In vitro end points for the assessment of cellular immune response-modulating drugs

Bibliography

• Larosa DF, Orange JS. 1. Lymphocytes. J Allergy Clin Immunol 2008;121(2 Suppl):S364-9; quiz S412
   PubMed Web of Science ®Google Scholar
• Trikudanathan S, Sayegh MH. The evolution of the immunobiology of co-stimulatory pathways: clinical implications. Clin Exp Rheumatol 2007;25(5 Suppl 46):S12-21
   PubMed Web of Science ®Google Scholar
• Clarke JO, Mullin GE. A review of complementary and alternative approaches to immunomodulation. Nutr Clin Pract 2008;23(1):49-62
   PubMed Web of Science ®Google Scholar
• Brode S, Cooke A. Immune-potentiating effects of the chemotherapeutic drug cyclophosphamide. Crit Rev Immunol 2008;28(2):109-26
   PubMed Web of Science ®Google Scholar
• Ben-Ami R, Lewis RE, Kontoyiannis DP. Immunocompromised hosts: immunopharmacology of modern antifungals. Clin Infect Dis 2008;47(2):226-35
   PubMed Web of Science ®Google Scholar
• Dietert RR. New developments in the assessment of developmental immunotoxicology. J Immunotoxicol 2005;2(4):185-9
   PubMedGoogle Scholar
• Falchetti R, Fuggetta MP, Lanzilli G, et al. Effects of resveratrol on human immune cell function. Life Sci 2001;70(1):81-96
   PubMed Web of Science ®Google Scholar
• Fuggetta MP, Di Francesco P, Falchetti R, et al. Effect of morphine on cell-mediated immune responses of human lymphocytes against allogeneic malignant cells. J Exp Clin Cancer Res 2005;24(2):255-63
   PubMed Web of Science ®Google Scholar
• Fuggetta MP, Alvino E, Romani L, et al. Increase of natural killer activity of mouse lymphocytes following in vitro and in vivo treatment with lithium. Immunopharmacol Immunotoxicol 1988;10(1):79-91
   PubMed Web of Science ®Google Scholar
• Alvino E, Fuggetta MP, Tricarico M, Bonmassar E. 2'-2'-difluorodeoxycytidine: in vitro effects on cell-mediated immune response. Anticancer Res 1998;18(5A):3597-602
   PubMed Web of Science ®Google Scholar
• Tait AS, Butts CL, Sternberg EM. The role of glucocorticoids and progestins in inflammatory, autoimmune, and infectious disease. J Leukoc Biol 2008;84(4):924-31
   PubMed Web of Science ®Google Scholar
• Lang S, Picu A, Hofmann T, et al. COX-inhibitors relieve the immunosuppressive effect of tumor cells and improve functions of immune effectors. Int J Immunopathol Pharmacol2006;19(2):409-19
   Google Scholar
• Fuggetta MP, Graziani G, Aquino A, et al. Effect of hydrocortisone on human natural killer activity and its modulation by beta interferon. Int J Immunopharmacol 1988;10(6):687-94
   PubMed Web of Science ®Google Scholar
• Linnebacher M, Blauscha C, Wacke R, et al. An in vitro system for the determination of individualized immunosuppression. Transplant Proc 2008;40(4):918-20
   PubMed Web of Science ®Google Scholar
• Reed SG, Bertholet S, Coler RN, Friede M. New horizons in adjuvants for vaccine development. Trends Immunol 2008
   PubMedGoogle Scholar
• Gautam SC, Gao X, Dulchavsky S. Immunomodulation by curcumin. Adv Exp Med Biol 2007;595:321-41
   PubMed Web of Science ®Google Scholar
• Tovey MG, Lallemand C, Thyphronitis G. Adjuvant activity of type I interferons. Biol Chem 2008;389(5):541-5
   PubMed Web of Science ®Google Scholar
• Lanzilli G, Falchetti R, Tricarico M, et al. In vitro effects of an immunostimulating bacterial lysate on human lymphocyte function. Int J Immunopathol Pharmacol 2005;18(2):245-54
   PubMed Web of Science ®Google Scholar
• Bhathena A, Spear BB. Pharmacogenetics: improving drug and dose selection. Curr Opin Pharmacol 2008;8(5):639-46
   PubMed Web of Science ®Google Scholar
• Weber WW. Pharmacogenetics: from description to prediction. Clin Lab Med 2008;28(4):499-511
   PubMed Web of Science ®Google Scholar
• Stearns V, Rae JM. Pharmacogenetics and breast cancer endocrine therapy: CYP2D6 as a predictive factor for tamoxifen metabolism and drug response? Expert Rev Mol Med 2008;10:e34
   PubMedGoogle Scholar
• Haynes NM, van der Most RG, Lake RA, Smyth MJ. Immunogenic anti-cancer chemotherapy as an emerging concept. Curr Opin Immunol 2008;20(5):545-57
   PubMed Web of Science ®Google Scholar
• Leung DY, Bloom JW. Update on glucocorticoid action and resistance. J Allergy Clin Immunol 2003;111(1):3-22; quiz 3
   PubMed Web of Science ®Google Scholar
• Danesi R, Bocci G, Di Paolo, et al. Principles of immunopharmacology. In: Nijkamp FP, Parnham MJ, editors, Cytotoxic drugs. Birkhauser, 2005
   Google Scholar
• Luqmani YA. Mechanisms of drug resistance in cancer chemotherapy. Med Princ Pract 2005;14(Suppl 1):35-48
   PubMed Web of Science ®Google Scholar
• Johnston A, Gudjonsson JE, Sigmundsdottir H, et al. The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules. Clin Immunol 2005;114(2):154-63
   PubMed Web of Science ®Google Scholar
• Ransom JT. Mechanism of action of mycophenolate mofetil. Ther Drug Monit 1995;17(6):681-4
   PubMed Web of Science ®Google Scholar
• Gummert JF, Ikonen T, Morris RE. Newer immunosuppressive drugs: a review. J Am Soc Nephrol 1999;10(6):1366-80
   PubMed Web of Science ®Google Scholar
• Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci USA 1985;82(16):5328-31
   PubMed Web of Science ®Google Scholar
• Bonfante V, Bonadonna G, Villani F, Martini A. Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia. Recent Results Cancer Res 1980;74:192-9
   PubMedGoogle Scholar
• Hurteloup P, Ganzina F. Clinical studies with new anthracyclines: epirubicin, idarubicin, esorubicin. Drugs Exp Clin Res 1986;12(1-3):233-46
   PubMedGoogle Scholar
• Ormrod D, Jarvis B. Antithymocyte Globulin (Rabbit): a review of the use of Thymoglobulin (R)* in the prevention and treatment of acute renal allograft rejection. BioDrugs 2000;14(4):255
   Web of Science ®Google Scholar
• Zuckermann A, Grimm M, Czerny M, et al. Improved long-term results with thymoglobuline induction therapy after cardiac transplantation: a comparison of two different rabbit-antithymocyte globulines. Transplantation 2000;69(9):1890
   PubMed Web of Science ®Google Scholar
• Bayry J, Lacroix-Desmazes S, Kazatchkine MD, Kaveri SV. Monoclonal antibody and intravenous immunoglobulin therapy for rheumatic diseases: rationale and mechanisms of action. Nat Clin Pract Rheumatol 2007;3(5):262-72
   PubMedGoogle Scholar
• Maloney DG. Immunotherapy for non-Hodgkin's lymphoma: monoclonal antibodies and vaccines. J Clin Oncol 2005;23(26):6421-8
   PubMed Web of Science ®Google Scholar
• Dorner T, Kaufmann J, Wegener WA, et al. Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus. Arthritis Res Ther 2006;8(3):R74
   PubMed Web of Science ®Google Scholar
• Kon OM, Sihra BS, Loh LC, et al. The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma. Eur Respir J 2001;18(1):45-52
   PubMed Web of Science ®Google Scholar
• Taylor PC. Antibody therapy for rheumatoid arthritis. Curr Opin Pharmacol 2003;3(3):323-8
   PubMed Web of Science ®Google Scholar
• Lupo L, Panzera P, Tandoi F, et al. Basiliximab versus steroids in double therapy immunosuppression in liver transplantation: a prospective randomized clinical trial. Transplantation 2008;86(7):925-31
   PubMed Web of Science ®Google Scholar
• Rose JW, Burns JB, Bjorklund J, et al. Daclizumab phase II trial in relapsing and remitting multiple sclerosis: MRI and clinical results. Neurology 2007;69(8):785-9
   PubMed Web of Science ®Google Scholar
• Sobrin L, Huang JJ, Christen W, et al. Daclizumab for treatment of birdshot chorioretinopathy. Arch Ophthalmol 2008;126(2):186-91
   PubMed Web of Science ®Google Scholar
• Norman DJ. Mechanisms of action and overview of OKT3. Ther Drug Monit 1995;17(6):615-20
   PubMed Web of Science ®Google Scholar
• Rothe A, Power BE, Hudson PJ. Therapeutic advances in rheumatology with the use of recombinant proteins. Nat Clin Pract Rheumatol 2008;4(11):605-14
   PubMedGoogle Scholar
• Bingham CO 3rd. Emerging therapeutics for rheumatoid arthritis. Bull NYU Hosp Jt Dis 2008;66(3):210-5
   PubMedGoogle Scholar
• Baslund B, Tvede N, Danneskiold-Samsoe B, et al. Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study. Arthritis Rheum 2005;52(9):2686-92
   PubMed Web of Science ®Google Scholar
• Feldmann M, Maini RN. Lasker clinical medical research award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med 2003;9(10):1245-50
   PubMed Web of Science ®Google Scholar
• Knight DM, Trinh H, Le J, et al. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol 1993;30(16):1443-53
   PubMed Web of Science ®Google Scholar
• Olsson I, Gatanaga T, Gullberg U, et al. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. Eur Cytokine Netw 1993;4(3):169-80
   PubMed Web of Science ®Google Scholar
• Sieper J, Van Den Brande J. Diverse effects of infliximab and etanercept on T lymphocytes. Semin Arthritis Rheum 2005;34(5 Suppl1):23-7
   PubMed Web of Science ®Google Scholar
• Schuerwegh AJ, Van Offel JF, Stevens WJ, et al. Influence of therapy with chimeric monoclonal tumour necrosis factor-alpha antibodies on intracellular cytokine profiles of T lymphocytes and monocytes in rheumatoid arthritis patients. Rheumatology (Oxford) 2003;42(4):541-8
   PubMed Web of Science ®Google Scholar
• Armstrong V. Principles and practice of monitoring immunosuppressive drugs. Laboratoriums Medizin 2002;26(1/2):27-36
   Google Scholar
• Langford CA, Klippel JH, Balow JE, et al. Use of cytotoxic agents and cyclosporine in the treatment of autoimmune disease. Part 2: inflammatory bowel disease, systemic vasculitis, and therapeutic toxicity. Ann Intern Med 1998;129(1):49-58
   PubMed Web of Science ®Google Scholar
• Langford CA, Klippel JH, Balow JE, et al. Use of cytotoxic agents and cyclosporine in the treatment of autoimmune disease. Part 1: rheumatologic and renal diseases. Ann Intern Med 1998;128(12 Pt 1):1021-8
   PubMed Web of Science ®Google Scholar
• Hanke JH, Nichols LN, Coon ME. FK506 and rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA. Lymphokine Cytokine Res 1992;11(5):221-31
   PubMedGoogle Scholar
• Wang SC, Jordan ML, Tweardy DJ, et al. FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line. J Surg Res 1992;53(2):199-202
   PubMed Web of Science ®Google Scholar
• Dumont FJ, Staruch MJ, Koprak SL, et al. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. J Immunol 1990;144(1):251-8
   PubMed Web of Science ®Google Scholar
• Rao KL, Varalakshmi C, Ali AM, Khar A. Administration of anti-IL-12 antibody in vivo inhibits rejection of a rat histiocytoma and suppresses cytokine response in a tumour-bearing host. Immunology 1997;92(3):381-7
   PubMed Web of Science ®Google Scholar
• Roy S, Loh HH. Effects of opioids on the immune system. Neurochem Res 1996;21(11):1375-86
   PubMed Web of Science ®Google Scholar
• Sacerdote P. Opioid-induced immunosuppression. Curr Opin Support Palliat Care 2008;2(1):14-8
   PubMedGoogle Scholar
• McCarthy L, Wetzel M, Sliker JK, et al. Opioids, opioid receptors, and the immune response. Drug Alcohol Depend 2001;62(2):111-23
   PubMed Web of Science ®Google Scholar
• Cutolo M, Capellino S, Sulli A, et al. Estrogens and autoimmune diseases. Ann NY Acad Sci 2006;1089:538-47
   PubMed Web of Science ®Google Scholar
• Cutolo M, Seriolo B, Villaggio B, et al. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann NY Acad Sci 2002;966:131-42
   PubMed Web of Science ®Google Scholar
• Plotkin SA. Vaccines: past, present and future. Nat Med 2005;11(4 Suppl):S5-11
   PubMed Web of Science ®Google Scholar
• Koyama A. Re: history of bacillus Calmette-Guerin and bladder cancer: an immunotherapy success story: Herr HW, Morales A. J Urol 2008;179:53-6. J Urol 2008;180(5):2255; author reply
   PubMedGoogle Scholar
• Yokoi T, Amakawa R, Tanijiri T, et al. Mycobacterium bovis Bacillus Calmette-Guerin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int Immunol 2008;20(10):1321-9
   PubMed Web of Science ®Google Scholar
• Mitchell MS. Immunotherapy as part of combinations for the treatment of cancer. Int Immunopharmacol 2003;3(8):1051-9
   PubMed Web of Science ®Google Scholar
• Hurwitz AA, Foster BA, Kwon ED, et al. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res 2000;60(9):2444-8
   PubMed Web of Science ®Google Scholar
• van Elsas A, Sutmuller RP, Hurwitz AA, et al. Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J Exp Med 2001;194(4):481-9
   PubMed Web of Science ®Google Scholar
• Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392(6673):245-52
   PubMed Web of Science ®Google Scholar
• Kim JJ, Trivedi NN, Nottingham LK, et al. Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens. Eur J Immunol 1998;28(3):1089-103
   PubMed Web of Science ®Google Scholar
• Tazi A, Bouchonnet F, Grandsaigne M, et al. Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers. J Clin Invest 1993;91(2):566-76
   PubMed Web of Science ®Google Scholar
• Xiang Z, Ertl HC. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 1995;2(2):129-35
   PubMed Web of Science ®Google Scholar
• Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004;75(2):163-89
   PubMed Web of Science ®Google Scholar
• Wang K, Frank D, Ritz J. Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood 2000;95(10):3183
   PubMed Web of Science ®Google Scholar
• Gordon J, MacLean LD. A lymphocyte-stimulating factor produced in vitro. Nature 1965;208(5012):795-6
   PubMed Web of Science ®Google Scholar
• Smith KA. Interleukin-2: inception, impact, and implications. Science 1988;240(4856):1169-76
   PubMed Web of Science ®Google Scholar
• Van Belle H. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem 1976;22(7):972-6
   PubMed Web of Science ®Google Scholar
• Grishchenko SV, Lavrukhina LA, Ketiladze ES, et al. Results of combined therapy using levamisole for patients with influenza complicated by pneumonia. Vopr Virusol 1984;29(2):175-9
   PubMedGoogle Scholar
• Gomi K, Morimoto M, Nomoto K. Cytotoxic T-cell-mediated antitumor effect of levamisole against murine syngeneic fibrosarcoma. Cancer Res 1982;42(10):4197-202
   PubMed Web of Science ®Google Scholar
• Kang Y, Jin H, Zheng G, et al. The adjuvant effect of levamisole on killed viral vaccines. Vaccine 2005;23(48-49):5543-50
   PubMed Web of Science ®Google Scholar
• Mosca F, Tritto E, Muzzi A, et al. Molecular and cellular signatures of human vaccine adjuvants. Proc Natl Acad Sci USA 2008;105(30):10501-6
   PubMed Web of Science ®Google Scholar
• Seubert A, Monaci E, Pizza M, et al. The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells. J Immunol 2008;180(8):5402-12
   PubMed Web of Science ®Google Scholar
• Fraser CK, Diener KR, Brown MP, Hayball JD. Improving vaccines by incorporating immunological coadjuvants. Expert Rev Vaccines 2007;6(4):559-78
   PubMed Web of Science ®Google Scholar
• Hoebe K, Janssen E, Beutler B. The interface between innate and adaptive immunity. Nat Immunol 2004;5(10):971-4
   PubMed Web of Science ®Google Scholar
• Nevens F, Zuckerman JN, Burroughs AK, et al. Immunogenicity and safety of an experimental adjuvanted hepatitis B candidate vaccine in liver transplant patients. Liver Transpl 2006;12(10):1489-95
   PubMed Web of Science ®Google Scholar
• Tapping RI, Akashi S, Miyake K, et al. Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J Immunol 2000;165(10):5780-7
   PubMed Web of Science ®Google Scholar
• Ismaili J, Rennesson J, Aksoy E, et al. Monophosphoryl lipid A activates both human dendritic cells and T cells. J Immunol 2002;168(2):926-32
   PubMed Web of Science ®Google Scholar
• Stanley M. Mechanism of action of imiquimod. Papillomavirus Report 1999;10:23-9
   Google Scholar
• Stanley MA. Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential. Clin Exp Dermatol 2002;27(7):571-7
   PubMed Web of Science ®Google Scholar
• Wu JJ, Huang DB, Tyring SK. Resiquimod: a new immune response modifier with potential as a vaccine adjuvant for Th1 immune responses. Antiviral Res 2004;64(2):79-83
   PubMed Web of Science ®Google Scholar
• Glimcher L, Shen FW, Cantor H. Identification of a cell-surface antigen selectively expressed on the natural killer cell. J Exp Med 1977;145(1):1-9
   PubMed Web of Science ®Google Scholar
• Biassoni R, Bottino C, Cantoni C, Moretta A. Human natural killer receptors and their ligands. Curr Protoc Immunol 2002;Chapter 14:Unit 14 0
   PubMedGoogle Scholar
• Bosco MC, Puppo M, Blengio F, et al. Monocytes and dendritic cells in a hypoxic environment: spotlights on chemotaxis and migration. Immunobiology 2008;213(9-10):733-49
   PubMed Web of Science ®Google Scholar
• Verdijk P, Aarntzen EH, Punt CJ, et al. Maximizing dendritic cell migration in cancer immunotherapy. Expert Opin Biol Ther 2008;8(7):865-74
   PubMed Web of Science ®Google Scholar
• Piccirillo CA. Regulatory T cells in health and disease. Cytokine 2008;43(3):395-401
   PubMed Web of Science ®Google Scholar
• Yeretssian G, Labbe K, Saleh M. Molecular regulation of inflammation and cell death. Cytokine 2008;43(3):380-90
   PubMed Web of Science ®Google Scholar
• Kumagai Y, Takeuchi O, Akira S. Pathogen recognition by innate receptors. J Infect Chemother 2008;14(2):86-92
   PubMedGoogle Scholar
• Caligiuri MA. Human natural killer cells. Blood 2008;112(3):461-9
   PubMed Web of Science ®Google Scholar
• Waldhauer I, Steinle A. NK cells and cancer immunosurveillance. Oncogene 2008;27(45):5932-43
   PubMed Web of Science ®Google Scholar
• Claus M, Greil J, Watzl C. Comprehensive analysis of NK cell function in whole blood samples. J Immunol Methods 2009;341(1-2):154-64
   PubMed Web of Science ®Google Scholar
• Neri S, Mariani E, Meneghetti A, et al. Calcein-acetyoxymethyl cytotoxicity assay: standardization of a method allowing additional analyses on recovered effector cells and supernatants. Clin Diagn Lab Immunol 2001;8(6):1131-5
   PubMedGoogle Scholar
• Kolber MA, Quinones RR, Gress RE, Henkart PA. Measurement of cytotoxicity by target cell release and retention of the fluorescent dye bis-carboxyethyl-carboxyfluorescein (BCECF). J Immunol Methods 1988;108(1-2):255-64
   PubMed Web of Science ®Google Scholar
• Leibold W, Bridge S. 75Se-release: a short and long term assay system for cellular cytoxicity. Z Immunitatsforsch Immunobiol 1979;155(4):287-311
   PubMedGoogle Scholar
• Danks AM, Hammond DN, Wainer BH, et al. Cellular alterations produced by the experimental increase in intracellular calcium and the nature of protective effects from pretreatment with nimodipine. Brain Res Mol Brain Res 1992;16(1-2):168-72
   PubMedGoogle Scholar
• Zhang W, Wang Y, Hou Y. Effects of Chinese medicinal fungus water extract on tumor metastasis and some parameters of immune function. Int Immunopharmacol 2004;4(3):461-8
   PubMed Web of Science ®Google Scholar
• Konjevic G, Jurisic V, Spuzic I. Corrections to the original lactate dehydrogenase (LDH) release assay for the evaluation of NK cell cytotoxicity. J Immunol Methods 1997;200(1-2):199-201
   PubMed Web of Science ®Google Scholar
• Johann S, Blumel G, Lipp M, Forster R. A versatile flow cytometry-based assay for the determination of short- and long-term natural killer cell activity. J Immunol Methods 1995;185(2):209-16
   PubMed Web of Science ®Google Scholar
• Roitt I, Brostoff J. DK Male: immunology. CV Mosby Company, St. Louis 1996
   Google Scholar
• Sawyer DW, Donowitz GR, Mandell GL. Polymorphonuclear neutrophils: an effective antimicrobial force. Rev Infect Dis 1989;11(Suppl 7):S1532-44
   PubMedGoogle Scholar
• Lehmann AK, Sornes S, Halstensen A. Phagocytosis: measurement by flow cytometry. J Immunol Methods 2000;243(1-2):229-42
   PubMed Web of Science ®Google Scholar
• Hampton MB, Winterbourn CC. Methods for quantifying phagocytosis and bacterial killing by human neutrophils. J Immunol Methods 1999;232(1-2):15-22
   PubMed Web of Science ®Google Scholar
• Steigbigel RT, Lambert LH Jr, Remington JS. Phagocytic and bacterial properties of normal human monocytes. J Clin Invest 1974;53(1):131-42
   PubMed Web of Science ®Google Scholar
• Klebanoff S, Hamon C. Antimicrobial systems of mononuclear phagocytes. Mononuclear phagocytes Blackwell Scientific Publications, Oxford 1975;507-31
   Google Scholar
• Willcox MB, Golde DW, Cline MJ. Cytochemical reactions of human hematopoietic cells in liquid culture. J Histochem Cytochem 1976;24(9):979-83
   PubMed Web of Science ®Google Scholar
• Saresella M, Roda K, Speciale L, et al. A flow cytometric method for the analysis of phagocytosis and killing by polymorphonuclear leukocytes. Ann NY Acad Sci 1997;832:53-61
   PubMed Web of Science ®Google Scholar
• Steinkamp JA, Wilson JS, Saunders GC, Stewart CC. Phagocytosis: flow cytometric quantitation with fluorescent microspheres. Science 1982;215(4528):64-6
   PubMed Web of Science ®Google Scholar
• van Eeden SF, Klut ME, Walker BA, Hogg JC. The use of flow cytometry to measure neutrophil function. J Immunol Methods 1999;232(1-2):23-43
   PubMed Web of Science ®Google Scholar
• Hirt W, Nebe T, Birr C. Phagotest and Bursttest (Phagoburst), test kits for study of phagocyte functions. Wien Klin Wochenschr 1994;106(8):250-2
   PubMed Web of Science ®Google Scholar
• Shalekoff S, Tiemessen CT, Gray CM, Martin DJ. Depressed phagocytosis and oxidative burst in polymorphonuclear leukocytes from individuals with pulmonary tuberculosis with or without human immunodeficiency virus type 1 infection. Clin Diagn Lab Immunol 1998;5(1):41-4
   PubMedGoogle Scholar
• Sallusto F, Palermo B, Lenig D, et al. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur J Immunol 1999;29(5):1617-25
   PubMed Web of Science ®Google Scholar
• Khalil G, El-Sabban M, Al-Ghadban S, et al. Cytokine expression profile of sensitized human T lymphocytes following in vitro stimulation with amoxicillin. Eur Cytokine Netw 2008;19(3):131-41
   PubMed Web of Science ®Google Scholar
• Di Francesco P, Falchetti R, Gaziano R, et al. Differential effects of short-term or prolonged cocaine exposure on peripheral blood cells in mice. Life Sci 1994;54(25):2015-20
   PubMed Web of Science ®Google Scholar
• Pala P, Hussell T, Openshaw PJ. Flow cytometric measurement of intracellular cytokines. J Immunol Methods 2000;243(1-2):107-24
   PubMed Web of Science ®Google Scholar
• Sander B, Andersson J, Andersson U. Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure. Immunol Rev 1991;119:65-93
   PubMed Web of Science ®Google Scholar
• Suni MA, Picker LJ, Maino VC. Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry. J Immunol Methods 1998;212(1):89-98
   PubMed Web of Science ®Google Scholar
• Baran J, Kowalczyk D, Ozog M, Zembala M. Three-color flow cytometry detection of intracellular cytokines in peripheral blood mononuclear cells: comparative analysis of phorbol myristate acetate-ionomycin and phytohemagglutinin stimulation. Clin Diagn Lab Immunol 2001;8(2):303-13
   PubMedGoogle Scholar
• Falchetti R, Di Francesco P, Lanzilli G, et al. Determination of cytokine co-expression in individual splenic CD4+ and CD8+ T cells from influenza virus-immune mice. Immunology 1998;95(3):346-51
   PubMed Web of Science ®Google Scholar
• Di Francesco P, Falchetti R, Gaziano R, et al. Effects of cocaine administration to influenza virus-immunized mice on cytokine profiles of individual splenic CD4+ and CD8+ T cells. Clin Exp Immunol 1999;118(3):428-34
   PubMed Web of Science ®Google Scholar
• Carson RT, Vignali DA. Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay. J Immunol Methods 1999;227(1-2):41-52
   PubMed Web of Science ®Google Scholar
• Morgan E, Varro R, Sepulveda H, et al. Cytometric bead array: a multiplexed assay platform with applications in various areas of biology. Clin Immunol 2004;110(3):252-66
   PubMed Web of Science ®Google Scholar
• Young SH, Antonini JM, Roberts JR, et al. Performance evaluation of cytometric bead assays for the measurement of lung cytokines in two rodent models. J Immunol Methods 2008;331(1-2):59-68
   PubMed Web of Science ®Google Scholar
• Givan AL, Fisher JL, Waugh M, et al. A flow cytometric method to estimate the precursor frequencies of cells proliferating in response to specific antigens. J Immunol Methods 1999;230(1-2):99-112
   PubMed Web of Science ®Google Scholar
• McCutcheon M, Wehner N, Wensky A, et al. A sensitive ELISPOT assay to detect low-frequency human T lymphocytes. J Immunol Methods 1997;210(2):149-66
   PubMed Web of Science ®Google Scholar
• Asai T, Storkus WJ, Whiteside TL. Evaluation of the modified ELISPOT assay for gamma interferon production in cancer patients receiving antitumor vaccines. Clin Diagn Lab Immunol 2000;7(2):145-54
   PubMedGoogle Scholar
• Waldrop SL, Pitcher CJ, Peterson DM, et al. Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. J Clin Invest 1997;99(7):1739-50
   PubMed Web of Science ®Google Scholar
• Kammula US, Lee KH, Riker AI, et al. Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens. J Immunol 1999;163(12):6867-75
   PubMed Web of Science ®Google Scholar
• Lee PP, Yee C, Savage PA, et al. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med 1999;5(6):677-85
   PubMed Web of Science ®Google Scholar
• McKee MD, Clay TM, Rosenberg SA, Nishimura MI. Quantitation of T-cell receptor frequencies by competitive PCR: generation and evaluation of novel TCR subfamily and clone specific competitors. J Immunother 1999;22(2):93-102
   PubMed Web of Science ®Google Scholar
• Wang XN, Proctor SJ, Dickinson AM. Frequency analysis of recipient-reactive helper and cytotoxic T lymphocyte precursors using a combined single limiting dilution assay. Transpl Immunol 1996;4(3):247-51
   PubMedGoogle Scholar
• Muul LM, Silvin C, James SP, Candotti F. Measurement of proliferative responses of cultured lymphocytes. Curr Protoc Immunol 2008;Chapter 7:Unit 7. 10. 1-7 24
   PubMedGoogle Scholar
• Lyons AB. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods 2000;243(1-2):147-54
   PubMed Web of Science ®Google Scholar
• Dolbeare F, Gratzner H, Pallavicini MG, Gray JW. Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc Natl Acad Sci USA 1983;80(18):5573-7
   PubMed Web of Science ®Google Scholar
• Rothaeusler K, Baumgarth N. Evaluation of intranuclear BrdU detection procedures for use in multicolor flow cytometry. Cytometry A 2006;69(4):249-59
   PubMedGoogle Scholar
• Luo H, Jiang BH, King SM, Chen YC. Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids. Nutr Cancer 2008;60(6):800-9
   PubMed Web of Science ®Google Scholar
• Sekhon BK, Roubin RH, Tan A, et al. High-throughput screening platform for anticancer therapeutic drug cytotoxicity. Assay Drug Dev Technol 2008;6(5):711-22
   PubMed Web of Science ®Google Scholar
• Ivanova L, Uhlig S. A bioassay for the simultaneous measurement of metabolic activity, membrane integrity, and lysosomal activity in cell cultures. Anal Biochem 2008;379(1):16-9
   PubMed Web of Science ®Google Scholar
• Dumitriu IE, Mohr W, Kolowos W, et al. 5,6-carboxyfluorescein diacetate succinimidyl ester-labeled apoptotic and necrotic as well as detergent-treated cells can be traced in composite cell samples. Anal Biochem 2001;299(2):247-52
   PubMed Web of Science ®Google Scholar
• Darzynkiewicz Z, Bedner E, Smolewski P, et al. Detection of caspases activation in situ by fluorochrome-labeled inhibitors of caspases (FLICA). Methods Mol Biol 2002;203:289-99
   PubMedGoogle Scholar
• Salzman G, Singham S, Johnston R, Bohren C. Light scattering and cytometry. Flow cytometry and sorting 1990;81-107
   Google Scholar
• Swat W, Ignatowicz L, Kisielow P. Detection of apoptosis of immature CD4+8+ thymocytes by flow cytometry. J Immunol Methods 1991;137(1):79-87
   PubMed Web of Science ®Google Scholar
• Darzynkiewicz Z, Traganos F, Staiano-Coico L, et al. Interaction of rhodamine 123 with living cells studied by flow cytometry. Cancer Res 1982;42(3):799-806
   PubMed Web of Science ®Google Scholar
• Shimizu S, Eguchi Y, Kamiike W, et al. Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors. Oncogene 1996;13(1):21-9
   PubMed Web of Science ®Google Scholar
• van Baalen CA, Gruters RA, Berkhoff EG, et al. FATT-CTL assay for detection of antigen-specific cell-mediated cytotoxicity. Cytometry A 2008;73(11):1058-65
   PubMed Web of Science ®Google Scholar
• Dzutsev AK, Belyakov IM, Isakov DV, et al. Estimation of low frequency antigen-presenting cells with a novel RELISPOT assay. J Immunol Methods 2008;333(1-2):71-8
   PubMed Web of Science ®Google Scholar
• Malyguine A, Strobl S, Zaritskaya L, et al. New approaches for monitoring CTL activity in clinical trials. Adv Exp Med Biol 2007;601:273-84
   PubMed Web of Science ®Google Scholar
• Klinman D. ELISPOT assay to detect cytokine-secreting murine and human cells. Curr Protoc Immunol 2008;Chapter 6:Unit 6. 19
   PubMedGoogle Scholar
• Czerkinsky C, Andersson G, Ekre HP, et al. Reverse ELISPOT assay for clonal analysis of cytokine production. I. Enumeration of gamma-interferon-secreting cells. J Immunol Methods 1988;110(1):29-36
   PubMed Web of Science ®Google Scholar
• Miyahira Y, Murata K, Rodriguez D, et al. Quantification of antigen specific CD8+ T cells using an ELISPOT assay. J Immunol Methods 1995;181(1):45-54
   PubMed Web of Science ®Google Scholar
• Vaquerano JE, Peng M, Chang JW, et al. Digital quantification of the enzyme-linked immunospot (ELISPOT). Biotechniques 1998;25(5):830-4, 6
   PubMed Web of Science ®Google Scholar
• Snyder JE, Bowers WJ, Livingstone AM, et al. Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nat Med 2003;9(2):231-5
   PubMed Web of Science ®Google Scholar
• Kwok WW, Ptacek NA, Liu AW, Buckner JH. Use of class II tetramers for identification of CD4+ T cells. J Immunol Methods 2002;268(1):71-81
   PubMed Web of Science ®Google Scholar
• Appay V, Rowland-Jones SL. The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular staining. J Immunol Methods 2002;268(1):9-19
   PubMed Web of Science ®Google Scholar
• Kosor E, Gagro A, Drazenovic V, et al. MHC tetramers: tracking specific immunity. Acta Med Croatica 2003;57(4):255-9
   PubMedGoogle Scholar
• Bustin SA. Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. J Mol Endocrinol 2002;29(1):23-39
   PubMed Web of Science ®Google Scholar
• Bustin SA, Benes V, Nolan T, Pfaffl MW. Quantitative real-time RT-PCR–a perspective. J Mol Endocrinol 2005;34(3):597-601
   PubMed Web of Science ®Google Scholar
• Schultz-Thater E, Frey DM, Margelli D, et al. Whole blood assessment of antigen specific cellular immune response by real time quantitative PCR: a versatile monitoring and discovery tool. J Transl Med 2008;6:58
   PubMedGoogle Scholar
• Panelli MC, Wang E, Monsurro V, Marincola FM. The role of quantitative PCR for the immune monitoring of cancer patients. Expert Opin Biol Ther 2002;2(5):557-64
   PubMed Web of Science ®Google Scholar
• Nolan T, Hands RE, Bustin SA. Quantification of mRNA using real-time RT-PCR. Nat Protoc 2006;1(3):1559-82
   PubMed Web of Science ®Google Scholar
• Brazeau DA. Combining genome-wide and targeted gene expression profiling in drug discovery: microarrays and real-time PCR. Drug Discov Today 2004;9(19):838-45
   PubMed Web of Science ®Google Scholar
• ICH, 2005. ICH S8: Immunotoxicology studies for human pharmaceuticals. Step 5 document, 13 October 2005
   Google Scholar
• Kleinschmidt-DeMasters BK, Tyler KL. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med 2005;353(4):369-74
   PubMed Web of Science ®Google Scholar
• Langer-Gould A, Atlas SW, Green AJ, et al. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 2005;353(4):375-81
   PubMed Web of Science ®Google Scholar
• Van Assche G, Van Ranst M, Sciot R, et al. Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 2005;353(4):362-8
   PubMed Web of Science ®Google Scholar