527
Views
53
CrossRef citations to date
0
Altmetric
Reviews

Approaches to erythrocyte-mediated drug delivery

&

Bibliography

  • Juliano R, Poste G, Tomlinson E. Perspective from the founding editors. Preface. Adv Drug Deliv Rev 2013;65:3-4
  • Mullertz A, Ogbonna A, Ren S, et al. New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs. J Pharm Pharmacol 2010;62:1622-36
  • Schafroth N, Arpagaus C, Jadhav UY, et al. Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process. Colloids Surf B Biointerfaces 2012;90:8-15
  • Williams HD, Trevaskis NL, Charman SA, et al. Strategies to address low drug solubility in discovery and development. Pharmacol Rev 2013;65:315-499
  • Alam MA, Ali R, Al-Jenoobi FI, et al. Solid dispersions: a strategy for poorly aqueous soluble drugs and technology updates. Expert Opin Drug Deliv 2012;9:1419-40
  • Lim SB, Banerjee A, Onyuksel H. Improvement of drug safety by the use of lipid-based nanocarriers. J Control Release 2012;163:34-45
  • Sun H, Meng F, Cheng R, et al. Reduction-sensitive degradable micellar nanoparticles as smart and intuitive delivery systems for cancer chemotherapy. Expert Opin Drug Deliv 2013;10:1109-22
  • Pohlmann AR, Fonseca FN, Paese K, et al. Poly(-caprolactone) microcapsules and nanocapsules in drug delivery. Expert Opin Drug Deliv 2013;10:623-38
  • Kuthati Y, Sung PJ, Weng CF, et al. Functionalization of mesoporous silica nanoparticles for targeting, biocompatibility, combined cancer therapies and theragnosis. J Nanosci Nanotechnol 2013;13:2399-430
  • Chacko AM, Li C, Pryma DA, et al. Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-brain barrier divide. Expert Opin Drug Deliv 2013;10:907-26
  • Dufes C, Al RM, Somani S. Transferrin and the transferrin receptor for the targeted delivery of therapeutic agents to the brain and cancer cells. Ther Deliv 2013;4:629-40
  • Seedial SM, Ghosh S, Saunders RS, et al. Local drug delivery to prevent restenosis. J Vasc Surg 2013;57:1403-14
  • Pierige F, Serafini S, Rossi L, et al. Cell-based drug delivery. Adv Drug Deliv Rev 2008;60:286-95
  • Rossi L, Serafini S, Pierige F, et al. Erythrocyte-based drug delivery. Expert Opin Drug Deliv 2005;2:311-22
  • Biagiotti S, Paoletti MF, Fraternale A, et al. Drug delivery by red blood cells. IUBMB Life 2011;63:621-31
  • Magnani M, Pierige F, Rossi L. Erythrocytes as a novel delivery vehicle for biologics: from enzymes to nucleic acid-based therapeutics. Ther Deliv 2012;3:405-14
  • Muzykantov VR. Drug delivery by red blood cells: vascular carriers designed by mother nature. Expert Opin Drug Deliv 2010;7:403-27
  • Carnemolla R, Muzykantov VR. Vascular targeting of antithrombotic agents. IUBMB Life 2011;63:632-9
  • Muzykantov VR. Drug delivery carriers on the fringes: natural red blood cells versus synthetic multilayered capsules. Expert Opin Drug Deliv 2013;10:1-4
  • Greineder CF, Howard MD, Carnemolla R, et al. Advanced drug delivery systems for antithrombotic agents. Blood 2013;122:1565-75
  • Antonelli A, Sfara C, Battistelli S, et al. New strategies to prolong the in vivo life span of iron-based contrast agents for MRI. PLoS One 2013;8:e78542
  • Antonelli A, Sfara C, Rahmer J, et al. Red blood cells as carriers in magnetic particle imaging. Biomed Tech (Berl) 2013;58:517-25
  • Antonelli A, Sfara C, Manuali E, et al. Encapsulation of superparamagnetic nanoparticles into red blood cells as new carriers of MRI contrast agents. Nanomedicine (Lond) 2011;6:211-23
  • Markov DE, Boeve H, Gleich B, et al. Human erythrocytes as nanoparticle carriers for magnetic particle imaging. Phys Med Biol 2010;55:6461-73
  • Rahmer J, Antonelli A, Sfara C, et al. Nanoparticle encapsulation in red blood cells enables blood-pool magnetic particle imaging hours after injection. Phys Med Biol 2013;58:3965-77
  • Flower R, Peiretti E, Magnani M, et al. Observation of erythrocyte dynamics in the retinal capillaries and choriocapillaris using ICG-loaded erythrocyte ghost cells. Invest Ophthalmol Vis Sci 2008;49:5510-16
  • Antonelli A, Sfara C, Mosca L, et al. New biomimetic constructs for improved in vivo circulation of superparamagnetic nanoparticles. J Nanosci Nanotechnol 2008;8:2270-8
  • Rossi L, Serafini S, Cenerini L, et al. Erythrocyte-mediated delivery of dexamethasone in patients with chronic obstructive pulmonary disease. Biotechnol Appl Biochem 2001;33:85-9
  • Rossi L, Castro M, D'Orio F, et al. Low doses of dexamethasone constantly delivered by autologous erythrocytes slow the progression of lung disease in cystic fibrosis patients. Blood Cells Mol Dis 2004;33:57-63
  • Annese V, Latiano A, Rossi L, et al. Erythrocytes-mediated delivery of dexamethasone in steroid-dependent IBD patients-a pilot uncontrolled study. Am J Gastroenterol 2005;100:1370-5
  • Castro M, Knafelz D, Rossi L, et al. Periodic treatment with autologous erythrocytes loaded with dexamethasone 21-phosphate for fistulizing pediatric Crohn's disease: case report. J Pediatr Gastroenterol Nutr 2006;42:313-15
  • Annese V, Latiano A, Rossi L, et al. The polymorphism of multi-drug resistance 1 gene (MDR1) does not influence the pharmacokinetics of dexamethasone loaded into autologous erythrocytes of patients with inflammatory bowel disease. Eur Rev Med Pharmacol Sci 2006;10:27-31
  • Castro M, Rossi L, Papadatou B, et al. Long-term treatment with autologous red blood cells loaded with dexamethasone 21-phosphate in pediatric patients affected by steroid-dependent Crohn disease. J Pediatr Gastroenterol Nutr 2007;44:423-6
  • Bossa F, Annese V, Valvano MR, et al. Erythrocytes-mediated delivery of dexamethasone 21-phosphate in steroid-dependent ulcerative colitis: a randomized, double-blind Sham-controlled study. Inflamm Bowel Dis 2013;19:1872-9
  • Bossa F, Latiano A, Rossi L, et al. Erythrocyte-mediated delivery of dexamethasone in patients with mild-to-moderate ulcerative colitis, refractory to mesalamine: a randomized, controlled study. Am J Gastroenterol 2008;103:2509-16
  • Chessa L, Leuzzi V, Plebani A, et al. Intra-erythrocyte infusion of dexamethasone reduces neurological symptoms in ataxia teleangiectasia patients: results of a phase 2 trial. Orphanet J Rare Dis 2014;9:5
  • Lucidi V, Tozzi AE, Bella S, et al. A pilot trial on safety and efficacy of erythrocyte-mediated steroid treatment in CF patients. BMC Pediatr 2006;6:17
  • Pierige F, De MC, Orlotti N, et al. Cytotoxic activity of 2-Fluoro-ara-AMP and 2-Fluoro-ara-AMP-loaded erythrocytes against human breast carcinoma cell lines. Int J Oncol 2010;37:133-42
  • Fraternale A, Rossi L, Magnani M. Encapsulation, metabolism and release of 2-fluoro-ara-AMP from human erythrocytes. Biochim Biophys Acta 1996;1291:149-54
  • Magnani M, Bianchi M, Rossi L, et al. Human red blood cells as bioreactors for the release of 2',3'-dideoxycytidine, an inhibitor of HIV infectivity. Biochem Biophys Res Commun 1989;164:446-52
  • Solimano F, Bischi GI, Bianchi M, et al. A nonlinear three-compartment model for the administration of 2′,3′-dideoxycytidine by using red blood cells as bioreactors. Bull Math Biol 1990;52:785-96
  • Benatti U, Giovine M, Damonte G, et al. Azidothymidine homodinucleotide-loaded erythrocytes and bioreactors for slow delivery of the antiretroviral drug azidothymidine. Biochem Biophys Res Commun 1996;220:20-5
  • Rossi L, Brandi G, Schiavano GF, et al. Heterodimer-loaded erythrocytes as bioreactors for slow delivery of the antiviral drug azidothymidine and the antimycobacterial drug ethambutol. AIDS Res Hum Retroviruses 1999;15:345-53
  • Ihler GM, Glew RH, Schnure FW. Enzyme loading of erythrocytes. Proc Natl Acad Sci USA 1973;70:2663-6
  • Dale GL, Beutler E. Enzyme replacement therapy in Gaucher's disease: a rapid, high-yield method for purification of glucocerebrosidase. Proc Natl Acad Sci USA 1976;73:4672-4
  • Beutler E, Dale GL, Guinto DE, et al. Enzyme replacement therapy in Gaucher's disease: preliminary clinical trial of a new enzyme preparation. Proc Natl Acad Sci USA 1977;74:4620-3
  • Bax BE, Bain MD, Fairbanks LD, et al. In vitro and in vivo studies with human carrier erythrocytes loaded with polyethylene glycol-conjugated and native adenosine deaminase. Br J Haematol 2000;109:549-54
  • Bax BE, Bain MD, Fairbanks LD, et al. A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency. Eur J Haematol 2007;79:338-48
  • Moran NF, Bain MD, Muqit MM, et al. Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE. Neurology 2008;71:686-8
  • Bax BE, Bain MD, Scarpelli M, et al. Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement. Neurology 2013;81:1269-71
  • Agrawal V, Woo JH, Borthakur G, et al. Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia. Protein Pept Lett 2013;20:392-402
  • Domenech C, Thomas X, Chabaud S, et al. l-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial. Br J Haematol 2011;153:58-65
  • Kwon YM, Chung HS, Moon C, et al. L-Asparaginase encapsulated intact erythrocytes for treatment of acute lymphoblastic leukemia (ALL). J Control Release 2009;139:182-9
  • Favretto ME, Cluitmans JC, Bosman GJ, et al. Human erythrocytes as drug carriers: loading efficiency and side effects of hypotonic dialysis, chlorpromazine treatment and fusion with liposomes. J Control Release 2013;170:343-51
  • Bax BE, Bain MD, Talbot PJ, et al. Survival of human carrier erythrocytes in vivo. Clin Sci (Lond) 1999;96:171-8
  • Magnani M, Rossi L, Fraternale A, et al. Targeting antiviral nucleotide analogues to macrophages. J Leukoc Biol 1997;62:133-7
  • Magnani M, Rossi L, Brandi G, et al. Targeting antiretroviral nucleoside analogues in phosphorylated form to macrophages: in vitro and in vivo studies. Proc Natl Acad Sci USA 1992;89:6477-81
  • Rossi L, Brandi G, Fraternale A, et al. Inhibition of murine retrovirus-induced immunodeficiency disease by dideoxycytidine and dideoxycytidine 5'-triphosphate. J Acquir Immune Defic Syndr 1993;6:1179-86
  • Magnani M, Rossi L, Fraternale A, et al. Feline immunodeficiency virus infection of macrophages: in vitro and in vivo inhibition by dideoxycytidine-5'-triphosphate-loaded erythrocytes. AIDS Res Hum Retroviruses 1994;10:1179-86
  • Chiarantini L, Rossi L, Fraternale A, et al. Modulated red blood cell survival by membrane protein clustering. Mol Cell Biochem 1995;144:53-9
  • Rossi L, Serafini S, Antonelli A, et al. Macrophage depletion induced by clodronate-loaded erythrocytes. J Drug Target 2005;13:99-111
  • Rossi L, Migliavacca B, Pierige F, et al. Prolonged islet allograft survival in diabetic mice upon macrophage depletion by clodronate-loaded erythrocytes. Transplantation 2008;85:648-50
  • Chow FS, Piekoszewski W, Jusko WJ. Effect of hematocrit and albumin concentration on hepatic clearance of tacrolimus (FK506) during rabbit liver perfusion. Drug Metab Dispos 1997;25:610-16
  • Walensky LD, Gascard P, Fields ME, et al. The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. J Cell Biol 1998;141:143-53
  • Foxwell BM, Frazer G, Winters M, et al. Identification of cyclophilin as the erythrocyte ciclosporin-binding protein. Biochim Biophys Acta 1988;938:447-55
  • Reichel C, von Falkenhausen M, Brockmeier D, et al. Characterization of cyclosporine A uptake in human erythrocytes. Eur J Clin Pharmacol 1994;46:417-19
  • Biagiotti S, Rossi L, Bianchi M, et al. Immunophilin-loaded erythrocytes as a new delivery strategy for immunosuppressive drugs. J Control Release 2011;154:306-13
  • Sudlow G, Birkett DJ, Wade DN. Further characterization of specific drug binding sites on human serum albumin. Mol Pharmacol 1976;12:1052-61
  • Ghuman J, Zunszain PA, Petitpas I, et al. Structural basis of the drug-binding specificity of human serum albumin. J Mol Biol 2005;353:38-52
  • Hamidi M, Azimi K, Mohammadi-Samani S. Co-encapsulation of a drug with a protein in erythrocytes for improved drug loading and release: phenytoin and bovine serum albumin (BSA). J Pharm Pharm Sci 2011;14:46-59
  • Muzykantov VR, Murciano JC, Taylor RP, et al. Regulation of the complement-mediated elimination of red blood cells modified with biotin and streptavidin. Anal Biochem 1996;241:109-19
  • Murciano JC, Medinilla S, Eslin D, et al. Prophylactic fibrinolysis through selective dissolution of nascent clots by tPA-carrying erythrocytes. Nat Biotechnol 2003;21:891-6
  • Ganguly K, Krasik T, Medinilla S, et al. Blood clearance and activity of erythrocyte-coupled fibrinolytics. J Pharmacol Exp Ther 2005;312:1106-13
  • Ganguly K, Goel MS, Krasik T, et al. Fibrin affinity of erythrocyte-coupled tissue-type plasminogen activators endures hemodynamic forces and enhances fibrinolysis in vivo. J Pharmacol Exp Ther 2006;316:1130-6
  • Danielyan K, Ganguly K, Ding BS, et al. Cerebrovascular thromboprophylaxis in mice by erythrocyte-coupled tissue-type plasminogen activator. Circulation 2008;118:1442-9
  • Stein SC, Ganguly K, Belfield CM, et al. Erythrocyte-bound tissue plasminogen activator is neuroprotective in experimental traumatic brain injury. J Neurotrauma 2009;26:1585-92
  • Pisapia JM, Xu X, Kelly J, et al. Microthrombosis after experimental subarachnoid hemorrhage: time course and effect of red blood cell-bound thrombin-activated pro-urokinase and clazosentan. Exp Neurol 2012;233:357-63
  • Armstead WM, Ganguly K, Kiessling JW, et al. Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation. J Cereb Blood Flow Metab 2009;29:1463-74
  • Armstead WM, Ganguly K, Riley J, et al. Red blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the newborn pig. Pediatr Crit Care Med 2011;12:e369-75
  • Zaitsev S, Danielyan K, Murciano JC, et al. Human complement receptor type 1-directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis. Blood 2006;108:1895-902
  • Zaitsev S, Spitzer D, Murciano JC, et al. Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther 2010;332:1022-31
  • Zaitsev S, Spitzer D, Murciano JC, et al. Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood 2010;115:5241-8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.