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Update on the endocannabinoid system as an anticancer target

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Pages 297-308 | Published online: 19 Jan 2011

Bibliography

  • Bisogno T, Ligresti A, Di Marzo V. The endocannabinoid signalling system: biochemical aspects. Pharmacol Biochem Behav 2005;81:224-38
  • Devane WA, Dysarz FA, Johnson MR, Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 1988;34:605-13
  • Matsuda LA, Lolait SJ, Brownstein MJ, Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990;346:561-4
  • Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993;365:61-5
  • Howlett AC, Barth F, Bonner TI, Classification of cannabinoid receptors. Pharmacol Rev 2002;54:161-202
  • Suarez J, Bermudez-Silva F, Mackie K, Immunohistochemical description of the endogenous cannabinoid systemin the rat cerebellum and functionally related nuclei. J Comp Neurol 2008;509:400-21
  • Benito C, Nunez E, Tolon RM, Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. J Neurosci 2003;23(35):11136-41
  • Benito C, Tolon RM, Pazos MR, Cannabinoid CB2 receptors in human brain inflammation. Br J Pharmacol 2008;153(2):277-85
  • Ryberg E, Larsson N, Sjogren S, The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 2007;152:1092-101
  • Baker D, Pryce G, Davies WL, Hiley CR. In silico patent searching reveals a new cannabinoid receptor. Trends Pharmacol Sci 2006;27(1):1-4
  • Liu J, Gao B, Mirshahi F, Functional CB1 cannabinoid receptors in human vascular endothelial cells. Biochem J 2000;346:835-40
  • Rueda D, Galve-Roperh I, Haro A, Guzman M. The CB1 cannabinoid receptor is coupled to the activation of c-Jun N terminal kinase. Mol Pharmacol 2000;58:814-20
  • Gomez del Pulgar T, Velasco G, Guzman M. The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. Biochem J 2000;347:369-73
  • Piomelli D. The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 2003;4(11):873-84
  • Bermudez-Silva FJ, Viveros MP, McPartland JM, Rodriguez de Fonseca F. The endocannabinoid system, eating behavior and energy homeostasis: the end or a new beginning? Pharmacol Biochem Behav 2010;95(4):375-82
  • Bifulco M, Di Marzo V. The endocannabinoid system as a target for the development of new drugs for cancer therapy. Nat Med 2002;8:547-50
  • Bifulco M, Laezza C, Pisanti S, Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 2006;148:123-35
  • Grimaldi C, Pisanti S, Laezza C, Anandamide inhibits adhesion and migration of breast cancer cells. Exp Cell Res 2006;312:363-73
  • Bifulco M, Laezza C, Valenti M, A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. FASEB J 2004;18(13):1606-8
  • Bifulco M, Laezza C, Gazzerro P, Pentimalli F. Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion. Oncol Rep 2007;17(4):813-16
  • Laezza C, Pisanti S, Malfitano AM, Bifulco M. The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. Endocr Relat Cancer 2008;15(4):965-74
  • Preet A, Ganju RK, Groopman JE. Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 2008;27(3):339-46
  • Galve-Roperh I, Sanchez C, Cortes ML, Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000;6(3):313-19
  • Bifulco M, Laezza C, Portella G, Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. FASEB J 2001;15:2745-7
  • Qamri Z, Preet A, Nasser MW, Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer. 2009;8(11):3117-29
  • Casanova ML, Blazquez C, Martinez-Palacio J, Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 2003;111:43-50
  • Carracedo A, Gironella M, Lorente M, Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 2006;66:6748-55
  • Blazquez C, Carracedo A, Barrado L, Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J 2006;20:2633-5
  • Parolaro D, Massi P. Cannabinoids as potential new therapy for the treatment of gliomas. Expert Rev Neurother 2008;8(1):37-49
  • Marczylo TH, Lam PMW, Amoako AA, Konj JC. Anandamide levels in human female reproductive tissues: solid-phase extraction and measurement by ultraperformance liquid chromatography tandem mass spectrometry. Anal Biochem 2010;400(2):155-62
  • Romero J, Orgado JM. Cannabinoids and neurodegenerative diseases. CNS Neurol Disord Drug Targets 2009;8(6):440-50
  • Petersen G, Moesgaard B, Schmid PC, Endocannabinoid metabolism in human glioblastomas and meningiomas compared to human non-tumour brain tissue. J Neurochem 2005;93:299-309
  • Pagotto U, Marsicano G, Fezza F, Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level. J Clin Endocrinol Metab 2001;86:2687-96
  • Nithipatikom K, Endsley MP, Isbell MA, 2-Arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion. Cancer Res 2004;64:8826-30
  • Ligresti A, Bisogno T, Matias I, Possible endocannabinoid control of colorectal cancer growth. Gastroenterology 2003;125:677-87
  • Schmid PC, Wold LE, Krebsbach RJ, Anandamide and other N-acylethanolamines in human tumors. Lipids 2002;37:907-12
  • Cianchi F, Papucci L, Schiavone N, Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells. Clin Cancer Res 2008;14(23):7691-700
  • Michalski CW, Oti FE, Erkan M, Cannabinoids in pancreatic cancer: correlation with survival and pain. Int J Cancer 2008;122:742-50
  • Guida M, Ligresti A, De Filippis D, The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma. Endocrinology 2010;151(3):921-8
  • Di Marzo V, Deutsch DG. Biochemistry of the endogenous ligands of cannabinoid receptors. Neurobiol Dis 1998;5(6 Pt B):386-404
  • Nomura DK, Long JZ, Niessen S, Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 2010;140(1):49-61
  • Thors L, Bergh A, Persson E, Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4. PLoS One 2010;5(8):e12275
  • Endsley M, Thill R, Choudhry I, Expression and function of fatty acid amide hydrolase in prostate cancer. Int J Cancer 2008;123:1318-26
  • Di Marzo V, Melck D, Orlando P, Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. Biochem J 2001;358:249-55
  • Petrosino S, Di Marzo V. FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels. Curr Opin Investig Drugs 2010;11(1):51-62
  • Naidu PS, Kinsey SG, Guo TL, Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase. J Pharmacol Exp Ther 2010;334(1):182-90
  • Gustafsson K, Wang X, Severa D, Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation. Int J Cancer 2008;123(5):1025-33
  • Joseph J, Niggemann B, Zaenker KS, Entschladen F. Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. Cancer Immunol Immunother 2004;53(8):723-8
  • Giuliano M, Pellerito O, Portanova P, Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: involvement of the transcription factor PPARg. Biochimie 2009;91(4):457-65
  • Czifra G, Varga A, Nyeste K, Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma. J Cancer Res Clin Oncol 2009;135(4):507-14
  • Stella N. Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. Glia 2010;58(9):1017-30
  • Parfienuk A, Flisiak R. Role of cannabinoids in chronic liver disease. World J Gastroenterol 2008;14:6109-14
  • Luca T, Di Benedetto G, Scuderi MR, The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi's sarcoma cells in vitro. Molecular and Cellular Pharmacology. Eur J Pharmacol 2009;616:16-21
  • De Jesus ML, Hostalot C, Garibi JM, Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas. Neurochem Int 2010;56(6-7):829-33
  • Schley M, Stander S, Kerner J, Predominant CB2 receptor expression in endothelial cells of glioblastoma in humans. Brain Res Bull 2009;79(5):333-7
  • Caffarel MM, Andradas C, Mira E, Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition. Mol Cancer 2010;9:196
  • Miyato H, Kitayama J, Yamashita H, Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines. J Surg Res 2009;155(1):40-7
  • Oesch S, Dagmar W, Wachtel M, Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma. Mol Cancer Ther 2009;8(7):1838-45
  • Cianchi F, Papucci L, Schiavone N, Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells. Clin Cancer Res 2008;14(23):7691-700
  • Caffarel MM, Sarrio D, Palacios J, Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res 2006;66(13):6615-21
  • Marincsak R, Toth BI, Czifra G, Increased expression of TRPV1 in squamous cell carcinoma of the human tongue. Oral Dis 2009;15(5):328-35
  • DeMorrow S, Francis H, Gaudio E, The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway. Am J Physiol Gastrointest Liver Physiol 2008;295:G1150-8
  • Cozzolino R, Cali G, Bifulco M, Laccetti P. A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis. Invest New Drugs 2010;28(2):115-23
  • Rukiyah TVD. Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes. Mol Carcinog 2009;48(8):724-32
  • De Petrocellis L, Melck D, Palmisano A, The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc Natl Acad Sci USA 1998;95(14):8375-80
  • Melck D, De Petrocellis L, Orlando P, Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology 2000;141(1):118-26
  • Laezza C, Pisanti S, Crescenzi E, Bifulco M. Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. FEBS Lett 2006;580(26):6076-82
  • Olea-Herrero N, Vara D, Malagarie-Cazenave S, Diaz-Laviada I Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: involvement of CB2. Br J Cancer 2009;101(6):940-50
  • Mimeault M, Pommery N, Henichart JP. Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines. Int J Cancer 2003;106(1):116-24
  • Xian XS, Park H, Cho YK, Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells. J Cell Biochem 2010;110:321-32
  • McKallip RJ, Lombard C, Fisher M, Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 2002;100(2):627-34
  • Jacobsson SO, Wallin T, Fowler CJ. Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors. J Pharmacol Exp Ther 2001;299(3):951-9
  • Massi P, Vaccani A, Bianchessi S, The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol Life Sci 2006;63(17):2057-66
  • Gallotta D, Nigro P, Cotugno R, Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathways. Biochem Pharmacol 2010;80:370-80
  • Velasco G, Galve-Roperh I, Sanchez C, Cannabinoids and ceramide: two lipids acting hand-by-hand. Life Sci 2005;77:1723-31
  • Zacchigna S, Zentilin L, Morini M, AAV-mediated gene transfer of tissue inhibitor of metalloproteinases-1 inhibits vascular tumor growth and angiogenesis in vivo. Cancer Gene Ther 2004;11:73-80
  • Ramer R, Hinz B. Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst 2008;100(1):59-69
  • Ramer R, Merkord J, Rohde H, Hinz B. Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1. Biochem Pharmacol 2010;79(7):955-66
  • Pisanti S, Borselli C, Oliviero O, Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy. J Cell Physiol 2007;211(2):495-503
  • Portella G, Laezza C, Laccetti P, Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. FASEB J 2003;17(12):1771-3
  • Pisanti S, Bifulco M. Endocannabinoid system modulation in cancer biology and therapy. Pharmacol Res 2009;60(2):107-16
  • Laezza C, Malfitano AM, Proto MC, Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells. Endocr Relat Cancer 2010;17(2):495-503
  • Ramer R, Brune K, Pahl A, Hinz B. R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism. Biochem Biophys Res Commun 2001;286:1144-52
  • Hinz B, Ramer R, Eichele K, R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts. Biochem Biophys Res Commun 2004;324(2):621-6
  • Patsos HA, Greenhough A, Hicks DJ, The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. Int J Oncol 2010;37(1):187-93
  • Van Dross RT. Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes. Mol Carcinog 2009;48(8):724-32
  • DeMorrow S, Glaser S, Francis H, Opposing action of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid raft. J Biol Chem 2007;282:13098-113
  • Hsu SS, Huang CJ, Cheng HH, Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. Toxicology 2007;231(1):21-9
  • Salazar M, Carracedo A, Salanueva IJ, Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest 2009;119(5):1359-72
  • Frampton G, Coufal M, Li H, Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling. Exp Cell Res 2010;316(9):1465-77
  • Pertwee RG. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 1997;74(2):129-80
  • Zanella MT, Ribeiro Filho FF. Emerging drugs for obesity therapy. Arq Bras Endocrinol Metabol 2009;53:271-80
  • Izzo AA, Borrelli F, Capasso R, Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 2009;30(10):515-27
  • Molina-Holgado F, Pinteaux E, Moore J, Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurones and glia. J Neurosci 2003;23:6470-4
  • Small-Howard AL, Shimoda LM, Adra CN, Turner H. Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells. Biochem J 2005;25:25
  • Aquila S, Guido C, Santoro A, Human sperm anatomy: ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction. Anat Rec (Hoboken) 2010;293(2):298-309
  • Johnson JR, Burnell-Nugent M, Lossignol D, Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain. J Pain Symptom Manage 2010;39(2):167-78
  • Guzman M, Duarte MJ, Blazquez C, A pilot clinical study of D9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Br J Cancer 2006;95:197-203

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