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Review

The influence of the telomere-telomerase system on diabetes mellitus and its vascular complications

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Bibliography

  • Shay JW, Wright WE. Hallmarks of telomeres in ageing research. J Pathol 2007;211(2):114-23
  • Zakian VA. Structure, function, and replication of Saccharomyces cerevisiae telomeres. Annu Rev Genet 1996;30:141-72
  • Griffith JD, Comeau L, Rosenfield S, et al. Mammalian telomeres end in a large duplex loop. Cell 1999;97(4):503-14
  • Sfeir A, de Lange T. Removal of shelterin reveals the telomere end-protection problem. Science 2012;336(6081):593-7
  • Frescas D, de Lange T. TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1. Mol Cell Biol 2014;34(7):1349-62
  • McKerlie M, Lin S, Zhu XD. ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance. Nucleic Acids Res 2012;40(9):3975-89
  • Shammas MA. Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care 2011;14(1):28-34
  • Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis 2010;31(1):9-18
  • Shay JW, Wright WE. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 2005;26(5):867-74
  • Allsopp RC, Vaziri H, Patterson C, et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992;89(21):10114-18
  • Codd V, Nelson CP, Albrecht E, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet 2013;45(4):422-7
  • Mangino M, Hwang SJ, Spector TD, et al. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet 2012;21(24):5385-94
  • Pooley KA, Bojesen SE, Weischer M, et al. A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet 2013;22(24):5056-64
  • Greenberg RA. Telomeres, crisis and cancer. Curr Mol Med 2005;5(2):213-18
  • Huang XQ, Wang J, Liu JP, et al. hTERT extends proliferative lifespan and prevents oxidative stress-induced apoptosis in human lens epithelial cells. Invest Ophthalmol Vis Sci 2005;46(7):2503-13
  • Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279(5349):349-52
  • Wieser M, Stadler G, Jennings P, et al. hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics. Am J Physiol Renal Physiol 2008;295(5):F1365-75
  • Lackner DH, Raices M, Maruyama H, et al. Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. EMBO J 2012;31(8):2024-33
  • Jeitany M, Pineda JR, Liu Q, et al. A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT). Int J Cancer 2014;136(7):1546-58
  • Nabetani A, Ishikawa F. Alternative lengthening of telomeres pathway: recombination-mediated telomere maintenance mechanism in human cells. J Biochem 2011;149(1):5-14
  • Heaphy CM, de Wilde RF, Jiao Y, et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science 2011;333(6041):425
  • Stolzing A, Sellers D, Llewelyn O, Scutt A. Diabetes induced changes in rat mesenchymal stem cells. Cells Tissues Organs 2010;191(6):453-65
  • Candido R, Toffoli B, Corallini F, et al. Human full-length osteoprotegerin induces the proliferation of rodent vascular smooth muscle cells both in vitro and in vivo. J Vasc Res 2010;47(3):252-61
  • Jeanclos E, Krolewski A, Skurnick J, et al. Shortened telomere length in white blood cells of patients with IDDM. Diabetes 1998;47:482-6
  • Astrup AS, Tarnow L, Jorsal A, et al. Telomere length predicts allcause mortality in patients with type 1 diabetes. Diabetologia 2010;53:45-8
  • You NC, Chen BH, Song Y, et al. A prospective study of leukocyte telomere length and risk of T2D in postmenopausal women. Diabetes 2012;61(11):2998-3004
  • Adaikalakoteswari A, Balasubramanyam M, Mohan V. Telomere shortening occurs in Asian Indian Type 2 diabetic patients. Diabet Med 2005;22:1151-6
  • Sampson MJ, Winterbone MS, Hughes JC, et al. Monocyte telomere shortening and oxidative DNA damage in T2D. Diabetes Care 2006;29:283-9
  • Adaikalakoteswari A, Balasubramanyam M, Ravikumar R, et al. Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy. Atherosclerosis 2007;195:83-9
  • Tentolouris N, Nzietchueng R, Cattan V, et al. White blood cells telomere length is shorter in males with T2D and microalbuminuria. Diabetes Care 2007;30:2909-15
  • Uziel O, Singer JA, Danicek V, et al. Telomere dynamics in arteries and mononuclear cells of diabetic patients: effect of diabetes and of glycemic control. Exp Gerontol 2007;42:971-8
  • Olivieri F, Lorenzi M, Antonicelli R, et al. Leukocyte telomere shortening in elderly Type2 DM patients with previous myocardial infarction. Atherosclerosis 2009;206:588-93
  • Salpea KD, Talmud PJ, Cooper JA, et al. Association of telomere length with T2D, oxidative stress and UCP2 gene variation. Atherosclerosis 2010;209:42-50
  • Zee RY, Castonguay AJ, Barton NS, et al. Mean leukocyte telomere length shortening and T2D mellitus: a case-control study. Transl Res 2010;155:166-9
  • Zhao J, Zhu Y, Lin J, et al. Short leukocyte telomere length predicts risk of diabetes in American Indians: the strong heart family study. Diabetes 2014;63(1):354-62
  • Harte AL, da Silva NF, Miller MA, et al. Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with T2D mellitus. Exp Diabetes Res 2012;2012:895185
  • Monickaraj F, Aravind S, Gokulakrishnan K, et al. Accelerated aging as evidenced by increased telomere shortening and mitochondrial DNA depletion in patients with T2D. Mol Cell Biochem 2012;365(1-2):343-50
  • Shen Q, Zhao X, Yu L, et al. Association of leukocyte telomere length with T2D in mainland Chinese populations. J Clin Endocrinol Metab 2012;97(4):1371-4
  • Xiao F, Zheng X, Cui M, et al. Telomere dysfunction-related serological markers are associated with T2D. Diabetes Care 2011;34(10):2273-8
  • Eisenberg DT, Salpea KD, Kuzawa CW, European Atherosclerosis Research Study II Group. Substantial variation in qPCR measured mean blood telomere lengths in young men from eleven European countries. Am J Hum Biol 2011;23(2):228-31
  • Diez Roux AV, Ranjit N, Jenny NS, et al. Race/ethnicity and telomere length in the Multi-Ethnic Study of Atherosclerosis. Aging Cell 2009;8(3):251-7
  • Zhao J, Miao K, Wang H, et al. Association between telomere length and T2D mellitus: a meta-analysis. PLoS One 2013;8(11):e79993
  • Gardner M, Bann D, Wiley L, et al. Gender and telomere length: systematic review and meta-analysis. Exp Gerontol 2014;51:15-27
  • Du M, Prescott J, Cornelis MC, et al. De Vivo. Genetic predisposition to higher body mass index or T2D and leukocyte telomere length in the Nurses’ Health Study. PLoS One 2013;8(2):e52240
  • Ma D, Zhu W, Hu S, et al. Association between oxidative stress and telomere length in Type 1 and Type 2 diabetic patients. J Endocrinol Invest 2013;36(11):1032-7
  • Saxena R, Bjonnes A, Prescott J, et al. Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort. Circ Cardiovasc Genet 2014;7(3):287-95
  • Xu J, Ye J, Wu Y, et al. Reduced fetal telomere length in gestational diabetes. PLoS One 2014;9(1):e86161
  • Cross JA, Brennan C, Gray T, et al. Absence of telomere shortening and oxidative DNA damage in the young adult offspring of women with pre-gestational type 1 diabetes. Diabetologia 2009;52(2):226-34
  • Ma D, Yu Y, Yu X, et al. The changes of leukocyte telomere length and telomerase activity after sitagliptin intervention in newly diagnosed T2D. Diabetes Metab Res Rev 2014. [Epub ahead of print]
  • New evidence: bariatric surgery also reverses the effects of aging. Telomeres, genetic biomarkers of aging, are found to be longer after the surgery. Duke Med Health News 2014;20(2):6
  • Tamura Y, Izumiyama-Shimomura N, Kimbara Y, et al. Ito H. beta-Cell Telomere Attrition in Diabetes: inverse Correlation Between HbA1c and Telomere Length. J Clin Endocrinol Metab 2014;99(8):2771-7
  • Kuhlow D, Florian S, von Figura G, et al. Telomerase deficiency impairs glucose metabolism and insulin secretion. Aging (Albany NY) 2010;2(10):650-8
  • Halvorsen TL, Beattie GM, Lopez AD, et al. Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. J Endocrinol 2000;166:103-9
  • Tavana O, Zhu C. Too many breaks (brakes): pancreatic beta-cell senescence leads to diabetes. Cell Cycle 2011;10(15):2471-84
  • Liew CW, Holman A, Kulkarni RN. The roles of telomeres and telomerase in beta-cell regeneration. Diabetes Obes Metab 2009;11(Suppl 4):21-9
  • Blazer S, Khankin E, Segev Y, et al. High glucose-induced replicative senescence: point of no return and effect of telomerase. Biochem Biophys Res Commun 2002;296:93-101
  • Krishnamurthy J, Ramsey MR, Ligon KL, et al. p16INK4a induces an age dependent decline in islet regenerative potential. Nature 2006;443:453-7
  • Nyblom HK, Bugliani M, Fung E, et al. Apoptotic, regenerative, and immunerelated signaling in human islets from T2D individuals. J Proteome Res 2009;8:5650-6
  • Li P, Tong Y, Yang H, et al. Mitochondrial translocation of human telomerase reverse transcriptase in cord blood mononuclear cells of newborns with gestational diabetes mellitus mothers. Diabetes Res Clin Pract 2014;103(2):310-18
  • Taubes G. Insulin resistance. Prosperity’s plague. Science 2009;325:256-60
  • Aviv A, Valdes A, Gardner JP, et al. Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation. J Clin Endocrinol Metab 2006;91:635-40
  • Demissie S, Levy D, Benjamin EJ, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell 2006;5:325-30
  • Gardner JP, Li S, Srinivasan SR, et al. Rise in insulin resistance is associated with escalated telomere attrition. Circulation 2005;111:2171-7
  • Monickaraj F, Gokulakrishnan K, Prabu P, et al. Convergence of adipocyte hypertrophy, telomere shortening and hypoadiponectinemia in obese subjects and in patients with T2D. Clin Biochem 2012;45(16-17):1432-8
  • Al-Attas OS, Al-Daghri NM, Alokail MS, et al. Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: the influence of circulating adiponectin. Eur J Endocrinol 2010;163(4):601-7
  • Al-Attas OS, Al-Daghri N, Bamakhramah A, et al. Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth. Acta Paediatr 2010;99(6):896-9
  • Nordfjäll K, Eliasson M, Stegmayr B, et al. Increased abdominal obesity, adverse psychosocial factors and shorter telomere length in subjects reporting early ageing; the MONICA Northern Sweden Study. Scand J Public Health 2008;36(7):744-52
  • Ahmad S, Heraclides A, Sun Q, et al. Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia. Diabet Med 2012;29(10):e377-81
  • Tzanetakou IP, Katsilambros NL, Benetos A, et al. “Is obesity linked to aging?”: adipose tissue and the role of telomeres. Ageing Res Rev 2012;11(2):220-9
  • Masi S, Gkranias N, Li K, et al. Association between short leukocyte telomere length, endotoxemia, and severe periodontitis in people with diabetes: a cross-sectional survey. Diabetes Care 2014;37(4):1140-7
  • Buss J, Havel PJ, Epel E, et al. Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite 2014;76:84-94
  • Avogaro A, de Kreutzenberg SV, Federici M, Fadini GP. The endothelium abridges insulin resistance to premature aging. J Am Heart Assoc 2013;2(3):e000262
  • Duong MT, Sahin E. RAP1: protector of telomeres, defender against obesity. Cell Rep 2013;3(6):1757-8
  • Monickaraj F, Aravind S, Nandhini P, et al. Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes. J Biosci 2013;38(1):113-22
  • Makino N, Maeda T, Oyama J, et al. Improving insulin sensitivity via activation of PPAR-gamma increases telomerase activity in the heart of OLETF rats. Am J Physiol Heart Circ Physiol 2009;297(6):H2188-95
  • Minamino T, Orimo M, Shimizu I, et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 2009;15(9):1082-7
  • Daubenmier J, Lin J, Blackburn E, et al. Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study. Psychoneuroendocrinology 2012;37(7):917-28
  • Shaheen F, Grammatopoulos DK, Müller J, et al. Extra-nuclear telomerase reverse transcriptase (TERT) regulates glucose transport in skeletal muscle cells. Biochim Biophys Acta 2014;1842(9):1762-9
  • Hamel FG. Telomeres and T2D. Transl Res 2010;155(4):164-5
  • Messier B, Leblond CP. Cell proliferation and migration as revealed by radioautography after injection of thymidine-H3 into male rats and mice. Am J Anat 1960;106:247-85
  • Brennand K, Huangfu D, Melton D. All beta cells contribute equally to islet growth and maintenance. PLoS Biol 2007;5:e163
  • Teta M, Rankin MM, Long SY, et al. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 2007;12:817-26
  • Marchetti P, Dotta F, Lauro D, Purrello F. An overview of pancreatic beta-cell defects in human T2D: implications for treatment. Regul Pept 2008;146:4-11
  • Wu HL, Wang Y, Zhang P, et al. Reversible immortalization of rat pancreatic beta cells with a novel immortalizing and tamoxifen-mediated self-recombination tricistronic vector. J Biotechnol 2011;151(3):231-41
  • Ravassard P, Hazhouz Y, Pechberty S, et al. Beta cell line exhibiting glucose-inducible insulin secretion. J Clin Invest 2011;121(9):3589-97
  • Berrone E, Beltramo E, Buttiglieri S, et al. Establishment and characterization of a human retinal pericyte line: a novel tool for the study of diabetic retinopathy. Int J Mol Med 2009;23(3):373-8
  • Rota M, LeCapitaine N, Hosoda T, et al. Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by the deletion of the p66shc gene. Circ Res 2006;99:42-52
  • Kajstura J, Fiordaliso F, Andreoli AM, et al. IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes 2001;50:1414-24
  • Han J, Zhong J, Wei W, et al. Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice. Diabetes 2008;57(8):2118-27
  • Kadam SS, Sudhakar M, Nair PD, Bhonde RR. Reversal of experimental diabetes in mice by transplantation of neo-islets generated from human amnion-derived mesenchymal stromal cells using immuno-isolatory macrocapsules. Cytotherapy 2010;12(8):982-91
  • Kadam SS, Bhonde RR. Islet neogenesis from the constitutively nestin expressing human umbilical cord matrix derived mesenchymal stem cells. Islets 2010;2(2):112-20
  • Wu Y, Zhao RC, Tredget EE. Concise review: bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration. Stem Cells 2010;28(5):905-15
  • Sun Q, Zhang Z, Sun Z. The potential and challenges of using stem cells for cardiovascular repair and regeneration. Genes Dis 2014;1(1):113-19
  • Park KS, Kim YS, Kim JH, et al. Influence of human allogenic bone marrow and cord blood-derived mesenchymal stem cell secreting trophic factors on ATP (adenosine-5′-triphosphate)/ADP (adenosine-5′-diphosphate) ratio and insulin secretory function of isolated human islets from cadaveric donor. Transplant Proc 2009;41(9):3813-18
  • Xu YX, Chen L, Hou WK, et al. Mesenchymal stem cells treated with rat pancreatic extract secrete cytokines that improve the glycometabolism of diabetic rats. Transplant Proc 2009;41(5):1878-84
  • Shibata T, Naruse K, Kamiya H, et al. Transplantation of bone marrow-derived mesenchymal stem cells improves diabetic polyneuropathy in rats. Diabetes 2008;57(11):3099-107
  • Shabbir A, Zisa D, Suzuki G, Lee T. Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol 2009;296(6):H1888-97
  • Tang H, Xiang Y, Jiang X, et al. Dual expression of hTERT and VEGF prolongs life span and enhances angiogenic ability of aged BMSCs. Biochem Biophys Res Commun 2013;440(4):502-8
  • Ebert R, Ulmer M, Zeck S, et al. Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro. Stem Cells 2006;24(5):1226-35
  • Testa R, Olivieri F, Sirolla C, et al. Leukocyte telomere length is associated with complications of T2D mellitus. Diabet Med 2011;28(11):1388-94
  • Karlseder J, Broccoli D, Dai Y, et al. Lange T. p53- and ATM dependent apoptosis induced by telomeres lacking TRF2. Science 1999;283:1321-5
  • Minamino T, Miyauchi H, Yoshida T, et al. Endothelial cell senescence in human atherosclerosis. Role of telomere in endothelial dysfunction. Circulation 2002;105:1541-4
  • Ogami M, Ikura Y, Ohsawa M, et al. Telomere shortening in human coronary artery diseases. Arterioscler Thromb Vasc Biol 2004;24:546-50
  • Lusis AJ. Atherosclerosis. Nature 2000;407:233-41
  • Rivard A, Andres V. Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases. Histol Histopathol 2000;15:557-71
  • Dzau VJ, Braun-Dullaeus RC, Sedding DG. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med 2002;8:1249-56
  • Andres V. Control of vascular cell proliferation and migration by cyclindependent kinase signalling: new perspectives and therapeutic potential. Cardiovasc Res 2004;63:11-21
  • Minamino T, Kourembanas S. Mechanisms of telomerase induction during vascular smooth muscle cell proliferation. Circ Res 2001;89:237-43
  • Ogawa D, Nomiyama T, Nakamachi T, et al. Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells. Circ Res 2006;98:e50-9
  • Matthews C, Gorenne I, Scott S, et al. Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress. Circ Res 2006;99:156-64
  • Jiang X, Dong M, Cheng J, et al. Decreased leukocyte telomere length (LTL) is associated with stroke but unlikely to be causative. PLoS One 2013;8(7):e68254
  • Gupta M, Shogreen MR, Braden GA, et al. Prevalence of telomerase in coronary artery atherosclerosis. J Anti-Aging Med 2000;3:15-24
  • Liu S-C, Wang S-S, Wu M-Z, et al. Activation of telomerase and expression of human telomerase reverse transcriptase in coronary atherosclerosis. Cardiovasc Pathol 2005;14:232-40
  • Fuster JJ, Andres V. Telomere biology and cardiovascular disease. Circ Res. 2006. 99:1167-80
  • Hayashi T, Kotani H, Yamaguchi T, et al. Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes. Proc Natl Acad Sci USA 2014;111(3):1168-73
  • Zhong W, Zou G, Gu J, Zhang J. L-arginine attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells. Diabetes Res Clin Pract 2010;89(1):38-45
  • Ding H, Yan F, Zhou LL, et al. Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population. Clin Interv Aging 2014;9:857-61
  • Cao Y, Li H, Mu F-T, et al. Telomerase activation causes vascular smooth muscle cell proliferation in genetic hypertension. FASEB J 2002;16:96-8
  • Benetos A, Gardner JP, Zureik M, et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension 2004;43(2):182-5
  • Serrano AL, Andrés V. Telomeres and cardiovascular disease: does size matter? Circ Res 2004;94(5):575-84
  • Vasan RS, Demissie S, Kimura M, et al. Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study. Circulation 2008;117(9):1138-44
  • Benetos A, Okuda K, Lajemi M, et al. Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 2001b;37(2 Pt 2):381;385
  • Aydos SE, Tükün A. Does telomere length affect blood pressure? Adv Ther 2007;24(2):269-72
  • Morgan RG, Ives SJ, Walker AE, et al. Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping. J Hypertens 2014;32(6):1293-9
  • Tristano A, Eugenia Chollet M, Willson ML, et al. Telomerase activity in peripheral blood leukocytes from patients with essential hypertension. Med Clin (Barc) 2003;120(10):365-9
  • Imanishi T, Moriwaki C, Hano T, et al. Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients withessential hypertension. J Hypertens 2005;23(10):1831-7
  • Nilsson PM. Impact of vascular aging on cardiovascular disease: the role of telomere biology.J Hypertens. 2012;30(Suppl):S9-12
  • Maeda T, Oyama JI, Sasaki M, et al. The correlation between the clinical laboratory data and the telomere length in peripheral blood leukocytes of Japanese female patients with hypertension. J Nutr Health Aging 2011;15(3):240-4
  • Wong LS, de Boer RA, Samani NJ, et al. Telomere biology in heart failure. Eur J Heart Fail 2008;10(11):1049-56
  • Fernández-Real JM, Moreno-Navarrete JM, Ortega F, Ricart W. Decreased serum creatinine concentration is associated with short telomeres of adipose tissue cells. Obesity (Silver Spring) 2011;19(7):1511-14
  • Fyhrquist F, Silventoinen K, Saijonmaa O, et al. Telomere length and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study. J Hum Hypertens 2011;25(12):711-18
  • Cortés MJ, Díez-Juan A, Pérez P, et al. Increased early atherogenesis in young versus old hypercholesterolemic rabbits by a mechanism independent of arterial cell proliferation. FEBS Lett 2002;522(1-3):99-103
  • Breslow JL. Mouse models of atherosclerosis. Science 1996;272:685-8
  • Collins K, Mitchell JR. Telomerase in the human organism. Oncogene 2002;21:564-79
  • Wong LS, van der Harst P, de Boer RA, et al. Aging, telomeres and heart failure. Heart Fail Rev 2010;15(5):479-86
  • Spyridopoulos I, Hoffmann J, Aicher A, et al. Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity. Circulation 2009;120(14):1364-72
  • Werner C, Hanhoun M, Widmann T, et al. Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis. J Am Coll Cardiol 2008;52(6):470-82
  • Oh H, Taffet GE, Youker KA, et al. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc Nat Acad Sci USA 2001;98:10308-13
  • Oh H, Wang SC, Prahash A, et al. Telomere attrition and Chk2 activation in human heart failure. Proc Natl Acad Sci USA 2003;100:5378-83
  • Kajstura J, Leri A, Finato N, et al. Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci USA 1998;95:8801-5
  • Anversa P, Kajstura J. Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circ Res 1998;83:1-14
  • Beltrami AP, Urbanek K, Kajstura J, et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001;344:1750-7
  • Quaini F, Urbanek K, Beltrami AP, et al. Chimerism of the transplanted heart. N Engl J Med 2002;346:5-15
  • Makino N, Sasaki M, Maeda T, Mimori K. Telomere biology in cardiovascular disease - role of insulin sensitivity in diabetic hearts. Exp Clin Cardiol 2010;15(4):e128-33
  • Kajstura J, Rota M, Urbanek K, et al. The telomere-telomerase axis and the heart. Antioxid Redox Signal 2006;8(11-12):2125-41
  • Sampson MJ, Hughes DA. Chromosomal telomere attrition as a mechanism for the increased risk of epithelial cancers and senescent phenotypes in T2D. Diabetologia 2006;49(8):1726-31
  • Mackenzie HS, Brenner BM. Fewer nephrons at birth: a missing link in the etiology of essential hypertension? Am J Kidney Dis 1995;26(1):91-8
  • Jennings BJ, Ozanne SE, Dorling MW, Hales CN. Early growth determines longevity in male rats and may be related to telomere shortening in the kidney. FEBS Lett 1999;448(1):4-8
  • Verzola D, Gandolfo MT, Gaetani G, et al. Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy. Am J Physiol Renal Physiol 2008;295(5):F1563-73
  • Fyhrquist F, Tiitu A, Saijonmaa O, FinnDiane Study Group. Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes. J Intern Med 2010;267(3):278-86
  • Astrup AS, Tarnow L, Jorsal A, et al. Telomere length predicts all-cause mortality in patients with type 1 diabetes. Diabetologia 2010;53(1):45-8
  • Honda S, Weigel A, Hjelmeland LM, Handa JT. Induction of telomere shortening and replicative senescence by cryopreservation. Biochem Biophys Res Commun 2001;282(2):493-8
  • Matsunaga H, Handa JT, Aotaki-Keen A, et al. Beta-galactosidase histochemistry and telomere loss in senescent retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 1999;40(1):197-202
  • Jayaguru P, Mohr S. Nuclear GAPDH: changing the fate of Müller cells in diabetes. J Ocul Biol Dis Infor 2011;4(1-2):34-41
  • Deissler H, Deissler H, Lang GK, Lang GE. Generation and characterization of iBREC: novel hTERT-immortalized bovine retinal endothelial cells. Int J Mol Med 2005;16(1):65-70

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