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Expert Opinion on Drug Delivery Volume 2, 2005 - Issue 2
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Review

Cationic liposomes for gene delivery

Sérgio Simões University of Coimbra, Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, Coimbra, Portugal. [email protected]
,
Ana Filipe University of Coimbra, Center for Neurosciences and Cell Biology, Coimbra, Portugal
,
Henrique Faneca University of Coimbra, Center for Neurosciences and Cell Biology, Coimbra, Portugal
,
Miguel Mano University of Coimbra, Center for Neurosciences and Cell Biology, Coimbra, Portugal
,
Nuno Penacho University of Coimbra, Center for Neurosciences and Cell Biology, Coimbra, Portugal
,
Nejat Düzgünes University of the Pacific, Department of Microbiology, School of Dentistry, San Francisco, CA 94115, USA
&
Maria Pedroso de Lima University of Coimbra, Department of Biochemistry, Coimbra, Portugal
 show all
Pages 237-254 | Published online: 12 May 2005

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  • ••The authors demonstrated for the firsttime that liposome-DNA complexes could be successfully re-administered to the nose of CF patients
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  • ••The authors observed transgene expressionand a significant antitumour activity in patients with malignant glioma following transfer of IFN-f3 gene via cationic liposomes
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Websites

  • http://www.wiley.co.uk/genmed/clinical/ The Journal of Gene Medicine website for Gene Therapy Clinical Trials Worldwide (2004)

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