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The expanding role of IL-7 and thymic stromal lymphopoietin as therapeutic target for rheumatoid arthritis

Bibliography

  • Sharma P, Pathak K. Are biological targets the final goal for rheumatoid arthritis therapy? Expert Opin Biol Ther 2012;12:1611-22
  • Choy EH, Pitzalis C, Cauli A, et al. Percentage of anti-CD4 monoclonal antibody-coated lymphocytes in the rheumatoid joint is associated with clinical improvement. Implications for the development of immunotherapeutic dosing regimens. Arthritis Rheum 1996;39:52-6
  • Yudoh K, Matsuno H, Nakazawa F, et al. Reduced expression of the regulatory CD4+ T cell subset is related to Th1/Th2 balance and disease severity in rheumatoid arthritis. Arthritis Rheum 2000;43:617-27
  • Giliani S, Mori L, DeSaint BG, et al. Interleukin-7 receptor alpha (IL-7Ralpha) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients. Immunol Rev 2005;203:110-26
  • van Roon JA, Verweij MC, Wenting-van WM, et al. Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact–dependent activation of CD4+ T cells and macrophages. Arthritis Rheum 2005;52:1700-10
  • Bingham CO III, Abramson SA. Mechanisms of inflammation. In: Tannenbaum H, Russell AS, editors, Mechanisms in rheumatology. Core Health Services, Toronto; 2001
  • Henderson B, Pettipher ER. Arthritogenic actions of recombinant IL-1 and tumour necrosis factor-alpha in the rabbit: evidence for synergistic interactions between cytokines in vivo. Clin Exp Immunol 1989;75:306-10
  • van Roon JA, Lafeber FP, Bijlsma JW. Synergistic activity of interleukin-4 and interleukin-10 in suppression of inflammation and joint destruction in rheumatoid arthritis. Arthritis Rheum 2001;44:3-12
  • Nawroth PP, Bank I, Handley D, et al. Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1. J Exp Med 1986;163:1363-75
  • Arend WP. Cytokine imbalance in the pathogenesis of rheumatoid arthritis: the role of interleukin-1 receptor antagonist. Semin Arthritis Rheum 2001;30(Suppl 2):1-6
  • Miyamoto T, Mori T, Yoshimyra A, et al. STAT3 is critical to promote inflammatory cytokines and RANKL expression in inflammatory arthritis. Arthiritis Res Ther 2012;14(Suppl 1):P43
  • McElroy CA, Dohm JA, Walsh ST. Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. Structure 2009;17:54-65
  • Goodwin RG, Lupton S, Schmierer A, et al. Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc Natl Acad Sci USA 1989;86:302-6
  • Kovanen PE, Leonard WJ. Cytokines and immunodeficiency diseases: critical roles of the gammac-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev 2004;202:67-83
  • Rihl M, Kellner H, Kellner W, et al. Identification of interleukin-7 as a candidate disease mediator in spondylarthritis. Arthritis Rheum 2008;58:3430-5
  • Pandey A, Ozaki K, Baumann H, et al. Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nat Immunol 2000;1:59-64
  • Park LS, Martin U, Garka K, et al. Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med 2000;192:659-70
  • Hartgring SA, Bijlsma JW, Lafeber FP, et al. Interleukin-7 induced immunopathology in arthritis. Ann Rheum Dis 2006;65(Suppl 3):iii69-74
  • van Roon JA, Glaudemans CA, Bijlsma JW, et al. Differentiation of naive CD4+ T cells towards T helper 2 cells is not impaired in rheumatoid arthritis patients. Arthritis Res Ther 2003;5:R269-76
  • Alderson MR, Tough TW, Ziegler SF, et al. Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes. J Exp Med 1991;173:923-30
  • Napolitano LA, Grant RM, Deeks SG, et al. Increased production of IL-7 accompanies HIV-1−mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 2001;7:73-9
  • Damas JK, Waehre T, Yndestad A, et al. Interleukin-7–mediated inflammation in unstable angina: possible role of chemokines and platelets. Circulation 2003;107:2670-6
  • Unsinger J, McGlynn M, Kasten KR, et al. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol 2010;184:3768-3779
  • Roth J, De Souza GEP. Fever induction pathways: evidence from responses to systemic or local cytokine formation. Braz J Med Biol Res 2001;34(3):301-14
  • Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nature Rev Immunol 2011;11:330-42
  • Ziegler SF, Tough TW, Franklin TL, et al. Induction of macrophage inflammatory protein-1beta gene expression in human monocytes by lipopolysaccharide and IL-7. J Immunol 1991;147:2234-9
  • Hartgring SAY, van Roon JAG, Wenting-van Wijk MW, et al. Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis. Arthritis Rheum 2009;60:2595-605
  • Sawa S, Kamimura D, Jin GH, et al. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med 2006;203:1459-70
  • van Roon JAG, van Rossum S, Jacobs KM, et al. Maturation of functional antigen presenting cells is inhibited by IL-7 blockade. Arthritis Rheum 2006;54:S598-8
  • van Amelsfort JM, van Roon JA, Noordegraaf M, et al. Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis. Arthritis Rheum 2007;56:732-42
  • Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood 2002;99:3892-904
  • Puel A, Leonard WJ. IL-7Ralpha-dependent signaling is required for T-cell development; basis for T-B+NK+ SCID in humans. Immunol Allergy Clin 2000;20:51-63
  • Schluns KS, Lefrancois L. Cytokine control of memory T-cell development and survival. Nat Rev Immunol 2003;3:269-79
  • Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006;203:1701-11
  • Goodwin RG, Lupton S, Schmierer A, et al. Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc Natl Acad Sci USA 1989;86:302-6
  • Giliani S, Mori L, de Saint BG, et al. Interleukin-7 receptor alpha (IL-7R alpha) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients. Immunol Rev 2005;203:110-26
  • Chou YK, Bourdette DN, Barnes D, et al. IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R alpha and gamma chains. J Neuroimmunol 1999;96:101-11
  • Lum JJ, Schnepple DJ, Nie Z, et al. Differential effects of interleukin-7 and interleukin-15 on NK cell anti-human immunodeficiency virus activity. J Virol 2004;78:6033-42
  • Mehrotra PT, Grant AJ, Siegel JP. Synergistic effects of IL-7 and IL-12 on human T cell activation. J Immunol 1995;154:5093-102
  • Sportes C, Hakim FT, Memon SA, et al. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J Exp Med 2008;205:1701-14
  • Van Roon JA, Lafeber FP. Role of interleukin-7 in degenerative and inflammatory joint diseases. Arthritis Res Ther 2008;10:107
  • Leistad L, Ostensen M, Faxvaag A. Detection of cytokine mRNA in human, articular cartilage from patients with rheumatoid arthritis and osteoarthritis by reverse transcriptase-polymerase chain reaction. Scand J Rheumatol 1998;27:61-7
  • Standiford TJ, Strieter RM, Allen RM, et al. IL-7 up-regulates the expression of IL-8 from resting and stimulated human blood monocytes. J Immunol 1992;149:2035-9
  • Girard D, Beaulieu AD. Absence of the IL-7 receptor component CDw127 indicates that gamma(c) expression alone is insufficient for IL-7 to modulate human neutrophil responses. Clin Immunol Immunopathol 1997;83:264-71
  • Colucci S, Brunetti G, Cantatore F, et al. Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFalpha, and IL-7 in an in vitro model derived from human psoriatic arthritis. J Pathol 2007;212:47-55
  • Sawa S, Kamimura D, Jin GH, et al. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7–dependent homeostatic proliferation of CD4+ T cells. J Exp Med 2006;203:1459-70
  • van Roon JA, Hartgring SA, Wenting-van WM, et al. Persistence of interleukin 7 activity and levels on tumour necrosis factor alpha blockade in patients with rheumatoid arthritis. Ann Rheum Dis 2007;66:664-9
  • Pickens SA, Chamberlain ND, Volin MV, et al. Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritis. Arthritis Rheum 2011;63:2884-93
  • Cope AP, Londei M, Chu NR, et al. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti- TNF antibodies in patients with rheumatoid arthritis. J Clin Invest 1994;94:749-60
  • Miyaura C, Onoe Y, Inada M, et al. Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency. Proc Natl Acad Sci USA 1997;94:9360-5
  • Toraldo G, Roggia C, Qian WP, et al. IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci USA 2003;100:125-30
  • Long IL7 is demonstrated to induce production of matrix metallo proteinase-13 (MMP-13)
  • De Benedetti F, Massa M, Pignatti P, et al. Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis. J Rheumatol 1995;22:1581-5
  • Churchman SM, Ponchel F. Interleukin-7 in rheumatoid arthritis. Rheumatology (Oxford) 2008;47:753-9
  • Girard D, Beaulieu AD. Absence of the IL-7 receptor component CDw127 indicates that gamma(c) expression alone is insufficient for IL-7 to modulate human neutrophil responses. Clin Immunol Immunopathol 1997;83:264-71
  • van Amelsfort JM, van Roon JA, Noordegraaf M, et al. Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis. Arthritis Rheum 2007;56:732-42
  • Hartgring SA, Willis CR, Alcorn D, et al. Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators. Arthritis Rheum 2010;62:2716-25
  • Park LS, Martin U, Garka K, et al. Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med 2000;192:659-70
  • Allakhverdi Z, Comeau MR, Jessup HK, et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med 2007;204:253-8
  • Soumelis V, Reche PA, Kanzler H, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 2002;3:673-80
  • Ying S, O'Connor B, Ratoff J, et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005;174:8183-90
  • Kato A, Favoreto S Jr, Avila PC, et al. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol 2007;179:1080-7
  • Moon PD, Kim H. The suppression of thymic stromal lymphopoietin expression by selenium. Amino Acids 2012;43:999-1004
  • Moon PD, Choi IH, Kim H. Berberine inhibits production of thymic stromal lymphopoietin by the blockade of caspase1 NF-kappaB pathway in mast cells. J Immunopharmacol 2011;11:1954-9
  • Moon PD, Choi IH, Kim H. Epigallocatechin-3-O-gallate inhibits the production of thymic stromal lymphopoietin by the blockade of caspase1 NF-kappaB pathway in mast cells. Amino Acids 2012;42:2513-19
  • Moon PD, Choi IH, Kim H. Naringenin inhibits the production of thymic stromal lymphopoietin by the blockade of RIP2 and caspase1 cascade signals in mast cells. Eur J Pharmacol 2011;671:128-32
  • Lee HC, Headley MB, Iseki M, et al. Cutting edge: inhibition of NF-kappaB-mediated TSLP expression by retinoid X receptor. J Immunol 2008;181:5189-93
  • Quentmeier H, Drexler HG, Fleckenstein D, et al. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Leukemia 2001;15(8):1286-92
  • Park LS, Martin U, Sims JE. Cloning of the murine thymic stromal lymphopoietin (Tslp) receptor. J Exp Med 2000;192:659-70
  • He R, Geha RS. Thymic stromal lymphopoietin. Ann NY Acad Sci 2010;1183:13-24
  • Al-Shami A, Spolski R, Kelly J, et al. A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med 2004;200:159-68
  • Puel A, Ziegler SF, Buckley RH, et al. Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat Genet 1998;20:394-7
  • Liu YJ, Soumelis V, Watanabe N, et al. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Ann Rev Immunol 2007;25:193-219
  • Rimoldi M, Chieppa M, Salucci V, et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 2005;6:507-14
  • Rochman Y, Leonard WJ. Thymic stromal lymphopoietin: a new cytokine in asthma. Curr Opin Pharmacol 2008;8:249-54
  • Yokoi T, Amakawa R, Tanijiri T, et al. Mycobacterium bovis bacillus calmette-guerin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int Immunol 2008;20:1321-9
  • Watanabe N, Hanabuchi S, Marloie-Provost MA, et al. Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential. Blood 2005;105:4749-51
  • Reche PA, Soumelis V, Gorman DM, et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol 2001;167:336-43
  • Mulherin D, Fitzgerald O, Bresnihan B. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum 1996;39:115-24
  • Koyama K, Ozawa T, Hatsushika K, et al. A possible role for TSLP in inflammatory arthritis. Biochem Biophys Res Commun 2007;357:99-104
  • Ozawa T, Koyama K, Ando T, et al. Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-kappaB pathway and interferon-gamma/dexamethasone. Mod Rheumatol 2007;17:459-63
  • Kimura MY, Pobezinsky LA, Guinter TI, et al. IL-7 signaling must be intermittent, not continuous, during CD8+ T cell homeostasis to promote cell survival instead of cell death. Nat Immunol 2013;14:143-51
  • Iolyeva M, Aebischer D, Proulx ST, et al. Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood 2013;122:2271-81
  • Vandergeeten C, Fromentin R, DaFonseca S, et al. Interleukin-7 promotes HIV persistence during antiretroviral therapy. Blood 2013;121(21):4321-9
  • Introini A, Vanpouille C, Lisco A, et al. Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo. PLoS Pathog 2013;9:e1003148
  • Sammicheli S, Ruffin N, Lantto R, et al. IL-7 modulates B cells survival and activation by inducing BAFF and CD70 expression in T cells. J Autoimmun 2012;38:304-14
  • Perales MA, Goldberg JD, Yuan J. Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation. Blood 2012;120:4882-91
  • Onder L, Narang P, Scandella E, et al. IL-7-producing stromal cells are critical for lymph node remodeling. Blood 2012;120(24):4675-83
  • Venet F, Foray AP, Villars-Méchin A. IL-7 restores lymphocyte functions in septic patients. J Immunol 2012;189:5073-81
  • Lee LF, Logronio K, Tu GH. Anti-IL-7 receptor-alpha reverses established type 1 diabetes in non-obese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci USA 2012;109:12674-9
  • Shalapour S, Deiser K, Kühl AA, et al. Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis. PLoS One 2012;7:e31939
  • Pellegrini M, Calzascia T, Toe JG, et al. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 2011;144(4):601-13
  • Hodge N, Srinivasula S, Hu Z, et al. Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance. Blood 2011;118:3244-53
  • Liu X, Leung S, Wang C, et al. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med 2010;16:191-7
  • Repass JF, Laurent MN, Carter C, et al. IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Genesis 2009;47:281-7
  • Sereti I, Dunham RM, Spritzler J, et al. IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection. Blood 2009;113:6304-14
  • Christmann RB, Mathes A, Affandi AJ, et al. Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor beta. Arthritis Rheum 2013;65:1335-46
  • Moret FM, Radstake TRDJ, Bijlsma JWJ, et al. Abatacept Efficacy Is Overruled By IL-7 In TSLP-Primed Myeloid Dendritic Cell Driven T Cell Activation From Rheumatoid Arthritis Patients. Arthritis Rheumatism, Volume 65, October 2013 Abstract Supplement Abstracts of the 2013 American College of Rheumatology/Association of Rheumatology Health Professionals Annual Meeting; 25 – 30 October 2013; San Diego, CA
  • Moret FM, Hack CE, Radstake TRDJ, et al. Increased TSLP Expression in joints of rheumatoid Aathritis patients causes increased activation of intra-articular myeloid dendritic cells with enhanced Th1 and Th17 cell activity. Arthritis & Rheumatism, Volume 64, November 2012 Abstract Supplement abstracts of the American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting; 9 – 14 November 2012; Washington, DC
  • Jeong H-J, Nam S-Y, Oh H-A, et al. Interleukin-32-induced thymic stromal lymphopoietin plays a critical role in macrophage differentiation through the activation of caspase-1 in vitro. Arthritis Res Ther 2012;14:R259
  • Roan F, Bell BD, Stollasek TA, et al. The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond. J Leukocyte Biol 2012;91:877-86
  • Hartgring SA, Willis CR, Dean CE Jr, et al. Critical proinflammatory role of thymic stromal lymphopoietin and its receptor in experimental autoimmune arthritis. Arthritis Rheum 2011;63:1878-87
  • Wu T, Wang J, Jia L, et al. Thymic stromal lymphopoietin: next research hotspot of carcinogenesis? Adv Biosci Biotech 2012;3:665-8

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