Thymosin β4 significantly reduces the signs of dryness in a murine controlled adverse environment model of experimental dry eye

Bibliography

• Nassar A, Tabbara KF, Aljurf M. Ocular manifestations of graft-versus disease. Saudi J Opthalmol 2013;27:215-22
   PubMedGoogle Scholar
• Espana EM, Shah S, Santhiago MR, et al. Graft versus host disease: clinical evaluation, diagnosis, and management. Graefes Arch Clin Opthalmol 2013;251:1237-66
   Google Scholar
• Goldstein AL, Hannappel E, Sosne G, et al. Thymosin beta 4: a multifunctional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther 2012;12:37-51
   PubMed Web of Science ®Google Scholar
• Sosne G, Qiu P, Christopherson PL, et al. Thymosin β4 suppression of corneal NFκB. A potential anti-inflammatory pathway. Exp Eye Res 2007;84:663-9
   PubMed Web of Science ®Google Scholar
• Qiu P, Wheater MK, Qiu Y, et al. Thymosin 4 inhibits TNF--induced NF-B activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J 2011;25:1815-26
   PubMed Web of Science ®Google Scholar
• Sosne G, Sliter EA, Barrett R, et al. Thymosin β4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp Eye Res 2002;74:293-9
   PubMed Web of Science ®Google Scholar
• Sosne G, Qiu P, Kupackus-Wheater M. Thymosin beta 4 suppression of corneal NFκB: A potential anti-inflammatory pathway. Clin Ophthalmol 2007;1:201-7
   PubMedGoogle Scholar
• Tang YQ, Yeaman MR, Selsted ME. Antimicrobial peptides from human platelets. Infect Immun 2002;70:6524-33
   PubMed Web of Science ®Google Scholar
• Sosne G, Hafeez S, Greenberry A2nd, et al. Thymosin beta 4 promotes human conjunctival epithelial cell migration. Curr Eye Res 2002;24:268-73
   PubMed Web of Science ®Google Scholar
• Bock-Marquette I, Saxena A, White MD, et al. Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 2004;432:466-72
   PubMed Web of Science ®Google Scholar
• Smart N, Risebro CA, Melville AA, et al. Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization. Nature 2007;445:177-82
   PubMed Web of Science ®Google Scholar
• Hinkel R, El-Aouni C, Olson T, et al. Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection. Circulation 2008;117:2232-40
   PubMed Web of Science ®Google Scholar
• Bock-Marquette I, Shrivastava S, Pipes GC, et al. Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. J Mol Cell Cardiol 2009;46:728-38
   PubMed Web of Science ®Google Scholar
• Kupatt C, Bock-Marquette I, Boekstegers P. Embryonic endothelial progenitor cell-mediated cardioprotection requires thymosin beta4. Trends Cardiovasc Med 2008;18:205-10
   PubMed Web of Science ®Google Scholar
• Qian L, Huang Y, Spencer CL, et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 2012;485:593-8
   PubMed Web of Science ®Google Scholar
• Santra M, Chopp M, Zhang ZG, et al. Tβ4 Mediates oligodendrocyte differentiation by upregulation p38 MAPK. Glia 2012;60:1826-38
   PubMed Web of Science ®Google Scholar
• Xiong Y, Zhang Y, Mahmood A, et al. Neuroprotective and neurorestorative effects of Tβ4 treatment initiated 6 hours after traumatic brain Injury in rats. J Neurosurg 2012;116:1081-92
   PubMed Web of Science ®Google Scholar
• Xiong Y, Mahmood A, Meng Y, et al. Treatment of traumatic brain injury with Tβ4 in rats. J Neurosurg 2011;114:102-15
   PubMed Web of Science ®Google Scholar
• Morris D, Chopp M, Zhang L, et al. Tβ4 Improves functional neurological outcome in a rat model of embolic stroke. Neuroscience 2010;169:674-82
   PubMed Web of Science ®Google Scholar
• Sosne G, Chan CC, Thai K, et al. Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo. Exp Eye Res 2001;72:605-8
   PubMed Web of Science ®Google Scholar
• Sosne G, Christopherson PL, Barrett RP, et al. Thymosin-beta 4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury. Invest Ophthalmol Vis Sci 2005;46:2388-95
   PubMed Web of Science ®Google Scholar
• Sosne G, Siddiqi A, Kurpakus-Wheater M. Thymosin-beta4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitro. Invest Ophthalmol Vis Sci 2004;45:1095-100
   PubMed Web of Science ®Google Scholar
• Sosne G, Qui P, Goldstein AL, et al. Biological activities of thymosin beta 4 defined by active sites in short peptide sequences. FASEB J 2010;24:2144-51
   PubMed Web of Science ®Google Scholar
• Dunn SP, Heidemann DG, Chow CY, et al. Treatment of chronic non-healing neurotrophic corneal epithelial defects with thymosin beta 4. Arch Ophthalmol 2010;24:2144-51
   Google Scholar
• Perex-Rico C, Germain F, Castro-Rebollo M, et al. Effect of topical 0.05% cyclosporine A on corneal endothelium in patients with dry eye disease. Int J Opthalmol 2013;6:471-4
   Web of Science ®Google Scholar
• Thomas PB, Samant DM, Zhu Z, et al. Long-term topical cyclosporine treatment improves tear production and reduces keratoconjuntivitis in rabbits with induced autoimmune dacryoadenitis. J Ocul Pharmacol 2009;25:285-92
   Google Scholar
• Knudsen L, Hansen BF, Jensen P, et al. Agonism and antagonism at the insulin receptor. PLoS ONE 2012;7(12):e51972
   PubMedGoogle Scholar
• Philp D, Kleinman HK. Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide. Ann NY Acad Sci 2010;1194:81-6
   PubMed Web of Science ®Google Scholar
• Dunn SP, Heidemann DG, Chow CY, et al. Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin β4. Ann NY Acad Sci 2010;1194:199-206
   PubMed Web of Science ®Google Scholar
• Sosne G, Dunn SP, Chaesik K. Thymosin β4 significantly improve signs and symptoms of severe dry eye in a Phase II randomized trial. CORNEA; In Press
   PubMed Web of Science ®Google Scholar