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In vitro and in vivo models of drug ototoxicity: studying the mechanisms of a clinical problem

, MD, , MD (Associate) & , PhD (Head)
Pages 1521-1534 | Published online: 14 Oct 2011

Bibliography

  • Yorgason JG, Kalinec GM, Luxford WM, Acetaminophen ototoxicity after acetaminophen/hydrocodone abuse: evidence from two parallel in vitro mouse models. Otolaryngol Head Neck Surg 2010;142(12):814-19; 9 e1-2
  • Schuknecht HF. Disorders of intoxication. In: Bussy KR. editor. Pathology of the ear. Lea and Febiger; Philadelphia: 1993. p. 255-77
  • Jahnke K. The blood-perilymph barrier. Arch Otorhinolaryngol 1980;228(1):29-34
  • Plontke SK, Wood AW, Salt AN. Analysis of gentamicin kinetics in fluids of the inner ear with round window administration. Otol Neurotol 2002;23(6):967-74
  • Yorgason JG, Fayad JN, Kalinec F. Understanding drug ototoxicity: molecular insights for prevention and clinical management. Expert Opin Drug Saf 2006;5(3):383-99
  • Fausti SA, Henry JA, Schaffer HI, High-frequency audiometric monitoring for early detection of aminoglycoside ototoxicity. J Infect Dis 1992;165(6):1026-32
  • Govaerts PJ, Claes J, van de Heyning PH, Aminoglycoside-induced ototoxicity. Toxicol Lett 1990;52(3):227-51
  • Light JP, Silverstein H, Jackson LE. Gentamicin perfusion vestibular response and hearing loss. Otol Neurotol 2003;24(2):294-8
  • Cohen-Kerem R, Kisilevsky V, Einarson TR, Intratympanic gentamicin for Meniere's disease: a meta-analysis. Laryngoscope 2004;114(12):2085-91
  • Fradis M, Brodsky A, Ben-David J, Chronic otitis media treated topically with ciprofloxacin or tobramycin. Arch Otolaryngol Head Neck Surg 1997;123(10):1057-60
  • Imamura S, Adams JC. Distribution of gentamicin in the guinea pig inner ear after local or systemic application. J Assoc Res Otolaryngol 2003;4(2):176-95
  • Schacht J. Molecular mechanisms of drug-induced hearing loss. Hear Res 1986;22:297-304
  • Williams SE, Zenner HP, Schacht J. Three molecular steps of aminoglycoside ototoxicity demonstrated in outer hair cells. Hear Res 1987;30(1):11-18
  • Conlon B, Aran J, Erre J, Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid. Hear Res 1999;128:40-4
  • Garetz SL, Altschuler RA, Schacht J. Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo. Hear Res 1994;77(1-2):81-7
  • Sha SH, Schacht J. Stimulation of free radical formation by aminoglycoside antibiotics. Hear Res 1999;128(1-2):112-18
  • Wu WJ, Sha SH, Schacht J. Recent advances in understanding aminoglycoside ototoxicity and its prevention. Audiol Neurootol 2002;7(3):171-4
  • Forge A, Li L. Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear Res 2000;139(1-2):97-115
  • Li L, Nevill G, Forge A. Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear. J Comp Neurol 1995;355(3):405-17
  • Jiang H, Sha SH, Forge A, Caspase-independent pathways of hair cell death induced by kanamycin in vivo. Cell Death Differ 2006;13(1):20-30
  • Shimizu A, Takumida M, Anniko M, Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity. Acta Otolaryngol 2003;123(4):459-65
  • Wang J, Van De Water TR, Bonny C, A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci 2003;23(24):8596-607
  • Kalinec G, Fernandez Zapico M, Urrutia R, Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss. Proc Natl Acad Sci USA 2005;102(44):16019-24
  • Ding D, Stracher A, Salvi RJ. Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hear Res 2002;164(1-2):115-26
  • Corbacella E, Lanzoni I, Ding D, Minocycline attenuates gentamicin induced hair cell loss in neonatal cochlear cultures. Hear Res 2004;197(1-2):11-18
  • Bodmer D, Brors D, Pak K, Rescue of auditory hair cells from aminoglycoside toxicity by Clostridium difficile toxin B, an inhibitor of the small GTPases Rho/Rac/Cdc42. Hear Res 2002;172(1-2):81-6
  • Pierre PV, Engmer C, Wallin I, High concentrations of thiosulfate in scala tympani perilymph after systemic administration in the guinea pig. Acta Otolaryngol 2009;129(2):132-7
  • Muldoon LL, Pagel MA, Kroll RA, Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity. Clin Cancer Res 2000;6(1):309-15
  • More SS, Akil O, Ianculescu AG, Role of the copper transporter, CTR1, in platinum-induced ototoxicity. J Neurosci 2010;30(28):9500-9
  • Bertolaso L, Martini A, Bindini D, Apoptosis in the OC-k3 immortalized cell line treated with different agents. Audiology 2001;40:327-35
  • Sha SH, Qiu JH, Schacht J. Aspirin to prevent gentamicin-induced hearing loss. N Engl J Med 2006;354(17):1856-7
  • Bates DE, Beaumont SJ, Baylis BW. Ototoxicity induced by gentamicin and furosemide. Ann Pharmacother 2002;36(3):446-51
  • Liu JX, Zhou XN, Yuan YG. Effects of furosemide on intracochlear oxygen tension in the guinea pig. Eur Arch Otorhinolaryngol 1996;253(6):367-70
  • Conlon BJ, McSwain SD, Smith DW. Topical gentamicin and ethacrynic acid: effects on cochlear function. Laryngoscope 1998;108(7):1087-9
  • Ding D, McFadden SL, Browne RW, Late dosing with ethacrynic acid can reduce gentamicin concentration in perilymph and protect cochlear hair cells. Hear Res 2003;185(1-2):90-6
  • McGhan LJ, Merchant SN. Erythromycin ototoxicity. Otol Neurotol 2003;24:701-2
  • Ress BD, Gross EM. Irreversible sensorineural hearing loss as a result of azithromycin ototoxicity. A case report. Ann Otol Rhinol Laryngol 2000;109(4):435-7
  • Stupp H, Kupper K, Lagler F, Inner ear concentrations and ototoxicity of different antibiotics in local and systemic application. Audiology 1973;12:350-63
  • Uzun C, Koten M, Adali MK, Reversible ototoxic effect of azithromycin and clarithromycin on transiently evoked otoacoustic emissions in guinea pigs. J Laryngol Otol 2001;115(8):622-8
  • van Zeijl LG, Conijn EA, Rodenburg M, Analysis of hearing loss due to cis-diamminedichloroplatinum-II. Arch Otorhinolaryngol 1984;239(3):255-62
  • Laurell G, Jungnelius U. High-dose cisplatin treatment: hearing loss and plasma concentrations. Laryngoscope 1990;100(7):724-34
  • Garetz SL, Schacht J. Ototoxicity: of mice and men. In: Van de Water TR, Fay RR, Popper AN. editors. Clinical aspects of hearing. Springer; New York: 1996. p. 116-54
  • Hinojosa R, Riggs LC, Strauss M, Temporal bone histopathology of cisplatin ototoxicity. Am J Otol 1995;16(6):731-40
  • Schweitzer VG, Hawkins JE, Lilly DJ, Ototoxic and nephrotoxic effects of combined treatment with cis-diamminedichloroplatinum and kanamycin in the guinea pig. Otolaryngol Head Neck Surg 1984;92(1):38-49
  • McAlpine D, Johnstone BM. The ototoxic mechanism of cisplatin. Hear Res 1990;47(3):191-203
  • Rybak LP, Husain K, Morris C, Effect of protective agents against cisplatin ototoxicity. Am J Otol 2000;21(4):513-20
  • Ding D, Lanzoni I, Corbacelli E, editors. PD98059 protects cochlear hair cells from cisplatin. 28th ARO Midwinter Meeting; 2005; New Orleans, LA, USA
  • Liu W, Staecker H, Stupak H, Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells. Neuroreport 1998;9(11):2609-14
  • Garcia-Berrocal JR, Nevado J, Ramirez-Camacho R, The anticancer drug cisplatin induces an intrinsic apoptotic pathway inside the inner ear. Br J Pharmacol 2007;152(7):1012-20
  • More SS, Akij O, Ianculescu AG, Role of the copper transporter, CTR1, in platinum-induced ototoxicity. J Neurosci 2010;30(28):9500-9
  • Kalinec GM, Webster P, Lim DJ, A cochlear cell line as an in vitro system for drug ototoxicity screening. Audiol Neurootol 2003;8:177-89
  • Rybak L, Whitworth C, Somani S. Application of antioxidants and other agents to prevent cisplatin ototoxicity. Laryngoscope 1999;109:1740-4
  • Rybak LP, Husain K, Whitworth C, Dose dependent protection by lipoic acid against cisplatin-induced ototoxicity in rats: antioxidant defense system. Toxicol Sci 1999;47(2):195-202
  • McFadden SL, Ding D, Salvemini D, M40403, a superoxide dismutase mimetic, protects cochlear hair cells from gentamicin, but not cisplatin toxicity. Toxicol Appl Pharmacol 2003;186:46-54
  • Videhult P, Laurell G, Wallin I, Kinetics of Cisplatin and its monohydrated complex with sulfur-containing compounds designed for local otoprotective administration. Exp Biol Med (Maywood) 2006;231(10):1638-45
  • Tamura Y, Ikeda O, Nakasone Y, Effect of sodium thiosulfate on cisplatin removal after intra-arterial embolization with a lipiodol-platinum suspension for hepatocellular carcinoma. Acta Radiol 2010;51(4):383-8
  • Boettcher FA, Salvi RJ. Salicylate ototoxicity: review and synthesis. Am J Otol 1991;12:33-47
  • Day RO, Graham GG, Bieri D, Concentration-response relationships for salicylate-induced ototoxicity in normal volunteers. Br J Clin Pharmacol 1989;28(6):695-702
  • Brien JA. Ototoxicity associated with salicylates. A brief review. Drug Saf 1993;9(2):143-8
  • Long GR, Tubis A. Modification of spontaneous and evoked otoacoustic emissions and associated psychoacoustic microstructure by aspirin consumption. J Acoust Soc Am 1988;84:1343-53
  • Stewart CE, Hudspeth AJ. Effects of salicylates and aminoglycosides on spontaneous otoacoustic emissions in the Tokay gecko. Proc Natl Acad Sci USA 2000;97(1):454-9
  • Huang ZW, Luo Y, Wu Z, Paradoxical enhancement of active cochlear mechanics in long-term administration of salicylate. J Neurophysiol 2005;93(4):2053-61
  • Zheng J, Madison LD, Oliver D, Prestin, the motor protein of outer hair cells. Audiol Neurootol 2002;7(1):9-12
  • Guitton MJ, Caston J, Ruel J, Salicylate induces tinnitus through activation of cochlear NMDA receptors. J Neurosci 2003;23(9):3944-52
  • Peng BG, Chen S, Lin X. Aspirin selectively augmented M-methyl-D-aspartate types of glutamate responses in cultured spiral ganglion neurons of mice. Neurosci Lett 2003;343:21-4
  • Sha SH, Schacht J. Salicylate attenuates gentamicin-induced ototoxicity. Lab Invest 1999;79(7):807-13
  • Hyppolito MA, de Oliveira JA, Rossato M. Cisplatin ototoxicity and otoprotection with sodium salicylate. Eur Arch Otorhinolaryngol 2006;263(9):798-803
  • Li G, Sha SH, Zotova E, Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action. Lab Invest 2002;82(5):585-96
  • McKinnon BJ, Lassen LF. Naproxen-associated sudden sensorineural hearing loss. Mil Med 1998;163(11):792-3
  • Chapman P. Naproxen and sudden hearing loss. J Laryngol Otol 1982;96(2):163-6
  • Blakley BW, Schilling H. Deafness associated with acetaminophen and codeine abuse. J Otolaryngol Head Neck Surg 2008;37(4):507-9
  • Friedman RA, House JW, Luxford WM, Profound hearing loss associated with hydrocodone/acetaminophen abuse. Am J Otol 2000;21(2):188-91
  • Ho T, Vrabec JT, Burton AW. Hydrocodone use and sensorineural hearing loss. Pain Physician 2007;10(3):467-72
  • Oh AK, Ishiyama A, Baloh RW. Deafness associated with abuse of hydrocodone/acetaminophen. Neurology 2000;54(12):2345
  • Harell M, Shea JJ, Emmett JR. Total deafness with chronic propoxyphene abuse. Laryngoscope 1978;88(9 Pt 1):1518-21
  • Lupin AJ, Harley CH. Letter: inner ear damage related to propoxyphene ingestion. Can Med Assoc J 1976;114(7):596
  • Ramsay BC. Complete nerve deafness after abuse of co-proxamol. Lancet 1991;338(8764):446-7
  • Curhan SG, Eavey R, Shargorodsky J, Analgesic use and the risk of hearing loss in men. Am J Med 2010;123(3):231-7
  • Yang TH, Liu SH, Young YH. A novel inner ear monitoring system for evaluating ototoxicity of gentamicin eardrops in guinea pigs. Laryngoscope 2010;120(6):1220-6
  • Poirrier AL, Van den Ackerveken P, Kim TS, Ototoxic drugs: difference in sensitivity between mice and guinea pigs. Toxicol Lett 2009;193(1):41-9
  • Campbell KC, Meech RP, Klemens JJ, Prevention of noise- and drug-induced hearing loss with D-methionine. Hear Res 2007;226(1-2):92-103
  • Mount RJ, Takeno S, Wake M, Carboplatin ototoxicity in the chinchilla: lesions of the vestibular sensory epithelium. Acta Otolaryngol Suppl 1995;519:60-5
  • Munguia R, Sahmkow SI, Funnell WR, Transtympanic Ringer's lactate application in the prevention of cisplatinum-induced ototoxicity in a chinchilla animal model. Otolaryngol Head Neck Surg 2010;143(1):134-40
  • Choe WT, Chinosornvatana N, Chang KW. Prevention of cisplatin ototoxicity using transtympanic N-acetylcysteine and lactate. Otol Neurotol 2004;25(6):910-15
  • Nader ME, Theoret Y, Saliba I. The role of intratympanic lactate injection in the prevention of cisplatin-induced ototoxicity. Laryngoscope 2010;120(6):1208-13
  • Wu WJ, Sha SH, McLaren JD, Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat. Hear Res 2001;158(1-2):165-78
  • Murillo-Cuesta S, Contreras J, Cediel R, Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice. Lab Anim 2009;44(2):124-31
  • Pawlowski KS, Si E, Wright CG, Ototoxicity of topical azithromycin solutions in the guinea pig. Arch Otolaryngol Head Neck Surg 2010;136(5):481-7
  • Daniel SJ, Munguia R. Ototoxicity of topical ciprofloxacin/dexamethasone otic suspension in a chinchilla animal model. Otolaryngol Head Neck Surg 2008;139(6):840-5
  • Saliba I, El Fata F, Ouelette V, Are intratympanic injections of N-acetylcysteine and methylprednisolone protective against Cisplatin-induced ototoxicity? J Otolaryngol Head Neck Surg 2010;39(3):236-43
  • Murphy D, Daniel SJ. Intratympanic dexamethasone to prevent cisplatin ototoxicity: a guinea pig model. Otolaryngol Head Neck Surg. 2011. [Epub ahead of print]
  • Kalinec F. High-Throughput screening of ototoxic and otoprotective pharmacological drugs. Volta Review 2005;105(3):385-408
  • Sundstrom L, Morrison B III, Bradley M, Organotypic cultures as tools for functional screening in the CNS. Drug Discov Today 2005;10(14):993-1000
  • Richardson GP, Russell IJ. Cochlear cultures as a model system for studying aminoglycoside induced ototoxicity. Hear Res 1991;53(2):293-311
  • Kotecha B, Richardson GP. Ototoxicity in vitro: effects of neomycin, gentamicin, dihydrostreptomycin, amikacin, spectinomycin, neamine, spermine and poly-L-lysine. Hear Res 1994;73(2):173-84
  • Kopke RD, Liu W, Gabaizadeh R, Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Am J Otol 1997;18(5):559-71
  • Cotanche DA. Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma. Hear Res 1987;30(2-3):181-95
  • Slattery EL, Warchol ME. Cisplatin ototoxicity blocks sensory regeneration in the avian inner ear. J Neurosci 2010;30(9):3473-81
  • Oshima K, Shin K, Diensthuber M, Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells. Cell 2010;141(4):704-16
  • Ciarimboli G, Deuster D, Knief A, Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol 2010;176(3):1169-80
  • Cunningham LL, Brandon CS. Heat shock inhibits both aminoglycoside- and cisplatin-induced sensory hair cell death. J Assoc Res Otolaryngol 2006;7(3):299-307
  • Taleb M, Brandon CS, Lee FS, Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock. J Assoc Res Otolaryngol 2008;9(3):277-89
  • Yu Y, Szczepek AJ, Haupt H, Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants. J Biomed Sci 2009;16:79
  • White PM, Doetzlhofer A, Lee YS, Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature 2006;441(7096):984-7
  • Doetzlhofer A, Basch ML, Ohyama T, Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell 2009;16(1):58-69
  • Kawamoto K, Izumikawa M, Beyer LA, Spontaneous hair cell regeneration in the mouse utricle following gentamicin ototoxicity. Hear Res 2009;247(1):17-26
  • Holley MC, Lawlor PW. Production of conditionally immortalised cell lines from a transgenic mouse. Audiol Neurootol 1997;2(1-2):25-35
  • Jat PS, Noble MD, Ataliotis P, Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse. Proc Natl Acad Sci USA 1991;88(12):5096-100
  • Seidman MD, Khan MJ, Bai U, Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. Am J Otol 2000;21(2):161-7
  • Kalinec GM, Webster P, Lim DJ, A cochlear cell line as an in vitro system for drug ototoxicity screening. Audiol Neurootol 2003;8(4):177-89
  • Whitfield TT. Zebrafish as a model for hearing and deafness. J Neurobiol 2002;53(2):157-71
  • Chiu LL, Cunningham LL, Raible DW, Using the zebrafish lateral line to screen for ototoxicity. J Assoc Res Otolaryngol 2008;9(2):178-90
  • Froehlicher M, Liedtke A, Groh KJ, Zebrafish (Danio rerio) neuromast: promising biological endpoint linking developmental and toxicological studies. Aquat Toxicol 2009;95(4):307-19
  • Dufourcq P, Roussigne M, Blader P, Mechano-sensory organ regeneration in adults: the zebrafish lateral line as a model. Mol Cell Neurosci 2006;33(2):180-7
  • Alexandre D, Ghysen A. Somatotopy of the lateral line projection in larval zebrafish. Proc Natl Acad Sci USA 1999;96(13):7558-62
  • Germana A, Laura R, Montalbano G, Expression of brain-derived neurotrophic factor and TrkB in the lateral line system of zebrafish during development. Cell Mol Neurobiol 2010;30(5):787-93
  • Warnecke A, Scheper V, Buhr I, Artemin improves survival of spiral ganglion neurons in vivo and in vitro. Neuroreport 2010;21(7):517-21

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