154
Views
7
CrossRef citations to date
0
Altmetric
Review

Angiogenesis in salivary gland tumors: from clinical significance to treatment

, , (Assistant Professor of Human Physiology) , &

Bibliography

  • Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 1986;8:177-84
  • Huvos AG, Paulino AG. Salivary glands. In: Sternberg SS, editor. Diagnostic surgical pathology. Lippincott. Williams and Wilkins; Philadelphia: 1999. p. 853-84
  • Ellis GL, Auclair PL, Eds. Atlas of tumor pathology. Tumors of the Salivary Glands. Washington Armed Forces Institute of Pathology; Washington, USA; 1996
  • Jones AV, Franklin CD. An analysis of oral and maxillofacial pathology found in adults over a 30-year period. J Oral Pathol Med 2006;35:392-401
  • Spiro RH. Distant metastasis in adenoid cystic carcinoma of salivary origin. Am J Surg 1997;174:495-8
  • Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer 1998;82:1217-24
  • Livolsi VA, Perzin KH. Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: a clinicopathologic study. Cancer 1977;39:2209-30
  • Evans HL, Luna MA. Polymouphous low-grade adenocarcinoma: a study of 40 cases with long-term follow up and an evaluation of the importance of papilary areas. Am J Surg Pathol 2000;24:1319-28
  • Barnes L, Everson JW, Reichart P, Sidransky D, Eds. World healty organization classification of tumours. Pathology and genetics of head and neck tumours. IARC Press; Lyon: 2005. p. 22-4
  • Mousa S. Angiogenesis: regulation and dysregulation. Mol Med Today 1998;97:101
  • Folberg R, Hendrix MJ, Maniotis AJ. Vasculogenic mimicry and tumor angiogenesis. Am J Pathol 2000;156:361-81
  • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008;358:2039-49
  • Liekens S, Clercq ED, Neyts J. Angiogenesis: Regulators and clinical applications. Biochem Pharmacol 2001;61:253-70
  • Griffioen AW, Barendz-Janson AF, Mayo KH, et al. Angiogenesis, a target for tumor therapy. J Lab Clin Med 1998;132:363-8
  • Folkman J. Tumor angiogenesis. In: Mendelsohn J, Howley P, Israel A, Liotta LA, editors. The molecular basis of cancer. W.B. Saunders Company; Philadelphia: 1995. p. 206-24
  • Yoo SY, Kwon SM. Angiogenesis and its therapeutic opportunities. Mediators Inflamm 2013;2013:127179
  • Dameron KM, Volpert OV, Tainsky MA, et al. Control of angiogenesis in fibroblasts by p53 regulation of thorombospongin-1. Science 1994;265:1582-4
  • Kowanetz M, Ferrara N. Vascular endothelial growth factor signaling pathways: therapeutic perspective. Clin Cancer Res 2006;12:5018-22
  • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23:1011-27
  • Sitohy B, Nagy JA, Dvorak HF. Anti-VEGF/VEGFR therapy for cancer: reassessing the target. Cancer Res 2012;72:1909-14
  • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002;20:4368-80
  • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004;25:581-611
  • Alvarez RH, Kantarjian HM, Cortes JE. Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc 2006;81:1241-57
  • Lindblom P, Gerhardt H, Liebner S, et al. Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev 2003;17:1835-40
  • Dong J, Grunstein J, Tejada M, et al. VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J 2004;23:2800-10
  • Eng L, Liu G. VEGF pathway polymorphisms as prognostic and pharmacogenetic factors in cancer: a 2013 update. Pharmacogenomics 2013;14:1659-67
  • Presta M, Dell’Era P, Mitola S, et al. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev 2005;16:159-78
  • Casanovas O, Hicklin DJ, Bergers G, et al. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005;8:299-309
  • Bach F, Uddin FJ, Burke D. Angiopoietins in malignancy. Eur J Surg Oncol 2007;33:7-15
  • Schor AM, Schor SL. Angiogenesis and tumour progression: migration-stimulating factor as a novel target for clinical intervention. Eye (Lond) 2010;24:450-8
  • Lau LF. CCN1/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci 2011;68:3149-63
  • Bagri A, Tessier-Lavigne M, Watts RJ. Neuropilins in tumor biology. Clin Cancer Res 2009;15:1860-4
  • Salgia R. Prognostic significance of angiogenesis and angiogenic growth factors in nonsmall cell lung cancer. Cancer 2011;117:3889-99
  • Hlatky L, Hahnfeldt P, Folkman J. Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn’t tell us. J Natl Cancer Inst 2002;94:883-93
  • Pathak AP, Hochfeld WE, Goodman SL, et al. Circulating and imaging markers for angiogenesis. Angiogenesis 2008;11:321-35
  • Cao Z, Bao M, Miele L, et al. Tumor vasculogenic mimicry is associated with poor prognosis in human cancer patients: a systematic review and meta-analysis. Eur J Cancer 2013;49:3914-23
  • Ruegg C, Mutter N. Anti-angiogenic therapies in cancer: achievements and open questions. Bull Cancer 2007;94:753-62
  • Brown AP, Citrin DE, Camphausen KA. Clinical biomarkers of angiogenesis inhibition. Cancer Metastasis Rev 2008;27:415-34
  • Tadbir AA, Pardis S, Ashkavandi ZJ, et al. Expression of Ki67 and CD105 as proliferation and angiogenesis markers in salivary gland tumors. Asian Pac J Cancer Prev 2012;13:5155-9
  • Cardoso SV, Souza KC, Faria PR, et al. Assessment of angiogenesis by CD105 antigen in epithelial salivary gland neoplasms with diverse metastatic behavior. BMC Cancer 2009;9:391
  • Costa AF, Demasi AP, Bonfitto VL, et al. Angiogenesis in salivary carcinomas with and without myoepithelial differentiation. Virchows Arch 2008;453:359-67
  • Dhanuthai K, Sappayatosok K, Yodsanga S, et al. An analysis of microvessel density in salivary gland tumours: a single centre study. Surgeon 2013;11:147-52
  • Soares AB, Juliano PB, Araujo VC, et al. Angiogenic switch during tumor progression of carcinoma ex-pleomorphic adenoma. Virchows Arch 2007;451:65-71
  • Vidal MT, de Oliveira Araújo IB, Gurgel CA, et al. Density of mast cells and microvessels in minor salivary gland tumors. Tumour Biol 2013;34:309-16
  • Faur AC, Lazar E, Cornianu M. Vascular endothelial growth factor (VEGF) expression and microvascular density in salivary gland tumours. APMIS 2014;122:418-26
  • Huang ZQ, Chen WL, Li HG, et al. Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel density. J Craniofac Surg 2010;21:1855-60
  • Barsky SH, Karlin NJ. Myoepithelial cells: autocrine and paracrine suppressors of breast cancer progression. J Mammary Gland Biol Neoplasia 2005;10:249-60
  • Yang X, Dai J, Li T, et al. Expression of EMMPRIN in adenoid cystic carcinoma of salivary glands: correlation with tumor progression and patients’ prognosis. Oral Oncol 2010;46:755-60
  • Zhang J, Peng B, Chen X. Expressions of nuclear factor kappaB, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: correlations with the angiogenesis and clinical outcome. Clin Cancer Res 2005;11:7334-43
  • Ou Yang KX, Liang J, Huang ZQ. Association of clinicopathologic parameters with the expression of inducible nitric oxide synthase and vascular endothelial growth factor in mucoepidermoid carcinoma. Oral Dis 2011;17:590-6
  • Shieh YS, Hung YJ, Hsieh CB, et al. Tumor-associated macrophage correlated with angiogenesis and progression of mucoepidermoid carcinoma of salivary glands. Ann Surg Oncol 2009;16:751-60
  • Shi L, Chen XM, Wang L, et al. Expression of caveolin-1 in mucoepidermoid carcinoma of the salivary glands: correlation with vascular endothelial growth factor, microvessel density, and clinical outcome. Cancer 2007;109:1523-31
  • Gleber-Netto FO, Florêncio TN, de Sousa SF, et al. Angiogenesis and lymphangiogenesis in mucoepidermoid carcinoma of minor salivary glands. J Oral Pathol Med 2012;41:603-9
  • Swelam W, Ida-Yonemochi H, Maruyama S, et al. Vascular endothelial growth factor in salivary pleomorphic adenomas: one of the reasons for their poorly vascularized stroma. Virchows Arch 2005;446:653-62
  • de Faria PR, Lima RA, Dias FL, et al. Vascular endothelial growth factor and thymidine phosphorylase expression in salivary gland tumors with distinct metastatic behavior. J Oral Pathol Med 2011;40:456-9
  • Lim JJ, Kang S, Lee MR, et al. Expression of vascular endothelial growth factor in salivary gland carcinomas and its relation to p53, Ki-67 and prognosis. J Oral Pathol Med 2003;32:552-61
  • Lequerica-Fernández P, Astudillo A, de Vicente JC. Expression of vascular endothelial growth factor in salivary gland carcinomas correlates with lymph node metastasis. Anticancer Res 2007;27:3661-6
  • Doi R, Kuratate I, Okamoto E, et al. Expression of p53 oncoprotein increases intratumoral microvessel formation in human salivary gland carcinomas. J Oral Pathol Med 1999;28:259-63
  • Zhang J, Peng B. NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro. Cell Prolif 2009;42:150-61
  • Zhang J, Peng B. In vitro angiogenesis and expression of nuclear factor kappaB and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma. BMC Cancer 2007;7:95
  • Younes MN, Park YW, Yazici YD, et al. Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Mol Cancer Ther 2006;5:2696-705
  • Lee SK, Kwon MS, Lee YS, et al. Prognostic value of expression of molecular markers in adenoid cystic cancer of the salivary glands compared with lymph node metastasis: a retrospective study. World J Surg Oncol 2012;10:266
  • Tang QL, Chen WL, Tan XY, et al. Expression and significance of Cyr61 in distant metastasis cells of human primary salivary adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112:228-36
  • Tadbir AA, Khademi B, Malekzadeh M, et al. Upregulation of serum vascular endothelial growth factor in patients with salivary gland tumor. Patholog Res Int 2013;2013:740582
  • Tampouris AI, Kandiloros D, Giotakis I, et al. The role of the VEGF-C/-D/flt-4 autocrine loop in the pathogenesis of salivary neoplasms. Pathol Res Pract 2012;208:151-6
  • Tang QL, Fan S, Li HG, et al. Expression of Cyr61 in primary salivary adenoid cystic carcinoma and its relation to Ki-67 and prognosis. Oral Oncol 2011;47:365-70
  • Choudhuri R, Zhang HT, Donnini S, et al. An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis. Cancer Res 1997;57:1814-19
  • Ruan M, Ji T, Wu Z, et al. Evaluation of expression of midkine in oral squamous cell carcinoma and its correlation with tumour angiogenesis. Int J Oral Maxillofac Surg 2007;36:159-64
  • Maeda S, Shinchi H, Kurahara H, et al. Clinical significance of midkine expression in pancreatic head carcinoma. Br J Cancer 2007;97:405-11
  • Ota T, Ota K, Jono H, et al. Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis. Oral Oncol 2010;46:657-61
  • Cai Y, Wang R, Zhao YF, et al. Expression of Neuropilin-2 in salivary adenoid cystic carcinoma: its implication in tumor progression and angiogenesis. Pathol Res Pract 2010;206:793-9
  • Ishibashi H, Shiratuchi T, Nakagawa K, et al. Hypoxia-induced angiogenesis of cultured human salivary gland carcinoma cells enhances vascular endothelial growth factor production and basic fibroblast growth factor release. Oral Oncol 2001;37:77-83
  • Demasi AP, Silva CA, Silva AD, et al. Expression of the vascular endothelial growth factor and angiopoietins in mucoepidermoid carcinoma of salivary gland. Head Neck Pathol 2012;6:10-15
  • Oshima Y, Yajima S, Yamazaki K, et al. Angiogenesis-related factors are molecular targets for diagnosis and treatment of patients with esophageal carcinoma. Ann Thorac Cardiovasc Surg 2010;16:389-93
  • Senetta R, Stella G, Pozzi E, et al. Caveolin-1 as a promoter of tumour spreading: when, how, where and why. J Cell Mol Med 2013;17:325-36
  • Aljorani LE, Bankfalvi A, Carey FA, et al. Migration-stimulating factor as a novel biomarker in salivary gland tumours. J Oral Pathol Med 2011;40:747-54
  • Sun ZJ, Chen G, Zhang W, et al. Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase. J Pharmacol Exp Ther 2010;334:500-12
  • Thornton K, Kim G, Maher VE, et al. Vandetanib for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease: U.S. Food and Drug Administration drug approval summary. Clin Cancer Res 2012;18:3722-30
  • Fujishiro Y, Tonogi M, Ochiai H, et al. The receptor tyrosine kinase inhibitor vandetanib activates Akt and increases side population in a salivary gland tumor cell line (A253). Int J Oncol 2012;41:362-8
  • Choi S, Sano D, Cheung M, et al. Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model. Clin Cancer Res 2008;14:5081-9
  • Rugo HS, Herbst RS, Liu G, et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol 2005;23:5474-83
  • Chau NG, Hotte SJ, Chen EX, et al. A phase II study of sunitinib in recurrent and/or metastatic adenoid cystic carcinoma (ACC) of the salivary glands: current progress and challenges in evaluating molecularly targeted agents in ACC. Ann Oncol 2012;23:1562-70
  • Thomson DJ, Silva P, Denton K, et al. Phase II trial of sorafenib in advanced salivary adenoid cystic carcinoma of the head and neck. Head Neck 2015;37(2):182-7
  • Welti J, Loges S, Dimmeler S, Carmeliet P. Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. J Clin Invest 2013;123:3190-200
  • Gacche RN, Meshram RJ. Angiogenic factors as potential drug target: efficacy and limitations of anti-angiogenic therapy. Biochim Biophys Acta 2014;1846:161-79

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.