Expert Opinion on Drug Discovery, Volume 4, Issue 5 (2009)

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Expert Opinion on Drug Discovery, Volume 4, Issue 5 (2009)

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Perspective

Article
Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?
Warren RJD Galloway & David R Spring
Pages: 467-472
Published online: 07 May 2009
AbstractforIs synthesis the main hurdle for the generation of diversity in compound libraries for screening? | Full Text | References | PDF (495 KB)
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Reviews

Article
In vitro end points for the assessment of cellular immune response-modulating drugs
Maria Pia Fuggetta PhD, Giulia Lanzilli PhD, Daniela Fioretti PhD & Monica Rinaldi PhD
Pages: 473-493
Published online: 07 May 2009
AbstractforIn vitro end points for the assessment of cellular immune response-modulating drugs | Full Text | References | PDF (397.4 KB)
  • 98 Views
  • 2 CrossRef citations
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Article
The ATM regulated DNA damage response pathway as a chemo- and radiosensitisation target
John P Alao PhD
Pages: 495-505
Published online: 07 May 2009
AbstractforThe ATM regulated DNA damage response pathway as a chemo- and radiosensitisation target | Full Text | References | PDF (312.9 KB)
  • 229 Views
  • 4 CrossRef citations
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Article
Zebrafish muscular disease models towards drug discovery
Hiromi Hirata
Pages: 507-513
Published online: 07 May 2009
AbstractforZebrafish muscular disease models towards drug discovery | Full Text | References | PDF (271.2 KB)
  • 87 Views
  • 5 CrossRef citations
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Article
Gene regulation as a potential avenue for the treatment of neurodegenerative disorders
David R Brown (Professor)
Pages: 515-524
Published online: 07 May 2009
AbstractforGene regulation as a potential avenue for the treatment of neurodegenerative disorders | Full Text | References | PDF (418.2 KB)
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Article
Smoothened antagonists: a promising new class of antitumor agents
Paola Gallinari, Gessica Filocamo, Philip Jones, Simonetta Pazzaglia & Christian Steinkühler
Pages: 525-544
Published online: 07 May 2009
AbstractforSmoothened antagonists: a promising new class of antitumor agents | Full Text | References | PDF (1.3 MB)
  • 112 Views
  • 10 CrossRef citations
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Article
Lead finding from medicinal plants with hepatoprotective potentials
Pulok K Mukherjee MPharm PhD FRSC, Atish K Sahoo MPharm, Nisha Narayanan MPharm, N Satheesh Kumar MPharm & S Ponnusankar MPharm
Pages: 545-576
Published online: 07 May 2009
AbstractforLead finding from medicinal plants with hepatoprotective potentials | Full Text | References | PDF (653.9 KB)
  • 147 Views
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Article
Animal studies trigger new insights on the use of methadone maintenance
Erin Cummins MA & Francesco Leri PhD
Pages: 577-586
Published online: 07 May 2009
AbstractforAnimal studies trigger new insights on the use of methadone maintenance | Full Text | References | PDF (312.9 KB)
  • 36 Views
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Case History

Article
Early development of the Toll-like receptor 9 agonist, PF-3512676, for the treatment of patients with advanced cancers
Ahmad A Tarhini MD MSc, John M Kirkwood MD & Arthur M Krieg MD
Pages: 587-603
Published online: 07 May 2009
AbstractforEarly development of the Toll-like receptor 9 agonist, PF-3512676, for the treatment of patients with advanced cancers | Full Text | References | PDF (464.4 KB)
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