311
Views
38
CrossRef citations to date
0
Altmetric
Reviews

Targeting TRPC6 channels in oesophageal carcinoma growth

, , , &
Pages 513-527 | Published online: 17 Mar 2010

Bibliography

  • Roderick HL, Cook SJ. Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival. Nat Rev Cancer 2008;8(5):361-75
  • Kahl CR, Means AR. Regulation of cell cycle progression by calcium/calmodulin-dependent pathways. Endocr Rev 2003;24(6):719-36
  • Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003;4(7):517-29
  • Aydar E, Yeo S, Djamgoz M, Palmer C. Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy. Cancer Cell Int 2009;9:23; published online 18 August 2009, doi:10.1186/1475-2867-9-23
  • Cai R, Ding X, Zhou K, Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells. Int J Cancer 2009;125(10):2281-7
  • de Groot JF, Piao Y, Lu L, Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation. J Neurooncol 2008;88(2):121-33
  • El Boustany C, Bidaux G, Enfissi A, Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepatology 2008;47(6):2068-77
  • Fixemer T, Wissenbach U, Flockerzi V, Bonkhoff H. Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene 2003;22(49):7858-61
  • Lehen'kyi V, Flourakis M, Skryma R, Prevarskaya N. TRPV6 channel controls prostate cancer cell proliferation via Ca2+/NFAT-dependent pathways. Oncogene 2007;26(52):7380-5
  • Lu F, Chen H, Zhou C, T-type Ca2+ channel expression in human esophageal carcinomas: a functional role in proliferation. Cell Calcium 2008;43(1):49-58
  • Thebault S, Flourakis M, Vanoverberghe K, Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. Cancer Res 2006;66(4):2038-47
  • Wang XT, Nagaba Y, Cross HS, The mRNA of L-type calcium channel elevated in colon cancer: protein distribution in normal and cancerous colon. Am J Pathol 2000;157(5):1549-62
  • Yang SL, Cao Q, Zhou KC, Transient receptor potential channel C3 contributes to the progression of human ovarian cancer. Oncogene 2009;28(10):1320-8
  • Zhang L, Barritt GJ. Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells. Cancer Res 2004;64(22):8365-73
  • Montell C. The TRP superfamily of cation channels. Sci STKE 2005;2005(272):re3; published online 22 February 2005, doi: 10.1126/stke.2722005re3
  • Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu Rev Physiol 2006;68:619-47
  • Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol Rev 2007;87(1):165-217
  • Prevarskaya N, Zhang L, Barritt G. TRP channels in cancer. Biochim Biophys Acta 2007;1772(8):937-46
  • Shi Y, Ding X, He ZH, Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer. Gut 2009;58(11):1443-50
  • Enzinger PC, Mayer RJ. Esophageal cancer. N Engl J Med 2003;349(23):2241-52
  • Finkelman RB, Belkin HE, Zheng B. Health impacts of domestic coal use in China. Proc Natl Acad Sci USA 1999;96(7):3427-31
  • Jemal A, Siegel R, Ward E, Cancer statistics, 2009. CA Cancer J Clin 2009;59(4):225-49
  • Higuchi K, Koizumi W, Tanabe S, Current management of esophageal squamous-cell carcinoma in Japan and other countries. Gastrointest Cancer Res 2009;3(4):153-61
  • Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 2007;7(4):281-94
  • Hofmann J. Protein kinase C isozymes as potential targets for anticancer therapy. Curr Cancer Drug Targets 2004;4(2):125-46
  • Rodriguez-Mora OG, LaHair MM, McCubrey JA, Franklin RA. Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells. Cancer Res 2005;65(12):5408-16
  • Berridge MJ, Lipp P, Bootman MD. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 2000;1(1):11-21
  • Ishiuchi S, Yoshida Y, Sugawara K, Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. J Neurosci 2007;27(30):7987-8001
  • Panner A, Wurster RD. T-type calcium channels and tumor proliferation. Cell Calcium 2006;40(2):253-9
  • Chigurupati S, Venkataraman R, Barrera D, Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res 2010;70(1):418-27
  • Guilbert A, Dhennin-Duthille I, Hiani YE, Expression of TRPC6 channels in human epithelial breast cancer cells. BMC Cancer 2008;8:125; published online 2 May 2008, doi:10.1186/1471-2407-8-125
  • Tsavaler L, Shapero MH, Morkowski S, Laus R. Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 2001 61(9):3760-9
  • Marenholz I, Heizmann CW, Fritz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem Biophys Res Commun 2004;322(4):1111-22
  • Lee OJ, Hong SM, Razvi MH, Expression of calcium-binding proteins S100A2 and S100A4 in Barrett's adenocarcinomas. Neoplasia 2006;8(10):843-50
  • Angst BD, Marcozzi C, Magee AI. The cadherin superfamily: diversity in form and function. J Cell Sci 2001;114(Pt 4):629-41
  • Li K, He W, Lin N, N-cadherin knock-down decreases invasiveness of esophageal squamous cell carcinoma in vitro. World J Gastroenterol 2009;15(6):697-704
  • Cosens DJ, Manning A. Abnormal electroretinogram from a Drosophila mutant. Nature 1969;224(5216):285-7
  • Wes PD, Chevesich J, Jeromin A, TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci USA 1995;92(21):9652-6
  • Vazquez G, Wedel BJ, Aziz O, The mammalian TRPC cation channels. Biochim Biophys Acta 2004;1742(1-3):21-36
  • Bolotina VM, Csutora P. CIF and other mysteries of the store-operated Ca2+-entry pathway. Trends Biochem Sci 2005;30(7):378-87
  • Varnai P, Hunyady L, Balla T. STIM and Orai: the long-awaited constituents of store-operated calcium entry. Trends Pharmacol Sci 2009;30(3):118-28
  • Singh BB, Lockwich TP, Bandyopadhyay BC, VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to agonist-stimulated Ca2+ influx. Mol Cell 2004;15(4):635-46
  • Miller BA. The role of TRP channels in oxidative stress-induced cell death. J Membr Biol 2006;209(1):31-41
  • Maroto R, Raso A, Wood TG, TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol 2005;7(2):179-85
  • Boulay G. Ca2+-calmodulin regulates receptor-operated Ca2+ entry activity of TRPC6 in HEK-293 cells. Cell Calcium 2002;32(4):201-7
  • Tang J, Lin Y, Zhang Z, Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of Trp channels. J Biol Chem 2001;276(24):21303-10
  • Zhang Z, Tang J, Tikunova S, Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain. Proc Natl Acad Sci USA 2001;98(6):3168-73
  • Tai Y, Feng S, Du W, Wang Y. Functional roles of TRPC channels in the developing brain. Pflugers Arch 2009;458(2):283-9
  • Mehta D, Ahmmed GU, Paria BC, RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability. J Biol Chem 2003;278(35):33492-500
  • Pocock TM, Foster RR, Bates DO. Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Am J Physiol Heart Circ Physiol 2004;286(3):H1015-26
  • Tiruppathi C, Minshall RD, Paria BC, Role of Ca2+ signaling in the regulation of endothelial permeability. Vascul Pharmacol 2002;39(4-5):173-85
  • Kuwahara K, Wang Y, McAnally J, TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest 2006;116(12):3114-26
  • Yu Y, Fantozzi I, Remillard CV, Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci USA 2004;101(38):13861-6
  • Reiser J, Polu KR, Moller CC, TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 2005;37(7):739-44
  • Winn MP, Conlon PJ, Lynn KL, A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 2005;308(5729):1801-4
  • Jia Y, Zhou J, Tai Y, Wang Y. TRPC channels promote cerebellar granule neuron survival. Nat Neurosci 2007;10(5):559-67
  • Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives of cells. Cell 2002;109(Suppl):S67-79
  • Ge R, Tai Y, Sun Y, Critical role of TRPC6 channels in VEGF-mediated angiogenesis. Cancer Lett 2009;283(1):43-51
  • Hamdollah Zadeh MA, Glass CA, Magnussen A, VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation 2008;15(7):605-14
  • Monteith GR, McAndrew D, Faddy HM, Roberts-Thomson SJ. Calcium and cancer: targeting Ca2+ transport. Nat Rev Cancer 2007;7(7):519-30
  • Freichel M, Vennekens R, Olausson J, Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models. Biochem Biophys Res Commun 2004;322(4):1352-8
  • Kunichika N, Landsberg JW, Yu Y, Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. Am J Respir Crit Care Med 2004;170(10):1101-7
  • Lin MJ, Leung GP, Zhang WM, Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res 2004;95(5):496-505
  • Yu Y, Sweeney M, Zhang S, PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am J Physiol Cell Physiol 2003;284(2):C316-30
  • Zhang H, Ding J, Fan Q, Liu S. TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-κB translocation. Exp Biol Med (Maywood) 2009;234(9):1029-36
  • Estacion M, Li S, Sinkins WG, Activation of human TRPC6 channels by receptor stimulation. J Biol Chem 2004;279(21):22047-56
  • Hofmann T, Obukhov AG, Schaefer M, Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 1999;397(6716):259-63
  • Brechard S, Melchior C, Plancon S, Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes. Cell Calcium 2008;44(5):492-506
  • Jardin I, Gomez LJ, Salido GM, Rosado JA. Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca2+ entry pathways. Biochem J 2009;420(2):267-76
  • Redondo PC, Jardin I, Lopez JJ, Intracellular Ca2+ store depletion induces the formation of macromolecular complexes involving hTRPC1, hTRPC6, the type II IP3 receptor and SERCA3 in human platelets. Biochim Biophys Acta 2008;1783(6):1163-76
  • Saleh SN, Albert AP, Peppiatt-Wildman CM, Large WA. Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes. J Physiol 2008;586(10):2463-76
  • Wang JS, Wang CL, Wen JF, Lithium inhibits proliferation of human esophageal cancer cell line Eca-109 by inducing a G2/M cell cycle arrest. World J Gastroenterol 2008;14(25):3982-9
  • Xia HH, Zhang ST, Lam SK, Expression of macrophage migration inhibitory factor in esophageal squamous cell carcinoma and effects of bile acids and NSAIDs. Carcinogenesis 2005;26(1):11-5
  • DeHaven WI, Smyth JT, Boyles RR, Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J Biol Chem 2008;283(28):19265-73
  • Maruyama T, Kanaji T, Nakade S, 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release. J Biochem 1997;122(3):498-505
  • Da Silva N, Herron CE, Stevens K, Metabotropic receptor-activated calcium increases and store-operated calcium influx in mouse Muller cells. Invest Ophthalmol Vis Sci 2008;49(7):3065-73
  • Mears D, Zimliki CL. Muscarinic agonists activate Ca2+ store-operated and -independent ionic currents in insulin-secreting HIT-T15 cells and mouse pancreatic beta-cells. J Membr Biol 2004;197(1):59-70
  • Enfissi A, Prigent S, Colosetti P, Capiod T. The blocking of capacitative calcium entry by 2-aminoethyl diphenylborate (2-APB) and carboxyamidotriazole (CAI) inhibits proliferation in Hep G2 and Huh-7 human hepatoma cells. Cell Calcium 2004;36(6):459-67
  • Weiss H, Amberger A, Widschwendter M, Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells. Int J Cancer 2001;92(6):877-82
  • Abdullaev IF, Bisaillon JM, Potier M, Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation. Circ Res 2008;103(11):1289-99
  • Liao Y, Erxleben C, Yildirim E, Orai proteins interact with TRPC channels and confer responsiveness to store depletion. Proc Natl Acad Sci USA 2007;104(11):4682-7
  • DeHaven WI, Jones BF, Petranka JG, TRPC channels function independently of STIM1 and Orai1. J Physiol 2009;587(Pt 10):2275-98
  • Busa WB, Nuccitelli R. An elevated free cytosolic Ca2+ wave follows fertilization in eggs of the frog, Xenopus laevis. J Cell Biol 1985;100(4):1325-9
  • Mochida S, Hunt T. Calcineurin is required to release Xenopus egg extracts from meiotic M phase. Nature 2007;449(7160):336-40
  • Rauh NR, Schmidt A, Bormann J, Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation. Nature 2005;437(7061):1048-52
  • Kao JP, Alderton JM, Tsien RY, Steinhardt RA. Active involvement of Ca2+ in mitotic progression of Swiss 3T3 fibroblasts. J Cell Biol 1990;111(1):183-96
  • Patel R, Holt M, Philipova R, Calcium/calmodulin-dependent phosphorylation and activation of human Cdc25-C at the G2/M phase transition in HeLa cells. J Biol Chem 1999;274(12):7958-68
  • Tai Y, Feng S, Ge R, TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci 2008;121(Pt 14):2301-7
  • Goel M, Sinkins WG, Schilling WP. Selective association of TRPC channel subunits in rat brain synaptosomes. J Biol Chem 2002;277(50):48303-10
  • Hofmann T, Schaefer M, Schultz G, Gudermann T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA 2002;99(11):7461-6
  • Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 2001;29(3):645-55
  • Geard CR, Jones JM, Schiff PB. Taxol and radiation. J Natl Cancer Inst Monogr 1993(15):89-94
  • Bomben VC, Sontheimer HW. Inhibition of transient receptor potential canonical channels impairs cytokinesis in human malignant gliomas. Cell Prolif 2008;41(1):98-121
  • Ekman S, Dreilich M, Lennartsson J, Esophageal cancer: current and emerging therapy modalities. Expert Rev Anticancer Ther 2008;8(9):1433-48
  • Shih CH, Ozawa S, Ando N, Vascular endothelial growth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus. Clin Cancer Res 2000;6(3):1161-8
  • Liu W, Zhang X, Sun W. Developments in treatment of esophageal/gastric cancer. Curr Treat Options Oncol 2008;9(4-6):375-87
  • Fiorio Pla A, Maric D, Brazer SC, Canonical transient receptor potential 1 plays a role in basic fibroblast growth factor (bFGF)/FGF receptor-1-induced Ca2+ entry and embryonic rat neural stem cell proliferation. J Neurosci 2005;25(10):2687-701
  • Kim SJ, Kim YS, Yuan JP, Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature 2003;426(6964):285-91
  • Clapham DE. SnapShot: mammalian TRP channels. Cell 2007;129(1):220
  • Malkia A, Madrid R, Meseguer V, Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors. J Physiol 2007;581(Pt 1):155-74
  • Xu SZ, Zeng F, Lei M, Generation of functional ion-channel tools by E3 targeting. Nat Biotechnol 2005;23(10):1289-93
  • Dietrich A, Chubanov V, Kalwa H, Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol Ther 2006;112(3):744-60
  • di Pietro M, Fitzgerald RC. Barrett's oesophagus: an ideal model to study cancer genetics. Hum Genet 2009;126(2):233-46
  • Reid BJ, Li X, Galipeau PC, Vaughan TL. Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis. Nat Rev Cancer 2010;10(2):87-101
  • Hori T, Yamashita Y, Ohira M, A novel orthotopic implantation model of human esophageal carcinoma in nude rats: CD44H mediates cancer cell invasion in vitro and in vivo. Int J Cancer 2001;92(4):489-96
  • Wang Z. Roles of K+ channels in regulating tumour cell proliferation and apoptosis. Pflugers Arch 2004;448(3):274-86
  • Fraser SP, Diss JK, Chioni AM, Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin Cancer Res 2005;11(15):5381-9
  • Ding XW, Luo HS, Luo B, Overexpression of hERG1 in resected esophageal squamous cell carcinomas: a marker for poor prognosis. J Surg Oncol 2008;97(1):57-62
  • Ding XW, Wang XG, Luo HS, Expression and prognostic roles of Eag1 in resected esophageal squamous cell carcinomas. Dig Dis Sci 2008;53(8):2039-44
  • Lastraioli E, Taddei A, Messerini L, hERG1 channels in human esophagus: evidence for their aberrant expression in the malignant progression of Barrett's esophagus. J Cell Physiol 2006;209(2):398-404
  • Choi J, Chiang A, Taulier N, A calmodulin-binding site on cyclin E mediates Ca2+-sensitive G1/S transitions in vascular smooth muscle cells. Circ Res 2006;98(10):1273-81
  • Sherbet GV, Lakshmi MS. S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis. Anticancer Res 1998;18(4A):2415-21
  • Scotto C, Delphin C, Deloulme JC, Baudier J. Concerted regulation of wild-type p53 nuclear accumulation and activation by S100B and calcium-dependent protein kinase C. Mol Cell Biol 1999;19(10):7168-80
  • Buchholz M, Ellenrieder V. An emerging role for Ca2+/calcineurin/NFAT signaling in cancerogenesis. Cell Cycle 2007;6(1):16-9
  • Rosales OR, Isales CM, Bhargava J. Overexpression of protein kinase C alpha and beta1 has distinct effects on bovine aortic endothelial cell growth. Cell Signal 1998;10(8):589-97
  • Goll DE, Thompson VF, Li H, The calpain system. Physiol Rev 2003;83(3):731-801
  • Janossy J, Ubezio P, Apati A, Calpain as a multi-site regulator of cell cycle. Biochem Pharmacol 2004;67(8):1513-21
  • Stifanese R, Averna M, De Tullio R, Role of the calpain-calpastatin system in the density-dependent growth arrest. Arch Biochem Biophys 2008;479(2):145-52
  • Catalano S, Giordano C, Rizza P, Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation. J Cell Physiol 2009;218(3):490-500
  • Karpurapu M, Wang D, Van Quyen D, Cyclin D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling. J Biol Chem 2010;285(5):3510-23
  • Medyouf H, Ghysdael J. The calcineurin/NFAT signaling pathway: a novel therapeutic target in leukemia and solid tumors. Cell Cycle 2008;7(3):297-303
  • Watanabe K, Kanno T, Oshima T, The NMDA receptor NR2A subunit regulates proliferation of MKN45 human gastric cancer cells. Biochem Biophys Res Commun 2008;367(2):487-90
  • Stepulak A, Sifringer M, Rzeski W, NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth. Proc Natl Acad Sci USA 2005;102(43):15605-10
  • Ikari A, Okude C, Sawada H, TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells. Biochem Biophys Res Commun 2008;369(4):1129-33
  • Hanano T, Hara Y, Shi J, Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci 2004;95(4):403-19
  • Yang ZH, Wang XH, Wang HP, Hu LQ. Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells. Asian J Androl 2009;11(2):157-65
  • El Hiani Y, Ahidouch A, Lehen'kyi V, Extracellular signal-regulated kinases 1 and 2 and TRPC1 channels are required for calcium-sensing receptor-stimulated MCF-7 breast cancer cell proliferation. Cell Physiol Biochem 2009;23(4-6):335-46
  • Sydorenko V, Shuba Y, Thebault S, Receptor-coupled, DAG-gated Ca2+-permeable cationic channels in LNCaP human prostate cancer epithelial cells. J Physiol 2003;548(Pt 3):823-36
  • Bollimuntha S, Singh BB, Shavali S, TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells. J Biol Chem 2005;280(3):2132-40
  • Pigozzi D, Ducret T, Tajeddine N, Calcium store contents control the expression of TRPC1, TRPC3 and TRPV6 proteins in LNCaP prostate cancer cell line. Cell Calcium 2006;39(5):401-15
  • Veliceasa D, Ivanovic M, Hoepfner FT, Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma. FEBS J 2007;274(24):6365-77
  • Vanden Abeele F, Lemonnier L, Thebault S, Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells. J Biol Chem 2004;279(29):30326-37
  • Yue D, Wang Y, Xiao JY, Expression of TRPC6 in benign and malignant human prostate tissues. Asian J Androl 2009;11(5):541-7
  • Prawitt D, Enklaar T, Klemm G, Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. Hum Mol Genet 2000;9(2):203-16
  • Ziglioli F, Frattini A, Maestroni U, Vanilloid-mediated apoptosis in prostate cancer cells through a TRPV-1 dependent and a TRPV-1-independent mechanism. Acta Biomed 2009;80(1):13-20
  • Amantini C, Ballarini P, Caprodossi S, Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis 2009;30(8):1320-9
  • Marincsak R, Toth BI, Czifra G, Increased expression of TRPV1 in squamous cell carcinoma of the human tongue. Oral Dis 2009;15(5):328-35
  • Bode AM, Cho YY, Zheng D, Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis. Cancer Res 2009;69(3):905-13
  • Amantini C, Mosca M, Nabissi M, Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation. J Neurochem 2007;102(3):977-90
  • Monet M, Gkika D, Lehen'kyi V, Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta 2009;1793(3):528-39
  • Caprodossi S, Lucciarini R, Amantini C, Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic stage. Eur Urol 2008;54(3):612-20
  • Vriens J, Janssens A, Prenen J, TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells. Cell Calcium 2004;36(1):19-28
  • Semenova SB, Vassilieva IO, Fomina AF, Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells. Am J Physiol Cell Physiol 2009;296(5):C1098-104
  • Wissenbach U, Niemeyer B, Himmerkus N, TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression. Biochem Biophys Res Commun 2004;322(4):1359-63
  • Bolanz KA, Hediger MA, Landowski CP. The role of TRPV6 in breast carcinogenesis. Mol Cancer Ther 2008;7(2):271-9
  • Chow J, Norng M, Zhang J, Chai J. TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells–Mechanisms behind a possible new ‘hot’ cancer treatment. Biochim Biophys Acta 2007;1773(4):565-76
  • Duncan LM, Deeds J, Cronin FE, Melastatin expression and prognosis in cutaneous malignant melanoma. J Clin Oncol 2001;19(2):568-76
  • Zeng X, Sikka SC, Huang L, Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation. Prostate Cancer Prostatic Dis 2009; published online 22 December 2009, doi: 10.1038/pcan.2009.55.
  • Suguro M, Tagawa H, Kagami Y, Expression profiling analysis of the CD5+ diffuse large B-cell lymphoma subgroup: development of a CD5 signature. Cancer Sci 2006;97(9):868-74
  • Jiang J, Li MH, Inoue K, Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res 2007;67(22):10929-38
  • Guilbert A, Gautier M, Dhennin-Duthille I, Evidence that TRPM7 is required for breast cancer cell proliferation. Am J Physiol Cell Physiol 2009;297(3):C493-502
  • Kim BJ, Park EJ, Lee JH, Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. Cancer Sci 2008;99(12):2502-9
  • Yamamura H, Ugawa S, Ueda T, TRPM8 activation suppresses cellular viability in human melanoma. Am J Physiol Cell Physiol 2008;295(2):C296-301
  • Li Q, Wang X, Yang Z, Menthol induces cell death via the TRPM8 channel in the human bladder cancer cell line T24. Oncology 2009;77(6):335-41
  • Zhou J, Du W, Zhou K, Critical role of TRPC6 channels in the formation of excitatory synapses. Nat Neurosci 2008;11(7):741-3

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.