Calcium-activated potassium channels – a therapeutic target for modulating nitric oxide in cardiovascular disease?

Bibliography

• Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000;101:1899-906
   PubMed Web of Science ®Google Scholar
• Suwaidi JA, Hamasaki S, Higano ST, Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 2000;101:948-54
   PubMed Web of Science ®Google Scholar
• Celermajer DS. Endothelial dysfunction: does it matter? Is it reversible? J Am Coll Cardiol 1997;30:325-33
   PubMed Web of Science ®Google Scholar
• Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarizations: past beliefs and present facts. Ann Med 2007;39:495-516
   PubMed Web of Science ®Google Scholar
• Nilius B, Droogmans G. Ion channels and their functional role in vascular endothelium. Physiol Rev 2001;81:1415-59
   PubMed Web of Science ®Google Scholar
• Wei AD, Gutman GA, Aldrich R, International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev 2005;57:463-72
   PubMed Web of Science ®Google Scholar
• Feletou M. Calcium-activated potassium channels and endothelial dysfunction: therapeutic options? Br J Pharmacol 2009;156:545-62
   PubMed Web of Science ®Google Scholar
• Kohler R, Kaistha BP, Wulff H. Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease. Expert Opin Ther Targets 2010;14:143-55
   PubMed Web of Science ®Google Scholar
• Stankevicius E, Lopez-Valverde V, Rivera L, Combination of Ca2+ -activated K+ channel blockers inhibits acetylcholine-evoked nitric oxide release in rat superior mesenteric artery. Br J Pharmacol 2006;149:560-72
   PubMed Web of Science ®Google Scholar
• McNeish AJ, Sandow SL, Neylon CB, Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery. Stroke 2006;37:1277-82
   PubMedGoogle Scholar
• Sheng JZ, Braun AP. Small- and intermediate-conductance Ca2+-activated K+ channels directly control agonist-evoked nitric oxide synthesis in human vascular endothelial cells. Am J Physiol Cell Physiol 2007;293:C458-67
   PubMed Web of Science ®Google Scholar
• Sheng JZ, Ella S, Davis MJ, Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation. FASEB J 2009;23:1138-45
   PubMed Web of Science ®Google Scholar
• Dalsgaard T, Kroigaard C, Bek T, Simonsen U. Role of calcium-activated potassium channels with small conductance in bradykinin-induced vasodilation of porcine retinal arterioles. Invest Ophthalmol Vis Sci 2009;50:3819-25
   PubMedGoogle Scholar
• Dalsgaard T, Kroigaard C, Misfeldt M, Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. Br J Pharmacol [Epub ahead of print, 14 April 2010, doi: 10.1111/j.1476-5381.2010.00803.x]
   Google Scholar
• Logsdon NJ, Kang J, Togo JA, A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. J Biol Chem 1997;272:32723-6
   PubMed Web of Science ®Google Scholar
• Roncarati R, Decimo I, Fumagalli G. Assembly and trafficking of human small conductance Ca2+-activated K+ channel SK3 are governed by different molecular domains. Mol Cell Neurosci 2005;28:314-25
   PubMedGoogle Scholar
• Jones HM, Hamilton KL, Papworth GD, Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1. J Biol Chem 2004;279:15531-40
   PubMedGoogle Scholar
• MacKinnon R. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature 1991;350:232-5
   PubMed Web of Science ®Google Scholar
• Burnham MP, Bychkov R, Feletou M, Characterization of an apamin-sensitive small-conductance Ca2+-activated K+ channel in porcine coronary artery endothelium: relevance to EDHF. Br J Pharmacol 2002;135:1133-43
   PubMed Web of Science ®Google Scholar
• Bychkov R, Burnham MP, Richards GR, Characterization of a charybdotoxin-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF. Br J Pharmacol 2002;137:1346-54
   PubMed Web of Science ®Google Scholar
• Chen MX, Gorman SA, Benson B, Small and intermediate conductance Ca2+-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum. Naunyn Schmiedebergs Arch Pharmacol 2004;369:602-15
   PubMed Web of Science ®Google Scholar
• Kohler R, Brakemeier S, Kuhn M, Impaired hyperpolarization in regenerated endothelium after balloon catheter injury. Circ Res 2001;89:174-9
   PubMed Web of Science ®Google Scholar
• Dora KA, Gallagher NT, McNeish A, Garland CJ. Modulation of endothelial cell KCa3.1 channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries. Circ Res 2008;102:1247-55
   PubMed Web of Science ®Google Scholar
• Sandow SL, Neylon CB, Chen MX, Garland CJ. Spatial separation of endothelial small- and intermediate-conductance calcium-activated potassium channels (KCa) and connexins: possible relationship to vasodilator function? J Anat 2006;209:689-98
   PubMedGoogle Scholar
• Absi M, Burnham MP, Weston AH, Effects of methyl beta-cyclodextrin on EDHF responses in pig and rat arteries; association between SKCa channels and caveolin-rich domains. Br J Pharmacol 2007;151:332-40
   PubMedGoogle Scholar
• Weston AH, Absi M, Ward DT, Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231. Circ Res 2005;97:391-8
   PubMed Web of Science ®Google Scholar
• Kroigaard C, Dalsgaard T, Simonsen U. Mechanisms underlying epithelium-dependent relaxation in rat bronchioles: analogy to EDHF-type relaxation in rat pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 2010;298:L531-42
   Google Scholar
• Sultan S, Gosling M, Abu-Hayyeh S, Flow-dependent increase of ICAM-1 on saphenous vein endothelium is sensitive to apamin. Am J Physiol Heart Circ Physiol 2004;287:H22-8
   Google Scholar
• Gebremedhin D, Kaldunski M, Jacobs ER, Coexistence of two types of Ca2+-activated K+ channels in rat renal arterioles. Am J Physiol 1996;270:F69-81
   Google Scholar
• Quignard JF, Feletou M, Edwards G, Role of endothelial cell hyperpolarization in EDHF-mediated responses in the guinea-pig carotid artery. Br J Pharmacol 2000;129:1103-12
   PubMedGoogle Scholar
• Gauthier KM, Spitzbarth N, Edwards EM, Campbell WB. Apamin-sensitive K+ currents mediate arachidonic acid-induced relaxations of rabbit aorta. Hypertension 2004;43:413-9
   PubMed Web of Science ®Google Scholar
• Neylon CB, Lang RJ, Fu Y, Molecular cloning and characterization of the intermediate-conductance Ca2+-activated K+ channel in vascular smooth muscle: relationship between K(Ca) channel diversity and smooth muscle cell function. Circ Res 1999;85:e33-43
   Web of Science ®Google Scholar
• Kohler R, Wulff H, Eichler I, Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation 2003;108:1119-25
   PubMed Web of Science ®Google Scholar
• Frank PG, Woodman SE, Park DS, Lisanti MP. Caveolin, caveolae, and endothelial cell function. Arterioscler Thromb Vasc Biol 2003;23:1161-8
   PubMed Web of Science ®Google Scholar
• Remillard CV, Yuan JX. Transient receptor potential channels and caveolin-1: good friends in tight spaces. Mol Pharmacol 2006;70:1151-4
   PubMedGoogle Scholar
• Saliez J, Bouzin C, Rath G, Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation: Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells. Circulation 2008;117:1065-74
   PubMedGoogle Scholar
• Ledoux J, Taylor MS, Bonev AD, Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections. Proc Natl Acad Sci USA 2008;105:9627-32
   PubMed Web of Science ®Google Scholar
• Bosch MA, Kelly MJ, Ronnekleiv OK. Distribution, neuronal colocalization, and 17beta-E2 modulation of small conductance calcium-activated K+ channel (SK3) mRNA in the guinea pig brain. Endocrinology 2002;143:1097-107
   PubMedGoogle Scholar
• Kolski-Andreaco A, Tomita H, Shakkottai VG, SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels. J Biol Chem 2004;279:6893-904
   PubMedGoogle Scholar
• Ren Y, Barnwell LF, Alexander JC, Regulation of surface localization of the small conductance Ca2+-activated potassium channel, Sk2, through direct phosphorylation by cAMP-dependent protein kinase. J Biol Chem 2006;281:11769-79
   PubMed Web of Science ®Google Scholar
• Bildl W, Strassmaier T, Thurm H, Protein kinase CK2 is coassembled with small conductance Ca2+-activated K+ channels and regulates channel gating. Neuron 2004;43:847-58
   PubMed Web of Science ®Google Scholar
• Gerlach AC, Gangopadhyay NN, Devor DC. Kinase-dependent regulation of the intermediate conductance, calcium-dependent potassium channel, hIK1. J Biol Chem 2000;275:585-98
   PubMedGoogle Scholar
• Srivastava S, Li Z, Ko K, Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. Mol Cell 2006;24:665-75
   PubMed Web of Science ®Google Scholar
• Hamilton KL, Syme CA, Devor DC. Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1. J Biol Chem 2003;278:16690-7
   PubMedGoogle Scholar
• Duffy SM, Cruse G, Lawley WJ, Bradding P. beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells. FASEB J 2005;19:1006-8
   PubMedGoogle Scholar
• Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem 2007;14:1437-57
   PubMed Web of Science ®Google Scholar
• Sankaranarayanan A, Raman G, Busch C, Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol 2009;75:281-95
   PubMed Web of Science ®Google Scholar
• Hougaard C, Eriksen BL, Jorgensen S, Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol 2007;151:655-65
   PubMed Web of Science ®Google Scholar
• Hougaard C, Jensen ML, Dale TJ, Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol 2009;76:569-78
   PubMed Web of Science ®Google Scholar
• Morimura K, Yamamura H, Ohya S, Imaizumi Y. Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells. J Pharmacol Sci 2006;100:237-41
   PubMedGoogle Scholar
• Strobaek D, Teuber L, Jorgensen TD, Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim Biophys Acta 2004;1665:1-5
   PubMed Web of Science ®Google Scholar
• Feletou M, Vanhoutte PM. EDHF: new therapeutic targets? Pharmacol Res 2004;49:565-80
   PubMedGoogle Scholar
• Brahler S, Kaistha A, Schmidt VJ, Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 2009;119:2323-32
   PubMed Web of Science ®Google Scholar
• Weston AH, Porter EL, Harno E, Edwards G. Impairment of endothelial SK channels and of downstream hyperpolarizing pathways in mesenteric arteries from spontaneously hypertensive rats. Br J Pharmacol [Epub ahead of print, 8 March 2010, doi: BPH657 [pii];10.1111/ j.1476-5381.2010.00657.x]
   Google Scholar
• Brondum E, Kold-Petersen H, Simonsen U, Aalkjaer C. NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats. Br J Pharmacol 2009;159:154-65
   PubMedGoogle Scholar
• Liu Y, Sellke EW, Feng J, Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass. Surgery 2008;144:239-44
   PubMedGoogle Scholar
• Feng J, Liu Y, Clements RT, Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegic arrest. Circulation 2008;118:S46-51
   Web of Science ®Google Scholar
• Parekh AB, Putney JW Jr. Store-operated calcium channels. Physiol Rev 2005;85:757-810
   PubMed Web of Science ®Google Scholar
• Nilius B, Talavera K, Owsianik G, Gating of TRP channels: a voltage connection? J Physiol 2005;567:35-44
   PubMed Web of Science ®Google Scholar
• Kamouchi M, Philipp S, Flockerzi V, Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells. J Physiol 1999;518(Pt 2):345-58
   PubMedGoogle Scholar
• Kohler R, Brakemeier S, Kuhn M, Expression of ryanodine receptor type 3 and TRP channels in endothelial cells: comparison of in situ and cultured human endothelial cells. Cardiovasc Res 2001;51:160-8
   PubMedGoogle Scholar
• Freichel M, Suh SH, Pfeifer A, Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol 2001;3:121-7
   PubMed Web of Science ®Google Scholar
• Zhang DX, Mendoza SA, Bubolz AH, Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. Hypertension 2009;53:532-8
   PubMedGoogle Scholar
• Marrelli SP, Eckmann MS, Hunte MS. Role of endothelial intermediate conductance KCa channels in cerebral EDHF-mediated dilations. Am J Physiol Heart Circ Physiol 2003;285:H1590-9
   PubMed Web of Science ®Google Scholar
• Fleming I, Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 2003;284:R1-12
   PubMed Web of Science ®Google Scholar
• Rodriguez-Rodriguez R, Stankevicius E, Herrera MD, Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide. Br J Pharmacol 2008;155:535-46
   PubMedGoogle Scholar
• Pollock JS, Forstermann U, Mitchell JA, Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci USA 1991;88:10480-4
   PubMed Web of Science ®Google Scholar
• Boger RH. L-Arginine therapy in cardiovascular pathologies: beneficial or dangerous? Curr Opin Clin Nutr Metab Care 2008;11:55-61
   PubMed Web of Science ®Google Scholar
• Chin-Dusting JP, Willems L, Kaye DM. l-arginine transporters in cardiovascular disease: a novel therapeutic target. Pharmacol Ther 2007;116:428-36
   PubMed Web of Science ®Google Scholar
• Bogle RG, Coade SB, Moncada S, Bradykinin and ATP stimulate l-arginine uptake and nitric oxide release in vascular endothelial cells. Biochem Biophys Res Commun 1991;180:926-32
   PubMed Web of Science ®Google Scholar
• Zharikov SI, Herrera H, Block ER. Role of membrane potential in hypoxic inhibition of l-arginine uptake by lung endothelial cells. Am J Physiol 1997;272:L78-84
   Google Scholar
• Bauersachs J, Bouloumie A, Fraccarollo D, Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial nitric oxide synthase and soluble guanylate cyclase expression: role of enhanced vascular superoxide production. Circulation 1999;100:292-8
   PubMed Web of Science ®Google Scholar
• Al-Mehdi AB, Zhao G, Dodia C, Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+. Circ Res 1998;83:730-7
   PubMed Web of Science ®Google Scholar
• Martens JR, Gelband CH. Alterations in rat interlobar artery membrane potential and K+ channels in genetic and nongenetic hypertension. Circ Res 1996;79:295-301
   PubMedGoogle Scholar
• Marchenko SM, Sage SO. Smooth muscle cells affect endothelial membrane potential in rat aorta. Am J Physiol 1994;267:H804-11
   Google Scholar
• Sohn HY, Keller M, Gloe T, The small G-protein Rac mediates depolarization-induced superoxide formation in human endothelial cells. J Biol Chem 2000;275:18745-50
   PubMed Web of Science ®Google Scholar
• Ghatta S, Nimmagadda D, Xu X, O'Rourke ST. Large-conductance, calcium-activated potassium channels: structural and functional implications. Pharmacol Ther 2006;110:103-16
   PubMed Web of Science ®Google Scholar
• Kohler R, Degenhardt C, Kuhn M, Expression and function of endothelial Ca2+-activated K+ channels in human mesenteric artery: a single-cell reverse transcriptase-polymerase chain reaction and electrophysiological study in situ. Circ Res 2000;87:496-503
   PubMed Web of Science ®Google Scholar
• Kwan HY, Shen B, Ma X, TRPC1 associates with BKCa channel to form a signal complex in vascular smooth muscle cells. Circ Res 2009;104:670-8
   PubMed Web of Science ®Google Scholar
• Nardi A, Olesen SP. BK channel modulators: a comprehensive overview. Curr Med Chem 2008;15:1126-46
   PubMedGoogle Scholar
• Kun A, Matchkov VV, Stankevicius E, NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats. Br J Pharmacol 2009;158:1465-76
   PubMed Web of Science ®Google Scholar
• Sones WR, Leblanc N, Greenwood IA. Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels. Br J Pharmacol 2009;158:521-31
   PubMedGoogle Scholar
• Bentzen BH, Nardi A, Calloe K, The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol 2007;72:1033-44
   PubMed Web of Science ®Google Scholar
• Nelson MT, Cheng H, Rubart M, Relaxation of arterial smooth muscle by calcium sparks. Science 1995;270:633-7
   PubMed Web of Science ®Google Scholar
• Perez GJ, Bonev AD, Patlak JB, Nelson MT. Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries. J Gen Physiol 1999;113:229-38
   PubMed Web of Science ®Google Scholar
• Bolotina VM, Najibi S, Palacino JJ, Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 1994;368:850-3
   PubMed Web of Science ®Google Scholar
• Hou S, Heinemann SH, Hoshi T. Modulation of BKCa channel gating by endogenous signaling molecules. Physiology (Bethesda) 2009;24:26-35
   PubMed Web of Science ®Google Scholar
• Schubert R, Nelson MT. Protein kinases: tuners of the BKCa channel in smooth muscle. Trends Pharmacol Sci 2001;22:505-12
   PubMed Web of Science ®Google Scholar
• Bychkov R, Pieper K, Ried C, Hydrogen peroxide, potassium currents, and membrane potential in human endothelial cells. Circulation 1999;99:1719-25
   PubMed Web of Science ®Google Scholar
• Brakemeier S, Eichler I, Knorr A, Modulation of Ca2+-activated K+ channel in renal artery endothelium in situ by nitric oxide and reactive oxygen species. Kidney Int 2003;64:199-207
   PubMed Web of Science ®Google Scholar
• Stankevicius E, Martinez AC, Mulvany MJ, Simonsen U. Blunted acetylcholine relaxation and nitric oxide release in arteries from renal hypertensive rats. J Hypertens 2002;20:1571-9
   PubMedGoogle Scholar
• Hein TW, Kuo L. LDLs impair vasomotor function of the coronary microcirculation: role of superoxide anions. Circ Res 1998;83:404-14
   PubMedGoogle Scholar
• Paravicini TM, Touyz RM. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 2008;31(Suppl 2):S170-80
   PubMedGoogle Scholar
• Munzel T, Sinning C, Post F, Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction. Ann Med 2008;40:180-96
   PubMed Web of Science ®Google Scholar
• Kris-Etherton PM, Lichtenstein AH, Howard BV, Antioxidant vitamin supplements and cardiovascular disease. Circulation 2004;110:637-41
   PubMed Web of Science ®Google Scholar
• Bjelakovic G, Nikolova D, Gluud LL, Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2008;CD007176: published online 16 April 2008, DOI: 10.1002/14651858.CD007176
   Google Scholar
• Grgic I, Eichler I, Heinau P, Selective blockade of the intermediate-conductance Ca2+-activated K+ channel suppresses proliferation of microvascular and macrovascular endothelial cells and angiogenesis in vivo. Arterioscler Thromb Vasc Biol 2005;25:704-9
   PubMedGoogle Scholar
• Wang ZH, Shen B, Yao HL, Blockage of intermediate-conductance-Ca2+-activated K+ channels inhibits progression of human endometrial cancer. Oncogene 2007;26:5107-14
   PubMed Web of Science ®Google Scholar
• Liegeois JF, Mercier F, Graulich A, Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry. Curr Med Chem 2003;10:625-47
   PubMed Web of Science ®Google Scholar
• Potier M, Joulin V, Roger S, Identification of SK3 channel as a new mediator of breast cancer cell migration. Mol Cancer Ther 2006;5:2946-53
   PubMed Web of Science ®Google Scholar