Risk of chemotherapy-induced neutropenic complications when treating patients with non-Hodgkin lymphoma

References

• Kuderer NM, Dale DC, Crawford J, et al. Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. Cancer. 2006;106:2258–2266.
   PubMed Web of Science ®Google Scholar
• Lewis MA, Hendrickson AW, Moynihan TJ. Oncologic emergencies: Pathophysiology, presentation, diagnosis, and treatment. CA Cancer J Clin. 2011;61:287–314.
   PubMed Web of Science ®Google Scholar
• Lyman GH, Dale DC, Crawford J. Incidence and predictors of low dose-intensity in adjuvant breast cancer chemotherapy: a nationwide study of community practices. J Clin Oncol. 2003;21:4524–4531.
   PubMed Web of Science ®Google Scholar
• Lyman GH, Dale DC, Friedberg J, et al. Incidence and predictors of low chemotherapy dose-intensity in aggressive non-Hodgkin’s lymphoma: a nationwide study. J Clin Oncol. 2004;22:4302–4311.
   PubMed Web of Science ®Google Scholar
• Lyman GH. Impact of chemotherapy dose intensity on cancer patient outcomes. J Natl Compr Canc Netw. 2009;7:99–108.
   PubMed Web of Science ®Google Scholar
• Shayne M, Culakova E, Wolff D, et al Dose intensity and hematologic toxicity in older breast cancer patients receiving systemic chemotherapy. Cancer. 2009;115:5319–5328.
   PubMed Web of Science ®Google Scholar
• Shayne M, Culakova E, Poniewierski MS, et al Dose intensity and hematologic toxicity in older cancer patients receiving systemic chemotherapy. Cancer. 2007;110:1611–1620.
   PubMed Web of Science ®Google Scholar
• Klastersky JA, Paesmans M. Treatment of febrile neutropenia is expensive: prevention is the answer. Onkologie. 2011;34:226–228.
   PubMedGoogle Scholar
• Hendricks AM, Loggers ET, Talcott JA. Costs of home versus inpatient treatment for fever and neutropenia: analysis of a multicenter randomized trial. J Clin Oncol. 2011;29:3984–3989.
   PubMed Web of Science ®Google Scholar
• Liou SY, Stephens JM, Carpiuc KT, et al Economic burden of haematological adverse effects in cancer patients: a systematic review. Clin Drug Investig. 2007;27:381–396.
   PubMed Web of Science ®Google Scholar
• Stokes ME, Muehlenbein CE, Marciniak MD, et al Neutropenia-related costs in patients treated with first-line chemotherapy for advanced non-small cell lung cancer. J Manag Care Pharm. 2009;15:669–682.
   PubMed Web of Science ®Google Scholar
• Cosler LE, Eldar-Lissai A, Culakova E, et al Therapeutic use of granulocyte colony-stimulating factors for established febrile neutropenia: effect on costs from a hospital perspective. Pharmacoeconomics. 2007;25:343–351.
   PubMed Web of Science ®Google Scholar
• Lyman GH. Risk assessment in oncology clinical practice. From risk factors to risk models. Oncology (Williston Park). 2003;17:8–13.
   PubMedGoogle Scholar
• Dale DC, McCarter GC, Crawford J, et al. Myelotoxicity and dose intensity of chemotherapy: reporting practices from randomized clinical trials. J Natl Compr Canc Netw. 2003;1:440–454.
   PubMedGoogle Scholar
• Lyman GH, Lyman CH, Agboola O. Risk models for predicting chemotherapy-induced neutropenia. Oncologist. 2005;10:427–437.
   PubMed Web of Science ®Google Scholar
• Crawford J, Dale DC, Kuderer NM, et al. Risk and timing of neutropenic events in adult cancer patients receiving chemotherapy: the results of a prospective nationwide study of oncology practice. J Natl Compr Canc Netw. 2008;6:109–118.
   PubMedGoogle Scholar
• Laskey RA, Poniewierski MS, Lopez MA, et al Predictors of severe and febrile neutropenia during primary chemotherapy for ovarian cancer. Gynecol Oncol. 2012;125:625–630.
   PubMed Web of Science ®Google Scholar
• Lyman GH, Delgado DJ. Risk and timing of hospitalization for febrile neutropenia in patients receiving CHOP, CHOP-R, or CNOP chemotherapy for intermediate-grade non-Hodgkin lymphoma. Cancer. 2003;98:2402–2409.
   PubMed Web of Science ®Google Scholar
• Smith TJ, Bohlke K, Lyman GH, et al. Recommendations for the use of WBC growth factors: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2015;33:3199–3212.
   PubMed Web of Science ®Google Scholar
• Aapro M, Crawford J, Kamioner D. Prophylaxis of chemotherapy-induced febrile neutropenia with granulocyte colony-stimulating factors: where are we now?. Support Care Cancer. 2010;18:529–541.
   PubMed Web of Science ®Google Scholar
• Coiffier B, Lepage E, Briere J, et al CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med. 2002;346:235–242.
   PubMed Web of Science ®Google Scholar
• Lyman GH, Morrison VA, Dale DC, et al Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin’s lymphoma receiving CHOP chemotherapy. Leuk Lymphoma. 2003;44:2069–2076.
   PubMed Web of Science ®Google Scholar
• Epelbaum R, Haim N, Ben-Shahar M, et al Dose-intensity analysis for CHOP chemotherapy in diffuse aggressive large cell lymphoma. Isr J Med Sci. 1988;24:533–538.
   PubMedGoogle Scholar
• Kwak LW, Halpern J, Olshen RA, et al Prognostic significance of actual dose intensity in diffuse large-cell lymphoma: results of a tree-structured survival analysis. J Clin Oncol. 1990;8:963–977.
   PubMed Web of Science ®Google Scholar
• Pettengell R, Schwenkglenks M, Bosly A. Association of reduced relative dose intensity and survival in lymphoma patients receiving CHOP-21 chemotherapy. Ann Hematol. 2008;87:429–430.
   PubMed Web of Science ®Google Scholar
• Wildiers H, Reiser M. Relative dose intensity of chemotherapy and its impact on outcomes in patients with early breast cancer or aggressive lymphoma. Crit Rev Oncol Hematol. 2011;77:221–240.
   PubMed Web of Science ®Google Scholar
• Bosly A, Bron D, Van Hoof A, et al Achievement of optimal average relative dose intensity and correlation with survival in diffuse large B-cell lymphoma patients treated with CHOP. Ann Hematol. 2008;87:277–283.
   PubMed Web of Science ®Google Scholar
• Campbell C, Sawka C, Franssen E, et al Delivery of full dose CHOP chemotherapy to elderly patients with aggressive non-Hodgkin’s lymphoma without G-CSF support. Leuk Lymphoma. 1999;35:119–127.
   PubMed Web of Science ®Google Scholar
• Case DC Jr., Desch CE, Kalman LA, et al Community-based trial of R-CHOP and maintenance rituximab for intermediate- or high-grade non-Hodgkin lymphoma with first-cycle filgrastim for older patients. Clin Lymphoma Myeloma. 2007;7:354–360.
   PubMedGoogle Scholar
• Pettengell R, Schwenkglenks M, Leonard R, et al Neutropenia occurrence and predictors of reduced chemotherapy delivery: results from the INC-EU prospective observational European neutropenia study. Support Care Cancer. 2008;16:1299–1309.
   PubMed Web of Science ®Google Scholar
• Denduluri N, Patt DA, Wang Y, et al. Dose delays, dose reductions, and relative dose intensity in patients with cancer who received adjuvant or neoadjuvant chemotherapy in community oncology practices. J Natl Compr Canc Netw. 2015;13:1383–1393.
   PubMed Web of Science ®Google Scholar
• Aviles A, Nambo MJ, Neri N, et al Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: results of a controlled clinical trial. Med Oncol. 2005;22:57–62.
   PubMed Web of Science ®Google Scholar
• Burton C, Linch D, Hoskin P, et al A phase III trial comparing CHOP to PMitCEBO with or without G-CSF in patients aged 60 plus with aggressive non-Hodgkin’s lymphoma. Br J Cancer. 2006;94:806–813.
   PubMed Web of Science ®Google Scholar
• Chamorey E, Gressin R, Peyrade F, et al Prospective randomized study comparing MEMID with a chop-like regimen in elderly patients with aggressive non-Hodgkin’s lymphoma. Oncology. 2005;69:19–26.
   PubMed Web of Science ®Google Scholar
• Coiffier B, Thieblemont C, Van Den Neste E, et al Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d’Etudes des Lymphomes de l’Adulte. Blood. 2010;116:2040–2045.
   PubMed Web of Science ®Google Scholar
• Cunningham D, Hawkes EA, Jack A, et al Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles. Lancet. 2013;381:1817–1826.
   PubMed Web of Science ®Google Scholar
• Delarue R, Tilly H, Mounier N, et al Dose-dense rituximab-CHOP compared with standard rituximab-CHOP in elderly patients with diffuse large B-cell lymphoma (the LNH03-6B study): a randomised phase 3 trial. Lancet Oncol. 2013;14:525–533.
   PubMed Web of Science ®Google Scholar
• Economopoulos T, Psyrri A, Dimopoulos MA, et al CEOP-21 versus CEOP-14 chemotherapy with or without rituximab for the first-line treatment of patients with aggressive lymphomas: results of the HE22A99 trial of the Hellenic Cooperative Oncology Group. Cancer J. 2007;13:327–334.
   PubMed Web of Science ®Google Scholar
• Federico M, Luminari S, Dondi A, et al R-CVP versus R-CHOP versus R-FM for the initial treatment of patients with advanced-stage follicular lymphoma: results of the FOLL05 trial conducted by the Fondazione Italiana Linfomi. J Clin Oncol. 2013;31:1506–1513.
   PubMed Web of Science ®Google Scholar
• Federico M, Luminari S, Gobbi PG, et al The length of treatment of aggressive non-Hodgkin’s lymphomas established according to the international prognostic index score: long-term results of the GISL LA03 study. Eur J Haematol. 2006;76:217–229.
   PubMed Web of Science ®Google Scholar
• Flinn IW, Van Der Jagt R, Kahl BS, et al Randomized trial of bendamustine-rituximab or R-CHOP/R-CVP in first-line treatment of indolent NHL or MCL: the BRIGHT study. Blood. 2014;123:2944–2952.
   PubMed Web of Science ®Google Scholar
• Foussard C, Colombat P, Maisonneuve H, et al Long-term follow-up of a randomized trial of fludarabine-mitoxantrone, compared with cyclophosphamide, doxorubicin, vindesine, prednisone (CHVP), as first-line treatment of elderly patients with advanced, low-grade non-Hodgkin’s lymphoma before the era of monoclonal antibodies. Ann Oncol. 2005;16:466–472.
   PubMed Web of Science ®Google Scholar
• Fridrik MA, Hausmaninger H, Lang A, et al Dose-dense therapy improves survival in aggressive non-Hodgkin’s lymphoma. Ann Hematol. 2010;89:273–282.
   PubMed Web of Science ®Google Scholar
• Habermann TM, Weller EA, Morrison VA, et al Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma. J Clin Oncol. 2006;24:3121–3127.
   PubMed Web of Science ®Google Scholar
• Hagenbeek A, Eghbali H, Monfardini S, et al Phase III intergroup study of fludarabine phosphate compared with cyclophosphamide, vincristine, and prednisone chemotherapy in newly diagnosed patients with stage III and IV low-grade malignant Non-Hodgkin’s lymphoma. J Clin Oncol. 2006;24:1590–1596.
   PubMed Web of Science ®Google Scholar
• Herold M, Haas A, Srock S, et al Rituximab added to first-line mitoxantrone, chlorambucil, and prednisolone chemotherapy followed by interferon maintenance prolongs survival in patients with advanced follicular lymphoma: an East German Study Group Hematology and Oncology Study. J Clin Oncol. 2007;25:1986–1992.
   PubMed Web of Science ®Google Scholar
• Hertzberg M, Matthews JP, Stone JM, et al A phase III randomized trial of high-dose CEOP + filgrastim versus standard-dose CEOP in patients with non-Hodgkin lymphoma: 10-year follow-up data: Australasian Leukaemia and Lymphoma Group (ALLG) NHL07 trial. Am J Hematol. 2014;89:536–541.
   PubMed Web of Science ®Google Scholar
• Hess G, Herbrecht R, Romaguera J, et al Phase III study to evaluate temsirolimus compared with investigator’s choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol. 2009;27:3822–3829.
   PubMed Web of Science ®Google Scholar
• Hiddemann W, Kneba M, Dreyling M, et al Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood. 2005;106:3725–3732.
   PubMed Web of Science ®Google Scholar
• Kalinka-Warzocha E, Wajs J, Lech-Maranda E, et al Randomized comparison of cladribine alone or in combination with cyclophosphamide, and cyclophosphamide, vincristine and prednisone in previously untreated low-grade B-cell non-Hodgkin lymphoma patients: final report of the Polish Lymphoma Research Group. Cancer. 2008;113:367–375.
   PubMed Web of Science ®Google Scholar
• Ketterer N, Coiffier B, Thieblemont C, et al Phase III study of ACVBP versus ACVBP plus rituximab for patients with localized low-risk diffuse large B-cell lymphoma (LNH03-1B). Ann Oncol. 2013;24:1032–1037.
   PubMed Web of Science ®Google Scholar
• Kluin-Nelemans HC, Hoster E, Hermine O, et al Treatment of older patients with mantle-cell lymphoma. N Engl J Med. 2012;367:520–531.
   PubMed Web of Science ®Google Scholar
• Leblond V, Johnson S, Chevret S, et al Results of a randomized trial of chlorambucil versus fludarabine for patients with untreated Waldenstrom macroglobulinemia, marginal zone lymphoma, or lymphoplasmacytic lymphoma. J Clin Oncol. 2013;31:301–307.
   PubMed Web of Science ®Google Scholar
• Marcus R, Imrie K, Solal-Celigny P, et al Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma. J Clin Oncol. 2008;26:4579–4586.
   PubMed Web of Science ®Google Scholar
• Merli F, Bertini M, Luminari S, et al Long term results of a randomized study performed by Intergruppo Italiano Linfomi comparing Mini-CEOP vs P-VEBEC in elderly patients with diffuse large B-cell lymphoma. Leuk Lymphoma. 2007;48:367–373.
   PubMed Web of Science ®Google Scholar
• Merli F, Luminari S, Rossi G, et al Cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab versus epirubicin, cyclophosphamide, vinblastine, prednisone and rituximab for the initial treatment of elderly “fit” patients with diffuse large B-cell lymphoma: results from the ANZINTER3 trial of the Intergruppo Italiano Linfomi. Leuk Lymphoma. 53;581-8:2012.
   Google Scholar
• Morel P, Munck JN, Coiffier B, et al Comparison of two high-dose cyclophosphamide, doxorubicin, vincristine, and prednisone derived regimens in patients aged under 60 years with low-intermediate risk aggressive lymphoma: a final analysis of the multicenter LNH93-2 protocol. Leuk Lymphoma. 2010;51:1668–1677.
   PubMed Web of Science ®Google Scholar
• Mori M, Kitamura K, Masuda M, et al Long-term results of a multicenter randomized, comparative trial of modified CHOP versus THP-COP versus THP-COPE regimens in elderly patients with non-Hodgkin’s lymphoma. Int J Hematol. 2005;81:246–254.
   PubMed Web of Science ®Google Scholar
• Nickenig C, Dreyling M, Hoster E, et al Combined cyclophosphamide, vincristine, doxorubicin, and prednisone (CHOP) improves response rates but not survival and has lower hematologic toxicity compared with combined mitoxantrone, chlorambucil, and prednisone (MCP) in follicular and mantle cell lymphomas: results of a prospective randomized trial of the German Low-Grade Lymphoma Study Group. Cancer. 2006;107:1014–1022.
   PubMed Web of Science ®Google Scholar
• Ohmachi K, Tobinai K, Kobayashi Y, et al Phase III trial of CHOP-21 versus CHOP-14 for aggressive non-Hodgkin’s lymphoma: final results of the Japan Clinical Oncology Group Study, JCOG 9809. Ann Oncol. 2011;22:1382–1391.
   PubMed Web of Science ®Google Scholar
• Pettengell R, Coiffier B, Narayanan G, et al Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial. Lancet Oncol. 2012;13:696–706.
   PubMed Web of Science ®Google Scholar
• Pfreundschuh M, Schubert J, Ziepert M, et al Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol. 2008;9:105–116.
   PubMed Web of Science ®Google Scholar
• Pfreundschuh M, Zwick C, Zeynalova S, et al Dose-escalated CHOEP for the treatment of young patients with aggressive non-Hodgkin’s lymphoma: II. Results of the randomized high-CHOEP trial of the German High-Grade Non-Hodgkin’s Lymphoma Study Group (DSHNHL). Ann Oncol. 2008;19:545–552.
   PubMed Web of Science ®Google Scholar
• Press OW, Unger JM, Rimsza LM, et al Phase III randomized intergroup trial of CHOP plus rituximab compared with CHOP chemotherapy plus (131)iodine-tositumomab for previously untreated follicular non-Hodgkin lymphoma: SWOG S0016. J Clin Oncol. 2013;31:314–320.
   PubMed Web of Science ®Google Scholar
• Recher C, Coiffier B, Haioun C, et al Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial. Lancet. 2011;378:1858–1867.
   PubMed Web of Science ®Google Scholar
• Robak T, Huang H, Jin J, et al Bortezomib-based therapy for newly diagnosed mantle-cell lymphoma. N Engl J Med. 2015;372:944–953.
   PubMed Web of Science ®Google Scholar
• Rummel MJ, Niederle N, Maschmeyer G, et al Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial. Lancet. 2013;381:1203–1210.
   PubMed Web of Science ®Google Scholar
• Salles G, Mounier N, De Guibert S, et al Rituximab combined with chemotherapy and interferon in follicular lymphoma patients: results of the GELA-GOELAMS FL2000 study. Blood. 2008;112:4824–4831.
   PubMed Web of Science ®Google Scholar
• Seymour JF, Pfreundschuh M, Trneny M, et al R-CHOP with or without bevacizumab in patients with previously untreated diffuse large B-cell lymphoma: final MAIN study outcomes. Haematologica. 2014;99:1343–1349.
   PubMed Web of Science ®Google Scholar
• Smith SM, Johnson J, Cheson BD, et al Recombinant interferon-alpha2b added to oral cyclophosphamide either as induction or maintenance in treatment-naive follicular lymphoma: final analysis of CALGB 8691. Leuk Lymphoma. 2009;50:1606–1617.
   PubMed Web of Science ®Google Scholar
• Taylor PR, White JM, Prescott RJ, et al The addition of oral idarubicin to a chlorambucil/dexamethasone combination has a significant impact on time to treatment failure but none on overall survival in patients with low grade non-Hodgkin’s lymphoma: results of the Scotland and Newcastle Lymphoma Group randomized NHL VIII trial. Leuk Lymphoma. 2006;47:2321–2330.
   PubMed Web of Science ®Google Scholar
• Van Oers MH, Klasa R, Marcus RE, et al Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial. Blood. 2006;108:3295–3301.
   PubMed Web of Science ®Google Scholar
• Verdonck LF, Notenboom A, De Jong DD, et al Intensified 12-week CHOP (I-CHOP) plus G-CSF compared with standard 24-week CHOP (CHOP-21) for patients with intermediate-risk aggressive non-Hodgkin lymphoma: a phase 3 trial of the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON). Blood. 2007;109:2759–2766.
   PubMed Web of Science ®Google Scholar
• Watanabe T, Tobinai K, Shibata T, et al Phase II/III study of R-CHOP-21 versus R-CHOP-14 for untreated indolent B-cell non-Hodgkin’s lymphoma: JCOG 0203 trial. J Clin Oncol. 2011;29:3990–3998.
   PubMed Web of Science ®Google Scholar
• Zucca E, Conconi A, Laszlo D, et al Addition of rituximab to chlorambucil produces superior event-free survival in the treatment of patients with extranodal marginal-zone B-cell lymphoma: 5-year analysis of the IELSG-19 Randomized Study. J Clin Oncol. 2013;31:565–572.
   PubMed Web of Science ®Google Scholar
• Kuderer NM, Wolff AC. Enhancing therapeutic decision making when options abound: toxicities matter. J Clin Oncol. 2014;32:1990–1993.
   PubMed Web of Science ®Google Scholar
• Aapro MS, Bohlius J, Cameron DA, et al update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours. Eur J Cancer. 2010;47(8–32):2011.
   Google Scholar
• Crawford J, Armitage J, Balducci L, et al. National comprehensive cancer network. Myeloid growth factors. J Natl Compr Canc Netw. 2013 Oct 1;11(10):1266–1690. PubMed PMID: 24142827.
   Google Scholar
• Kuderer NM, Lyman GH. Personalized medicine and cancer supportive care: appropriate use of colony-stimulating factor support of chemotherapy. J Natl Cancer Inst. 2011;103:910–913.
   PubMedGoogle Scholar
• Lyman GH, Kuderer NM, Crawford J, et al. Predicting individual risk of neutropenic complications in patients receiving cancer chemotherapy. Cancer. 2011;117:1917–1927.
   PubMed Web of Science ®Google Scholar
• Lyman GH, Dale DC, Legg JC, et al Assessing patients’ risk of febrile neutropenia: is there a correlation between physician-assessed risk and model-predicted risk?. Cancer Med. 2015;4:1153–1160.
   PubMed Web of Science ®Google Scholar
• Zelenetz AD, Gordon LI, Wierda WG, et al. National comprehensive cancer network. Non-Hodgkin’s lymphomas, version 4.2014. J Natl Compr Canc Netw. 2014;Sep;12(9):1282–1303. PubMed PMID: 25190696.
   Google Scholar
• Nastoupil LJ, Rose AC, Flowers CR. Diffuse large B-cell lymphoma: current treatment approaches. Oncology (Williston Park). 2012;26:488–495.
   PubMed Web of Science ®Google Scholar
• Budman DR, Berry DA, Cirrincione CT, et al Dose and dose intensity as determinants of outcome in the adjuvant treatment of breast cancer. The Cancer and Leukemia Group B. J Natl Cancer Inst. 1998;90:1205–1211.
   PubMed Web of Science ®Google Scholar
• Bonadonna G, Valagussa P, Moliterni A, et al Adjuvant cyclophosphamide, methotrexate, and fluorouracil in node-positive breast cancer: the results of 20 years of follow-up. N Engl J Med. 1995;332:901–906.
   PubMed Web of Science ®Google Scholar
• Culakova E, Thota R, Poniewierski MS, et al. Patterns of chemotherapy-associated toxicity and supportive care in US oncology practice: a nationwide prospective cohort study. Cancer Med. 2014;3:434–444.
   PubMed Web of Science ®Google Scholar