Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials

Bibliography

• American Cancer Society: Cancer Facts and Figures 2009., Atlanta, 2009. Available from: http://www.cancer.org/downloads/STT/500809web.pdf [Last accessed 8 March 2010]
   Google Scholar
• Day TA, Davis BK, Gillespie MB, Oral cancer treatment. Curr Treat Options Oncol 2003;4:27-41
   PubMedGoogle Scholar
• Futerman AH, Hannun YA. The complex life of simple sphingolipids. EMBO Rep 2004;5:777-82
   PubMed Web of Science ®Google Scholar
• Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004;4:604-16
   PubMed Web of Science ®Google Scholar
• Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science 1996;274:1855-9
   PubMed Web of Science ®Google Scholar
• Hannun YA, Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol 2000;10:73-80
   PubMed Web of Science ®Google Scholar
• Hannun YA, Obeid LM. Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci 1996;20:73-7
   Google Scholar
• Mathias S, Pena LA, Kolesnick RN. Signal transduction of stress via ceramide. Biochem J 1998;335(Pt 3):465-80
   Google Scholar
• Yao B, Zhang Y, Delikat S, Phosphorylation of Raf by ceramide-activated protein kinase. Nature 1995;378:307-10
   PubMed Web of Science ®Google Scholar
• Chalfant CE, Rathman K, Pinkerman RL, De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem 2002;277:12587-95
   PubMed Web of Science ®Google Scholar
• Dobrowsky RT, Hannun YA. Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem 1992;267:5048-51
   PubMed Web of Science ®Google Scholar
• Kashiwagi K, Shirai Y, Kuriyama M, Importance of C1B domain for lipid messenger-induced targeting of protein kinase C. J Biol Chem 2002;277:18037-45
   PubMed Web of Science ®Google Scholar
• Deiss LP, Galinka H, Berissi H, Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J 1996;15:3861-70
   PubMed Web of Science ®Google Scholar
• Pattingre S, Bauvy C, Carpentier S, Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem 2009;284:2719-28
   PubMed Web of Science ®Google Scholar
• Scarlatti F, Bauvy C, Ventruti A, Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem 2004;279:18384-91
   PubMed Web of Science ®Google Scholar
• Daido S, Kanzawa T, Yamamoto A, Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 2004;64:4286-93
   PubMed Web of Science ®Google Scholar
• Xin M, Deng X. Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation. J Biol Chem 2006;281:18859-67
   PubMed Web of Science ®Google Scholar
• Lin SS, Bassik MC, Suh H, PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem 2006;281:23003-12
   PubMed Web of Science ®Google Scholar
• Reynolds CP, Maurer BJ, Kolesnick RN. Ceramide synthesis and metabolism as a target for cancer therapy. Cancer Lett 2004;206:169-80
   PubMed Web of Science ®Google Scholar
• Verheij M, van Blitterswijk WJ, Bartelink H. Radiation-induced apoptosis–the ceramide-SAPK signaling pathway and clinical aspects. Acta Oncol 1998;37:575-81
   PubMed Web of Science ®Google Scholar
• Nishina H, Wada T, Katada T. Physiological roles of SAPK/JNK signaling pathway. J Biochem 2004;136:123-6
   PubMed Web of Science ®Google Scholar
• Verheij M, Bose R, Lin XH, Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996;380:75-9
   PubMed Web of Science ®Google Scholar
• Kolesnick R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 2002;110:3-8
   PubMed Web of Science ®Google Scholar
• Huwiler A, Zangemeister-Wittke U. Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. Crit Rev Oncol Hematol 2007;63:150-9
   Google Scholar
• Radin NS. Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come? Eur J Biochem 2001;268:193-204
   PubMedGoogle Scholar
• Saddoughi SA, Song P, Ogretmen B. Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem 2008;49:413-40
   PubMedGoogle Scholar
• Hanada K, Kumagai K, Tomishige N, Yamaji T. CERT-mediated trafficking of ceramide. Biochim Biophys Acta 2009;1791:684-91
   PubMed Web of Science ®Google Scholar
• Swanton C, Marani M, Pardo O, Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell 2007;11:498-512
   PubMed Web of Science ®Google Scholar
• Gouaze V, Yu JY, Bleicher RJ, Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy. Mol Cancer Ther 2004;3:633-9
   PubMed Web of Science ®Google Scholar
• Liu Y-Y, Han T-Y, Giuliano AE, Cabot MC. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells. J Biol Chem 1999;274:1140-6
   PubMed Web of Science ®Google Scholar
• Liu YY, Han TY, Giuliano AE, Cabot MC. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J 2001;15:719-30
   PubMed Web of Science ®Google Scholar
• Chalfant CE, Ogretmen B, Galadari S, FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. J Biol Chem 2001;276:44848-55
   PubMedGoogle Scholar
• Liu Y-Y, Han TY, Yu JY, Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells. J Lipid Res 2004;45:933-40
   PubMed Web of Science ®Google Scholar
• Liu YY, Yu JY, Yin D, A role for ceramide in driving cancer cell resistance to doxorubicin. FASEB J 2008;22:2541-51
   PubMed Web of Science ®Google Scholar
• Weiss M, Hettmer S, Smith P, Ladisch S. Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase. Cancer Res 2003;63:3654-8
   PubMed Web of Science ®Google Scholar
• Chalfant CE, Spiegel S. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci 2005;118:4605-12
   PubMed Web of Science ®Google Scholar
• Gomez-Munoz A, Kong JY, Parhar K, Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway. FEBS Lett 2005;579:3744-50
   Google Scholar
• Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 2009;9:550-62
   PubMed Web of Science ®Google Scholar
• Elojeimy S, Liu X, McKillop JC, Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther 2007;15:1259-63
   PubMed Web of Science ®Google Scholar
• Kim WJ, Okimoto RA, Purton LE, Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias. Blood 2008;111:4716-22
   PubMed Web of Science ®Google Scholar
• Ruckhaberle E, Rody A, Engels K, Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Res Treat 2008;112:41-52
   PubMed Web of Science ®Google Scholar
• Coward J, Ambrosini G, Musi E, Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway. Autophagy 2009;5:184-93
   PubMed Web of Science ®Google Scholar
• Noda T, Iwai S, Hamada M, Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. Apoptosis 2009;14:287-97
   Google Scholar
• Senkal CE, Ponnusamy S, Rossi MJ, Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther 2006;317:1188-99
   PubMed Web of Science ®Google Scholar
• Mahdy AE, Cheng JC, Li J, Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther 2009;17:430-8
   PubMed Web of Science ®Google Scholar
• Grammatikos G, Teichgräber V, Carpinteiro A, Overexpression of acid sphingomyelinase sensitizes glioma cells to chemotherapy. Antioxid Redox Signal 2007;9:1449-56
   Google Scholar
• Holman D, Turner LS, El-Zawahry A, Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemother Pharmacol 2008;61:231-42
   PubMed Web of Science ®Google Scholar
• Liu X, Elojeimy S, Stehouwer Turner L, Implementation of acid ceramidase inhibitors as adjuncts to increase the efficacy of cancer therapy. In: Ochiai T, Shimada H, Tagawa M, editors, Gene Therapy 2007. 1st edition. 21st Century's Center of Excellence Program of Japanese Ministry of Education and Science: Chiba; 2007. p. 58-65
   Google Scholar
• Saad AF, Meacham WD, Bai A, The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther 2007;6:1455-60
   PubMed Web of Science ®Google Scholar
• French KJ, Upson JJ, Keller SN, Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther 2006;318:596-603
   PubMed Web of Science ®Google Scholar
• Carvajal RD, Merrill AH Jr, Dials H, A phase I clinical study of safingol followed by cisplatin: promising activity in refractory adrenocortical cancer with novel pharmacology. J Clin Oncol 2006;24:13044
   Google Scholar
• Yuan Y, Chi F, Wang S, Wang Z. Significance of ceramide and DNA ploidy in laryngeal carcinogenesis. ORL J Otorhinolaryngol Relat Spec 2007;69:283-8
   Google Scholar
• Chi FL, Yuan YS, Wang SY, Wang ZM. Study on ceramide expression and DNA content in patients with healthy mucosa, leukoplakia, and carcinoma of the larynx. Arch Otolaryngol Head Neck Surg 2004;130:307-10
   Google Scholar
• Young MR, Neville BW, Chi AC, Autocrine motility-stimulatory pathways of oral premalignant lesion cells. Clin Exp Metastasis 2007;24:131-9
   Google Scholar
• Koybasi S, Senkal CE, Sundararaj K, Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem 2004;279:44311-9
   PubMed Web of Science ®Google Scholar
• Karahatay S, Thomas K, Koybasi S, Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C18-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett 2007;256:101-11
   PubMed Web of Science ®Google Scholar
• Marques Filho MF, Walder F, Takahashi HK, Glycosphingolipid expression in squamous cell carcinoma of the upper aerodigestive tract. Braz J Otorhinolaryngol 2006;72:25-30
   Google Scholar
• Bolot G, David MJ, Taki T, Analysis of glycosphingolipids of human head and neck carcinomas with comparison to normal tissue. Biochem Mol Biol Int 1998;46:125-35
   PubMedGoogle Scholar
• Fish RG. Role of gangliosides in tumour progression: a molecular target for cancer therapy? Med Hypotheses 1996;46:140-4
   PubMed Web of Science ®Google Scholar
• Miller AV, Alvarez SE, Spiegel S, Lebman DA. Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol 2008;28:4142-51
   PubMed Web of Science ®Google Scholar
• Bergelin N, Blom T, Heikkilä J, Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2. Endocrinology 2009;150:2055-63
   Google Scholar
• Senchenkov A, Litvak DA, Cabot MC. Targeting ceramide metabolism – a strategy for overcoming drug resistance. J Natl Cancer Inst 2001;93:347-57
   PubMed Web of Science ®Google Scholar
• Dumitru CA, Weller M, Gulbins E. Ceramide metabolism determines glioma cell resistance to chemotherapy. J Cell Physiol 2009;221:688-95
   PubMed Web of Science ®Google Scholar
• Rath G, Schneider C, Langlois B, De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma. Int J Biochem Cell Biol 2009;41:1165-72
   Google Scholar
• Kolesnick R, Fuks Z. Radiation and ceramide-induced apoptosis. Oncogene 2003;22:5897-906
   PubMed Web of Science ®Google Scholar
• Chmura SJ, Nodzenski E, Beckett MA, Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res 1997;57:1270-5
   PubMed Web of Science ®Google Scholar
• Chmura SJ, Nodzenski E, Kharbanda S, Down-regulation of ceramide production abrogates ionizing radiation-induced cytochrome c release and apoptosis. Mol Pharmacol 2000;57:792-6
   PubMed Web of Science ®Google Scholar
• Alphonse G, Bionda C, Aloy MT, Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels. Oncogene 2004;23:2703-15
   PubMed Web of Science ®Google Scholar
• Radin NS. Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria. Bioorg Med Chem 2003;11:2123-42
   PubMed Web of Science ®Google Scholar
• Stover TC, Sharma A, Robertson GP, Kester M. Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma. Clin Cancer Res 2005;11:3465-74
   PubMed Web of Science ®Google Scholar
• Shabbits JA, Mayer LD. Intracellular delivery of ceramide lipids via liposomes enhances apoptosis in vitro. Biochim Biophys Acta 2003;1612:98-106
   PubMed Web of Science ®Google Scholar
• Norris JS, Bielawska A, Day T, Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report. Cancer Gene Ther 2006;13:1045-51
   PubMed Web of Science ®Google Scholar
• Selzner M, Bielawska A, Morse MA, Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res 2001;61:1233-40
   PubMed Web of Science ®Google Scholar
• Szulc ZM, Mayroo N, Bai A, Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents. Bioorg Med Chem 2008;16:1015-31
   PubMed Web of Science ®Google Scholar
• Liu X, Elojeimy S, El-Zawahry AM, Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Mol Ther 2006;14:637-46
   PubMed Web of Science ®Google Scholar
• Litvak DA, Bilchik AJ, Cabot MC. Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy. J Gastrointest Surg 2003;7:140-148; discussion 148
   PubMed Web of Science ®Google Scholar
• Kawamori T, Osta W, Johnson KR, Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J 2006;20:386-8
   PubMed Web of Science ®Google Scholar
• Taha TA, Kitatani K, El-Alwani M, Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J 2006;20:482-4
   PubMedGoogle Scholar
• Van Brocklyn JR, Jackson CA, Pearl DK, Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines. J Neuropathol Exp Neurol 2005;64:695-705
   PubMed Web of Science ®Google Scholar
• Barry JM, Lisa M, Carolyn B, Synergistic cytotoxicity in solid tumor cell lines betwen N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. J Natl Cancer Inst 2000;92:1897
   Google Scholar
• Hamada M, Sumi T, Iwai S, Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol. Apoptosis 2006;11:47-56
   Google Scholar
• French KJ, Schrecengost RS, Lee BD, Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res 2003;63:5962-9
   PubMed Web of Science ®Google Scholar
• Senkal CE, Ponnusamy S, Rossi MJ, Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther 2007;6:712-22
   PubMed Web of Science ®Google Scholar
• Uchida T, Horiguchi S, Tanaka Y, Phase I study of alpha-galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer. Cancer Immunol Immunother 2008;57:337-45
   PubMedGoogle Scholar
• Ishikawa A, Motohashi S, Ishikawa E, A phase I study of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer. Clin Cancer Res 2005;11:1910-7
   PubMed Web of Science ®Google Scholar
• Visentin B, Vekich JA, Sibbald BJ, Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 2006;9:225-38
   PubMed Web of Science ®Google Scholar
• O'Brien N, Jones ST, Williams DG, Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. J Lipid Res 2009;50:2245-57
   PubMed Web of Science ®Google Scholar
• Liu Q, Zhao X, Frissora F, FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood 2008;111:275-84
   PubMed Web of Science ®Google Scholar
• Lahiri S, Park H, Laviad EL, Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. J Biol Chem 2009;284:16090-8
   Google Scholar
• Berdyshev EV, Gorshkova I, Skobeleva A, FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. J Biol Chem 2009;284:5467-77
   PubMedGoogle Scholar
• Neviani P, Santhanam R, Oaks JJ, FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J Clin Invest 2007;117:2408-21
   PubMed Web of Science ®Google Scholar
• Yasui H, Hideshima T, Raje N, FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res 2005;65:7478-84
   Google Scholar
• Salinas NR, Oshima CT, Cury PM, FTY720 and lung tumor development. Int Immunopharmacol 2009;9:689-93
   PubMedGoogle Scholar
• Shen Y, Wang X, Xia W, Antiproliferative and overadditive effects of rapamycin and FTY720 in pancreatic cancer cells in vitro. Transplant Proc 2008;40:1727-33
   Google Scholar
• Shen Y, Cai M, Xia W, FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells. Cancer Lett 2007;254:288-97
   PubMedGoogle Scholar
• Zhou C, Ling MT, Kin-Wah Lee T, FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase. Cancer Lett 2006;233:36-47
   PubMed Web of Science ®Google Scholar
• Azuma H, Takahara S, Ichimaru N, Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. Cancer Res 2002;62:1410-9
   PubMed Web of Science ®Google Scholar
• Nagaoka Y, Otsuki K, Fujita T, Uesato S. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. Biol Pharm Bull 2008 31:1177-81
   Google Scholar