The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections

Bibliography

• Otto M. Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus. Annu Rev Microbiol 2010;64:143-62
   PubMed Web of Science ®Google Scholar
• DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated methicillin-resistant Staphylococcus aureus. Lancet 2010;375:1557-68
   PubMed Web of Science ®Google Scholar
• Daum RS. Clinical practice. Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N Engl J Med 2007;357:380-90
   PubMed Web of Science ®Google Scholar
• Lindsay JA, Holden MT. Staphylococcus aureus: superbug, super genome? Trends Microbiol 2004;12:378-85
   PubMed Web of Science ®Google Scholar
• Klevens RM, Morrison MA, Nadle J, Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 2007;298:1763-71
   PubMed Web of Science ®Google Scholar
• Moran GJ, Krishnadasan A, Gorwitz RJ, Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med 2006;355:666-74
   PubMed Web of Science ®Google Scholar
• Broughan J, Anderson R, Anderson AS. Strategies for and advances in the development of Staphylococcus aureus prophylactic vaccines. Expert Rev Vaccines 2011;10:695-708
   PubMed Web of Science ®Google Scholar
• Spellberg B, Daum R. Development of a vaccine against Staphylococcus aureus. Semin Immunopathol 2011;34:335-48
   Google Scholar
• Schaffer AC, Lee JC. Vaccination and passive immunisation against Staphylococcus aureus. Int J Antimicrob Agents 2008;32(Suppl 1):S71-8
   Google Scholar
• Dedent A, Kim HK, Missiakas D, Schneewind O. Exploring Staphylococcus aureus pathways to disease for vaccine development. Semin Immunopathol 2011;34:317-33
   Google Scholar
• Li M, Cheung GY, Hu J, Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains. J Infect Dis 2010;202:1866-76
   PubMed Web of Science ®Google Scholar
• Wang R, Braughton KR, Kretschmer D, Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 2007;13:1510-14
   PubMed Web of Science ®Google Scholar
• Bhakdi S, Tranum-Jensen J. Alpha-toxin of Staphylococcus aureus. Microbiol Rev 1991;55:733-51
   PubMedGoogle Scholar
• Cheung GY, Wang R, Khan BA, Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. Infect Immun 2011;79:1927-35
   PubMed Web of Science ®Google Scholar
• Diep BA, Otto M. The role of virulence determinants in community-associated MRSA pathogenesis. Trends Microbiol 2008;16:361-9
   PubMed Web of Science ®Google Scholar
• Novick RP. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol 2003;48:1429-49
   PubMed Web of Science ®Google Scholar
• Gillaspy AF, Hickmon SG, Skinner RA, Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis. Infect Immun 1995;63:3373-80
   PubMed Web of Science ®Google Scholar
• Cheung AL, Eberhardt KJ, Chung E, Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. J Clin Invest 1994;94:1815-22
   PubMed Web of Science ®Google Scholar
• Abdelnour A, Arvidson S, Bremell T, The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect Immun 1993;61:3879-85
   PubMed Web of Science ®Google Scholar
• Miller LS, Cho JS. Immunity against Staphylococcus aureus cutaneous infections. Nat Rev Immunol 2011;11:505-18
   PubMed Web of Science ®Google Scholar
• Graves SF, Kobayashi SD, DeLeo FR. Community-associated methicillin-resistant Staphylococcus aureus immune evasion and virulence. J Mol Med 2010;88:109-14
   PubMedGoogle Scholar
• DeLeo FR, Diep BA, Otto M. Host defense and pathogenesis in Staphylococcus aureus infections. Infect Dis Clin North Am 2009;23:17-34
   PubMed Web of Science ®Google Scholar
• Voyich JM, Braughton KR, Sturdevant DE, Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol 2005;175:3907-19
   PubMed Web of Science ®Google Scholar
• Ventura CL, Malachowa N, Hammer CH, Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics. PLoS One 2010;5:e11634
   PubMed Web of Science ®Google Scholar
• Dumont AL, Nygaard TK, Watkins RL, Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis. Mol Microbiol 2011;79:814-25
   PubMed Web of Science ®Google Scholar
• Kaneko J, Kamio Y. Bacterial two-component and hetero-heptameric pore-forming cytolytic toxins: structures, pore-forming mechanism, and organization of the genes. Biosci Biotechnol Biochem 2004;68:981-1003
   PubMed Web of Science ®Google Scholar
• Prevost G, Mourey L, Colin DA, Menestrina G. Staphylococcal pore-forming toxins. Curr Top Microbiol Immunol 2001;257:53-83
   PubMed Web of Science ®Google Scholar
• Morinaga N, Kaihou Y, Noda M. Purification, cloning and characterization of variant LukE-LukD with strong leukocidal activity of staphylococcal bi-component leukotoxin family. Microbiol Immunol 2003;47:81-90
   PubMed Web of Science ®Google Scholar
• Kaneko J, Muramoto K, Kamio Y. Gene of LukF-PV-like component of Panton-Valentine leukocidin in Staphylococcus aureus P83 is linked with lukM. Biosci Biotechnol Biochem 1997;61:541-4
   PubMed Web of Science ®Google Scholar
• Choorit W, Kaneko J, Muramoto K, Kamio Y. Existence of a new protein component with the same function as the LukF component of leukocidin or gamma-hemolysin and its gene in Staphylococcus aureus P83. FEBS Lett 1995;357:260-4
   Google Scholar
• von Eiff C, Friedrich AW, Peters G, Becker K. Prevalence of genes encoding for members of the staphylococcal leukotoxin family among clinical isolates of Staphylococcus aureus. Diagn Microbiol Infect Dis 2004;49:157-62
   Google Scholar
• Prevost G, Couppie P, Prevost P, Epidemiological data on Staphylococcus aureus strains producing synergohymenotropic toxins. J Med Microbiol 1995;42:237-45
   PubMed Web of Science ®Google Scholar
• Prevost G, Cribier B, Couppie P, Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities. Infect Immun 1995;63:4121-9
   PubMed Web of Science ®Google Scholar
• Rahman A, Izaki K, Kamio Y. Gamma-hemolysin genes in the same family with lukF and lukS genes in methicillin resistant Staphylococcus aureus. Biosci Biotechnol Biochem 1993;57:1234-6
   PubMed Web of Science ®Google Scholar
• Gravet A, Colin DA, Keller D, Characterization of a novel structural member, LukE-LukD, of the bi-component staphylococcal leucotoxins family. FEBS Lett 1998;436:202-8
   PubMed Web of Science ®Google Scholar
• Alonzo F III, Benson MA, Chen J, Staphylococcus aureus leukocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo. Mol Microbiol 2011;83:423-35
   Google Scholar
• Diep BA, Gill SR, Chang RF, Complete genome sequence of USA300, an epidemic clone of community-acquired methicillin-resistant Staphylococcus aureus. Lancet 2006;367:731-9
   PubMed Web of Science ®Google Scholar
• Otto M. A MRSA-terious enemy among us: end of the PVL controversy? Nat Med 2011;17:169-70
   PubMed Web of Science ®Google Scholar
• Otto M. Panton-Valentine leukocidin antibodies for the treatment of MRSA skin infections? Expert Rev Anti Infect Ther 2011;9:389-92
   PubMed Web of Science ®Google Scholar
• Vandenesch F, Naimi T, Enright MC, Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis 2003;9:978-84
   PubMed Web of Science ®Google Scholar
• del Giudice P, Blanc V, de Rougemont A, Primary skin abscesses are mainly caused by Panton-Valentine leukocidin-positive Staphylococcus aureus strains. Dermatology 2009;219:299-302
   Google Scholar
• Badiou C, Dumitrescu O, Croze M, Panton-Valentine leukocidin is expressed at toxic levels in human skin abscesses. Clin Microbiol Infect 2008;14:1180-3
   Google Scholar
• Labandeira-Rey M, Couzon F, Boisset S, Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science 2007;315:1130-3
   PubMed Web of Science ®Google Scholar
• Brown EL, Dumitrescu O, Thomas D, The Panton-Valentine leukocidin vaccine protects mice against lung and skin infections caused by Staphylococcus aureus USA300. Clin Microbiol Infect 2009;15:156-64
   Web of Science ®Google Scholar
• Tseng CW, Kyme P, Low J, Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLoS One 2009;4:e6387
   PubMed Web of Science ®Google Scholar
• Bubeck Wardenburg J, Schneewind O. Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med 2008;205:287-94
   PubMed Web of Science ®Google Scholar
• Villaruz AE, Bubeck Wardenburg J, Khan BA, A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation. J Infect Dis 2009;200:724-34
   PubMed Web of Science ®Google Scholar
• Olsen RJ, Kobayashi SD, Ayeras AA, Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates. Am J Pathol 2010;176:1346-54
   PubMed Web of Science ®Google Scholar
• Montgomery CP, Daum RS. Transcription of inflammatory genes in the lung after infection with community-associated methicillin-resistant Staphylococcus aureus: a role for Panton-Valentine leukocidin? Infect Immun 2009;77:2159-67
   PubMed Web of Science ®Google Scholar
• Voyich JM, Otto M, Mathema B, Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis 2006;194:1761-70
   PubMed Web of Science ®Google Scholar
• Nilsson IM, Hartford O, Foster T, Tarkowski A. Alpha-toxin and gamma-toxin jointly promote Staphylococcus aureus virulence in murine septic arthritis. Infect Immun 1999;67:1045-9
   PubMed Web of Science ®Google Scholar
• Supersac G, Piemont Y, Kubina M, Assessment of the role of gamma-toxin in experimental endophthalmitis using a hlg-deficient mutant of Staphylococcus aureus. Microb Pathog 1998;24:241-51
   PubMed Web of Science ®Google Scholar
• Thomas D, Chou S, Dauwalder O, Lina G. Diversity in Staphylococcus aureus enterotoxins. Chem Immunol Allergy 2007;93:24-41
   PubMedGoogle Scholar
• Wilson GJ, Seo KS, Cartwright RA, A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia. PLoS Pathog 2011;7:e1002271
   PubMed Web of Science ®Google Scholar
• Bachert C, Gevaert P, Zhang N, Role of staphylococcal superantigens in airway disease. Chem Immunol Allergy 2007;93:214-36
   Google Scholar
• Dinges MM, Orwin PM, Schlievert PM. Exotoxins of Staphylococcus aureus. Clin Microbiol Rev 2000;13:16-34
   PubMed Web of Science ®Google Scholar
• Dellabona P, Peccoud J, Kappler J, Superantigens interact with MHC class II molecules outside of the antigen groove. Cell 1990;62:1115-21
   PubMed Web of Science ®Google Scholar
• Choi YW, Kotzin B, Herron L, Interaction of Staphylococcus aureus toxin “superantigens” with human T cells. Proc Natl Acad Sci USA 1989;86:8941-5
   PubMed Web of Science ®Google Scholar
• Fraser JD, Proft T. The bacterial superantigen and superantigen-like proteins. Immunol Rev 2008;225:226-43
   PubMed Web of Science ®Google Scholar
• Langford MP, Stanton GJ, Johnson HM. Biological effects of staphylococcal enterotoxin A on human peripheral lymphocytes. Infect Immun 1978;22:62-8
   PubMed Web of Science ®Google Scholar
• Drake CG, Kotzin BL. Superantigens: biology, immunology, and potential role in disease. J Clin Immunol 1992;12:149-62
   PubMed Web of Science ®Google Scholar
• Ono HK, Omoe K, Imanishi K, Identification and characterization of two novel staphylococcal enterotoxins, types S and T. Infect Immun 2008;76:4999-5005
   PubMed Web of Science ®Google Scholar
• Fitzgerald JR, Monday SR, Foster TJ, Characterization of a putative pathogenicity island from bovine Staphylococcus aureus encoding multiple superantigens. J Bacteriol 2001;183:63-70
   PubMed Web of Science ®Google Scholar
• Johns MB Jr, Khan SA. Staphylococcal enterotoxin B gene is associated with a discrete genetic element. J Bacteriol 1988;170:4033-9
   PubMed Web of Science ®Google Scholar
• Schmitz FJ, MacKenzie CR, Geisel R, Enterotoxin and toxic shock syndrome toxin-1 production of methicillin resistant and methicillin sensitive Staphylococcus aureus strains. Eur J Epidemiol 1997;13:699-708
   Google Scholar
• Baba T, Takeuchi F, Kuroda M, Genome and virulence determinants of high virulence community-acquired MRSA. Lancet 2002;359:1819-27
   PubMed Web of Science ®Google Scholar
• Czop JK, Bergdoll MS. Staphylococcal enterotoxin synthesis during the exponential, transitional, and stationary growth phases. Infect Immun 1974;9:229-35
   PubMedGoogle Scholar
• Gaskill ME, Khan SA. Regulation of the enterotoxin B gene in Staphylococcus aureus. J Biol Chem 1988;263:6276-80
   Google Scholar
• Regassa LB, Couch JL, Betley MJ. Steady-state staphylococcal enterotoxin type C mRNA is affected by a product of the accessory gene regulator (agr) and by glucose. Infect Immun 1991;59:955-62
   PubMed Web of Science ®Google Scholar
• Munson SH, Tremaine MT, Betley MJ, Welch RA. Identification and characterization of staphylococcal enterotoxin types G and I from Staphylococcus aureus. Infect Immun 1998;66:3337-48
   PubMed Web of Science ®Google Scholar
• Tremaine MT, Brockman DK, Betley MJ. Staphylococcal enterotoxin A gene (sea) expression is not affected by the accessory gene regulator (agr). Infect Immun 1993;61:356-9
   Google Scholar
• Schlievert PM, Blomster DA. Production of staphylococcal pyrogenic exotoxin type C: influence of physical and chemical factors. J Infect Dis 1983;147:236-42
   Google Scholar
• Tseng CW, Zhang S, Stewart GC. Accessory gene regulator control of staphyloccoccal enterotoxin d gene expression. J Bacteriol 2004;186:1793-801
   Google Scholar
• Andrey DO, Renzoni A, Monod A, Control of the Staphylococcus aureus toxic shock tst promoter by the global regulator SarA. J Bacteriol 2010;192:6077-85
   Google Scholar
• Kusch K, Hanke K, Holtfreter S, The influence of SaeRS and sigma(B) on the expression of superantigens in different Staphylococcus aureus isolates. Int J Med Microbiol 2011;301:488-99
   PubMed Web of Science ®Google Scholar
• Vojtov N, Ross HF, Novick RP. Global repression of exotoxin synthesis by staphylococcal superantigens. Proc Natl Acad Sci USA 2002;99:10102-7
   Google Scholar
• Neumann B, Engelhardt B, Wagner H, Holzmann B. Induction of acute inflammatory lung injury by staphylococcal enterotoxin B. J Immunol 1997;158:1862-71
   Google Scholar
• Strandberg KL, Rotschafer JH, Vetter SM, Staphylococcal superantigens cause lethal pulmonary disease in rabbits. J Infect Dis 2010;202:1690-7
   Google Scholar
• De Boer ML, Kum WW, Chow AW. Staphylococcus aureus isogenic mutant, deficient in toxic shock syndrome toxin-1 but not staphylococcal enterotoxin A production, exhibits attenuated virulence in a tampon-associated vaginal infection model of toxic shock syndrome. Can J Microbiol 1999;45:250-6
   PubMed Web of Science ®Google Scholar
• Abdelnour A, Bremell T, Tarkowski A. Toxic shock syndrome toxin 1 contributes to the arthritogenicity of Staphylococcus aureus. J Infect Dis 1994;170:94-9
   Google Scholar
• de Azavedo JC, Foster TJ, Hartigan PJ, Expression of the cloned toxic shock syndrome toxin 1 gene (tst) in vivo with a rabbit uterine model. Infect Immun 1985;50:304-9
   Google Scholar
• Zhang S, Stewart GC. Characterization of the promoter elements for the staphylococcal enterotoxin D gene. J Bacteriol 2000;182:2321-5
   PubMed Web of Science ®Google Scholar
• Xiong YQ, Willard J, Yeaman MR, Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis. J Infect Dis 2006;194:1267-75
   PubMed Web of Science ®Google Scholar
• Liang X, Ji Y. Alpha-toxin interferes with integrin-mediated adhesion and internalization of Staphylococcus aureus by epithelial cells. Cell Microbiol 2006;8:1656-68
   Google Scholar
• Walev I, Martin E, Jonas D, Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions. Infect Immun 1993;61:4972-9
   PubMed Web of Science ®Google Scholar
• Thelestam M, Mollby R, Wadstrom T. Effects of staphylococcal alpha-, beta-, delta-, and gamma-hemolysins on human diploid fibroblasts and HeLa cells: evaluation of a new quantitative as say for measuring cell damage. Infect Immun 1973;8:938-46
   PubMedGoogle Scholar
• Ezepchuk YV, Leung DY, Middleton MH, Staphylococcal toxins and protein A differentially induce cytotoxicity and release of tumor necrosis factor-alpha from human keratinocytes. J Invest Dermatol 1996;107:603-9
   PubMed Web of Science ®Google Scholar
• Valeva A, Walev I, Pinkernell M, Transmembrane beta-barrel of staphylococcal alpha-toxin forms in sensitive but not in resistant cells. Proc Natl Acad Sci USA 1997;94:11607-11
   Google Scholar
• Hocke AC, Temmesfeld-Wollbrueck B, Schmeck B, Perturbation of endothelial junction proteins by Staphylococcus aureus alpha-toxin: inhibition of endothelial gap formation by adrenomedullin. Histochem Cell Biol 2006;126:305-16
   Google Scholar
• Bartlett AH, Foster TJ, Hayashida A, Park PW. Alpha-toxin facilitates the generation of CXC chemokine gradients and stimulates neutrophil homing in Staphylococcus aureus pneumonia. J Infect Dis 2008;198:1529-35
   PubMed Web of Science ®Google Scholar
• Inoshima I, Inoshima N, Wilke GA, A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med 2011;17:1310-14
   PubMed Web of Science ®Google Scholar
• Wilke GA, Bubeck Wardenburg J. Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury. Proc Natl Acad Sci USA 2010;107:13473-8
   PubMed Web of Science ®Google Scholar
• Bubeck Wardenburg J, Patel RJ, Schneewind O. Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia. Infect Immun 2007;75:1040-4
   PubMed Web of Science ®Google Scholar
• Bubeck Wardenburg J, Bae T, Otto M, Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med 2007;13:1405-6
   PubMed Web of Science ®Google Scholar
• Kebaier C, Chamberland RR, Allen IC, Staphylococcus aureus alpha-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome. J Infect Dis 2012;205:807-17
   Google Scholar
• Davis BK, Wen H, Ting JP. The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol 2011;29:707-35
   PubMed Web of Science ®Google Scholar
• Mariathasan S, Weiss DS, Newton K, Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006;440:228-32
   PubMed Web of Science ®Google Scholar
• Munoz-Planillo R, Franchi L, Miller LS, Nunez G. A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the NLRP3 inflammasome. J Immunol 2009;183:3942-8
   Google Scholar
• Kretschmer D, Gleske AK, Rautenberg M, Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus. Cell Host Microbe 2010;7:463-73
   PubMed Web of Science ®Google Scholar
• Queck SY, Jameson-Lee M, Villaruz AE, RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell 2008;32:150-8
   PubMed Web of Science ®Google Scholar
• Chatterjee SS, Chen L, Joo HS, Distribution and regulation of the mobile genetic element-encoded phenol-soluble modulin psm-mec in methicillin-resistant Staphylococcus aureus. PLoS One 2011;6:e28781
   PubMed Web of Science ®Google Scholar
• Janzon L, Lofdahl S, Arvidson S. Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus. Mol Gen Genet 1989;219:480-5
   Google Scholar
• Queck SY, Khan BA, Wang R, Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA. PLoS Pathog 2009;5:e1000533
   PubMed Web of Science ®Google Scholar
• Periasamy S, Joo HS, Duong AC, How Staphylococcus aureus biofilms develop their characteristic structure. Proc Natl Acad Sci USA 2012;109:1281-6
   PubMed Web of Science ®Google Scholar
• Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 1999;284:1318-22
   PubMed Web of Science ®Google Scholar
• Mellor IR, Thomas DH, Sansom MS. Properties of ion channels formed by Staphylococcus aureus delta-toxin. Biochim Biophys Acta 1988;942:280-94
   PubMed Web of Science ®Google Scholar
• Wang R, Khan BA, Cheung GY, Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. J Clin Invest 2011;121:238-48
   PubMed Web of Science ®Google Scholar
• Cheung GY, Otto M. Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins: implications for diagnosis and pathogenesis. Microbes Infect 2011
   Google Scholar
• Giese B, Glowinski F, Paprotka K, Expression of delta-toxin by Staphylococcus aureus mediates escape from phago-endosomes of human epithelial and endothelial cells in the presence of beta-toxin. Cell Microbiol 2011;13:316-29
   PubMedGoogle Scholar
• Hongo I, Baba T, Oishi K, Phenol-soluble modulin alpha 3 enhances the human neutrophil lysis mediated by Panton-Valentine leukocidin. J Infect Dis 2009;200:715-23
   PubMed Web of Science ®Google Scholar
• Coleman DC, Arbuthnott JP, Pomeroy HM, Birkbeck TH. Cloning and expression in Escherichia coli and Staphylococcus aureus of the beta-lysin determinant from Staphylococcus aureus: evidence that bacteriophage conversion of beta-lysin activity is caused by insertional inactivation of the beta-lysin determinant. Microb Pathog 1986;1:549-64
   Google Scholar
• Peacock SJ, Justice A, Griffiths D, Determinants of acquisition and carriage of Staphylococcus aureus in infancy. J Clin Microbiol 2003;41:5718-25
   PubMed Web of Science ®Google Scholar
• Lebon A, Labout JA, Verbrugh HA, Dynamics and determinants of Staphylococcus aureus carriage in infancy: the Generation R Study. J Clin Microbiol 2008;46:3517-21
   PubMed Web of Science ®Google Scholar
• Wertheim HF, Melles DC, Vos MC, The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis 2005;5:751-62
   PubMed Web of Science ®Google Scholar
• Croze M, Dauwalder O, Dumitrescu O, Serum antibodies against Panton-Valentine leukocidin in a normal population and during Staphylococcus aureus infection. Clin Microbiol Infect 2009;15:144-8
   PubMed Web of Science ®Google Scholar
• Colque-Navarro P, Jacobsson G, Andersson R, Levels of antibody against 11 Staphylococcus aureus antigens in a healthy population. Clin Vaccine Immunol 2010;17:1117-23
   PubMed Web of Science ®Google Scholar
• Verkaik NJ, de Vogel CP, Boelens HA, Anti-staphylococcal humoral immune response in persistent nasal carriers and noncarriers of Staphylococcus aureus. J Infect Dis 2009;199:625-32
   PubMed Web of Science ®Google Scholar
• Holtfreter S, Kolata J, Broker BM. Towards the immune proteome of Staphylococcus aureus - The anti-S. aureus antibody response. Int J Med Microbiol 2010;300:176-92
   PubMed Web of Science ®Google Scholar
• Verkaik NJ, Dauwalder O, Antri K, Immunogenicity of toxins during Staphylococcus aureus infection. Clin Infect Dis 2010;50:61-8
   PubMed Web of Science ®Google Scholar
• Jacobsson G, Colque-Navarro P, Gustafsson E, Antibody responses in patients with invasive Staphylococcus aureus infections. Eur J Clin Microbiol Infect Dis 2010;29:715-25
   PubMed Web of Science ®Google Scholar
• Hermos CR, Yoong P, Pier GB. High levels of antibody to panton-valentine leukocidin are not associated with resistance to Staphylococcus aureus-associated skin and soft-tissue infection. Clin Infect Dis 2010;51:1138-46
   PubMed Web of Science ®Google Scholar
• Holtfreter S, Roschack K, Eichler P, Staphylococcus aureus carriers neutralize superantigens by antibodies specific for their colonizing strain: a potential explanation for their improved prognosis in severe sepsis. J Infect Dis 2006;193:1275-8
   Google Scholar
• Grumann D, Ruotsalainen E, Kolata J, Characterization of infecting strains and superantigen-neutralizing antibodies in Staphylococcus aureus bacteremia. Clin Vaccine Immunol 2011;18:487-93
   PubMed Web of Science ®Google Scholar
• Laventie BJ, Rademaker HJ, Saleh M, Heavy chain-only antibodies and tetravalent bispecific antibody neutralizing Staphylococcus aureus leukotoxins. Proc Natl Acad Sci USA 2011;108:16404-9
   PubMed Web of Science ®Google Scholar
• Gauduchon V, Cozon G, Vandenesch F, Neutralization of Staphylococcus aureus Panton-Valentine leukocidin by intravenous immunoglobulin in vitro. J Infect Dis 2004;189:346-53
   PubMed Web of Science ®Google Scholar
• Loffler B, Hussain M, Grundmeier M, Staphylococcus aureus Panton-Valentine leukocidin is a very potent cytotoxic factor for human neutrophils. PLoS Pathog 2010;6:e1000715
   PubMed Web of Science ®Google Scholar
• Yoong P, Pier GB. Antibody-mediated enhancement of community-acquired methicillin-resistant Staphylococcus aureus infection. Proc Natl Acad Sci USA 2010;107:2241-6
   PubMed Web of Science ®Google Scholar
• Cribier B, Prevost G, Couppie P, Staphylococcus aureus leukocidin: a new virulence factor in cutaneous infections? An epidemiological and experimental study. Dermatology 1992;185:175-80
   PubMedGoogle Scholar
• ClinicalTrials.gov; A service of the U.S. National Institutes of Health. Staphylococcus aureus Toxoids Phase 1–2 Vaccine Trial. Available from: http://clinicaltrials.gov/ct2/show/NCT01011335
   Google Scholar
• Takei S, Arora YK, Walker SM. Intravenous immunoglobulin contains specific antibodies inhibitory to activation of T cells by staphylococcal toxin superantigens. J Clin Invest 1993;91:602-7
   PubMed Web of Science ®Google Scholar
• Holtfreter S, Bauer K, Thomas D, egc-Encoded superantigens from Staphylococcus aureus are neutralized by human sera much less efficiently than are classical staphylococcal enterotoxins or toxic shock syndrome toxin. Infect Immun 2004;72:4061-71
   PubMed Web of Science ®Google Scholar
• Burian M, Grumann D, Holtfreter S, Expression of staphylococcal superantigens during nasal colonization is not sufficient to induce a systemic neutralizing antibody response in humans. Eur J Clin Microbiol Infect Dis 2011;31:251-6
   Google Scholar
• Rusnak JM, Kortepeter M, Ulrich R, Laboratory exposures to staphylococcal enterotoxin B. Emerg Infect Dis 2004;10:1544-9
   PubMed Web of Science ®Google Scholar
• Gill DM. Bacterial toxins: a table of lethal amounts. Microbiol Rev 1982;46:86-94
   PubMedGoogle Scholar
• Tilahun ME, Rajagopalan G, Shah-Mahoney N, Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies. Infect Immun 2010;78:2801-11
   Google Scholar
• Varshney AK, Wang X, Cook E, Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. J Biol Chem 2011;286:9737-47
   PubMed Web of Science ®Google Scholar
• LeClaire RD, Hunt RE, Bavari S. Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination. Infect Immun 2002;70:2278-81
   PubMed Web of Science ®Google Scholar
• Kum WW, Chow AW. Inhibition of staphylococcal enterotoxin A-induced superantigenic and lethal activities by a monoclonal antibody to toxic shock syndrome toxin-1. J Infect Dis 2001;183:1739-48
   Google Scholar
• Boles JW, Pitt ML, LeClaire RD, Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity. Clin Immunol 2003;108:51-9
   PubMed Web of Science ®Google Scholar
• Hu DL, Omoe K, Narita K, Intranasal vaccination with a double mutant of staphylococcal enterotoxin C provides protection against Staphylococcus aureus infection. Microbes Infect 2006;8:2841-8
   PubMed Web of Science ®Google Scholar
• Hu DL, Omoe K, Sasaki S, Vaccination with nontoxic mutant toxic shock syndrome toxin 1 protects against Staphylococcus aureus infection. J Infect Dis 2003;188:743-52
   PubMed Web of Science ®Google Scholar
• Buonpane RA, Churchill HR, Moza B, Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists. Nat Med 2007;13:725-9
   PubMedGoogle Scholar
• Hong-Geller E, Mollhoff M, Shiflett PR, Gupta G. Design of chimeric receptor mimics with different TcRVbeta isoforms. Type-specific inhibition of superantigen pathogenesis. J Biol Chem 2004;279:5676-84
   Google Scholar
• Tkaczyk C, Hua L, Varkey R, Identification of anti-alpha toxin mAbs that reduce severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency. Clin Vaccine Immunol 2012;19:377-85
   PubMed Web of Science ®Google Scholar
• Kennedy AD, Bubeck Wardenburg J, Gardner DJ, Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model. J Infect Dis 2010;202:1050-8
   PubMed Web of Science ®Google Scholar
• Ragle BE, Bubeck Wardenburg J. Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia. Infect Immun 2009;77:2712-18
   PubMed Web of Science ®Google Scholar
• Brown EL, Bowden MG, Bryson RS, Pediatric antibody response to community-acquired Staphylococcus aureus infection is directed to Panton-Valentine leukocidin. Clin Vaccine Immunol 2009;16:139-41
   PubMedGoogle Scholar
• Nolte FS, Kapral FA. Immunogenicity of Staphylococcus aureus delta-toxin. Infect Immun 1981;31:1251-60
   Google Scholar
• Otto M. Novel targeted immunotherapy approaches for staphylococcal infection. Expert Opin Biol Ther 2010;10:1049-59
   PubMed Web of Science ®Google Scholar
• Leysath CE, Chen KH, Moayeri M, Mouse monoclonal antibodies to anthrax edema factor protect against infection. Infect Immun 2011;79:4609-16
   PubMed Web of Science ®Google Scholar
• Cheng LW, Stanker LH, Henderson TD II, Antibody protection against botulinum neurotoxin intoxication in mice. Infect Immun 2009;77:4305-13
   Google Scholar
• Babcock GJ, Broering TJ, Hernandez HJ, Human monoclonal antibodies directed against toxins A and B prevent Clostridium difficile-induced mortality in hamsters. Infect Immun 2006;74:6339-47
   PubMed Web of Science ®Google Scholar
• Deresinski S, Herrera V. Immunotherapies for Staphylococcus aureus: current challenges and future prospects. Infect Control Hosp Epidemiol 2010;31(Suppl 1):S45-7
   Google Scholar