkwijk J. Comparison of antiproliferative effects of experimental and established antipsoriatic drugs on human kerationocytes, using a simple 96-well-plate assay. In Vitro Cell Dev Biol Anim 2003;39:36-42
   PubMed Web of Science ®Google Scholar
• Miquel J, Bernd A, Sempere JM, The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr 2002;34:37-46
   PubMed Web of Science ®Google Scholar
• Hanselmann C, Mauch C, Werner S. Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis? Biochem J 2001;353:459-66
   PubMed Web of Science ®Google Scholar
• Heng MC, Song MK, Heng MK. Elevated phosphorylase kinase activity in psoriatic epidermis: correlation with increased phosphorylation and psoriatic activity. Br J Dermatol 1994;130:298-306
   PubMed Web of Science ®Google Scholar
• Heng MC, Song MK, Harker J, Heng MK. Drug-induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological and immunohistochemical parameters. Br J Dermatol 2000;143:937-49
   PubMed Web of Science ®Google Scholar
• Lebwohl M. Innovations in the treatment of psoriasis. J Am Acad Dermatol 2004;51(1 Suppl):S40-1
   Google Scholar
• Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J 2009;11:495-510
   PubMed Web of Science ®Google Scholar
• Moos PJ, Edes K, Mullally JE, Fitzpatrick FA. Curcumin impairs tumor suppressor p53 function in colon cancer cells. Carcinogenesis 2004;25:1611-17
   PubMed Web of Science ®Google Scholar
• Somasundaram S, Edmund NA, Moore DT, Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res 2002;62:3868-75
   PubMed Web of Science ®Google Scholar
• Liu YL, Yang HP, Gong L, Hypomethylation effects of curcumin, demethoxycurcumin and bisdemethoxycurcumin on WIF-1 promoter in non-small cell lung cancer cell lines. Mol Med Rep 2011;4:675-9
   PubMed Web of Science ®Google Scholar
• Jiao Y, Wilkinson J IV, Di X, Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood 2009;113:462-9
   PubMed Web of Science ®Google Scholar
• Karunagaran D, Rashmi R, Kumar TR. Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets 2005;5:117-29
   PubMed Web of Science ®Google Scholar
• Cipriani B, Borsellino G, Knowles H, Curcumin inhibits activation of Vgamma9Vdelta2 T cells by phosphoantigens and induces apoptosis involving apoptosis-inducing factor and large scale DNA fragmentation. J Immunol 2001;167:3454-62
   PubMed Web of Science ®Google Scholar
• O'Sullivan-Coyne G, O'Sullivan GC, O'Donovan TR, Curcumin induces apoptosis-independent death in oesophageal cancer cells. Br J Cancer 2009;101:1585-95
   PubMed Web of Science ®Google Scholar
• Magalska A, Brzezinska A, Bielak-Zmijewska A, Curcumin induces cell death without oligonucleosomal DNA fragmentation in quiescent and proliferating human CD8+ cells. Acta Biochim Pol 2006;53:531-8
   PubMed Web of Science ®Google Scholar
• Jung C, Maeder V, Funk F, Release of phenols from Lupinus albus L. roots exposed to Cu and their possible role in Cu detoxification. Plant Soil 2003;252:301-12
   Web of Science ®Google Scholar
• Rice-Evans C, Miller N, Paganga G. Antioxidant properties of phenolic compounds. Trends Plant Sci 1997;2:152-9
   Web of Science ®Google Scholar
• Motterlini R, Foresti R, Bassi R, Green CJ. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 2000;28:1303-12
   PubMed Web of Science ®Google Scholar
• Yoshino M, Haneda M, Naruse M, Prooxidant activity of curcumin: copper-dependent formation of 8-hydroxy-2′-deoxyguanosine in DNA and induction of apoptotic cell death. Toxicol In Vitro 2004;18:783-9
   PubMed Web of Science ®Google Scholar
• Atsumi T, Fujisawa S, Tonosaki K. Relationship between intracellular ROS production and membrane mobility in curcumin- and tetrahydrocurcumin-treated human gingival fibroblasts and human submandibular gland carcinoma cells. Oral Dis 2005;11:236-42
   PubMed Web of Science ®Google Scholar
• Moran JF, Klucas RV, Grayer RJ, Complexes of iron with phenolic compounds from soybean nodules and other legume tissues: prooxidant and antioxidant properties. Free Radic Biol Med 1997;22:861-70
   PubMed Web of Science ®Google Scholar
• Arora A, Nair MG, Strasburg GM. Structure-activity relationships for antioxidant activities of a series of flavonoids in a liposomal system. Free Radic Biol Med 1998;24:1355-63
   PubMed Web of Science ®Google Scholar
• Ohara K, Mizukami W, Tokunaga A, Kinetic study of the mechanism of free-radical scavenging action in curcumin: effects of solvent and pH. Bull Chem Soc Jpn 2005;78:615-21
   Web of Science ®Google Scholar
• Arora A, Byrem TM, Nair MG, Strasburg GM. Modulation of liposomal membrane fluidity by flavonoids and isoflavonoids. Arch Biochem Biophys 2000;373:102-9
   PubMed Web of Science ®Google Scholar
• Verstraeten SV, Keen CL, Schmitz HH, Flavan-3-ols and procyanidins protect liposomes against lipid oxidation and disruption of the bilayer structure. Free Radic Biol Med 2003;34:84-92
   PubMed Web of Science ®Google Scholar
• Adams BK, Cai J, Armstrong J, EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anticancer Drugs 2005;16:263-75
   PubMed Web of Science ®Google Scholar
• Galati G, Sabzevari O, Wilson JX, O'Brien PJ. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 2002;177:91-104
   PubMed Web of Science ®Google Scholar
• Sandur SK, Ichikawa H, Pandey MK, Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free Radic Biol Med 2007;43:568-80
   PubMed Web of Science ®Google Scholar
• Fang J, Lu J, Holmgren A. Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. J Biol Chem 2005;280:25284-90
   PubMed Web of Science ®Google Scholar
• Jurrmann N, Brigelius-Flohe R, Bol GF. Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells. J Nutr 2005;135:1859-64
   PubMed Web of Science ®Google Scholar
• Shoba G, Joy D, Joseph T, Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998;64:353-6
   PubMed Web of Science ®Google Scholar
• Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm 2007;4:807-18
   PubMed Web of Science ®Google Scholar
• Fang JY, Hung CF, Chiu HC, Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin. J Pharm Pharmacol 2003;55:1175
   PubMed Web of Science ®Google Scholar
• Shahani K, Panyam J. Highly loaded, sustained-release microparticles of curcumin for chemoprevention. J Pharm Sci 2011;100:2599-609
   PubMed Web of Science ®Google Scholar
• Bhawana Basniwal RK, Buttar HS, Curcumin nanoparticles: preparation, characterization, and antimicrobial study. J Agric Food Chem 2011;59:2056-61
   PubMed Web of Science ®Google Scholar
• Zhang F, Koh GY, Jeansonne DP, A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity. J Pharm Sci 2011;100:2778-89
   PubMed Web of Science ®Google Scholar
• Shishir S, Krishna M, Bharat A. Turmeric as Cure-Cumin. Dietary Modulation of Cell Signaling Pathways: CRC Press; 2008
   Google Scholar
• Mosley CA, Liotta DC, Snyder JP. Highly active anticancer curcumin analogues. Adv Exp Med Biol 2007;595:77-103
   PubMed Web of Science ®Google Scholar
• Cen L, Hutzen B, Ball S, New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. BMC Cancer 2009;9:99
   PubMedGoogle Scholar
• Singh RK, Rai D, Yadav D, Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid. Eur J Med Chem 2010;45:1078-86
   PubMed Web of Science ®Google Scholar
• Dubey SK, Sharma AK, Narain U, Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties. Eur J Med Chem 2008;43:1837-46
   PubMed Web of Science ®Google Scholar
• Sardjiman SS, Reksohadiprodjo MS, Hakim L, 1,5-Diphenyl-1,4-pentadiene-3-ones and cyclic analogues as antioxidative agents. Synthesis and structure-activity relationship. Eur J Med Chem 32:625-30
   Web of Science ®Google Scholar
• Markaverich BM, Schauweker TH, Gregory RR, Nuclear type II sites and malignant cell proliferation: inhibition by 2,6-bis-benzylidenecyclohexanones. Cancer Res 1992;52:2482-8
   PubMed Web of Science ®Google Scholar
• El-Subbagh HI, Abu-Zaid SM, Mahran MA, Synthesis and biological evaluation of certain alpha,beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents. J Med Chem 2000;43:2915-21
   PubMed Web of Science ®Google Scholar
• Sreejayan N, Rao MN. Free radical scavenging activity of curcuminoids. Arzneimittelforschung 1996;46:169-71
   PubMed Web of Science ®Google Scholar
• Sahu SC, Washington MC. Effect of ascorbic acid and curcumin on quercetin-induced nuclear DNA damage, lipid peroxidation and protein degradation. Cancer Lett 1992;63:237-41
   PubMed Web of Science ®Google Scholar
• Tsai Y-M, Chien C-F, Lin L-C, Tsai T-H. Curcumin and its nano-formulation: The kinetics of tissue distribution and blood-brain barrier penetration. Int J Pharm 2011;416:331-8
   PubMed Web of Science ®Google Scholar
• Sharma KK, Chandra S, Basu DK. Synthesis and antiarthritic study of a new orally active diferuloyl methane (curcumin) gold complex. Inorg Chim Acta 1987;135:47-8
   Web of Science ®Google Scholar
• Vajragupta O, Boonchoong P, Watanabe H, Manganese complexes of curcumin and its derivatives: evaluation for the radical scavenging ability and neuroprotective activity. Free Radic Biol Med 2003;35:1632-44
   PubMed Web of Science ®Google Scholar
• Krishnankutty K, Venugopalan P. Metal chelates of curcuminoids. synthesis and reactivity in Inorganic and Metal-Organic. Chemistry (Easton) 1998;28:1313-25
   Google Scholar
• Thompson KH, Bohmerle K, Polishchuk E, Complementary inhibition of synoviocyte, smooth muscle cell or mouse lymphoma cell proliferation by a vanadyl curcumin complex compared to curcumin alone. J Inorg Biochem 2004;98:2063-70
   PubMed Web of Science ®Google Scholar
• Mohammadi K, Thompson KH, Patrick BO, Synthesis and characterization of dual function vanadyl, gallium and indium curcumin complexes for medicinal applications. J Inorg Biochem 2005;99:2217-25
   PubMed Web of Science ®Google Scholar
• Parvathy KS, Negi PS, Srinivas P. Antioxidant, antimutagenic and antibacterial activities of curcumin-beta-diglucoside. Food Chem 2009;115:265-71
   Web of Science ®Google Scholar
• Dubey SK, Sharma AK, Narain U, Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties. Eur J Med Chem 2008;43:1837-46
   PubMed Web of Science ®Google Scholar
• Mishra S, Karmodiya K, Surolia N, Surolia A. Synthesis and exploration of novel curcumin analogues as anti-malarial agents. Bioorg Med Chem 2008;16:2894-902
   PubMed Web of Science ®Google Scholar
• Liang G, Yang S, Jiang L, Synthesis and anti-bacterial properties of mono-carbonyl analogues of curcumin. Chem Pharm Bull (Tokyo) 2008;56:162-7
   PubMed Web of Science ®Google Scholar
• Manju S, Sreenivasan K. Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability. J Colloid Interface Sci 2011;359:318-25
   PubMed Web of Science ®Google Scholar
• Aggarwal S, Ndinguri MW, Solipuram R, [DLys6]-LHRH-curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo. Int J Cancer 2011;129(7):1611-23
   PubMed Web of Science ®Google Scholar
• Mourtas S, Canovi M, Zona C, Curcumin-decorated nanoliposomes with very high affinity for amyloid-beta1-42 peptide. Biomaterials 2011;32:1635-45
   PubMed Web of Science ®Google Scholar
• Kumar S, Misra A, Tripathi S, Misra K. Study on curcumin-oligonucleotide conjugate as a probable anticancer agent: its hybridisation with telomere target sequence 5′-GGGATTGGGATT-3′. Nucleic Acids Symp Ser (Oxf) 2001(1):137-8
   Google Scholar