The role of cytokines in the regulation of drug disposition: extended functional pleiotropism?

Bibliography

• Wilkinson GR. Drug metabolism and variability among patients in drug response. N Engl J Med 2005;352:2211-21
   PubMed Web of Science ®Google Scholar
• Aitken AE, Richardson TA, Morgan ET. Regulation of drug-metabolizing enzymes and transporters in inflammation. Annu Rev Pharmacol Toxicol 2006;46:123-49
   PubMed Web of Science ®Google Scholar
• Xia CQ, Milton MN, Gan LS. Evaluation of drug-transporter interactions using in vitro and in vivo models. Curr Drug Metab 2007;8:341-63
   PubMed Web of Science ®Google Scholar
• Thomas SA. Drug transporters relevant to HIV therapy. J HIV Ther 2004;9:92-6
   PubMedGoogle Scholar
• Hider SL, Hoggard P, Khoo S, Drug efflux transporters in rheumatoid arthritis: comment on the article by Kremer. Arthritis Rheum 2005;52:670; author reply 2
   PubMed Web of Science ®Google Scholar
• Kroetz DL. Role for drug transporters beyond tumor resistance: hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity. J Clin Oncol 2006;24:4225-7
   PubMed Web of Science ®Google Scholar
• Konig SK, Herzog M, Theile D, Impact of drug transporters on cellular resistance towards saquinavir and darunavir. J Antimicrob Chemother 2010;65:2319-28
   PubMed Web of Science ®Google Scholar
• Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005;205:275-92
   PubMed Web of Science ®Google Scholar
• Bazzoli C, Jullien V, Le Tiec C, Intracellular pharmacokinetics of antiretroviral drugs in HIV-infected patients, and their correlation with drug action. Clin Pharmacokinet 2010;49:17-45
   PubMed Web of Science ®Google Scholar
• van de Kerkhof EG, de Graaf IA, Ungell AL, Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. Drug Metab Dispos 2008;36:604-13
   PubMed Web of Science ®Google Scholar
• Dickinson L, Khoo S, Back DJ. Differences in the pharmacokinetics of protease inhibitors between healthy volunteers and HIV-infected persons. Curr Opin HIV AIDS 2008;3:296-305
   PubMed Web of Science ®Google Scholar
• Jonsson EN, Macintyre F, James I, Bridging the pharmacokinetics and pharmacodynamics of UK-279,276 across healthy volunteers and stroke patients using a mechanistically based model for target-mediated disposition. Pharm Res 2005;22:1236-46
   PubMed Web of Science ®Google Scholar
• Perez-Ruixo JJ, Piotrovskij V, Zhang S, Population pharmacokinetics of tipifarnib in healthy subjects and adult cancer patients. Br J Clin Pharmacol 2006;62:81-96
   PubMed Web of Science ®Google Scholar
• Welage LS, Carver PL, Revankar S, Alterations in gastric acidity in patients infected with human immunodeficiency virus. Clin Infect Dis 1995;21:1431-8
   PubMed Web of Science ®Google Scholar
• Merry C, Mulcahy F, Lloyd J. Alpha-1-acid glycoprotein concentrations in HIV disease. Implications for treatment with protease inhibitors. AIDS 1996;10:21
   Google Scholar
• Fellay J, Marzolini C, Decosterd L, Variations of CYP3A activity induced by antiretroviral treatment in HIV-1 infected patients. Eur J Clin Pharmacol 2005;60:865-73
   PubMed Web of Science ®Google Scholar
• Slain D, Pakyz A, Israel DS, Variability in activity of hepatic CYP3A4 in patients infected with HIV. Pharmacotherapy 2000;20:898-907
   PubMed Web of Science ®Google Scholar
• van den Ouweland FA, Franssen MJ, van de Putte LB, Naproxen pharmacokinetics in patients with rheumatoid arthritis during active polyarticular inflammation. Br J Clin Pharmacol 1987;23:189-93
   PubMed Web of Science ®Google Scholar
• McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007;7:429-42
   PubMed Web of Science ®Google Scholar
• Gharaee-Kermani M, Phan SH. Role of cytokines and cytokine therapy in wound healing and fibrotic diseases. Curr Pharm Des 2001;7:1083-103
   PubMed Web of Science ®Google Scholar
• Garcia VE, Quiroga MF, Ochoa MT, Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns. J Immunol 2001;167:5719-24
   PubMed Web of Science ®Google Scholar
• Becker Y. The changes in the T helper 1 (Th1) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers - a review and hypothesis. Virus Genes 2004;28:5-18
   PubMed Web of Science ®Google Scholar
• Howell WM, Rose-Zerilli MJ. Cytokine gene polymorphisms, cancer susceptibility, and prognosis. J Nutr 2007;137:194S-199S
   PubMed Web of Science ®Google Scholar
• Smyth MJ, Thia KY, Street SE, Differential tumor surveillance by natural killer (NK) and NKT cells. J Exp Med 2000;191:661-8
   PubMed Web of Science ®Google Scholar
• Shankaran V, Ikeda H, Bruce AT, IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001;410:1107-11
   PubMed Web of Science ®Google Scholar
• Moore RJ, Owens DM, Stamp G, Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med 1999;5:828-31
   PubMed Web of Science ®Google Scholar
• Hilbert DM, Kopf M, Mock BA, Interleukin 6 is essential for in vivo development of B lineage neoplasms. J Exp Med 1995;182:243-8
   PubMed Web of Science ®Google Scholar
• Renton KW. Regulation of drug metabolism and disposition during inflammation and infection. Expert Opin Drug Metab Toxicol 2005;1:629-40
   PubMedGoogle Scholar
• Carcillo JA, Doughty L, Kofos D, Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive Care Med 2003;29:980-4
   PubMed Web of Science ®Google Scholar
• Thomas H, Coley HM. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 2003;10:159-65
   PubMedGoogle Scholar
• Janneh O, Jones E, Chandler B, Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes. J Antimicrob Chemother 2007;60:987-93
   PubMed Web of Science ®Google Scholar
• Owen A. The impact of host pharmacogenetics on antiretroviral drug disposition. Curr Infect Dis Rep 2006;8:401-8
   PubMedGoogle Scholar
• Ford J, Hoggard PG, Owen A, A simplified approach to determining P-glycoprotein expression in peripheral blood mononuclear cell subsets. J Immunol Methods 2003;274:129-37
   PubMed Web of Science ®Google Scholar
• Cauda R, Lucia MB, Ortona L, A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients. Immunol Lett 1998;60:19-21
   PubMed Web of Science ®Google Scholar
• Lucia MB, Rutella S, Rumi C, Detection of P-glycoprotein efflux activity on peripheral blood lymphocyte subsets from HIV+ patients. Eur J Histochem 1997; 41:(Suppl 2):195-6
   PubMed Web of Science ®Google Scholar
• Ludescher C, Pall G, Irschick EU, Differential activity of P-glycoprotein in normal blood lymphocyte subsets. Br J Haematol 1998;101:722-7
   PubMed Web of Science ®Google Scholar
• Aggarwal S, Tsuruo T, Gupta S. Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR 1 gene, in T cell subsets from aging humans. J Clin Immunol 1997;17:448-54
   PubMed Web of Science ®Google Scholar
• Zhang J, Alston MA, Huang H, Human T cell cytokine responses are dependent on multidrug resistance protein-1. Int Immunol 2006;18:485-93
   PubMed Web of Science ®Google Scholar
• Oselin K, Mrozikiewicz PM, Pahkla R, Quantitative determination of the human MRP1 and MRP2 mRNA expression in FACS-sorted peripheral blood CD4+, CD8+, CD19+, and CD56+ cells. Eur J Haematol 2003;71:119-23
   PubMed Web of Science ®Google Scholar
• Owen A, Chandler B, Bray PG, Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4. J Virol 2004;78:12022-9
   PubMed Web of Science ®Google Scholar
• Gupta S, Gollapudi S. P-glycoprotein (MDR 1 gene product) in cells of the immune system: its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection. J Clin Immunol 1993;13:289-301
   PubMed Web of Science ®Google Scholar
• Kock K, Grube M, Jedlitschky G, Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy. Clin Pharmacokinet 2007;46:449-70
   PubMed Web of Science ®Google Scholar
• Bleasby K, Castle JC, Roberts CJ, Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition. Xenobiotica 2006;36:963-88
   PubMed Web of Science ®Google Scholar
• Jung N, Lehmann C, Rubbert A, Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection. Drug Metab Dispos 2008;36:1616-23
   PubMed Web of Science ®Google Scholar
• Janneh O, Chandler B, Hartkoorn R, Intracellular accumulation of efavirenz and nevirapine is independent of P-glycoprotein activity in cultured CD4 T cells and primary human lymphocytes. J Antimicrob Chemother 2009;64:1002-7
   PubMed Web of Science ®Google Scholar
• Rajagopal A, Simon SM. Subcellular localization and activity of multidrug resistance proteins. Mol Biol Cell 2003;14:3389-99
   PubMed Web of Science ®Google Scholar
• Sun H, Huang Y, Frassetto L, Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metab Dispos 2004;32:1239-46
   PubMed Web of Science ®Google Scholar
• Huber RD, Gao B, Sidler Pfandler MA, Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Am J Physiol Cell Physiol 2007;292:C795-806
   PubMed Web of Science ®Google Scholar
• Liptrott NJ, Khoo SH, Back DJ, Detection of ABCC2, CYP2B6 and CYP3A4 in human peripheral blood mononuclear cells using flow cytometry. J Immunol Methods 2008;339:270-4
   PubMed Web of Science ®Google Scholar
• Liptrott NJ, Penny M, Bray PG, The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC. Br J Pharmacol 2009;156:497-508
   PubMed Web of Science ®Google Scholar
• Chandramohan A, Eapen A, Govil S, Determining standard liver volume: assessment of existing formulae in Indian population. Indian J Gastroenterol 2007;26:22-5
   PubMedGoogle Scholar
• Lang T, Klein K, Fischer J, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics 2001;11:399-415
   PubMedGoogle Scholar
• Nelson DR, Koymans L, Kamataki T, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 1996;6:1-42
   PubMedGoogle Scholar
• de Lange E. Potential role of ABC transporters as a detoxification system at the blood-CSF barrier. Adv Drug Deliv Rev 2004;56:1793-809
   PubMed Web of Science ®Google Scholar
• Vasquez EM, Petrenko Y, Jacobssen V, An assessment of P-glycoprotein expression and activity in peripheral blood lymphocytes of transplant candidates. Transplant Proc 2005;37:175-7
   PubMed Web of Science ®Google Scholar
• Drach J, Gsur A, Hamilton G, Involvement of p-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes. Blood 1996;88:1747-54
   PubMed Web of Science ®Google Scholar
• Pati S, Pelser CB, Dufraine J, Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma. Blood 2002;99:3771-9
   PubMed Web of Science ®Google Scholar
• Leier I, Jedlitschky G, Buchholz U, The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem 1994;269:27807-10
   PubMed Web of Science ®Google Scholar
• Randolph GJ. Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators. Semin Immunol 2001;13:267-74
   PubMed Web of Science ®Google Scholar
• van de Ven R, de Jong MC, Reurs AW, Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentiation. J Immunol 2006;176:5191-8
   Google Scholar
• Zhang Y, Benet LZ. The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. Clin Pharmacokinet 2001;40:159-68
   PubMed Web of Science ®Google Scholar
• Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 1995;13:129-34
   PubMed Web of Science ®Google Scholar
• Lown KS, Mayo RR, Leichtman AB, Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther 1997;62:248-60
   PubMed Web of Science ®Google Scholar
• Gomez DY, Wacher VJ, Tomlanovich SJ, The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clin Pharmacol Ther 1995;58:15-19
   PubMed Web of Science ®Google Scholar
• Albermann N, Schmitz-Winnenthal FH, Z'Graggen K, Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. Biochem Pharmacol 2005;70:949-58
   PubMed Web of Science ®Google Scholar
• Fardel O, Le Vee M. Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines. Expert Opin Drug Metab Toxicol 2009;5:1469-81
   PubMed Web of Science ®Google Scholar
• Piquette-Miller M, Pak A, Kim H, Decreased expression and activity of P-glycoprotein in rat liver during acute inflammation. Pharm Res 1998;15:706-11
   PubMed Web of Science ®Google Scholar
• Smol'nikova VV, Voznyuk AV, Potapnev MP. Cytokine-induced differentiation and proliferation of human T lymphocytes in vitro: effects of interleukin 2 and interleukin 6. Bull Exp Biol Med 2000;129:567-70
   PubMed Web of Science ®Google Scholar
• Belliard AM, Tardivel S, Farinotti R, Effect of hr-IL2 treatment on intestinal P-glycoprotein expression and activity in Caco-2 cells. J Pharm Pharmacol 2002;54:1103-9
   PubMed Web of Science ®Google Scholar
• Hosten B, Abbara C, Petit B, Effect of interleukin-2 pretreatment on paclitaxel absorption and tissue disposition after oral and intravenous administration in mice. Drug Metab Dispos 2008;36:1729-35
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Tsujimura S. [Multi-drug resistance in the treatments of autoimmune diseases]. Nihon Rinsho Meneki Gakkai Kaishi 2006;29:319-24
   PubMedGoogle Scholar
• Elkahwaji J, Robin MA, Berson A, Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. Biochem Pharmacol 1999;57:951-4
   PubMed Web of Science ®Google Scholar
• Geier A, Dietrich CG, Voigt S, Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. Hepatology 2003;38:345-54
   PubMed Web of Science ®Google Scholar
• Hebenstreit D, Horejs-Hoeck J, Duschl A. JAK/STAT-dependent gene regulation by cytokines. Drug News Perspect 2005;18:243-9
   PubMed Web of Science ®Google Scholar
• Prickett TD, Brautigan DL. Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. Mol Cell Biol 2007;27:4217-27
   PubMed Web of Science ®Google Scholar
• Leu JI, Crissey MA, Leu JP, Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury. Mol Cell Biol 2001;21:414-24
   PubMed Web of Science ®Google Scholar
• Madonna S, Scarponi C, Sestito R, The IFN-gamma-dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Kruppel-like factor-4, and it is dysregulated in psoriatic keratinocytes. J Immunol 2010;185:2467-81
   PubMed Web of Science ®Google Scholar
• Natarajan C, Bright JJ. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J Immunol 2002;168:6506-13
   PubMed Web of Science ®Google Scholar
• Senn JJ, Klover PJ, Nowak IA, Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 2002;51:3391-9
   PubMed Web of Science ®Google Scholar
• Bentires-Alj M, Barbu V, Fillet M, NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene 2003;22:90-7
   PubMed Web of Science ®Google Scholar
• Vilaboa NE, Galan A, Troyano A, Regulation of multidrug resistance 1 (MDR1)/P-glycoprotein gene expression and activity by heat-shock transcription factor 1 (HSF1). J Biol Chem 2000;275:24970-6
   PubMed Web of Science ®Google Scholar
• Rohlff C, Glazer RI. Regulation of the MDR1 promoter by cyclic AMP-dependent protein kinase and transcription factor Sp1. Int J Oncol 1998;12:383-6
   Google Scholar
• Salminen A, Huuskonen J, Ojala J, Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev 2008;7:83-105
   PubMed Web of Science ®Google Scholar
• Puga I, Rao A, Macian F. Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells. Immunity 2008;29:193-204
   PubMedGoogle Scholar
• Vega MI, Huerta-Yepez S, Martinez-Paniagua M, Rituximab-mediated cell signaling and chemo/immuno-sensitization of drug-resistant B-NHL is independent of its Fc functions. Clin Cancer Res 2009;15:6582-94
   Google Scholar
• Sukhai M, Piquette-Miller M. Regulation of the multidrug resistance genes by stress signals. J Pharm Pharm Sci 2000;3:268-80
   PubMed Web of Science ®Google Scholar
• Barancik M, Bohacova V, Kvackajova J, SB203580, a specific inhibitor of p38-MAPK pathway, is a new reversal agent of P-glycoprotein-mediated multidrug resistance. Eur J Pharm Sci 2001;14:29-36
   PubMed Web of Science ®Google Scholar
• Shinoda C, Maruyama M, Fujishita T, Doxorubicin induces expression of multidrug resistance-associated protein 1 in human small cell lung cancer cell lines by the c-jun N-terminal kinase pathway. Int J Cancer 2005;117:21-31
   PubMed Web of Science ®Google Scholar
• Bailey-Dell KJ, Hassel B, Doyle LA, Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene. Biochim Biophys Acta 2001;1520:234-41
   PubMed Web of Science ®Google Scholar
• Yu Q, Kovacs C, Yue FY, The role of the p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and phosphoinositide-3-OH kinase signal transduction pathways in CD40 ligand-induced dendritic cell activation and expansion of virus-specific CD8+ T cell memory responses. J Immunol 2004;172:6047-56
   Google Scholar
• Chiarini F, Del Sole M, Mongiorgi S, The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism. Leukemia 2008;22:1106-16
   PubMed Web of Science ®Google Scholar
• Kamimura D, Ishihara K, Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 2003;149:1-38
   PubMed Web of Science ®Google Scholar
• Moshage H. Cytokines and the hepatic acute phase response. J Pathol 1997;181:257-66
   PubMed Web of Science ®Google Scholar
• Hatle KM, Neveu W, Dienz O, Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression. Mol Cell Biol 2007;27:2952-66
   PubMed Web of Science ®Google Scholar
• Chen YL, Le Vraux V, Leneveu A, Acute-phase response, interleukin-6, and alteration of cyclosporine pharmacokinetics. Clin Pharmacol Ther 1994;55:649-60
   PubMed Web of Science ®Google Scholar
• Cantwell CA, Sterneck E, Johnson PF. Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1. Mol Cell Biol 1998;18:2108-17
   PubMed Web of Science ®Google Scholar
• Matsumura K, Saito T, Takahashi Y, Identification of a novel polymorphic enhancer of the human CYP3A4 gene. Mol Pharmacol 2004;65:326-34
   PubMed Web of Science ®Google Scholar
• Huang W, Glass CK. Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. Arterioscler Thromb Vasc Biol 2010;30:1542-9
   PubMed Web of Science ®Google Scholar
• Tirona RG, Kim RB. Nuclear receptors and drug disposition gene regulation. J Pharm Sci 2005;94:1169-86
   PubMed Web of Science ®Google Scholar
• Synold TW, Dussault I, Forman BM. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 2001;7:584-90
   PubMed Web of Science ®Google Scholar
• Wang W, Prosise WW, Chen J, Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability. Protein Eng Des Sel 2008;21:425-33
   PubMed Web of Science ®Google Scholar
• Schote AB, Turner JD, Schiltz J, Nuclear receptors in human immune cells: expression and correlations. Mol Immunol 2007;44:1436-45
   PubMed Web of Science ®Google Scholar
• Wang H, LeCluyse EL. Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clin Pharmacokinet 2003;42:1331-57
   PubMed Web of Science ®Google Scholar
• Tangirala RK, Bischoff ED, Joseph SB, Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci USA 2002;99:11896-901
   PubMed Web of Science ®Google Scholar
• Hevener AL, Olefsky JM, Reichart D, Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 2007;117:1658-69
   PubMed Web of Science ®Google Scholar
• Chow EK, Razani B, Cheng G. Innate immune system regulation of nuclear hormone receptors in metabolic diseases. J Leukoc Biol 2007;82:187-95
   PubMed Web of Science ®Google Scholar
• Zhou C, Tabb MM, Nelson EL, Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. J Clin Invest 2006;116:2280-9
   PubMed Web of Science ®Google Scholar
• Gu X, Ke S, Liu D, Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents. J Biol Chem 2006;281:17882-9
   PubMed Web of Science ®Google Scholar
• Assenat E, Gerbal-Chaloin S, Larrey D, Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology 2004;40:951-60
   PubMed Web of Science ®Google Scholar
• Teng S, Piquette-Miller M. The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. J Pharmacol Exp Ther 2005;312:841-8
   PubMed Web of Science ®Google Scholar
• Guerrero JM, Pozo D, Garcia-Maurino S, Nuclear receptors are involved in the enhanced IL-6 production by melatonin in U937 cells. Biol Signals Recept 2000;9:197-202
   PubMedGoogle Scholar
• Bai B, Yamamoto K, Sato H, Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line (Caco-2). Inflammation 2005;29:141-6
   PubMed Web of Science ®Google Scholar
• Sunman JA, Hawke RL, LeCluyse EL, Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metab Dispos 2004;32:359-63
   PubMed Web of Science ®Google Scholar
• Yang XO, Pappu BP, Nurieva R, T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 2008;28:29-39
   PubMed Web of Science ®Google Scholar
• He YW, Beers C, Deftos ML, Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. J Immunol 2000;164:5668-74
   PubMed Web of Science ®Google Scholar
• Gorski JC, Hall SD, Becker P, In vivo effects of interleukin-10 on human cytochrome P450 activity. Clin Pharmacol Ther 2000;67:32-43
   PubMed Web of Science ®Google Scholar
• Coste A, Dubourdeau M, Linas MD, PPARgamma promotes mannose receptor gene expression in murine macrophages and contributes to the induction of this receptor by IL-13. Immunity 2003;19:329-39
   PubMed Web of Science ®Google Scholar
• Mencarelli A, Migliorati M, Barbanti M, Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells. Biochem Pharmacol 2010;80:1700-7
   PubMed Web of Science ®Google Scholar
• Le Vee M, Jouan E, Moreau A, Regulation of drug transporter mRNA expression by interferon-gamma in primary human hepatocytes. Fundam Clin Pharmacol 2010
   Google Scholar
• Hao XR, Cao DL, Hu YW, IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner. Atherosclerosis 2009;203:417-28
   PubMed Web of Science ®Google Scholar