Nur77: a potential therapeutic target in cancer

Bibliography

• Chawnshang C, Kokontis J, Shutsung L, Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. J Steroid Biochem 1989;34:391-5
   Google Scholar
• Flaig R, Greschik H, Peluso-Iltis C, Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain. J Biol Chem 2005;280:19250-8
   Web of Science ®Google Scholar
• Wang Z, Benoit G, Liu J, Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 2003;423:555-60
   PubMed Web of Science ®Google Scholar
• Baker KD, Shewchuk LM, Kozlova T, The drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell 2003;113:731-42
   PubMed Web of Science ®Google Scholar
• Liu ZG, Smith SW, McLaughlin KA, Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature 1994;367:281-4
   PubMedGoogle Scholar
• Woronicz JD, Calnan B, Ngo V, Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature 1994;367:277-81
   PubMedGoogle Scholar
• Cainan BJ, Szychowski S, Chan FKM, A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 1995;3:273-82
   Google Scholar
• Cheng LE, Chan FK, Cado D, Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J 1997;16:1865-75
   PubMedGoogle Scholar
• Wang T, Jiang Q, Chan C, Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINOR. Blood 2009;113:2906-13
   Google Scholar
• Kuang AA, Cado D, Winoto A. Nur77 transcription activity correlates with its apoptotic function in vivo. Eur J Immunol 1999;29:3722-8
   Google Scholar
• Zhang XK. Targeting Nur77 translocation. Expert Opin Ther Targets 2007;11:69-79
   PubMed Web of Science ®Google Scholar
• Kolluri SK, Bruey-Sedano N, Cao X, Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. Mol Cell Biol 2003;23:8651-67
   PubMed Web of Science ®Google Scholar
• Wu H, Lin Y, Li W, Regulation of Nur77 expression by beta-catenin and its mitogenic effect in colon cancer cells. FASEB J 2010;25:192-205
   Google Scholar
• Bras A, Albar JP, Leonardo E, Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells. Cell Death Differ 2000;7:262-71
   PubMed Web of Science ®Google Scholar
• Suzuki S, Suzuki N, Mirtsos C, Nur77 as a survival factor in tumor necrosis factor signaling. Proc Natl Acad Sci USA 2003;100:8276-80
   PubMed Web of Science ®Google Scholar
• Moran AE, Holzapfel KL, Xing Y, T cell receptor signal strength in treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med 2011;208:1279-89
   Web of Science ®Google Scholar
• Zeng H, Qin L, Zhao D, Orphan nuclear receptor TR3/Nur77 regulates VEGF-A–induced angiogenesis through its transcriptional activity. J Exp Med 2006;203:719-29
   PubMed Web of Science ®Google Scholar
• Zhao D, Qin L, Bourbon PM, Orphan nuclear transcription factor TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctions. Proc Natl Acad Sci USA 2011;108:12066-71
   Google Scholar
• Yoo YG, Yeo MG, Kim DK, Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha. J Biol Chem 2004;279:53365-73
   PubMedGoogle Scholar
• Alexopoulou A, Leao M, Caballero O, Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines. Breast Cancer Res 2010;12:1-17
   Google Scholar
• Malewicz M, Kadkhodaei B, Kee N, Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. Genes Dev 2011;25:2031-40
   PubMed Web of Science ®Google Scholar
• Zhao BX, Chen HZ, Du XD, Orphan receptor TR3 enhances p53 transactivation and represses DNA double-strand break repair in hepatoma cells under ionizing radiation. Mol Endocrinol 2011;25:1337-50
   PubMedGoogle Scholar
• Pearen MA, Muscat GEO. Nuclear hormone receptor 4A signaling: implications for metabolic disease. Mol Endocrinol 2010;24:1891-903
   PubMed Web of Science ®Google Scholar
• Stocco CO, Zhong L, Sugimoto Y, Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77. J Biol Chem 2000;275:37202-11
   PubMed Web of Science ®Google Scholar
• Kelly S, McKenna T, Young L. Modulation of steroidogenic enzymes by orphan nuclear transcriptional regulation may control diverse production of cortisol and androgens in the human adrenal. J Endocrinol 2004;181:355-65
   PubMed Web of Science ®Google Scholar
• Wilson TE, Mouw AR, Weaver CA, The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol Cell Biol 1993;13:861-8
   PubMed Web of Science ®Google Scholar
• Martin LJ, Tremblay JJ. The human 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in Steroidogenic Cells. Endocrinology 2005;146:861-9
   PubMed Web of Science ®Google Scholar
• Youn HD, Liu JO. Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2. Immunity 2000;13:85-94
   PubMed Web of Science ®Google Scholar
• Dequiedt F, Kasler H, Fischle W, HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity 2003;18:687-98
   PubMed Web of Science ®Google Scholar
• Hsu HC, Zhou T, Mountz JD. Nur77 family of nuclear hormone receptors. Curr Drug Targets 2004;3:413-23
   Google Scholar
• Han YH, Cao X, Lin B, Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. Oncogene 2006;25:2974-86
   PubMed Web of Science ®Google Scholar
• Pekarsky Y, Hallas C, Palamarchuk A, Akt phosphorylates and regulates the orphan nuclear receptor Nur77. Proc Natl Acad Sci USA 2001;98:3690-4
   PubMed Web of Science ®Google Scholar
• Chen HZ, Zhao BX, Zhao Wu, Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria. Carcinogenesis 2008;29:2078-88
   PubMed Web of Science ®Google Scholar
• Wingate AD, Campbell DG, Peggie M, Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. Biochem J 2006;393:715-24
   PubMedGoogle Scholar
• Wang A, Rud J, Olson CM, Phosphorylation of Nur77 by the MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T Cells. J Immunol 2009;183:3268-77
   PubMedGoogle Scholar
• Slagsvold HH, Østvold AC, Fallgren AB, Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2. Biochem Biophys Res Commun 2002;291:1146-50
   PubMed Web of Science ®Google Scholar
• Chen HZ, Liu QF, Li L, The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling. Gut 2011; published online August 28, 2011; doi: 10.1136/gutjnl-2011-300783
   Google Scholar
• Chen HZ, Li L, Wang WJ, Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis. Oncogene 2011; published online October 17, 2011; doi: 10.1038/onc.2011.463
   Google Scholar
• Kang SA, Na H, Kang HJ, Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1. Biochem Pharmacol 2010;80:867-73
   Google Scholar
• Galleguillos D, Vecchiola A, Fuentealba JA, PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1. J Biol Chem 2004;279:2005-11
   PubMed Web of Science ®Google Scholar
• Wilson TE, Fahrner TJ, Johnston M, Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 1991;252:1296-300
   PubMed Web of Science ®Google Scholar
• Philips A, Lesage S, Gingras R, Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells. Mol Cell Biol 1997;17:5946-51
   PubMed Web of Science ®Google Scholar
• Perlmann T, Jansson L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev 1995;9:769-82
   PubMed Web of Science ®Google Scholar
• Zetterstrom RH, Solomin L, Mitsiadis T, Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1. Mol Endocrinol 1996;10:1656-66
   PubMed Web of Science ®Google Scholar
• Wansa KD, Harris JM, Muscat GE. The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment. J Biol Chem 2002;277:33001-11
   PubMed Web of Science ®Google Scholar
• Rambaud J, Desroches J, Balsalobre A, TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77. J Biol Chem 2009;284:14147-56
   PubMedGoogle Scholar
• Kelly SN, McKenna TJ, Young LS. Coregulatory protein–orphan nuclear receptor interactions in the human adrenal cortex. J Endocrinol 2005;186:33-42
   Google Scholar
• Rajpal A, Cho YA, Yelent B, Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. EMBO J 2003;22:6526-36
   PubMed Web of Science ®Google Scholar
• Harant H, Lindley IJD. Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. Nucleic Acids Res 2004;32:5280-90
   PubMed Web of Science ®Google Scholar
• You B, Jiang YY, Chen S, The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression. Circ Res 2009;104:742-9
   PubMed Web of Science ®Google Scholar
• Evans PC. Nur77. Circ Res 2009;104:707-9
   PubMed Web of Science ®Google Scholar
• de Leseleuc L, Denis F. Inhibition of apoptosis by Nur77 through NF-[kappa]B activity modulation. Cell Death Differ 2005;13:293-300
   Google Scholar
• El-Asmar B, Giner XC, Tremblay JJ. Transcriptional cooperation between NF-kappaB p50 and CCAAT/enhancer binding protein beta regulates Nur77 transcription in Leydig cells. J Mol Endocrinol 2009;42:131-8
   Google Scholar
• Karin M, Cao Y, Greten FR, NF-[kappa]B in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002;2:301-10
   PubMed Web of Science ®Google Scholar
• Li GD, Fang JX, Chen HZ, Negative regulation of transcription coactivator p300 by orphan receptor TR3. Nucleic Acids Res 2007;35:7348-59
   Google Scholar
• Zhao BX, Chen HZ, Lei NZ, p53 mediates the negative regulation of MDM2 by orphan receptor TR3. EMBO J 2006;25:5703-15
   PubMed Web of Science ®Google Scholar
• Lee SO, Andey T, Jin UH, The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. Oncogene 2011; published online on November 14, 2011; doi: 10.1038/onc.2011.504.
   Google Scholar
• Lammi J, Rajalin A-M, Huppunen J, Cross-talk between the NR3B and NR4A families of orphan nuclear receptors. Biochem Biophys Res Commun 2007;359:391-7
   Google Scholar
• Yeo MG, Yoo YG, Choi HS, Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells. Mol Endocrinol 2005;19:950-63
   PubMedGoogle Scholar
• Song KH, Park YY, Park KC, The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation. Mol Endocrinol 2004;18:1929-40
   PubMed Web of Science ®Google Scholar
• Choi JW, Park SC, Kang GH, Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma. Cancer Res 2004;64:35-9
   PubMedGoogle Scholar
• Kim BY, Kim H, Cho EJ, Nur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradation. Exp Mol Med 2008;40:71-83
   PubMed Web of Science ®Google Scholar
• Wang H, Huang ZQ, Xia L, Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science 2001;293:853-7
   PubMed Web of Science ®Google Scholar
• Barrero MJ, Malik S. Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation. Mol Cell 2006;24:233-43
   PubMed Web of Science ®Google Scholar
• Lei NZ, Zhang XY, Chen HZ, A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3. Nucleic Acids Res 2009;37:832-48
   Google Scholar
• Villalba M, Bushway P, Altman A. Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD. J Immunol 2001;166:5955-63
   PubMedGoogle Scholar
• Kim H, Kim BY, Soh JW, A novel function of Nur77: physical and functional association with protein kinase C. Biochem Biophys Res Commun 2006;348:950-6
   Google Scholar
• Thompson J, Burger NL, Whang H, Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis. Eur J Immunol 2010;40:2041-9
   PubMedGoogle Scholar
• Zeng JZ, Zhang XK. Nongenomic actions of retinoids: role of Nur77 and RXR in the regulation of apoptosis and inflammation. Anti Inflamm Anti Allergy Agents Med Chem 2007;6:315-31
   Google Scholar
• Rajalin AM, Aarnisalo P. Cross-talk between NR4A orphan nuclear receptors and beta-catenin signaling pathway in osteoblasts. Arch Biochem Biophys 2011;509:44-51
   PubMedGoogle Scholar
• Smith AG, Lim W, Pearen M, Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells. Pigment Cell Melanoma Res 2011;24:551-63
   Google Scholar
• Sun Z, Cao X, Jiang MM, Inhibition of [beta]-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. Oncogene 2011; pubished online on October 10, 2011; doi: 10.1038/onc.2011.448
   Google Scholar
• Cho SD, Lee SO, Chintharlapalli S, Activation of nerve growth factor-induced B[alpha] by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. Mol Pharmacol 2010;77:396-404
   PubMed Web of Science ®Google Scholar
• Cho SD, Yoon K, Chintharlapalli S, Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and independent pathways. Cancer Res 2007;67:674-83
   PubMed Web of Science ®Google Scholar
• Lee SO, Abdelrahim M, Yoon K, Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer Res 2010;70:6824-36
   PubMed Web of Science ®Google Scholar
• Safe S, Kim K, Li X, NR4A orphan receptors and cancer. Nuclear Recept Signal 2011;9:e002
   Google Scholar
• Kolluri SK, Zhu X, Zhou X, A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell 2008;14:285-98
   PubMed Web of Science ®Google Scholar
• Luciano F, Krajewska M, Ortiz-Rubio P, Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. Blood 2007;109:3849-55
   PubMed Web of Science ®Google Scholar
• Yip KW, Godoi PH, Zhai D, A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors. J Biomol Screen 2008;13:665-73
   Google Scholar
• Ferlini C, Cicchillitti L, Raspaglio G, Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res 2009;69:6906-14
   PubMed Web of Science ®Google Scholar
• Zhan Y, Du X, Chen H, Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol 2008;4:548-56
   PubMed Web of Science ®Google Scholar
• Liu JJ, Zeng HN, Zhang LR, A unique pharmacophore for activation of the nuclear orphan receptor Nur77 in vivo and in vitro. Cancer Res 2010;70:3628-37
   PubMed Web of Science ®Google Scholar
• Lee SO, Li X, Khan S, Targeting NR4A1 (TR3) in cancer cells and tumors. Expert Opin Ther Targets 2011;15:195-206
   PubMed Web of Science ®Google Scholar
• Liu J, Zhou W, Li SS, Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues. Cancer Res 2008;68:8871-80
   PubMed Web of Science ®Google Scholar
• Chen YL, Jian MH, Lin CC, The induction of orphan nuclear receptor Nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma cell therapy. Mol Pharmacol 2008;74:1046-58
   PubMed Web of Science ®Google Scholar
• Lin PC, Chen YL, Chiu SC, Orphan nuclear receptor, Nurr-77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor. J Neurochem 2008;106:1017-26
   PubMed Web of Science ®Google Scholar
• Liu P, Sheu J, Lin P, Expression of Nur77 induced by an n -butylidenephthalide derivative promotes apoptosis and inhibits cell growth in oral squamous cell carcinoma. Invest New Drugs 2012;30:79-89
   PubMed Web of Science ®Google Scholar
• Chang LF, Lin PC, Ho LI, Overexpression of the orphan receptor Nur77 and its translocation induced by PCH4 may inhibit malignant glioma cell growth and induce cell apoptosis. J Surg Oncol 2011;103:442-50
   Google Scholar
• Yao LM, He JP, Chen HZ, Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis. Carcinogenesis 2012;33:301-11
   Google Scholar
• Kochel I, Rapak A, Ziolo E, Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004. Biochem Biophys Res Commun 2005;334:1102-6
   PubMed Web of Science ®Google Scholar
• Ke N, Claassen G, Yu DH, Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis. Cancer Res 2004;64:8208-12
   PubMed Web of Science ®Google Scholar
• Szafranska AE, Davison TS, John J, MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene 2007;26:4442-52
   PubMed Web of Science ®Google Scholar
• Ng YY, van Kessel B, Lokhorst HM, Gene-expression profiling of CD34+ cells from various hematopoietic stem-cell sources reveals functional differences in stem-cell activity. J Leukoc Biol 2004;75:314-23
   PubMedGoogle Scholar
• Panepucci RA, Calado RT, Rocha V, Higher expression of transcription targets and components of the nuclear factor-kappaB pathway is a distinctive feature of umbilical cord blood CD34+ precursors. Stem Cells 2007;25:189-96
   Google Scholar
• Fumoto T, Yamaguchi T, Hirose F, Orphan nuclear receptor Nur77 accelerates the initial phase of adipocyte differentiation in 3T3-L1 cells by promoting mitotic clonal expansion. J Biochem 2007;141:181-92
   PubMed Web of Science ®Google Scholar
• Au WS, Payne VA, O'Rahilly S, The NR4A family of orphan nuclear receptors are not required for adipogenesis. Int J Obes 2007;32:388-92
   Google Scholar
• Mullican SE, Zhang S, Konopleva M, Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat Med 2007;13:730-5
   PubMed Web of Science ®Google Scholar
• Maruoka H, Sasaya H, Shimamura Y, Dibutyryl-cAMP up-regulates nur77 expression via histone modification during neurite outgrowth in PC12 cells. J Biochem 2010;148:93-101
   Google Scholar
• Hanna RN, Carlin LM, Hubbeling HG, The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes. Nat Immunol 2011;12:778-85
   PubMed Web of Science ®Google Scholar
• Fassett M, Jiang WY, D'Alise AM, Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc Natl Acad Sci USA 2012;109:3891-6
   PubMed Web of Science ®Google Scholar
• Xu D, Huang YJ, Li Y, Orphan nuclear receptor Nur77 is required for the differentiation of C6 glioma cells induced by cholera toxin. Acta Pharmacol Sin 2009;30:1543-9
   Google Scholar
• Mu X, Chang C. TR3 orphan nuclear receptor mediates apoptosis through up-regulating E2F1 in human prostate cancer LNCaP cells. J Biol Chem 2003;278:42840-5
   Google Scholar
• Hiromura M, Suizu F, Narita M, Identification of nerve growth factor-responsive element of the TCL1 promoter as a novel negative regulatory element. J Biol Chem 2006;281:27753-64
   Google Scholar
• Pei L, Waki H, Vaitheesvaran B, NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med 2006;12:1048-55
   PubMed Web of Science ®Google Scholar
• Chao LC, Zhang Z, Pei L, Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle. Mol Endocrinol 2007;21:2152-63
   PubMedGoogle Scholar
• Pei L, Castrillo A, Tontonoz P. Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol Endocrinol 2006;20:786-94
   PubMed Web of Science ®Google Scholar
• You B, Jiang YY, Chen S, The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression. Circ Res 2009;104:742-9
   PubMed Web of Science ®Google Scholar
• Zhao Y, Liu Y, Zheng D. Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77. FEBS J 2008;275:1025-38
   PubMed Web of Science ®Google Scholar
• Gruber F, Hufnagl P, Hofer-Warbinek R, Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNF alpha -induced PAI-1 expression. Blood 2003;101:3042-8
   PubMed Web of Science ®Google Scholar
• Song KH. Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression. Biochem Biophys Res Commun 2010;392:63-6
   Google Scholar
• Robert NM, Martin LJ, Tremblay JJ. The orphan nuclear receptor NR4A1 regulates insulin-like 3 gene transcription in Leydig cells. Biol Reprod 2006;74:322-30
   Google Scholar
• Philips A, Maira M, Mullick A, Antagonism between Nur77 and glucocorticoid receptor for control of transcription. Mol Cell Biol 1997;17:5952-9
   PubMed Web of Science ®Google Scholar
• Martin LJ, Boucher N, Brousseau C, The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I. Mol Endocrinol 2008;22:2021-37
   PubMedGoogle Scholar
• Song KH, Park YY, Kee HJ, Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2. J Biol Chem 2006;281:15605-14
   PubMed Web of Science ®Google Scholar
• Liu S, Wu Q, Ye XF, Induction of apoptosis by TPA and VP-16 is through translocation of TR3. World J Gastroenterol 2002;8:446-50
   Google Scholar
• Wu Q, Liu S, Ye XF, Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells. Carcinogenesis 2002;23:1583-92
   PubMed Web of Science ®Google Scholar
• Yang H, Bushue N, Bu P, Induction and intracellular localization of Nur77 dictate fenretinide-induced apoptosis of human liver cancer cells. Biochem Pharmacol 2010;79:948-54
   PubMed Web of Science ®Google Scholar
• Yang H, Nie Y, Li Y, ERK1/2 deactivation enhances cytoplasmic Nur77 expression level and improves the apoptotic effect of fenretinide in human liver cancer cells. Biochem Pharmacol 2011;81:910-16
   Google Scholar
• Chintharlapalli S, Burghardt R, Papineni S, Activation of Nur77 by selected 1,1-bis(3′-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J Biol Chem 2005;280:24903-14
   PubMed Web of Science ®Google Scholar
• Chen JG, Fiskus W, Eaton K, Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77–based mechanism. Blood 2009;113:4038-48
   PubMed Web of Science ®Google Scholar