The role of blood–ocular barrier transporters in retinal drug disposition: an overview

Bibliography

• Del Amo EM, Urtti A. Current and future ophthalmic drug delivery systems. A shift to the posterior segment. Drug Discov Today 2008;13:135-43
   PubMed Web of Science ®Google Scholar
• Myles ME, Neumann DM, Hill JM. Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresis. Adv Drug Deliv Rev 2005;57:2063-79
   PubMed Web of Science ®Google Scholar
• Urtti A, Pipkin JD, Rork G, Controlled drug delivery devices for experimental ocular studies with timolol 2. Ocular and systemic absorption in rabbits. Int J Pharm 1990;61:241-9
   Web of Science ®Google Scholar
• Cunha-Vaz JG. The blood-ocular barriers: past, present, and future. Doc Ophthalmol 1997;93:149-57
   PubMed Web of Science ®Google Scholar
• Hosoya K, Tachikawa M. Inner blood-retinal barrier transporters: role of retinal drug delivery. Pharm Res 2009;26:2055-65
   PubMed Web of Science ®Google Scholar
• Epstein DL, Grant WM. Carbonic anhydrase inhibitor side effects. Serum chemical analysis. Arch Ophthalmol 1977;95:1378-82
   PubMed Web of Science ®Google Scholar
• Do C, Kong C, Chan C, Mechanisms of Aqueous Humor Formation. In: Tombran-Tink J, Barnstable C, editors, Ocular transporters in ophthalmic diseases and drug delivery. Humana Press-Springer, Totowa, NJ; 2008. p. 61-86
   Google Scholar
• Raviola G, Raviola E. Intercellular junctions in the ciliary epithelium. Invest Ophthalmol Vis Sci 1978;17:958-81
   PubMed Web of Science ®Google Scholar
• Fautsch MP, Johnson DH. Aqueous humor outflow: what do we know? Where will it lead us? Invest Ophthalmol Vis Sci 2006;47:4181-7
   PubMed Web of Science ®Google Scholar
• Bert RJ, Caruthers SD, Jara H, Demonstration of an anterior diffusional pathway for solutes in the normal human eye with high spatial resolution contrast-enhanced dynamic MR imaging. Invest Ophthalmol Vis Sci 2006;47:5153-62
   PubMed Web of Science ®Google Scholar
• Hornof M, Toropainen E, Urtti A. Cell culture models of the ocular barriers. Eur J Pharm Biopharm 2005;60:207-25
   PubMed Web of Science ®Google Scholar
• Tomi M, Hosoya K. Molecular mechanisms of the inner blood-retinal barrier transporters. In: Tombran-Tink J, Barnstable C, editors, Ocular transporters in ophthalmic diseases and drug delivery. Humana Press-Springer, Totowa, NJ; 2008. p. 139-54
   Google Scholar
• Mannermaa E, Vellonen KS, Urtti A. Drug transport in corneal epithelium and blood-retina barrier: emerging role of transporters in ocular pharmacokinetics. Adv Drug Deliv Rev 2006;58:1136-63
   PubMed Web of Science ®Google Scholar
• Urtti A. Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv Drug Deliv Rev 2006;58:1131-5
   PubMed Web of Science ®Google Scholar
• Kim SH, Lutz RJ, Wang NS, Transport barriers in transscleral drug delivery for retinal diseases. Ophthalmic Res 2007;39:244-54
   PubMed Web of Science ®Google Scholar
• Dean M, Annilo T. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Annu Rev Genomics Hum Genet 2005;6:123-42
   PubMed Web of Science ®Google Scholar
• Calcagno AM, Kim IW, Wu CP, ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions. Curr Drug Deliv 2007;4:324-33
   PubMedGoogle Scholar
• Leslie EM, Deeley RG, Cole SP. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 2005;204:216-37
   PubMed Web of Science ®Google Scholar
• BenEzra D, Maftzir G. Ocular penetration of cyclosporin A. The rabbit eye. Invest Ophthalmol Vis Sci 1990;31:1362-6
   PubMed Web of Science ®Google Scholar
• BenEzra D, Maftzir G. Ocular penetration of cyclosporine A in the rat eye. Arch Ophthalmol 1990;108:584-7
   PubMed Web of Science ®Google Scholar
• BenEzra D, Maftzir G, de Courten C, Ocular penetration of cyclosporin A. III: The human eye. Br J Ophthalmol 1990;74:350-2
   PubMed Web of Science ®Google Scholar
• Holash JA, Stewart PA. The relationship of astrocyte-like cells to the vessels that contribute to the blood-ocular barriers. Brain Res 1993;629:218-24
   PubMed Web of Science ®Google Scholar
• Hosoya K, Tomi M. Advances in the cell biology of transport via the inner blood-retinal barrier: establishment of cell lines and transport functions. Biol Pharm Bull 2005;28:1-8
   PubMed Web of Science ®Google Scholar
• Tachikawa M, Toki H, Tomi M, Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells. Microvasc Res 2008;75:68-72
   PubMed Web of Science ®Google Scholar
• Tomi M, Hosoya K. Application of magnetically isolated rat retinal vascular endothelial cells for the determination of transporter gene expression levels at the inner blood-retinal barrier. J Neurochem 2004;91:1244-8
   PubMed Web of Science ®Google Scholar
• Hosoya K, Tomi M, Ohtsuki S, Conditionally immortalized retinal capillary endothelial cell lines (TR-iBRB) expressing differentiated endothelial cell functions derived from a transgenic rat. Exp Eye Res 2001;72:163-72
   PubMed Web of Science ®Google Scholar
• Maines LW, Antonetti DA, Wolpert EB, Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells. Neuropharmacology 2005;49:610-7
   PubMed Web of Science ®Google Scholar
• Shen J, Cross ST, Tang-Liu DD, Evaluation of an immortalized retinal endothelial cell line as an in vitro model for drug transport studies across the blood-retinal barrier. Pharm Res 2003;20:1357-63
   PubMed Web of Science ®Google Scholar
• Kennedy BG, Mangini NJ. P-glycoprotein expression in human retinal pigment epithelium. Mol Vis 2002;8:422-30
   PubMed Web of Science ®Google Scholar
• Steuer H, Jaworski A, Elger B, Functional characterization and comparison of the outer blood-retina barrier and the blood-brain barrier. Invest Ophthalmol Vis Sci 2005;46:1047-53
   PubMed Web of Science ®Google Scholar
• Wu J, Zhang JJ, Koppel H, P-glycoprotein regulates a volume-activated chloride current in bovine non-pigmented ciliary epithelial cells. J Physiol 1996;491(Pt 3):743-55
   PubMed Web of Science ®Google Scholar
• Schlingemann RO, Hofman P, Klooster J, Ciliary muscle capillaries have blood-tissue barrier characteristics. Exp Eye Res 1998;66:747-54
   PubMed Web of Science ®Google Scholar
• Cunha-Vaz JG, Maurice DM. The active transport of fluorescein by the retinal vessels and the retina. J Physiol 1967;191:467-86
   Google Scholar
• Engler CB, Sander B, Larsen M, Fluorescein transport across the human blood-retina barrier in the direction vitreous to blood. Quantitative assessment in vivo. Acta Ophthalmol (Copenh) 1994;72:655-62
   PubMed Web of Science ®Google Scholar
• Engler CB, Sander B, Larsen M, Probenecid inhibition of the outward transport of fluorescein across the human blood-retina barrier. Acta Ophthalmol (Copenh) 1994;72:663-7
   PubMed Web of Science ®Google Scholar
• Aukunuru JV, Sunkara G, Bandi N, Expression of multidrug resistance-associated protein (MRP) in human retinal pigment epithelial cells and its interaction with BAPSG, a novel aldose reductase inhibitor. Pharm Res 2001;18:565-72
   PubMed Web of Science ®Google Scholar
• Mannermaa E, Vellonen KS, Ryhanen T, Efflux protein expression in human retinal pigment epithelium cell lines. Pharm Res 2009;26:1785-91
   PubMed Web of Science ®Google Scholar
• Tagami M, Kusuhara S, Honda S, Expression of ATP-binding cassette transporters at the inner blood-retinal barrier in a neonatal mouse model of oxygen-induced retinopathy. Brain Res 2009;1283:186-93
   PubMed Web of Science ®Google Scholar
• Pelis RM, Shahidullah M, Ghosh S, Localization of multidrug resistance-associated protein 2 in the nonpigmented ciliary epithelium of the eye. J Pharmacol Exp Ther 2009;329:479-85
   PubMed Web of Science ®Google Scholar
• Boulton M, Rozanowska M, Rozanowski B. Retinal photodamage. J Photochem Photobiol B 2001;64:144-61
   PubMed Web of Science ®Google Scholar
• Asashima T, Hori S, Ohtsuki S, ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells. Pharm Res 2006;23:1235-42
   PubMed Web of Science ®Google Scholar
• Katayama K, Ohshima Y, Tomi M, Application of microdialysis to evaluate the efflux transport of estradiol 17-beta glucuronide across the rat blood-retinal barrier. J Neurosci Methods 2006;156:249-56
   PubMed Web of Science ®Google Scholar
• Gao B, Wenzel A, Grimm C, Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epithelium. Invest Ophthalmol Vis Sci 2002;43:510-4
   PubMed Web of Science ®Google Scholar
• Ito A, Yamaguchi K, Onogawa T, Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina. Invest Ophthalmol Vis Sci 2002;43:858-63
   PubMed Web of Science ®Google Scholar
• Gao B, Huber RD, Wenzel A, Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium. Exp Eye Res 2005;80:61-72
   PubMed Web of Science ®Google Scholar
• Ito A, Yamaguchi K, Tomita H, Distribution of rat organic anion transporting polypeptide-E (oatp-E) in the rat eye. Invest Ophthalmol Vis Sci 2003;44:4877-84
   PubMed Web of Science ®Google Scholar
• Betz AL, Goldstein GW. Transport of hexoses, potassium and neutral amino acids into capillaries isolated from bovine retina. Exp Eye Res 1980;30:593-605
   PubMed Web of Science ®Google Scholar
• Rizwan AN, Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res 2007;24:450-70
   PubMed Web of Science ®Google Scholar
• Hosoya K, Makihara A, Tsujikawa Y, Roles of inner blood-retinal barrier organic anion transporter 3 in the vitreous/retina-to-blood efflux transport of p-aminohippuric acid, benzylpenicillin, and 6-mercaptopurine. J Pharmacol Exp Ther 2009;329:87-93
   PubMed Web of Science ®Google Scholar
• Mori S, Ohtsuki S, Takanaga H, Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs. J Neurochem 2004;90:931-41
   PubMed Web of Science ®Google Scholar
• Sweet DH, Miller DS, Pritchard JB, Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 2002;277:26934-43
   PubMed Web of Science ®Google Scholar
• Chen ZS, Lee K, Kruh GD. Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. J Biol Chem 2001;276:33747-54
   PubMed Web of Science ®Google Scholar
• Smeets PH, van Aubel RA, Wouterse AC, Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J Am Soc Nephrol 2004;15:2828-35
   PubMed Web of Science ®Google Scholar
• Uchida Y, Kamiie J, Ohtsuki S, Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter. Pharm Res 2007;24:2281-96
   PubMed Web of Science ®Google Scholar
• Barza M, Kane A, Baum J. Pharmacokinetics of intravitreal carbenicillin, cefazolin, and gentamicin in rhesus monkeys. Invest Ophthalmol Vis Sci 1983;24:1602-6
   PubMed Web of Science ®Google Scholar
• Somervaille TC, Hann IM, Harrison G, Intraocular relapse of childhood acute lymphoblastic leukaemia. Br J Haematol 2003;121:280-8
   PubMed Web of Science ®Google Scholar
• Rajan PD, Kekuda R, Chancy CD, Expression of the extraneuronal monoamine transporter in RPE and neural retina. Curr Eye Res 2000;20:195-204
   PubMed Web of Science ®Google Scholar
• Han YH, Sweet DH, Hu DN, Characterization of a novel cationic drug transporter in human retinal pigment epithelial cells. J Pharmacol Exp Ther 2001;296:450-7
   PubMed Web of Science ®Google Scholar
• Zhang N, Kannan R, Okamoto CT, Characterization of brimonidine transport in retinal pigment epithelium. Invest Ophthalmol Vis Sci 2006;47:287-94
   PubMed Web of Science ®Google Scholar
• Wheeler L, WoldeMussie E, Lai R. Role of alpha-2 agonists in neuroprotection. Surv Ophthalmol 2003;48(Suppl 1):S47-51
   PubMed Web of Science ®Google Scholar
• Ferencz JR, Gilady G, Harel O, Topical brimonidine reduces collateral damage caused by laser photocoagulation for choroidal neovascularization. Graefes Arch Clin Exp Ophthalmol 2005;243:877-80
   PubMed Web of Science ®Google Scholar
• Acheampong AA, Shackleton M, John B, Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes. Drug Metab Dispos 2002;30:421-9
   PubMed Web of Science ®Google Scholar
• Tachikawa M, Takeda Y, Tomi M, Involvement of OCTN2 in the transport of acetyl-L-carnitine across the inner blood-retinal barrier. Invest Ophthalmol Vis Sci 2010;51:430-6
   PubMed Web of Science ®Google Scholar
• Kano T, Kato Y, Ito K, Carnitine/organic cation transporter OCTN2 (Slc22a5) is responsible for renal secretion of cephaloridine in mice. Drug Metab Dispos 2009;37:1009-16
   PubMed Web of Science ®Google Scholar
• Hosoya K, Minamizono A, Katayama K, Vitamin C transport in oxidized form across the rat blood-retinal barrier. Invest Ophthalmol Vis Sci 2004;45:1232-9
   PubMed Web of Science ®Google Scholar
• Takata K, Kasahara T, Kasahara M, Ultracytochemical localization of the erythrocyte/HepG2-type glucose transporter (GLUT1) in the ciliary body and iris of the rat eye. Invest Ophthalmol Vis Sci 1991;32:1659-66
   PubMed Web of Science ®Google Scholar
• Takata K, Kasahara T, Kasahara M, Ultracytochemical localization of the erythrocyte/HepG2-type glucose transporter (GLUT1) in cells of the blood-retinal barrier in the rat. Invest Ophthalmol Vis Sci 1992;33:377-83
   PubMed Web of Science ®Google Scholar
• Bridges CC, Ola MS, Prasad PD, Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells. Am J Physiol Cell Physiol 2001;281:C1825-36
   PubMed Web of Science ®Google Scholar
• Tomi M, Tajima A, Tachikawa M, Function of taurine transporter (Slc6a6/TauT) as a GABA transporting protein and its relevance to GABA transport in rat retinal capillary endothelial cells. Biochim Biophys Acta 2008;1778:2138-42
   PubMed Web of Science ®Google Scholar
• Tomi M, Terayama T, Isobe T, Function and regulation of taurine transport at the inner blood-retinal barrier. Microvasc Res 2007;73:100-6
   PubMed Web of Science ®Google Scholar
• Tornquist P, Alm A. Carrier-mediated transport of amino acids through the blood-retinal and the blood-brain barriers. Graefes Arch Clin Exp Ophthalmol 1986;224:21-5
   PubMed Web of Science ®Google Scholar
• Nakashima T, Tomi M, Katayama K, Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier. J Neurochem 2004;89:1454-61
   PubMed Web of Science ®Google Scholar
• Yoneyama D, Shinozaki Y, Lu WL, Involvement of system A in the retina-to-blood transport of l-proline across the inner blood-retinal barrier. Exp Eye Res 2010;90:507-13
   PubMed Web of Science ®Google Scholar
• del Amo EM, Urtti A, Yliperttula M. Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2. Eur J Pharm Sci 2008;35:161-74
   PubMed Web of Science ®Google Scholar
• Tomi M, Mori M, Tachikawa M, L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier. Invest Ophthalmol Vis Sci 2005;46:2522-30
   PubMed Web of Science ®Google Scholar
• Gandhi MD, Pal D, Mitra AK. Identification and functional characterization of a Na(+)-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells. Int J Pharm 2004;275:189-200
   PubMedGoogle Scholar
• Yamamoto A, Akanuma SI, Tachikawa M, Involvement of LAT1 and LAT2 in the high- and low-affinity transport of L-leucine in human retinal pigment epithelial cells (ARPE-19 cells). J Pharm Sci 2010;99:2475-82
   PubMed Web of Science ®Google Scholar
• Kaneko S, Ando A, Okuda-Ashitaka E, Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2007;48:464-71
   PubMed Web of Science ®Google Scholar
• Nakauchi T, Ando A, Ueda-Yamada M, Prevention of ornithine cytotoxicity by nonpolar side chain amino acids in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2003;44:5023-8
   PubMed Web of Science ®Google Scholar
• Tomi M, Kitade N, Hirose S, Cationic amino acid transporter 1-mediated L-arginine transport at the inner blood-retinal barrier. J Neurochem 2009;111:716-25
   PubMed Web of Science ®Google Scholar
• Tomi M, Hosoya K, Takanaga H, Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier. Invest Ophthalmol Vis Sci 2002;43:774-9
   PubMed Web of Science ®Google Scholar
• Hosoya K, Saeki S, Terasaki T. Activation of carrier-mediated transport of L-cystine at the blood-brain and blood-retinal barriers in vivo. Microvasc Res 2001;62:136-42
   PubMed Web of Science ®Google Scholar
• Bridges CC, Kekuda R, Wang H, Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2001;42:47-54
   PubMed Web of Science ®Google Scholar
• Uchino H, Kanai Y, Kim do K, Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol 2002;61:729-37
   PubMed Web of Science ®Google Scholar
• Bodis-Wollner I. Visual electrophysiology in Parkinson's disease: PERG, VEP and visual P300. Clin Electroencephalogr 1997;28:143-7
   PubMedGoogle Scholar
• Bhaskar PA, Vanchilingam S, Bhaskar EA, Effect of L-dopa on visual evoked potential in patients with Parkinson's disease. Neurology 1986;36:1119-21
   PubMed Web of Science ®Google Scholar
• Averbuch-Heller L, Tusa RJ, Fuhry L, A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus. Ann Neurol 1997;41:818-25
   PubMed Web of Science ®Google Scholar
• Kaneko A, Suzuki S. Eye-preservation treatment of retinoblastoma with vitreous seeding. Jpn J Clin Oncol 2003;33:601-7
   PubMed Web of Science ®Google Scholar
• Hosoya K, Kyoko H, Toyooka N, Evaluation of amino acid-mustard transport as L-type amino acid transporter 1 (LAT1)-mediated alkylating agents. Biol Pharm Bull 2008;31:2126-30
   PubMed Web of Science ®Google Scholar
• Poitry-Yamate CL, Poitry S, Tsacopoulos M. Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina. J Neurosci 1995;15:5179-91
   PubMed Web of Science ®Google Scholar
• Morris ME, Felmlee MA. Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J 2008;10:311-21
   PubMed Web of Science ®Google Scholar
• Hughes PM, Olejnik O, Chang-Lin JE, Topical and systemic drug delivery to the posterior segments. Adv Drug Deliv Rev 2005;57:2010-32
   PubMed Web of Science ®Google Scholar
• Gerhart DZ, Leino RL, Drewes LR. Distribution of monocarboxylate transporters MCT1 and MCT2 in rat retina. Neuroscience 1999;92:367-75
   PubMed Web of Science ®Google Scholar
• Chidlow G, Wood JP, Graham M, Expression of monocarboxylate transporters in rat ocular tissues. Am J Physiol Cell Physiol 2005;288:C416-28
   PubMed Web of Science ®Google Scholar
• Philp NJ, Wang D, Yoon H, Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. Invest Ophthalmol Vis Sci 2003;44:1716-21
   PubMed Web of Science ®Google Scholar
• Philp NJ, Yoon H, Grollman EF. Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE. Am J Physiol 1998;274:R1824-8
   PubMed Web of Science ®Google Scholar
• Alm A, Tornquist P. Lactate transport through the blood-retinal and the blood-brain barrier in rats. Ophthalmic Res 1985;17:181-4
   PubMed Web of Science ®Google Scholar
• Hosoya K, Kondo T, Tomi M, MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: a possible route for delivery of monocarboxylic acid drugs to the retina. Pharm Res 2001;18:1669-76
   PubMed Web of Science ®Google Scholar
• Majumdar S, Gunda S, Pal D, Functional activity of a monocarboxylate transporter, MCT1, in the human retinal pigmented epithelium cell line, ARPE-19. Mol Pharm 2005;2:109-17
   PubMed Web of Science ®Google Scholar
• Ganapathy V, Smith SB, Prasad PD. SLC19: the folate/thiamine transporter family. Pflugers Arch 2004;447:641-6
   PubMed Web of Science ®Google Scholar
• Brzezinska A, Winska P, Balinska M. Cellular aspects of folate and antifolate membrane transport. Acta Biochim Pol 2000;47:735-49
   PubMed Web of Science ®Google Scholar
• Golnik KC, Schaible ER. Folate-responsive optic neuropathy. J Neuroophthalmol 1994;14:163-9
   PubMed Web of Science ®Google Scholar
• Knox DL, Chen MF, Guilarte TR, Nutritional amblyopia. Folic acid, vitamin B-12, and other vitamins. Retina 1982;2:288-93
   PubMed Web of Science ®Google Scholar
• Chancy CD, Kekuda R, Huang W, Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium. J Biol Chem 2000;275:20676-84
   PubMed Web of Science ®Google Scholar
• Bridges CC, El-Sherbeny A, Ola MS, Transcellular transfer of folate across the retinal pigment epithelium. Curr Eye Res 2002;24:129-38
   PubMed Web of Science ®Google Scholar
• Hosoya K, Fujita K, Tachikawa M. Involvement of reduced folate carrier 1 in the inner blood-retinal barrier transport of methyltetrahydrofolate. Drug Metab Pharmacokinet 2008;23:285-92
   PubMed Web of Science ®Google Scholar
• Hardwig PW, Pulido JS, Bakri SJ. The safety of intraocular methotrexate in silicone-filled eyes. Retina 2008;28:1082-6
   PubMed Web of Science ®Google Scholar
• Baldwin SA, Beal PR, Yao SY, The equilibrative nucleoside transporter family, SLC29. Pflugers Arch 2004;447:735-43
   PubMed Web of Science ®Google Scholar
• Ghiardi GJ, Gidday JM, Roth S. The purine nucleoside adenosine in retinal ischemia-reperfusion injury. Vision Res 1999;39:2519-35
   PubMed Web of Science ®Google Scholar
• Lutty GA, McLeod DS. Retinal vascular development and oxygen-induced retinopathy: a role for adenosine. Prog Retin Eye Res 2003;22:95-111
   PubMed Web of Science ®Google Scholar
• Nagase K, Tomi M, Tachikawa M, Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier. Biochim Biophys Acta 2006;1758:13-9
   PubMed Web of Science ®Google Scholar
• Majumdar S, Macha S, Pal D, Mechanism of ganciclovir uptake by rabbit retina and human retinal pigmented epithelium cell line ARPE-19. Curr Eye Res 2004;29:127-36
   PubMed Web of Science ®Google Scholar
• Williams EF, Chu TC, Socci RR, Comparison of nucleoside transport binding sites in rabbit iris-ciliary body and cultured rabbit nonpigmented ciliary epithelial cells. J Ocul Pharmacol Ther 1996;12:461-9
   PubMed Web of Science ®Google Scholar
• Yao SY, Ng AM, Sundaram M, Transport of antiviral 3′-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol Membr Biol 2001;18:161-7
   PubMed Web of Science ®Google Scholar
• Duvvuri S, Gandhi MD, Mitra AK. Effect of P-glycoprotein on the ocular disposition of a model substrate, quinidine. Curr Eye Res 2003;27:345-53
   PubMed Web of Science ®Google Scholar
• Sunkara G, Ayalasomayajula SP, DeRuiter J, Probenecid treatment enhances retinal and brain delivery of N-4-benzoylaminophenylsulfonylglycine: an anionic aldose reductase inhibitor. Brain Res Bull 2010;81:327-32
   PubMed Web of Science ®Google Scholar
• Gaudana R, Jwala J, Boddu SH, Recent perspectives in ocular drug delivery. Pharm Res 2009;26:1197-216
   PubMed Web of Science ®Google Scholar
• Mitra AK. Role of transporters in ocular drug delivery system. Pharm Res 2009;26:1192-6
   PubMed Web of Science ®Google Scholar
• Stoilov I, Akarsu AN, Alozie I, Sequence analysis and homology modeling suggest that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1. Am J Hum Genet 1998;62:573-84
   PubMed Web of Science ®Google Scholar
• Zhang T, Xiang CD, Gale D, Drug transporter and cytochrome P450 mRNA expression in human ocular barriers: implications for ocular drug disposition. Drug Metab Dispos 2008;36:1300-7
   PubMed Web of Science ®Google Scholar
• Zhao C, Shichi H. Immunocytochemical study of cytochrome P450 (1A1/1A2) induction in murine ocular tissues. Exp Eye Res 1995;60:143-52
   PubMed Web of Science ®Google Scholar