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Review

Type I interferons and their therapeutic role in Th2-regulated inflammatory disorders

&
Pages 469-481 | Published online: 03 Mar 2005

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  • ••Key paper demonstrating the importanceof another Th2 cytokine (IL-5) in UC, providing the basis for the concept of a Th2-linked disease.
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  • ••Important study showing that IFN-atherapy might be superior to local steroid therapy in left-sided UC.
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  • •First report supporting a role for IFN-I3 therapy in UC.
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  • ••First controlled study in UC showing superior efficacy of IFN-I3 compared to placebo.
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  • TILG H, VOGELSANG H, LUDWICZEK 0 et al.: A randomised placebo controlled trial of pegylated interferon alpha in active ulcerative colitis. Gut (2003) 52(12):1728–1733.
  • ••First placebo-controlled study withpegylated IFN-a in UC.
  • GNIADEK P, AKTAS 0, WANDINGER KP et al.: Systemic IFN-beta treatment induces apoptosis of peripheral immune cells in MS patients. J. Neuroimmunol (2003) 137(1–2):187–196.
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  • •Demonstrates the role of Th2 cytokines with respect to treatment success in MS.
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  • ••Key paper paving the way for futurestudies with type I IFNs in allergic asthma.
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  • ••Important study supporting the majortherapeutic role for IFN-a in this disorder.
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  • ••First report of the efficacy of a type I IFNin myocardial virus-related diseases.
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