666
Views
76
CrossRef citations to date
0
Altmetric
Review

Advances in oral controlled drug delivery: the role of drug–polymer and interpolymer non-covalent interactions

, PharmD, , PhD (Associate Professor) , , PhD (Assistant Professor) , , PhD (Assistant Professor) , , PharmD (Professor) & , PhD (Professor)

Bibliography

  • Amidon GL, Lennernas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification - the correlation of in-vitro drug product dissolution and in-vivo bioavailability. Pharm Res 1995;12(3):413-20
  • Mrsny RJ. Oral drug delivery research in Europe. J Control Release 2012;161(2):247-53
  • MP-Advisors. Innovative drug delivery systems opportunities for generic & specialty pharmaceutical companies. Available from: http://www.reportsnreports.com/reports/275193-innovative-drug-delivery-systems-opportunities-for-generic-specialty-pharmaceutical-companies.html 2014
  • Das NG, Das SK. Controlle-release of oral dosage forms. Formulation Fill Finish 2003;10-16
  • Crowley P, Martini L. Drug-excipient interactions. Pharm Techol Eur 2001;13(3):26-34
  • Srikanth MV, Sunil SA, Rao NS, et al. Ion-exchange resins as controlled drug delivery carriers. J Sci Res 2010;2:597-611
  • Anand V, Kandarapu R, Garg S. Ion-exchange resins: carrying drug delivery forward. Drug Discov Today 2001;17:905-14
  • Ichikawa H, Fujioka K, Adeyeye MC, Fukumori Y. Use of ion-exchange resins to prepare 100 microm-sized microcapsules with prolonged drug-release by the Wurster process. Int J Pharm 2001;216:67-76
  • Shamma RN, Basalious EB, Shoukri RA. Development and optimization of a multiple-unit controlled release formulation of a freely water soluble drug for once-daily administration. Int J Pharm 2011;405:102-12
  • Pongjanyakul T, Prakongpan S, Rungsardthong U, et al. Characteristics and in vitro release of dextromethorphan resonates. Powder Technol 2005;152:100-6
  • Jeong SH, Park K. Drug loading and release properties of ion-exchange resin complexes as a drug delivery matrix. Int J Pharm 2008;361:26-32
  • Jeong SH, Park K. Development of sustained release fast-disintegrating tablets using various polymer-coated ion-exchange resin complexes. Int J Pharm 2008;361:195-204
  • Bettini R, Colombo P, Peppas NA. Solubility effects on drug transport through ph-sensitive, swelling-controlled release systems - transport of theophylline and metoclopramide monohydrochloride. J Control Release 1995;37(1-2):105-11
  • Li L, Ni R, Shao Y, Mao S. Carrageenan and its applications in drug delivery. Carbohydr Polym 2014;103:1-11
  • Bonferoni MC, Rossi S, Tamayo M, et al. On the employment of lambda-carrageenan in a matrix system. 1. Sensitivity to dissolution medium and comparison with Na carboxymethylcellulose and xanthan gum. J Control Release 1993;26(2):119-27
  • Bonferoni MC, Rossi S, Ferrari F, et al. Characterization of a diltiazem-lambda carrageenan complex. Int J Pharm 2000;200(2):207-16
  • Moreno-Villoslada I, Oyarzun F, Miranda V, et al. Binding of chlorpheniramine maleate to pharmacologically important alginic acid,carboxymethylcellulose, kappa-carageenan, and iota-carrageenan as studied by diafiltration. J Appl Polym Sci 2005;98:598-602
  • Pavli M, Baumgartner S, Kos P, Kogej K. Doxazosin-carrageenan interactions: a novel approach for studying drug-polymer interactions and relation to controlled drug release. Int J Pharm 2011;421(1):110-19
  • Pavli M, Vrecer F, Baumgartner S. Matrix tablets based on carrageenans with dual controlled release of doxazosin mesylate. Int J Pharm 2010;400(1-2):15-23
  • Bonferoni MC, Rossi S, Ferrari F, et al. Factorial analysis of the influence of dissolution medium on drug release from carrageenan-diltiazem complexes. AAPS PharmSciTech 2000;1(2):E15
  • Bonferoni MC, Sandri G, Rossi S, et al. Polyelectrolyte-drug complexes of lambda carrageenan and basic drugs: relevance of particle size and moisture content on compaction and drug release behavior. Drug Dev Ind Pharm 2008;34(11):1188-95
  • Aguzzi C, Bonferoni MC, Fortich MR, et al. Influence of complex solubility on formulations based on lambda carrageenan and basic drugs. AAPS PharmSciTech 2002;3(3):E27
  • Bettini R, Bonferoni MC, Colombo P, et al. Drug release kinetics and front movement in matrix tablets containing diltiazem or metoprolol/lamda-carrageenan complexes. BioMed Res Int 2014;2014:8
  • Bonferoni MC, Rossi S, Ferrari F, et al. On the employment of lambda carrageenan in a matrix system. III. Optimization of a lambda carrageenan-HPMC hydrophilic matrix. J Control Release 1998;51(2-3):231-9
  • Li L, Wang L, Shao Y, et al. Elucidation of release characteristics of highly soluble drug trimetazidine hydrochloride from chitosan-carrageenan matrix tablets. J Pharm Sci 2013;102(8):2644-54
  • Rigo MVR, Allemandi DA, Manzo RH. Swellable drug-polyelectrolyte matrices of drug-carboxymethylcellulose complexes. Characterization and delivery properties. Drug Deliv 2009;16(2):108-15
  • Battistini FD, Olivera ME, Manzo RH. Equilibrium and release properties of hyaluronic acid-drug complexes. Eur J Pharm Sci 2013;49(4):588-94
  • Porcar L, Codoner A, Gomez CM, et al. Interactions of quinine with polyacrylic and poly-L-glutamic acids in aqueous solutions. Eur Polym J 2004;40(4):819-28
  • Boonsongrit Y, Mitrevej A, Mueller BW. Chitosan drug binding by ionic interaction. Eur J Pharm Biopharm 2006;62(3):267-74
  • Boonsongrit Y, Mueller BW, Mitrevej A. Characterization of drug-chitosan interaction by H-1 NMR, FTIR and isothermal titration calorimetry. Eur J Pharm Biopharm 2008;69(1):388-95
  • Ma ZS, Yeoh HH, Lim LY. Formulation pH modulates the interaction of insulin with chitosan nanoparticles. J Pharm Sci 2002;91(6):1396-404
  • Mao SR, Bakowsky U, Jintapattanakit A, Kissel T. Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin. J Pharm Sci 2006;95(5):1035-48
  • Jintapattanakit A, Junyaprasert VB, Mao S, et al. Peroral delivery of insulin using chitosan derivatives: a comparative study of polyelectrolyte nanocomplexes and nanoparticles. Int J Pharm 2007;342(1-2):240-9
  • Rodriguez R, Alvarez-Lorenzo C, Concheiro A. Interactions of ibuprofen with cationic polysaccharides in aqueous dispersions and hydrogels rheological and diffusional implications. Eur J Pharm Sci 2003;20(4-5):429-38
  • Bernkop-Schnurch A, Schuhbauer H, Clausen AE, Hanel R. Development of a sustained release dosage form for alpha-lipoic acid. I. design and in vitro evaluation. Drug Dev Ind Pharm 2004;30(1):27-34
  • Quinteros DA, Rigo VR, Kairuz AEJ, et al. Interaction between a cationic polymethacrylate (Eudragit E100) and anionic drugs. Eur J Pharm Sci 2008;33(1):72-9
  • Ramirez-Rigo MV, Olivera ME, Rubio M, Manzo RH. Enhanced intestinal permeability and oral bioavailability of enalapril maleate upon complexation with the cationic polymethacrylate Eudragit E100. Eur J Pharm Sci 2014;55:1-11
  • Palmer D, Levina M, Nokhodchi A, et al. The influence of sodium carboxymethylcellulose on drug release from polyethylene oxide extended release matrices. AAPS PharmSciTech 2011;12(3):862-71
  • Dabbagh MA, Ford JL, Rubinstein MH, et al. Release of propranolol hydrochloride from matrix tablets containing sodium carboxymethylcellulose and hydroxypropylmethylcellulose. Pharm Dev Technol 1999;4(3):313-24
  • Takka S. Propranolol hydrochloride-anionic polymer binding interaction. Farmaco 2003;58:1051-6
  • Takka S, Rajbhandari S, Sakr A. Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets. Eur J Pharm Biopharm 2001;52(1):75-82
  • Palmer D, Levina M, Douroumis D, et al. Mechanism of synergistic interactions and its influence on drug release from extended release matrices manufactured using binary mixtures of polyethylene oxide and sodium carboxymethylcellulose. Colloids Surf B Biointerfaces 2013;104:174-80
  • Miyajima M, Koshika A, Okada J, et al. Effect of polymer crystallinity on papaverine release from poly (L-lactic acid) matrix. J Control Release 1997;49(2-3):207-15
  • Miyajima M, Koshika A, Okada J, Ikeda M. Effect of polymer/basic drug interactions on the two-stage diffusion-controlled release from a poly(L-lactic acid) matrix. J Control Release 1999;61(3):295-304
  • Moustafine RI, Zaharov IM, Kemenova VA. Physicochemical characterization and drug release properties of Eudragit (R) E PO/Eudragit (R) L 100-55 interpolyelectrolyte complexes. Eur J Pharm Biopharm 2006;63(1):26-36
  • Tsuchida E. Formation of polyelectrolyte complexes and their structures. J Macromol Sci Pure 1994;31(1):1-15
  • Thunemann AF, Muller M, Dautzenberg H, et al. Polyelectrolyte complexes. Adv Polym Sci 2004;166:113-71
  • Moustafine RI, Kabanova TV, Kemenova VA, Van den Mooter G. Characteristics of interpolyelectrolyte complexes of Eudragit E100 with Eudragit L100. J Control Release 2005;103(1):191-8
  • Moustafine RI, Bukhovets AV, Garipova VR, et al. Comparative evaluation of new carriers for controlled drug delivery based on Eudragit EPO/L100 interpolyelectrolyte complexes. Pharm Chem J 2012;46(8):507-11
  • Moustafine RI, Bobyleva VL, Bukhovets AV, et al. Structural transformations during swelling of polycomplex matrices based on countercharged (meth)acrylate copolymers (EudragitR EPO/EudragitR L 100-55). J Pharm Sci 2011;100(3):874-85
  • Mustafin RI, Bilan AB, Bukhovets AV, Kemenova VA. Comparative Study of Structural and Compositional Changes of Polycomplex Matrices Based on Eudragit (R) Epo and Eudragit (R) L100. Pharm Chem J 2011;45(2):114-17
  • Mustafin RI, Bukhovets AV, Sitenkov AY, et al. Synthesis and characterization of a new carrier based on eudragit (R) Epo/S100 interpolyelectrolyte complex for controlled colon-specific drug delivery. Pharm Chem J 2011;45(9):568-74
  • Moustafine RI, Bukhovets AV, Sitenkov AY, et al. Eudragit E PO as a complementary material for designing oral drug delivery systems with controlled release properties: comparative evaluation of new interpolyelectrolyte complexes with countercharged eudragit L100 copolymers. Mol Pharm 2013;10(7):2630-41
  • Moustafine RI, Bodrov AV, Kemenova VA, et al. Drug release modification by interpolymer interaction between countercharged types of Eudragit (R) RL 30D and FS 30D in double-layer films. Int J Pharm 2012;439(1-2):17-21
  • Moustafine RI, Margulis EB, Sibgatullina LF, et al. Comparative evaluation of interpolyelectrolyte complexes of chitosan with Eudragit (R) L100 and Eudragit (R) L100-55 as potential carriers for oral controlled drug delivery. Eur J Pharm Biopharm 2008;70(1):215-25
  • Moustafine RI, Salachova AR, Frolova ES, et al. Interpolyelectrolyte complexes of Eudragit (R) E PO with sodium alginate as potential carriers for colonic drug delivery: monitoring of structural transformation and composition changes during swellability and release evaluating. Drug Dev Ind Pharm 2009;35(12):1439-51
  • Prado HJ, Matulewicz MC, Bonelli P, Cukierman AL. Basic butylated methacrylate copolymer/kappa-carrageenan interpolyelectrolyte complex: preparation, characterization and drug release behaviour. Eur J Pharm Biopharm 2008;70(1):171-8
  • Prado HJ, Matulewicz MC, Bonelli PR, Cukierman AL. Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes. Int J Pharm 2012;429(1-2):12-21
  • Gupta VK, Beckert TE, Deusch NJ, et al. Investigation of potential ionic interactions between anionic and cationic polymethacrylates of multiple coatings of novel colonic delivery system. Drug Dev Ind Pharm 2002;28(2):207-15
  • Moustafine RI. Role of macromolecular interactions of pharmaceutically acceptable polymers in functioning oral drug delivery systems. Russ J Gen Chem 2014;84(2):364-7
  • Mustafin RI. Interpolymer combinations of chemically complementary grades of eudragit copolymers: a new direction in the design of peroral solid dosage forms of drug delivery systems with controlled release (Review). Pharm Chem J 2011;45(5):285-95
  • Assaad E, Wang YJ, Zhu XX, Mateescu MA. Polyelectrolyte complex of carboxymethyl starch and chitosan as drug carrier for oral administration. Carbohydr Polym 2011;84(4):1399-407
  • de la Torre PM, Enobakhare Y, Torrado G, Torrado S. Release of amoxicillin from polyionic complexes of chitosan and poly(acrylic acid). study of polymer/polymer and polymer/drug interactions within the network structure. Biomaterials 2003;24(8):1499-506
  • de la Torre PM, Torrado G, Torrado S. Poly (acrylic acid) chitosan interpolymer complexes for stomach controlled antibiotic delivery. J Biomed Mater Res B Appl Biomater 2005;72(1):191-7
  • de la Torre PM, Torrado S, Torrado S. Interpolymer complexes of poly(acrylic acid) and chitosan: influence of the ionic hydrogel-forming medium. Biomaterials 2003;24(8):1459-68
  • Torrado S, Prada P, de la Torre PM, Torrado S. Chitosan-poly(acrylic) acid polyionic complex: in vivo study to demonstrate prolonged gastric retention. Biomaterials 2004;25(5):917-23
  • Bigucci F, Luppi B, Cerchiara T, et al. Chitosan/pectin polyelectrolyte complexes: selection of suitable preparative conditions for colon-specific delivery of vancomycin. Eur J Pharm Sci 2008;35(5):435-41
  • Abdelbary GA, Tadros MI. Design and in vitro/in vivo evaluation of novel nicorandil extended release matrix tablets based on hydrophilic interpolymer complexes and a hydrophobic waxy polymer. Eur J Pharm Biopharm 2008;69(3):1019-28
  • Park SH, Chun MK, Choi HK. Preparation of an extended-release matrix tablet using chitosan/Carbopol interpolymer complex. Int J Pharm 2008;347(1-2):39-44
  • Friciu M, Canh Le T, Ispas-Szabo P, Mateescu MA. Carboxymethyl starch and lecithin complex as matrix for targeted drug delivery: I. Monolithic mesalamine forms for colon delivery. Eur J Pharm Biopharm 2013;85(3 Pt A):521-30
  • Alvarez-Fuentes J, Caraballo I, Boza A, et al. Study of a complexation process between naltrexone and Eudragit® L as an oral controlled release system. Int J Pharm 1997;148:219-30
  • Holgado MA, Iruin A, Alvarez-Fuentes J, Fernandez-Arevalo M. Development and in vitro evaluation of a controlled release formulation to produce wide dose interval morphine tablets. Eur J Pharm Biopharm 2008;70(2):544-9
  • Alvarez-Fuentes J, Fernandez-Arevalo M, Holgado MA, et al. Characterization of morphine coprecipitates: a biopharmaceutical study. Pharmazie 1994;49:834-9
  • Alvarez-Fuentes J, Fernández-Arévalo M, Holgado MA, et al. Morphine polymeric coprecipitates for controller release: elaboration and characterization. Drug Dev Ind Pharm 1994;20:2409-24
  • Papageorgiou GZ, Papadimitriou S, Karavas E, et al. Improvement in chemical and physical stability of fluvastatin drug through hydrogen bonding interactions with different polymer matrices. Curr Drug Deliv 2009;6:101-12
  • Ozeki T, Yuasa H, Kanaya Y. Application of the solid dispersion method to the controlled release of medicine. 9. Difference in the release of flurbiprofen from solid dispersions with poly(ethylene oxide) and hydroxypropylcellulose and the interaction between medicine and polymers. Int J Pharm 1997;155(2):209-17
  • Ozeki T, Yuasa H, Kanaya Y. Controlled release from solid dispersion composed of poly(ethylene oxide)-Carbopol (R) interpolymer complex with various cross-linking degrees of Carbopol (R). J Control Release 2000;63(3):287-95
  • Khutoryanskiy VV. Hydrogen-bonded interpolymer complexes as materials for pharmaceutical applications. Int J Pharm 2007;334(1-2):15-26
  • Nanaki SG, Koutsidis IA, Koutri I, et al. Miscibility study of chitosan/2-hydroxyethyl starch blends and evaluation of their effectiveness as drug sustained release hydrogels. Carbohydr Polym 2012;87(2):1286-94
  • Clausen AE, Bernkop-Schnurch A. Direct compressible polymethacrylic acid-starch compositions for site-specific drug delivery. J Control Release 2001;75(1-2):93-102
  • Klouda L, Mikos AG. Thermoresponsive hydrogels in biomedical applications. Eur J Pharm Biopharm 2008;68(1):34-45
  • Coughlan DC, Quilty FP, Corrigan OI. Effect of drug physicochemical properties on swelling/deswelling kinetics and pulsatile drug release from thermoresponsive poly(N-isopropylacrylamide) hydrogels. J Control Release 2004;98(1):97-114
  • Coughlan DC, Corrigan OI. Drug-polymer interactions and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems. Int J Pharm 2006;313(1-2):163-74
  • Le Tien C, Lacroix M, Ispas-Szabo P, Mateescu MA. N-acylated chitosan: hydrophobic matrices for controlled drug release. J Control Release 2003;93(1):1-13
  • Costache AD, Sheihet L, Zaveri K, et al. Polymer-drug interactions in tyrosine-derived triblock copolymer nanospheres: a computational modeling approach. Mol Pharm 2009;6(5):1620-7
  • Machackova M, Tokarsky J, Capkova P. A simple molecular modeling method for the characterization of polymeric drug carriers. Eur J Pharm Sci 2013;48(1-2):316-22
  • Marsac PJ, Shamblin SL, Taylor LS. Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility. Pharm Res 2006;23(10):2417-26
  • Elviri L, DeRobertis S, Baldassarre S, Bettini R. Desorption electrospray ionization high-resolution mass spectrometry for the fast investigation of natural polysaccharide interactions with a model drug in controlled release systems. Rapid Commun Mass Spectrom 2014;28(13):1544-52
  • Korsmeyer RW, Gurny R, Doelker E, et al. Mechanism of solute release from porous hydrophilic polymers. Int J Pharm 1983;15:25-35
  • Peppas NA, Sahlin JJ. A simple equation for the description of solute release. 3. coupling of diffusion and relaxation. Int J Pharm 1989;57(2):169-72
  • Tamimi F, Torres J, Bettini R, et al. Doxycycline sustained release from brushite cements for the treatment of periodontal diseases. J Biomed Mater Res A 2008;85(3):707-14
  • Colombo P, Sonvico F, Colombo G, Bettini R. Novel platforms for oral drug delivery. Pharm Res 2009;26(3):601-11

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.