Gene transfer mediated by stem cell grafts to treat CNS injury

Bibliography

• Auriel E, Bornstein NM. Neuroprotection in acute ischemic stroke–current status. J Cell Mol Med 2010;14:2200-2
   PubMed Web of Science ®Google Scholar
• Nesathurai S. Steroids and spinal cord injury: revisiting the NASCIS 2 and NASCIS 3 trials. J Trauma 1998;45:1088-93
   PubMed Web of Science ®Google Scholar
• Jain KK. Neuroprotection in traumatic brain injury. Drug Discov Today 2008;13:1082-9
   PubMed Web of Science ®Google Scholar
• Fisher M. New approaches to neuroprotective drug development. Stroke 2011;42:S24-7
   PubMed Web of Science ®Google Scholar
• Shuaib A, Hussain MS. The past and future of neuroprotection in cerebral ischaemic stroke. Eur Neurol 2008;59:4-14
   PubMed Web of Science ®Google Scholar
• Lu P, Jones LL, Snyder EY, Tuszynski MH. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol 2003;181:115-29
   PubMed Web of Science ®Google Scholar
• Tang Y, Yasuhara T, Hara K, Transplantation of bone marrow-derived stem cells: a promising therapy for stroke. Cell Transplant 2007;16:159-69
   PubMed Web of Science ®Google Scholar
• Park KI, Teng YD, Snyder EY. The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat Biotechnol 2002;20:1111-17
   PubMed Web of Science ®Google Scholar
• Cao Q, He Q, Wang Y, Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury. J Neurosci 2010;30:2989-3001
   PubMed Web of Science ®Google Scholar
• Yamashita T, Deguchi K, Nagotani S, Gene and stem cell therapy in ischemic stroke. Cell Transplant 2009;18:999-1002
   PubMed Web of Science ®Google Scholar
• Blesch A, Lu P, Tuszynski MH. Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res Bull 2002;57:833-8
   PubMed Web of Science ®Google Scholar
• Taha MF. Cell based-gene delivery approaches for the treatment of spinal cord injury and neurodegenerative disorders. Curr Stem Cell Res Ther 2010;5:23-36
   PubMedGoogle Scholar
• Blits B, Boer GJ, Verhaagen J. Pharmacological, cell, and gene therapy strategies to promote spinal cord regeneration. Cell Transplant 2002;11:593-613
   PubMed Web of Science ®Google Scholar
• Park IH, Zhao R, West JA, Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008;451:141-6
   PubMed Web of Science ®Google Scholar
• Takahashi K, Tanabe K, Ohnuki M, Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72
   PubMed Web of Science ®Google Scholar
• Naegele JR, Maisano X, Yang J, Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy. Neuropharmacology 2010;58:855-64
   PubMed Web of Science ®Google Scholar
• Wright KT, El Masri W, Osman A, Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications. Stem Cells 2011;29:169-78
   PubMed Web of Science ®Google Scholar
• Naldini L. Ex vivo gene transfer and correction for cell-based therapies. Nat Rev Genet 2011;5:301-15
   Google Scholar
• Imitola J, Raddassi K, Park KI, Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci USA 2004;101:18117-22
   PubMed Web of Science ®Google Scholar
• Benedetti S, Pirola B, Pollo B, Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 2000;6:447-50
   PubMed Web of Science ®Google Scholar
• Aboody KS, Brown A, Rainov NG, Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 2000;97:12846-51
   PubMed Web of Science ®Google Scholar
• Sykova E, Jendelova P. In vivo tracking of stem cells in brain and spinal cord injury. Prog Brain Res 2007;161:367-83
   PubMed Web of Science ®Google Scholar
• Rosenkranz K, Kumbruch S, Lebermann K, The chemokine SDF-1/CXCL12 contributes to the ‘homing’ of umbilical cord blood cells to a hypoxic-ischemic lesion in the rat brain. J Neurosci Res 2010;88:1223-33
   PubMed Web of Science ®Google Scholar
• Ahmed AU, Tyler MA, Thaci B, A comparative study of neural and mesenchymal stem cell-based carriers for oncolytic adenovirus in a model of malignant glioma. Mol Pharm 2011;8:1559-72
   PubMedGoogle Scholar
• Wang JM, Zeng YS, Wu JL, Cograft of neural stem cells and Schwann cells overexpressing TrkC and neurotrophin-3 respectively after rat spinal cord transection. Biomaterials 2011;32:7454-68
   PubMed Web of Science ®Google Scholar
• Bonner JF, Connors TM, Silverman WF, Grafted neural progenitors integrate and restore synaptic connectivity across the injured spinal cord. J Neurosci 2011;31:4675-86
   PubMed Web of Science ®Google Scholar
• Lee HJ, Kim KS, Park IH, Kim SU. Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS One 2007;2:e156
   PubMed Web of Science ®Google Scholar
• Hwang DH, Kim HM, Kang YM, Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair. Cell Transplant 2011; published online 1 July 2011; doi: 10.3727/096368910X557155
   Web of Science ®Google Scholar
• Lee SI, Kim BG, Hwang DH, Overexpression of Bcl-XL in human neural stem cells promotes graft survival and functional recovery following transplantation in spinal cord injury. J Neurosci Res 2009;87:3186-97
   PubMed Web of Science ®Google Scholar
• Lee HJ, Park IH, Kim HJ, Kim SU. Human neural stem cells overexpressing glial cell line-derived neurotrophic factor in experimental cerebral hemorrhage. Gene Ther 2009;16:1066-76
   PubMed Web of Science ®Google Scholar
• Kurozumi K, Nakamura K, Tamiya T, Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Mol Ther 2005;11:96-104
   PubMed Web of Science ®Google Scholar
• Kurozumi K, Nakamura K, Tamiya T, BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol Ther 2004;9:189-97
   PubMed Web of Science ®Google Scholar
• Lu P, Jones LL, Tuszynski MH. BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol 2005;191:344-60
   PubMed Web of Science ®Google Scholar
• Sasaki M, Radtke C, Tan AM, BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury. J Neurosci 2009;29:14932-41
   PubMed Web of Science ®Google Scholar
• Romero MI, Rangappa N, Li L, Extensive sprouting of sensory afferents and hyperalgesia induced by conditional expression of nerve growth factor in the adult spinal cord. J Neurosci 2000;20:4435-45
   PubMed Web of Science ®Google Scholar
• Totoiu MO, Keirstead HS. Spinal cord injury is accompanied by chronic progressive demyelination. J Comp Neurol 2005;486:373-83
   PubMed Web of Science ®Google Scholar
• Keirstead HS, Nistor G, Bernal G, Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci 2005;25:4694-705
   PubMed Web of Science ®Google Scholar
• Kim HM, Hwang DH, Lee JE, Ex vivo VEGF delivery by neural stem cells enhances proliferation of glial progenitors, angiogenesis, and tissue sparing after spinal cord injury. PLoS One 2009;4:e4987
   PubMedGoogle Scholar
• Bradbury EJ, Moon LD, Popat RJ, Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 2002;416:636-40
   PubMed Web of Science ®Google Scholar
• Hellal F, Hurtado A, Ruschel J, Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science 2011;331:928-31
   PubMed Web of Science ®Google Scholar
• Asher RA, Morgenstern DA, Fidler PS, Neurocan is upregulated in injured brain and in cytokine-treated astrocytes. J Neurosci 2000;20:2427-38
   PubMed Web of Science ®Google Scholar
• Logan A, Green J, Hunter A, Inhibition of glial scarring in the injured rat brain by a recombinant human monoclonal antibody to transforming growth factor-beta2. Eur J Neurosci 1999;11:2367-74
   PubMed Web of Science ®Google Scholar
• Moon LD, Fawcett JW. Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGFbeta1 and beta2. Eur J Neurosci 2001;14:1667-77
   PubMed Web of Science ®Google Scholar
• Jeong SR, Jang DY, Kim SS, Hepatocyte growth factor inhibits glial scar formation and decreases production of chondroitin sulfate proteoglycans after spinal cord injury. Program No. 365.5/CC74. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2009
   Google Scholar
• Iannotti CA, Clark M, Horn KP, A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI. Exp Neurol 2011;1:3-15
   Google Scholar
• Pluchino S, Zanotti L, Rossi B, Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 2005;436:266-71
   PubMed Web of Science ®Google Scholar
• Ben-Hur T. Immunomodulation by neural stem cells. J Neurol Sci 2008;265:102-4
   PubMed Web of Science ®Google Scholar
• Madri JA. Modeling the neurovascular niche: implications for recovery from CNS injury. J Physiol Pharmacol 2009;60(Suppl 4):95-104
   PubMedGoogle Scholar
• Shyu WC, Lin SZ, Yen PS, Stromal cell-derived factor-1alpha promotes neuroprotection, angiogenesis, and mobilization/homing of bone marrow-derived cells in stroke rats. J Pharmacol Exp Ther 2008;324:834-49
   PubMed Web of Science ®Google Scholar
• Makri G, Lavdas AA, Katsimpardi L, Transplantation of embryonic neural stem/precursor cells overexpressing BM88/Cend1 enhances the generation of neuronal cells in the injured mouse cortex. Stem Cells 2010;28:127-39
   PubMed Web of Science ®Google Scholar
• Papastefanaki F, Chen J, Lavdas AA, Grafts of Schwann cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury. Brain 2007;130:2159-74
   PubMed Web of Science ®Google Scholar
• Hargus G, Cui Y, Schmid JS, Tenascin-R promotes neuronal differentiation of embryonic stem cells and recruitment of host-derived neural precursor cells after excitotoxic lesion of the mouse striatum. Stem Cells 2008;26:1973-84
   PubMed Web of Science ®Google Scholar
• Chen J, Bernreuther C, Dihne M, Schachner M. Cell adhesion molecule L1-transfected embryonic stem cells with enhanced survival support regrowth of corticospinal tract axons in mice after spinal cord injury. J Neurotrauma 2005;22:896-906
   PubMed Web of Science ®Google Scholar
• Miki Y, Nonoguchi N, Ikeda N, Vascular endothelial growth factor gene-transferred bone marrow stromal cells engineered with a herpes simplex virus type 1 vector can improve neurological deficits and reduce infarction volume in rat brain ischemia. Neurosurgery 2007;61:586-94
   PubMed Web of Science ®Google Scholar
• Rosenstein JM, Krum JM. New roles for VEGF in nervous tissue – beyond blood vessels. Exp Neurol 2004;187:246-53
   PubMed Web of Science ®Google Scholar
• Jin K, Zhu Y, Sun Y, Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci USA 2002;99:11946-50
   PubMed Web of Science ®Google Scholar
• Onda T, Honmou O, Harada K, Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia. J Cereb Blood Flow Metab 2008;28:329-40
   PubMed Web of Science ®Google Scholar
• Liu H, Honmou O, Harada K, Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia. Brain 2006;129:2734-45
   PubMed Web of Science ®Google Scholar
• Toyama K, Honmou O, Harada K, Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia. Exp Neurol 2009;216:47-55
   PubMed Web of Science ®Google Scholar
• Maina F, Klein R. Hepatocyte growth factor, a versatile signal for developing neurons. Nat Neurosci 1999;2:213-17
   PubMed Web of Science ®Google Scholar
• Zhao MZ, Nonoguchi N, Ikeda N, Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector. J Cereb Blood Flow Metab 2006;26:1176-88
   PubMed Web of Science ®Google Scholar
• Shi E, Jiang X, Wang L, Intrathecal injection of hepatocyte growth factor gene-modified marrow stromal cells attenuates neurologic injury induced by transient spinal cord ischemia in rabbits. Anesthesiology 2010;113:1109-17
   PubMed Web of Science ®Google Scholar
• Liu JP, Baker J, Perkins ASL, Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993;75:59-72
   PubMed Web of Science ®Google Scholar
• Ozdinler PH, Macklis JD. IGF-I specifically enhances axon outgrowth of corticospinal motor neurons. Nat Neurosci 2006;9:1371-81
   PubMed Web of Science ®Google Scholar
• Hollis ER II, Lu P, Blesch A, Tuszynski MH. IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury. Exp Neurol 2009;215:53-9
   PubMed Web of Science ®Google Scholar
• Rabinovich GA, Baum LG, Tinari N, Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response? Trends Immunol 2002;23:313-20
   PubMed Web of Science ®Google Scholar
• Ishibashi S, Kuroiwa T, Sakaguchi M, Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke. Exp Neurol 2007;207:302-13
   PubMed Web of Science ®Google Scholar
• Horie H, Kadoya T, Hikawa N, Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy. J Neurosci 2004;24:1873-80
   PubMed Web of Science ®Google Scholar
• Yamane J, Nakamura M, Iwanami A, Transplantation of galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets. J Neurosci Res 2010;88:1394-405
   PubMed Web of Science ®Google Scholar
• Kim BG, Hwang DH, Lee SI, Stem cell-based cell therapy for spinal cord injury. Cell Transplant 2007;16:357-66
   Web of Science ®Google Scholar
• Snyder EY, Park KI. Limitations in brain repair. Nat Med 2002;8:928-30
   PubMed Web of Science ®Google Scholar
• Okada S, Ishii K, Yamane J, In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury. FASEB J 2005;19:1839-41
   PubMed Web of Science ®Google Scholar
• Hill CE, Guller Y, Raffa SJ, A calpain inhibitor enhances the survival of Schwann cells in vitro and after transplantation into the injured spinal cord. J Neurotrauma 2010;27:1685-95
   PubMed Web of Science ®Google Scholar
• Karimi-Abdolrezaee S, Eftekharpour E, Wang J, Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. J Neurosci 2006;26:3377-89
   PubMed Web of Science ®Google Scholar
• Ikegami T, Nakamura M, Yamane J, Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury. Eur J Neurosci 2005;22:3036-46
   PubMed Web of Science ®Google Scholar
• Kim BG, Dai HN, Lynskey JV, Degradation of chondroitin sulfate proteoglycans potentiates transplant-mediated axonal remodeling and functional recovery after spinal cord injury in adult rats. J Comp Neurol 2006;497:182-98
   PubMed Web of Science ®Google Scholar
• Karimi-Abdolrezaee S, Eftekharpour E, Wang J, Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord. J Neurosci 2010;30:1657-76
   PubMed Web of Science ®Google Scholar
• Nomura H, Tator CH, Shoichet MS. Bioengineered strategies for spinal cord repair. J Neurotrauma 2006;23:496-507
   PubMed Web of Science ®Google Scholar
• Teng YD, Lavik EB, Qu X, Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci USA 2002;99:3024-9
   PubMed Web of Science ®Google Scholar
• Kim BG, Kang YM, Phi JH, Implantation of polymer scaffolds seeded with neural stem cells in a canine spinal cord injury model. Cytotherapy 2010;12:841-5
   PubMed Web of Science ®Google Scholar
• Hanna J, Wernig M, Markoulaki S, Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 2007;318:1920-3
   PubMed Web of Science ®Google Scholar
• Okita K, Nakagawa M, Hyenjong H, Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008;322:949-53
   PubMed Web of Science ®Google Scholar
• Stadtfeld M, Nagaya M, Utikal J, Induced pluripotent stem cells generated without viral integration. Science 2008;322:945-9
   PubMed Web of Science ®Google Scholar
• Gutierrez-Aranda I, Ramos-Mejia V, Bueno C, Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection. Stem Cells 2010;28:1568-70
   PubMed Web of Science ®Google Scholar
• Straley KS, Foo CW, Heilshorn SC. Biomaterial design strategies for the treatment of spinal cord injuries. J Neurotrauma 2009;27:1-19
   Web of Science ®Google Scholar
• Potter W, Kalil RE, Kao WJ. Biomimetic material systems for neural progenitor cell-based therapy. Front Biosci 2008;13:806-21
   PubMed Web of Science ®Google Scholar
• Silva GA, Czeisler C, Niece KL, Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science 2004;303:1352-5
   PubMed Web of Science ®Google Scholar
• Tuszynski MH, Thal L, Pay M, A phase I clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med 2005;11:551-5
   PubMed Web of Science ®Google Scholar
• Tuszynski MH, Roberts J, Senut MC, Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther 1996;3:305-14
   PubMed Web of Science ®Google Scholar
• Conner JM, Darracq MA, Roberts J, Tuszynski MH. Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation. Proc Natl Acad Sci USA 2001;98:1941-6
   PubMed Web of Science ®Google Scholar
• Lindholm P, Voutilainen MH, Lauren J, Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature 2007;448:73-7
   PubMed Web of Science ®Google Scholar
• Honma Y, Araki T, Gianino S, Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron 2002;35:267-82
   PubMedGoogle Scholar
• Yabe T, Sanagi T, Yamada H. The neuroprotective role of PEDF: implication for the therapy of neurological disorders. Curr Mol Med 2010;10:259-66
   PubMed Web of Science ®Google Scholar
• Ruff CA, Wilcox JT, Fehlings MG. Cell-based transplantation strategies to promote plasticity following spinal cord injury. Exp Neurol 2011; published online 17 February 2011; doi:10.1016/j.expneurol.2011.02.010
   PubMed Web of Science ®Google Scholar
• Hacein-Bey-Abina S, Hauer J, Lim A, Efficacy of gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 2010;363:355-64
   PubMed Web of Science ®Google Scholar
• Aiuti A, Cattaneo F, Galimberti S, Gene therapy for immunodeficiency due to adenosine deaminase deficiency. N Engl J Med 2009;360:447-58
   PubMed Web of Science ®Google Scholar
• Howe SJ, Mansour MR, Schwarzwaelder K, Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest 2008;118:3143-50
   PubMed Web of Science ®Google Scholar
• Cartier N, Hacein-Bey-Abina S, Bartholomae CC, Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science 2009;326:818-23
   PubMed Web of Science ®Google Scholar