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Class 3 semaphorins as a therapeutic target

, MD PhD, , &
Pages 933-944 | Published online: 26 Jul 2012

Bibliography

  • Wadsworth WG, Hedgecock EM. Guidance of neuroblast migrations and axonal projections in Caenorhabditis elegans. Curr Opin Neurobiol 1992;2(1):36-41
  • Culotti JG. Axon guidance mechanisms in caenorhabditis elegans. Curr Opin Genet Dev 1994;4(4):587-95
  • Kolodkin AL, Matthes DJ, O'Connor TP, Fasciclin IV: sequence, expression, and function during growth cone guidance in the grasshopper embryo. Neuron 1992;9(5):831-45
  • Grenningloh G, Goodman CS. Pathway recognition by neuronal growth cones: genetic analysis of neural cell adhesion molecules in Drosophila. Curr Opin Neurobiol 1992;2(1):42-7
  • Raper JA. Semaphorins and their receptors in vertebrates and invertebrates. Curr Opin Neurobiol 2000;10(1):88-94
  • Tessier-Lavigne M, Goodman CS. The molecular biology of axon guidance. Science 1996;274(5290):1123-33
  • Yazdani U, Terman JR. The semaphorins. Genome Biol 2006;7(3):211
  • He Z, Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 1997;90(4):739-51
  • Fujisawa H. Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development. J Neurobiol 2004;59(1):24-33
  • Takahashi T, Fournier A, Nakamura F, Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 1999;99(1):59-69
  • Tamagnone L, Artigiani S, Chen H, Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 1999;99(1):71-80
  • Kolodkin AL, Levengood DV, Rowe EG, Neuropilin is a semaphorin III receptor. Cell 1997;90(4):753-62
  • Goshima Y, Sasaki Y, Nakayama T, Functions of semaphorins in axon guidance and neuronal regeneration. Jpn J Pharmacol 2000;82(4):273-9
  • Tamagnone L, Comoglio PM. Signalling by semaphorin receptors: cell guidance and beyond. Trends Cell Biol 2000;10(9):377-83
  • Takamatsu H, Kumanogoh A. Diverse roles for semaphorin-plexin signaling in the immune system. Trends Immunol 2012;33(3):127-35
  • Goshima Y, Ito T, Sasaki Y, Nakamura F. Semaphorins as signals for cell repulsion and invasion. J Clin Invest 2002;109(8):993-8
  • Neufeld G, Kessler O. The semaphorins: versatile regulators of tumour progression and tumour angiogenesis. Nat Rev Cancer 2008;8(8):632-45
  • Kaneko S, Iwanami A, Nakamura M, A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat Med 2006;12(12):1380-9
  • Sawaki H, Nakamura F, Aihara M, Intranasal administration of semaphorin-3A alleviates sneezing and nasal rubbing in a murine model of allergic rhinitis. J Pharmacol Sci 2011;117(1):34-44
  • Shirvan A, Kimron M, Holdengreber V, Anti-semaphorin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy. J Biol Chem 2002;277(51):49799-807
  • Hayashi M, Nakashima T, Taniguchi M, Osteoprotection by semaphorin. 3A. Nature 2012;485(7396):69-74
  • Casazza A, Fu X, Johansson I, Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models. Arterioscler Thromb Vasc Biol 31(4):741-9
  • Zhou Y, Gunput RA, Pasterkamp RJ. Semaphorin signaling: progress made and promises ahead. Trends Biochem Sci 2008;33(4):161-70
  • Antipenko A, Himanen JP, van Leyen K, Structure of the semaphorin-3A receptor binding module. Neuron 2003;39(4):589-98
  • Appleton BA, Wu P, Maloney J, Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding. EMBO J 2007;26(23):4902-12
  • Nogi T, Yasui N, Mihara E, Structural basis for semaphorin signalling through the plexin receptor. Nature 2011;467(7319):1123-7
  • Janssen BJ, Robinson RA, Perez-Branguli F, Structural basis of semaphorin-plexin signalling. Nature 2010;467(7319):1118-22
  • Massa SM, Yang T, Xie Y, Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest 2010;120(5):1774-85
  • Cazorla M, Premont J, Mann A, Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest 2011;121(5):1846-57
  • He H, Yang T, Terman JR, Zhang X. Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration. Proc Natl Acad Sci USA 2009;106(37):15610-15
  • Oinuma I, Katoh H, Negishi M. Molecular dissection of the semaphorin 4D receptor plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neurons. J Neurosci 2004;24(50):11473-80
  • Toyofuku T, Yoshida J, Sugimoto T, FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat Neurosci 2005;8(12):1712-19
  • Aizawa H, Wakatsuki S, Ishii A, Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nat Neurosci 2001;4(4):367-73
  • Song H, Ming G, He Z, Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science 1998;281(5382):1515-18
  • Sasaki Y, Cheng C, Uchida Y, Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 2002;35(5):907-20
  • Uchida Y, Ohshima T, Sasaki Y, Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells 2005;10(2):165-79
  • Hung RJ, Yazdani U, Yoon J, Mical links semaphorins to F-actin disassembly. Nature 2011;463(7282):823-7
  • Lyness SA, Zarow C, Chui HC. Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis. Neurobiol Aging 2003;24(1):1-23
  • Schwartz M, Yoles E, Levin LA. 'Axogenic' and 'somagenic' neurodegenerative diseases: definitions and therapeutic implications. Mol Med Today 1999;5(11):470-3
  • Good PF, Alapat D, Hsu A, A role for semaphorin 3A signaling in the degeneration of hippocampal neurons during Alzheimer's disease. J Neurochem 2004;91(3):716-36
  • Cole AR, Noble W, van Aalten L, Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem 2007;103(3):1132-44
  • De Winter F, Vo T, Stam FJ, The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease. Mol Cell Neurosci 2006;32(1-2):102-17
  • Duplan L, Bernard N, Casseron W, Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death. J Neurosci 2010;30(2):785-96
  • Yamashita N, Goshima Y. Collapsin response mediator proteins regulate neuronal development and plasticity by switching their phosphorylation status. Mol Neurobiol 2012;45(2):234-46
  • Morita A, Yamashita N, Sasaki Y, Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling. J Neurosci 2006;26(11):2971-80
  • Sahay A, Kim CH, Sepkuty JP, Secreted semaphorins modulate synaptic transmission in the adult hippocampus. J Neurosci 2005;25(14):3613-20
  • Yamashita N, Morita A, Uchida Y, Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1. J Neurosci 2007;27(46):12546-54
  • Barnes G, Puranam RS, Luo Y, McNamara JO. Temporal specific patterns of semaphorin gene expression in rat brain after kainic acid-induced status epilepticus. Hippocampus 2003;13(1):1-20
  • Gant JC, Thibault O, Blalock EM, Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy. Epilepsia 2009;50(4):629-45
  • Holtmaat AJ, Gorter JA, De Wit J, Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. A novel molecular event potentially contributing to mossy fiber sprouting. Exp Neurol 2003;182(1):142-50
  • De Winter F, Oudega M, Lankhorst AJ, Injury-induced class 3 semaphorin expression in the rat spinal cord. Exp Neurol 2002;175(1):61-75
  • Hou ST, Keklikian A, Slinn J, Sustained up-regulation of semaphorin 3A, Neuropilin1, and doublecortin expression in ischemic mouse brain during long-term recovery. Biochem Biophys Res Commun 2008;367(1):109-15
  • Montolio M, Messeguer J, Masip I, A semaphorin 3A inhibitor blocks axonal chemorepulsion and enhances axon regeneration. Chem Biol 2009;16(7):691-701
  • Williams A, Piaton G, Aigrot MS, Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?. Brain 2007;130(Pt 10):2554-65
  • Syed YA, Hand E, Mobius W, Inhibition of CNS remyelination by the presence of semaphorin 3A. J Neurosci 2011;31(10):3719-28
  • Roodink I, Kats G, van Kempen L, Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression. Am J Pathol 2008;173(6):1873-81
  • Herman JG, Meadows GG. Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells. Int J Oncol 2007;30(5):1231-8
  • Chakraborty G, Kumar S, Mishra R, Semaphorin 3A Suppresses Tumor Growth and Metastasis in Mice Melanoma Model. PLoS One 2012;7(3):e33633
  • Wu F, Zhou Q, Yang J, Endogenous axon guiding chemorepulsant semaphorin-3F inhibits the growth and metastasis of colorectal carcinoma. Clin Cancer Res 2011;17(9):2702-11
  • Bagci T, Wu JK, Pfannl R, Autocrine semaphorin 3A signaling promotes glioblastoma dispersal. Oncogene 2009;28(40):3537-50
  • Pan H, Wanami LS, Dissanayake TR, Bachelder RE. Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells. Breast Cancer Res Treat 2009;118(1):197-205
  • Staton CA, Shaw LA, Valluru M, Expression of class 3 semaphorins and their receptors in human breast neoplasia. Histopathology 2011:59(2):274-82
  • Yacoub M, Coulon A, Celhay O, Differential expression of the semaphorin 3A pathway in prostatic cancer. Histopathology 2009;55(4):392-8
  • Pan H, Bachelder RE. Autocrine Semaphorin3A stimulates eukaryotic initiation factor 4E-dependent RhoA translation in breast tumor cells. Exp Cell Res 2010;316(17):2825-32
  • Wong OG, Nitkunan T, Oinuma I, Plexin-B1 mutations in prostate cancer. Proc Natl Acad Sci USA 2007;104(48):19040-5
  • Xiang RH, Hensel CH, Garcia DK, Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer. Genomics 1996;32(1):39-48
  • Blanc V, Nariculam J, Munson P, A role for class 3 semaphorins in prostate cancer. Prostate 2011;71(6):649-58
  • Gaur P, Bielenberg DR, Samuel S, Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis. Clin Cancer Res 2009;15(22):6763-70
  • Nguyen QD, Rodrigues S, Rodrigue CM, Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts. Mol Cancer Ther 2006;5(8):2070-7
  • Barresi V, Vitarelli E, Cerasoli S. Semaphorin3A immunohistochemical expression in human meningiomas: correlation with the microvessel density. Virchows Arch 2009;454(5):563-71
  • Maione F, Capano S, Regano D, Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice. J Clin Invest 2012;122(5):1832-48
  • Bachelder RE, Lipscomb EA, Lin X, Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer Res 2003;63(17):5230-3
  • Muller MW, Giese NA, Swiercz JM, Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer. Int J Cancer 2007;121(11):2421-33
  • Kigel B, Varshavsky A, Kessler O, Neufeld G. Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. PLoS One 2008;3(9):e3287
  • Kagoshima M, Ito T. Diverse gene expression and function of semaphorins in developing lung: positive and negative regulatory roles of semaphorins in lung branching morphogenesis. Genes Cells 2001;6(6):559-71
  • Tedeschi A, Nguyen T, Steele SU, The tumor suppressor p53 transcriptionally regulates cGKI expression during neuronal maturation and is required for cGMP-dependent growth cone collapse. J Neurosci 2009;29(48):15155-60
  • Pan SH, Chao YC, Hung PF, The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1. J Clin Invest 2011;121(8):3189-205
  • Shih JY, Yang SC, Hong TM, Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. J Natl Cancer Inst 2001;93(18):1392-400
  • Takamatsu H, Takegahara N, Nakagawa Y, Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. Nat Immunol 2011;11(7):594-600
  • Kikutani H, Kumanogoh A. Semaphorins in interactions between T cells and antigen-presenting cells. Nat Rev Immunol 2003;3(2):159-67
  • Zhang L, Schmidt RE, Yan Q, Snider WD. NGF and NT-3 have differing effects on the growth of dorsal root axons in developing mammalian spinal cord. J Neurosci 1994;14(9):5187-201
  • Messersmith EK, Leonardo ED, Shatz CJ, Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord. Neuron 1995;14(5):949-59
  • Yamaguchi J, Nakamura F, Aihara M, Semaphorin3A alleviates skin lesions and scratching behavior in NC/Nga mice, an atopic dermatitis model. J Invest Dermatol 2008;128(12):2842-9
  • Tominaga M, Ogawa H, Takamori K. Decreased production of semaphorin 3A in the lesional skin of atopic dermatitis. Br J Dermatol 2008;158(4):842-4
  • Negi O, Tominaga M, Tengara S, Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. J Dermatol Sci 2012;66(1):37-43
  • Okawa T, Yamaguchi Y, Takada S, Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model. J Dermatol Sci 2012;66(2):136-43
  • Tominaga M, Tengara S, Kamo A, Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis. J Dermatol Sci 2009;55(1):40-6
  • Catalano A, Caprari P, Moretti S, Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function. Blood 2006;107(8):3321-9
  • Lepelletier Y, Moura IC, Hadj-Slimane R, Immunosuppressive role of semaphorin-3A on T cell proliferation is mediated by inhibition of actin cytoskeleton reorganization. Eur J Immunol 2006;36(7):1782-93
  • Lepelletier Y, Smaniotto S, Hadj-Slimane R, Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions. Proc Natl Acad Sci USA 2007;104(13):5545-50
  • Sarris M, Andersen KG, Randow F, Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity 2008;28(3):402-13
  • Togari A, Mogi M, Arai M, Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts. Brain Res 2000;878(1-2):204-9
  • Hida T YN, Usui H, Nakamura F, GSK3beta/Axin-1/beta-Catenin complex is involved in semaphorin3A signaling. J Neurosci 2012; in press
  • Joyal JS, Sitaras N, Binet F, Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood 2011;117(22):6024-35
  • Vacca A, Scavelli C, Serini G, Loss of inhibitory semaphorin 3A (SEMA3A) autocrine loops in bone marrow endothelial cells of patients with multiple myeloma. Blood 2006;108(5):1661-7
  • Ueyama H, Horibe T, Nakajima O, Semaphorin 3A lytic hybrid peptide binding to neuropilin-1 as a novel anti-cancer agent in pancreatic cancer. Biochem Biophys Res Commun 2011;414(1):60-6
  • Catalano A. The neuroimmune semaphorin-3A reduces inflammation and progression of experimental autoimmune arthritis. J Immunol 2010;185(10):6373-83
  • Wen H, Lei Y, Eun SY, Ting JP. Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm. J Exp Med 2010;207(13):2943-57
  • Wen HZ, Jiang H, Li L, Semaphorin 3A attenuates electrical remodeling at infarct border zones in rats after myocardial infarction. Tohoku J Exp Med 2011;225(1):51-7

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