150
Views
24
CrossRef citations to date
0
Altmetric
Reviews

Lead finding from medicinal plants with hepatoprotective potentials

, MPharm PhD FRSC, , MPharm, , MPharm, , MPharm & , MPharm
Pages 545-576 | Published online: 07 May 2009

Bibliography

  • Mukherjee PK, Wahile A. Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. J Ethnopharmacol 2006;103:25-35
  • Shahani S. Evaluation of hepatoprotective efficacy of APCL-A polyherbal formulation in vivo in rats. Indian Drugs 1999;36:628-31
  • Subramoniam A, Pushpangadan P. Development of phytomedicine for liver diseases. Indian J Pharmacol 1999;31:166-75
  • Recknagel RO. A new direction in the study of carbon tetrachloride hepatotoxicity. Life Sci 1983;33:401-8
  • Wendel A, Feurensteins S, Konz KH. Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo. Biochem Pharmacol 1987;28:2051-3
  • Dianzani MU, Muzia G, Biocca ME, Canuto RA. Lipid peroxidation in fatty liver induced by caffeine in rats. Int J Tissue React 1991;13:79-85
  • Scott LND. A review of plants used in the treatment of liver disease: Part1. Altern Med Rev 1998;3:410-21
  • Mukherjee PK, Wahile A, Kumar V, et al. Marker profiling of botanicals used for hepatoprotection in Indian system of medicine. Drug Inf J 2006;40:131-9
  • Aniya Y, Miyagi A, Nakandakari N, et al. Free radical scavenging action of the medicinal herb Limonium wrightii from the Okinawa islands. Phytomedicine 2002;9:239-44
  • Achuthan CR, Babu BH, Padikkala J. Antioxidant and Hepatoprotective effects of Rosa damascena. Pharm Biol 2003;41:357-61
  • Gupta AK, Misra N. Hepatoprotective activity of aqueous ethanolic extract of Chamomile capitula in paracetamol intoxicated albino rats. Am J Pharmacol Toxicol 2006;1:17-20
  • Jayasekhar P, Mohanan PV, Rathinam K. Hepatoprotective activity of ethyl acetate extract of Acacia catechu. Indian J Pharmacol 1997;29:426-8
  • Ray D, Sharatchandra K, Thokchom IS. Antipyretic, antidiarrhoeal, hypoglycaemic and hepatoprotective activities of ethyl acetate extract of Acacia catechu Willd. in albino rats. Indian J Pharmacol 2006;38:408-13
  • Babu BH, Shylesh BS, Padikkala J. Antioxidant and hepatoprotective effect of Acanthus ilicifolius. Fitoterapia 2001;72:272-7
  • Hukkeri VI, Jaiprakash B, Lavhale MS, et al. Comparative study of leaves and bark of Ailanthus excelsa Roxb for hepatoprotective activity. Indian Drugs 2003;40:355-7
  • Chandan BK, Saxena AK, Shukla S, et al. Hepatoprotective potential of Aloe barbadensis Mill against carbon tetrachloride induced hepatotoxicity. J Ethnopharmacol 2007;111:560-6
  • Gole MK, Dasgupta S, Sur RK, Ghosal J. Hepatoprotective effect of Amoora rohituka. Pharm Biol 1997;35:318-22
  • Trivedi NP, Rawal UM. Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice. Ind J Exp Biol 2001;39:41-6
  • Kapil A, Koul IB, Banerjee SK, Gupta BD. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochem Pharmacol 1993;46:182-5
  • Visen PK, Shukla B, Patnaik GK, Dhawan BN. Andrographolide protects rat hepatocytes against paracetamol-induced damage. J Ethnopharmacol 1993;40:131-6
  • Gole MK, Dasgupta S. Role of plant metabolites in toxic liver injury. Asia Pac J Clin Nutr 2002;11:48-50
  • Singh A, Handa SS. Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats. J Ethnopharmacol 1995;49:119-26
  • Shivashangari KS, Ravikumar V, Devaki T. Evaluation of the protective efficacy of Asteracantha longifolia on acetaminophen-induced liver damage in rats. J Med Food 2004;7:245-51
  • Koul A, Binepal G, Gangar SC. Impediment of diethylnitrosamine induced hepatotoxicity in male Balb/c mice by pretreatment with aqueous Azadirachta indica leaf extract. Indian J Exp Biol 2007;45:359-66
  • Chattopadhyay RR, Sarkar SK, Ganguly S, et al. Hepatoprotective activity of Azadirachta indica leaves against paracetamol induced hepatic damage in rats. Indian J Exp Biol 1992;30:738-40
  • Kale BP, Kothekar MA, Tayade HP, et al. Effect of aqueous extract of Azadirachta indica leaves on hepatotoxicity induced by antitubercular drugs in rats. Indian J Pharmacol 2003;35:177-80
  • Ghosh T, Maity TK, Dash GK, et al. Hepatoprotective activity of ethanolic extract of Bacopa monnieri Linn aerial parts against CCl4-induced hepatotoxicity in rats. Nat Prod Sci 2007;13:61-7
  • Jaiprakash B, Aland R, Karadi RV, et al. Heptoprotective activity of bark of Balanites aegyptiaca Linn. J Nat Remedies 2003;3:205-7
  • Gupta M, Mazumder UK, Kumar TS, et al. Antioxidant and hepatoprotective effects of Bauhinia racemosa against paracetamol and carbon tetrachloride induced liver damage in rats. Iranian J Pharmacol Ther 2004;3:12-20
  • Murugesh KM, Yeligar VC, Maiti BM, Maity TK. Hepatoprotective and antioxidant role of Berberis tinctoria Lesch leaves on paracetamol induced hepatic damage in rats. Iranian J Pharmacol Ther 2005;4:64-9
  • Agarwal M, Srivastava VK, Saxena KK, Kumar A. Hepatoprotective activity of Beta vulgaris against CCl4-induced hepatic injury in rats. Fitoterapia 2006;77:91-3
  • Rawat AKS, Mehrotra S, Tripathi SC, Shome U. Hepatoprotective activity of Boerhaavia diffusa L roots a popular Indian ethnomedicine. J Ethnopharmacol 1997;56:61-6
  • Chandan BK, Sharma AK, Anand KK. Boerhaavia diffusa: a study of its hepatoprotective activity. J Ethnopharmacol 1991;31:299-307
  • Gupta M, Mazumder UK, Kumar RS. Hepatoprotective effects and antioxidant role of Caesalpinia bonducella on paracetamol-induced hepatic damage in rats. Nat Prod Sci 2003;9:186-91
  • Sarkar K, Ghosh A, Sil PC. Preventive and curative role of a 43kD protein from the leaves of the herb Cajanus indicus L on thioacetamide-induced hepatotoxicity in vivo. Hepatol Res 2005;33:39-49
  • Datta S, Sinha S, Bhattacharyya P. Hepatoprotective activity of a herbal protein CI-1, purified from Cajanus indicus against beta-galactosamine HCl toxicity in isolated rat hepatocytes. Phytother Res 1999;13:508-12
  • Sinha M, Manna P, Sil PC. Amelioration of galactosamine-induced nephrotoxicity by a protein isolated from the leaves of the herb, Cajanus indicus L. BMC Complement Altern Med 2007;7:11
  • Qureshi AA, Prakash T, Patil T, et al. Hepatoprotective and antioxidant activities of flowers of Calotropis procera (Ait) R. Br. in CCl4 induced hepatic damage. Indian J Exp Biol 2007;45:304-10
  • Anand KK, Gupta VN, Rangari V, et al. Structure and hepatoprotective activity of a biflavonoid from Canarium manii. Planta Med 1992;58:493-5
  • Ali M, Ramachandram R, Rafiullah MRM, et al. Prevention of carbon tetrachloride-induced hepatotoxicity by the ethanol extract of Capparis moonii fruits in rats. Pharm Biol 2004;42:286-8
  • Balasubramanian R, Balasundaram J, Subramanian K, Narayanan M. Effect of dried fruits of Carica papaya Linn on Hepatotoxicity. Biol Pharm Bull 2002;25:1645-6
  • Bhakta T, Mukherjee PK, Mukherjee K, et al. Evaluation of hepatoprotective activity of Cassia fistula leaf extract. J Ethnopharmacol 1999;66:277-82
  • Pradeep K, Victor Raj Mohan C, Gobi Anand K, Karthikeyan S. Effect of pretreatment of Cassia fistula Linn leaf extract against subacute CCl4 induced hepatotoxicity in rats. Phytother Res 2005;19:391-404
  • Jafri MA, Jalis Subhani M, Javed K, Singh S. Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxication in rats. J Ethnopharmacol 1999;66:355-61
  • Mukerjee A, Visen PKS, Saraf SA. Evaluation of hepatoprotective activity of Citrullus colocynthis roots against CCl4 induced toxicity in albino rats. Nat Prod Sci 2007;13:23-6
  • Venkata RN, Prasad MVV, Prasannaraju Y. Hepatoprotective activity of Coccinia grandis (Linn.) fruit extracts on carbontetrachloride induced liver damage in rats. Chem Asian J 2005;17:1780-4
  • Mantena SK, Mutalik S, Srinivasa H, et al. Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus Linn. Biol Pharm Bull 2005;28:468-72
  • Venukumar MR, Latha MS. Hepatoprotective effect of the methanolic extract of Curculigo orchioides in CCl4-treated male rats. Indian J Pharmacol 2002;34:269-75
  • Song EK, Cho H, Kim JS, et al. Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med 2001;67:876-7
  • Bishayee A, Sarkar A, Chatterjee M. Hepatoprotective activity of carrot (Daucus carota L.) against carbon tetrachloride intoxication in mouse liver. J. Ethnopharmacol 1995;47:69-74
  • Prasad MVV, Balakrishna K, Carey MW. Hepatoprotective activity of roots of Desmodium gangeticum (Linn.) DC. Asian J Chem 2005;17:2847-9
  • Datta GK, Chakrabartya M, Ghosh S, Debnath PK. Hepatoprotective effect of Desmotrichum fimbriatum Bl in mice with carbon tetrachloride-induced liver damage. Biomed Res 2002;13:81-4
  • Mankani KL, Krishna V, Manjunatha BK, et al. Hepatoprotective effects of the triterpenes isolated from the stem bark of Diospyros cordifolia Roxb. J Nat Remedies 2006;6:147-52
  • Mondal SK, Chakraborty G, Gupta M, Mazumder UK. Hepatoprotective activity of Diospyros malabarica bark in carbon Tetrachloride intoxicated rats. Eur Bull Drug Res 2005;13:25-30
  • Singh B, Saxena AK, Chandan BK, et al. In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian J Physiol Pharmacol 2001;45:435-41
  • Tabassum N, Agrawal SS. Hepatoprotective activity of Eclipta alba Hassk against paracetamol induced hepatocellular damage in mice. JK Pract 2004;11:78-280
  • Saxena AK, Singh B, Anand KK. Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J Ethnopharmacol 1993;40:155-61
  • Tasduq SA, Kaisar P, Gupta DK, et al. Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti-tuberculosis drugs induced liver toxicity. Phytother Res 2005;19:193-7
  • Jose JK, Kuttan R. Hepatoprotective activity of Emblica officinalis and Chyavanaprash. J Ethnopharmacol 2000;72:135-40
  • Bhattacharya A, Kumar M, Ghosal S, Bhattacharya SK. Effect of bioactive tannoid principles of Emblica officinalis on iron-induced hepatic toxicity in rats. Phytomedicine 2000;7:173-5
  • Vishwakarma SL, Goyal RK. Hepatoprotective activity of Enicostemma littorale in CC14-induced liver damage. J Nat Remedies 2004;4:120-6
  • Gupta M, Mazumder UK, Sambath KR, et al. Antioxidant and protective effects of Ervatamia coronaria Stapf., leaves against carbon tetrachloride-induced liver injury. Eur Bull Drug Res 2004;12:13-22
  • Mandal SC, Saraswathi B, Kumar CK, et al. Protective effect of leaf extract of Ficus hispida Linn. against paracetamol-induced hepatotoxicity in rats. Phytother Res 2000;14:457-9
  • Mandal SC, Maity TK, Das J, et al. Hepatoprotective activity of Ficus racemosa leaf extract on liver damage caused by carbon tetrachloride in rats. Phytother Res 1999;13:430-2
  • Ozbek H, Ugras S, Bayram I, et al. Hepatoprotective effect of Foeniculum vulgare essential oil: a carbon-tetrachloride induced liver fibrosis model in rats. Scand J Lab Anim Sci 2004;31:9-17
  • Rao KS, Mishra SH. Hepatoprotective activity of the whole plants of Fumaria indica. Indian J Pharm Sci 1997;59:165-70
  • Nimbkar SR, Juvekar AR, Jogalekar SN. Hepatoprotective activity of Fumaria indica in hepatotoxicity induced by anti-tubercular drugs treatment. Indian Drugs 2000;37:537-42
  • Shenoy KA, Somayaji SN, Bairy KL. Evaluation of hepatoprotective activity of Ginkgo biloba in rats. Indian J Physiol Pharmacol 2002;46:167-74
  • Naik SR, Panda VS. Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents. Liver Int 2007;27:393-9
  • Sathiyanarayanan L, Arulmozhi S, Chidambaranathan N. Anticholesterolemic, Hepatoprotective and Antioxidant activity of Glinus lotoides linn against ethanol induced liver damage in rats. Pharmacognosy Magazine 2006;2:7
  • Van Rossum TG, Vulto AG, Hop WC. Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial. J Gastroenterol Hepatol 1999;4:1093-9
  • Rajesh MG, Latha MS. Protective activity of Glycyrrhiza glabra Linn on carbon tetrachloride-induced peroxidative damage. Indian J Pharmacol 2004;36:284-7
  • Gomes A, Das M, Sur P, et al. Glycosmis arborea extract as a hepatoprotective agent. Phytother Res 2003;17:571-4
  • De S, Ravishankar B, Bhavsar GC. An investigation on the hepatoprotective activity of Gymnosporia montana. Planta Medica 1994;60:301-4
  • Habbu P, Hukkeri VI, Hunasagi BS, et al. Screening of Hedychium spicatum for hepatoprotective activity in albino rats. Indian Drugs 2002;39:117-9
  • Sadasivan S, Latha PG, Sasikumar JM, et al. Hepatoprotective studies on Hedyotis corymbosa (L.) Lam. J Ethnopharmacol 2006;106:245-9
  • Suja SR, Latha PG, Pushpangadan P, Rajasekharan S. Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) hook against carbon tetrachloride-induced liver damage in Wistar rats. J Ethnopharmacol 2004;92:61-6
  • Baheti JR, Goyal RK, Shah GB. Hepatoprotective activity of Hemidesmus indicus R. Br. in rats. Indian J Exp Biol 2006;44:399-402
  • Essa MM, Subramanian P, Suthakar G, et al. Influence of Hibiscus sabdariffa (Gongura) on the levels of circulatory lipid peroxidation products and liver marker enzymes in experimental hyperammonemia. J Appl Biomed 2006;4:53-8
  • Shanmugasundaram P, Venkataraman S. Hepatoprotective and antioxidant effects of Hygrophila auriculata (K. Schum) Heine Acanthaceae root extract. J Ethnopharmacol 2006;104:124-8
  • Shahjahan M, Vani G, Shyamala Devi CS. Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity. J Med Food 2005;8:261-5
  • Singh B, Saxena AK, Chandan BK, et al. Hepatoprotective activity of indigtone-a bioactive fraction from Indigofera tinctoria Linn. Phytother Res 2001;15:294-7
  • Singh B, Chandan BK, Sharma N, et al. Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria linn. Phytother Res 2006;20:831-9
  • Rao KS, Mishra SH. Screening of anti-inflammatory and hepatoprotective activities of alantolactone, isolated from the roots of Inula racemosa. Indian Drugs 1997;34:571-5
  • Yadav NP, Dixit VK. Hepatoprotective activity of leaves of Kalanchoe pinnata Pers. J Ethnopharmacol 2003;86:197-202
  • Jalalpure SS, Patil MB, Jabshetti MS. Effect of Lawsonia alba leaf extracts on carbon tetrachloride-induced hepatic damage in albino rats. J Nat Remedies 2003;3:97-100
  • Bhandarkar M, Khan A. Protective effect of Lawsonia alba Lam., against CCl4 induced hepatic damage in albino rats. Indian J Exp Biol 2003;41:85-7
  • Ahmed S, Rahman A, Alam A, et al. Evaluation of the efficacy of Lawsonia alba in the alleviation of carbon tetrachloride-induced oxidative stress. J Ethnopharmacol 2000;69:157-64
  • Manjunatha BK, Vidya SM, Dhiman P, et al. Hepatoprotective activity of Leucas hirta against CCl4 induced hepatic damage in rats. Indian J Exp Biol 2005;43:722-7
  • Souza MG, Singh R, Reddy PP, et al. Hepatoprotective activity of fruit pulp extract of Litchi chinensis Sonner on carbon tetrachloride induced hepatotoxicity in albino rats. Internet J Altern Med 2007;4(1):1-6
  • Lauria P, Sharma VN, Vanjani S, Sangal BC. The effect of luffa echinata in liver injury. Finland J Pharm 1976;8:129-33
  • Kumar VP, Shashidhara S, Kumar MM, Sridhara BY. Effect of luffa echinata on lipid peroxidation and free radical scavenging activity. J Pharm Pharmacol 2000;52:891-4
  • Shreedhara CS, Vaidya VP. Screening of momordica dioica for hepatoprotective, antioxidant, and anti-inflammatory activities. Nat Prod Sci 2006;12:157-61
  • Thirupathi K, Sathesh Kumar S, Govardhan P, et al. Protective effect of momordica dioica against hepatic damage caused by carbon tetrachloride in rats. Acta Pharm Sin 2006;48:213-22
  • Pari L, Kumar NA. Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. J Med Food 2002;5:171-7
  • Morita T, Jinno K, Kawagishi H, et al. Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/ D-galactosamine-induced liver injury. J Agric Food Chem 2003;51:1560-5
  • Ali S, Khursheed AA, Jafry MA, et al. Nardostachys jatamansi protects against liver damage induced by thioacetamide in rats. J Ethnopharmacol 2000;71:359-63
  • Rai S, Wahile A, Mukherjee K, et al. Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds. J Ethnopharmacol 2006;104:322-7
  • Mukherjee PK, Saha K, Pal M, Saha BP. Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats. J Ethnopharmacol 1997;58:207-13
  • Mukherjee PK, Saha K, Das J, et al. Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera. Planta Med 1997;63:367-9
  • Mukherjee PK, Saha K, Balasubramanian R, et al. Studies on psychopharmacological effects of Nelumbo nucifera Gaertn rhizome extract. J Ethnopharmacol 1996;54:63-7
  • Mukherjee PK, Das J, Saha K, et al. Antipyretic activity of Nelumbo nucifera rhizome extract. Indian J Exp Biol 1996;34:275-6
  • Rao GMM, Pushpangadan P, Shirwaikar A. Hepatoprotective activity of Nelumbo nucifera Geartn flower: an ethnopharmacological study. Acta Pharm Tur 2005;47:79-88
  • Hukkeri VI, Akki KS, Sureban RR, et al. Hepatoprotective activity of the leaves of Nyctanthes arbor-tristis Linn. Indian J Pharm Sci 2006;68:542-3
  • Bhandarkar MR, Khan A. Antihepatotoxic effect of Nymphaea stellata willd., against carbon tetrachloride-induced hepatic damage in albino rats. J Ethnopharmacol 2004;91:61-4
  • Ravikumar V, Shivashangari KS, Devaki T. Hepatoprotective activity of Tridax procumbens against D-galactosamine/ lipopolysaccharide-induced hepatitis in rats. J Ethnopharmacol 2005;101:55-60
  • Chattopadhyay RR, Sarkar SK, Ganguly S, et al. Hepatoprotective activity of Ocimum sanctum leaf extract against paracetamol induced hepatic damage in rats. Indian J Pharmacol 1992;24:163-5
  • Suresh Kumar S, Sujatha C, Syamala J, et al. Protective effect of root extract of Operculina turpethum Linn against paracetamol-induced hepatotoxicity in rats. Indian J Pharm Sci 2006;68:32-5
  • Sureshkumar SV, Mishra SH. Hepatoprotective effect of extracts from Pergularia daemia Forsk. J Ethnopharmacol 2006;107:164-8
  • Ajith TA, Janardhanan KK. Antioxidant and antihepatotoxic activities of Phellinus rimosus (Berk) Pilat. J Ethnopharmacol 2002;81:387-91
  • Ajith TA, Sheena N, Janardhanan KK. Phellinus rimosus protects carbon tetrachloride-induced chronic hepatotoxicity in rats: antioxidant defense mechanism. Pharm Biol 2006;44:467-74
  • Lima CF, Fernandes FM, Pereira WC. Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels. Life Sci 2006;79:2056-68
  • Khatoon S, Rai V, Rawat AK, Mehrotra S. Comparative pharmacognostic studies of three Phyllanthus species. J Ethnopharmacol 2006;104:79-86
  • Asha VV, Akhila S, Wills PJ, Subramoniam A. Further studies on the antihepatotoxic activity of Phyllanthus maderaspatensis Linn. J Ethnopharmacol 2004;92:67-70
  • Shamasundar KV, Singh B, Thakur RS, et al. Antihepatoprotective principles of Phyllanthus niruri herbs. J Ethnopharmacol 1985;14:41-4
  • Harish R, Shivanandappa T. Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chem 2006;95:180-5
  • Tabassum N, Chattervedi S, Aggrawal SS, Ahmed N. Hepatoprotective studies on Phyllanthus niruri on paracetamol induced liver cell damage in albino mice. JK Pract 2005;12:211-212
  • Saravanan R, Prakasam A, Ramesh B, Pugalendi KV. Influence of Piper betle on hepatic marker enzymes and tissue antioxidant status in ethanol-treated wistar rats. J Med Food 2002;5:197-204
  • Saravanan R, Ramesh B, Pugalendi KV. Effect of piper bettle on hepatotoxicity and antioxidant defense in ethanol-treated rats. JHSMP 2006;12:61-72
  • Shyamal S, Latha PG, Shine VJ, et al. Hepatoprotective effects of Pittosporum neelgherrense Wight & Arn a popular Indian ethnomedicine. J Ethnopharmacol 2006;107:151-5
  • Dhanabal SP, Syamala G, Kumar MNS, Suresh B. Hepatoprotective activity of the Indian medicinal plant Polygala arvensis on D-galactosamine-induced hepatic injury in rats. Fitoterapia 2006;77:472-4
  • Devi PK, Devaki T. Protective effect of Premna tomentosa on acetaminophen-induced acute hepatitis in rats. Med Sci Res 1998;26:785-7
  • Roy CK, Kamath JV, Asad M. Hepatoprotective activity of Psidium guajava Linn leaf extract. Indian J Exp Biol 2006;44:305-11
  • Mankani KL, Krishna V, Manjunatha BK, et al. Evaluation of hepatoprotective activity of stem bark of Pterocarpus marsupium Roxb. Indian J Pharmacol 2005;37:165-8
  • Manjunatha BK. Hepatoprotective activity of Pterocarpus santalinus L.f., an endangered medicinal plant. Indian J Pharmcol 2006;38:25-8
  • Dhanabal SP, Syamala G, Elango K, Suresh B. Protective effect of Pterocarpus santalinus on galactosamine induced liver damage. Nat Prod Sci 2006;12:8-13
  • Sethuraman MG, Lalitha KG, Rajkapoor B. Hepatoprotective activity of Sarcostemma brevistigma again carbon tetrachloride-induced hepatic damage in rats. Curr Sci 2003;84:1186-7
  • Pari L, Uma A. Protective effect of Sesbania grandiflora against erythromycin estolate-induced hepatotoxicity. Therapie 2003;58:439-43
  • Rao KS, Mishra SH. Anti-inflammatory and hepatoprotective activities of Sida rhombifolia linn. Indian J Pharmacol 1997;29:110-6
  • Dhalwal K, Shinde V, Mahadik KR, Kadam SS. Hepatoprotective activity of Sida rhombifolia ssp. retusa against thioacetamide and allyl alcohol intoxication in rats. Pharmacologyonline 2006;3:259-66
  • Bosisio E, Benelli C, Pirola O. Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. Pharmacol Res 1992;25:147-54
  • Miguez MP, Anundi I, Sainz-Pardo LA. Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P4502E1. Chem Biol Interact 1994;91:51-63
  • Raju K, Anbuganapathi G, Gokulakrishnan V, et al. Effect of dried fruits of Solanum nigrum Linn against CCl4-induced hepatic damage in rats. Biol Pharm Bull 2003;26:168-9
  • Vijayan P, Prashanth HC, Preethi V, et al. Hepatoprotective effect of the total alkaloid fraction of Solanum pseudocapsicum leaves. Pharm Biol 2003;41:443-8
  • Shahjahan M, Sabitha KE, Jainu M, Shyamala Devi CS. Effect of Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats. Indian J Med Res 2004;120:194-8
  • Visen PKS, Saraswat B, Raj K, et al. Prevention of galactosamine-induced hepatic damage by the natural product loganin from the plant Strychnos nux-vomica: studies on isolated hepatocytes and bile flow in rat. Phytother Res 1998;12:405-8
  • Sanmugapriya E, Venkataraman S. Studies on hepatoprotective and antioxidant actions of Strychnos potatorum Linn seeds on CCl4-induced acute hepatic injury in experimental rats. J Ethnopharmacol 2006;105:154-60
  • Mukherjee S, Sur A, Maiti BR. Hepatoprotective effect of Swertia chirata on rat. Indian J Exp Biol 1997;35:384-8
  • Karan M, Vasisht K, Handa SS. Antihepatotoxic activity of Swertia chirata on carbon tetrachloride induced hepatotoxicity in rats. Phytother Res 1999;13:24-30
  • Karan M, Vasisht K, Handa SS. Antihepatotoxic activity of Swertia chirata on paracetamol and galactosamine induced hepatotoxicity in rats. Phytother Res 1999;13:95-101
  • Murthy MSR, Srinivasan M. Hepatotprotective effect of Tephrosia pupurea in experimental animals. Indian J Pharmacol 1993;25:34-6
  • Jain A, Singhai AK, Dixit VK. A comparative study of ethanol extract of leaves of Tephrosia purpurea pers and the flavonoid isolated for hepatoprotective activity. Indian J Pharm Sci 2006;68:740-3
  • Shankar MB, Parikh JR, Geetha M, et al. Hepatoprotective activity of a benzopyrone from Tephrosia purpurea Pers. J Nat Remedies 2005;5:115-20
  • Manna P, Sinha M, Sil PC. Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement Altern Med 2006;6:1-10
  • Tasduq SA, Singh K, Satti NK, et al. Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination. Hum Exp Toxicol 2006;25:111-8
  • Ilavarasan R, Vasudevan M, Anbazhagan S, et al. Hepatoprotective activity of Thespesia populnea bark extracts against carbon tetrachloride-induced liver toxicity in rats. Nat Prod Sci 2003;9:83-6
  • Singh SS, Pandey SC, Srivastava S, et al. Chemistry and medicinal properties of Tinospora cordifolia (Guduchi). Indian J Pharmacol 2003;35:83-91
  • Nagarkatti DS, Rege NN, Desai NK, Dahanukar SA. Modulation of kupffer cell activity by Tinospora cordifolia in liver damage. J Postgrad Med 1994;40:65-7
  • Bishayi B, Roychowdhuy S, Ghosh S, Sengupta M. Hepatoprotective and immunomodulatory properties of Tinospora cordifolia. J Toxicol Sci 2002;27:139-46
  • Mehta RS, Shankar MB, Geetha M, Saluja AK. Preliminary evaluation of hepatoprotective activity of Trianthema portulacastrum Linn. J Nat Remedies 2003;3:180-4
  • Kumar G, Banu GS, Pappa PV, et al. Hepatoprotective activity of Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats. J Ethnopharmacol 2004;92:37-40
  • Pande MS, Banerjee G, Mishra SH. Hepatoprotective activity of fruits of T. terrestris Linn. Phytomedica 2005;6:123-7
  • Jagadeesan G, Kavitha AV. Recovery of phosphatase and transaminase activity of mercury intoxicated Mus musculus (Linn.) liver tissue by Tribulus terrestris (Linn.) (Zygophyllaceae) extract. Tropical Biomed 2006;23:45-51
  • Subramoniam A, Evans DA, Rajasekharan S, Pushpangadan P. Hepatoprotective activity of Trichopus zeylanicus extract against paracetamol-induced hepatic damage in rats. Indian J Exp Biol 1998;36:385-9
  • Vipul G, Patel N, Rao VN, et al. Hepatoprotective activity of alcoholic and aqueous extracts of leaves of Tylophora indica (Linn.) in rats. Indian J Pharmacol 2007;39:43-7
  • Sharma AK, Anand KK, Pushpangadan P, et al. Hepatoprotective effects of Wedelia calendulacea. J Ethnopharmacol 1989;25:93-102
  • Pathak N, Khandelwal S. Modulation of cadmium induced alterations in murine thymocytes by piperine: oxidative stress, apoptosis, phenotyping and blastogenesis. Biochem Pharmacol 2006;72:486-97
  • Yao P, Nussler A, Liu L, et al. Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J Hepatol 2007;47:253-61
  • Mandal AK, Das S, Basu MK, et al. Hepatoprotective activity of liposomal flavonoid against arsenite-induced liver fibrosis. J Pharmacol Exp Ther 2007;320:994-1001
  • Janbaz KH, Saeed SA, Gilani AH. Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents. Phytomedicine 2004;11:424-30
  • Singab AN, Youssef DT, Noaman E, Kotb S. Hepatoprotective effect of flavonol glycosides rich fraction from Egyptian Vicia calcarata Desf against CCl4-induced liver damage in rats. Arch Pharm Res 2005;28:791-8
  • Agarwal R, Agarwal C, Ichikawa H, et al. Anticancer potential of silymarin: from bench to bed side. Anticancer Res 2006;26:4457-98
  • Das SK, Vasudevan DM. Protective effects of silymarin, a milk thistle (Silybium marianum) derivative on ethanol-induced oxidative stress in liver. Indian J Biochem Biophys 2006;43:306-11
  • Daba MH, Abdel-Rahman MS. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol Lett 1998;95:23-9
  • Adnyana IK, Tezuka Y, Banskota AH, et al. Hepatoprotective constituents of the seeds of Combretum quadrangulare. Biol Pharm Bull 2000;23:1328-32
  • Naik RS, Mujumdar AM, Ghaskadbi S. Protection of liver cells from ethanol cytotoxicity by curcumin in liver slice culture in vitro. J Ethnopharmacol 2004;95:31-7
  • Maiti K, Mukherjee K, Gantait A, et al. Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats. Int J Pharm 2007;330:155-63
  • Zhao ZS, O'brien PJ. The prevention of CCl4-induced liver necrosis in mice by naturally occurring methylenedioxybenzenes. Toxicol Appl Pharmacol 1996;140:411-21
  • Matsuda H, Ninomiya K, Morikawa T, Yoshikawa M. Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae Rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury. Bioorg Med Chem Lett 1998;8:339-44
  • Jeong HG, You HJ, Park SJ, et al. Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression. Pharmacol Res 2002;46:221-7
  • Nasyrov KM, Chepurina LS, Kireeva RM. The hepatoprotective and cholagogic action of glycyrrhizic acid derivatives. Eksp Klin Farmakol 1995;58:60-3
  • Liu J, Liu Y, Mao Q, Klaassen CD. The effects of 10 triterpenoid compounds on experimental liver injury in mice. Fundam Appl Toxicol 1994;22:34-40
  • Shim SB, Kim NJ, Kim DH. Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid from the rhizomes of Glycyrrhiza uralensis. Planta Med 2000;66:40-3
  • Kinjo J, Hirakawa T, Tsuchihashi R, et al. Hepatoprotective constituents in plants 14. Effects of soyasapogenol B, sophoradiol, and their glucuronides on the cytotoxicity of tert-butyl hydroperoxide to HepG2 cells. Biol Pharm Bull 2003;26:1357-60
  • Gao J, Tang X, Dou H, et al. Hepatoprotective activity of Terminalia catappa L leaves and its two triterpenoids. J Pharm Pharmacol 2004;56:1449-55
  • Saraswat B, Visen PK, Agarwal DP. Ursolic acid isolated from Eucalyptus tereticornis protects against ethanol toxicity in isolated rat hepatocytes. Phytother Res 2000;14:163-6
  • Shukla B, Visen S, Patnaik GK, et al. Hepatoprotective activity in the rat of ursolic acid isolated from eucalyptus hybrid. Phytother Res 1992;6:74-9
  • Shukla B, Visen PKS, Patnaik GK, Dhawan BN. The hepatoprotective principle of Picrorrhiza kurroa. Planta Med 1992;57:29-33
  • Liu J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 1995;49:57-68
  • Zhang LZ, Li XF. Study on the mechanism of oleanolic acid against experimental liver injury in rats. Tradit Med Clin Pharmacol 1992;8:24-6
  • Liu J, Liu YP, Madhu C, Klaassen CD. Protective effects of oleanolic acid on acetaminophen hepatotoxicity in mice. J Pharmacol Exp Ther 1993;226:400-8
  • Balanehru S, Nagarajan B. Protective effect of oleanolic acid and ursolic acid against lipid peroxidation. Biochem Int 1991;24:981-90
  • Liu YP, Liu J, Klaassen CD. The protection of oleanolic acid on d-galactosamine/endotoxin-induced hepatotoxicity. Toxicologist 1993;13:720-2
  • Ghosh J, Das J, Manna P, Sil PC. Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway. Toxicol In Vitro 2008;22(8):1918-26
  • Manna P, Sinha M, Pal P, Sil PC. Arjunolic acid, a triterpenoid saponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes. Chem Biol Interact 2007;170(3):187-200
  • Manna P, Sinha M, Sil PC. Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways. Toxicology 2009;257(1-2):53-63
  • Lee CY, Peng WH, Cheng HY, et al. Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride. Am J Chin Med 2006;34:471-82
  • Anand KK, Singh B, Saxena AK, et al. 3, 4, 5-trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica-bioassay guided activity. Pharmacol Res 1997;36:315-21
  • Diallo B, Vanhaelen FR, Vanhaelen M, et al. Further studies on the hepatoprotective effects of Cochlospermum tinctorium rhizomes. J Ethnopharmacol 1992;36:137-42
  • Ito M, Shimura H, Watanabe N, et al. Hepatoprotective compounds from Canarium album and Euphorbia nematocypha. Chem Pharm Bull (Tokyo) 1990;38:2201-3
  • Singh K, Khanna AK, Chander R. Hepatoprotective activity of ellagic acid against carbon tetrachloride induced hepatotoxicity in rats. Indian J Exp Biol 1999;37:1025-6
  • Vidhya N, Devaraj SN. Antioxidant effect of eugenol in rat intestine. Indian J Exp Biol 1999;37:1192-5
  • Reicks MM, Crankshaw D. Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse. Xenobiotica 1993;23:809-19
  • Lee EJ, Kim SR, Kim J, Kim YC. Hepatoprotective phenylpropanoids from Scrophularia buergeriana roots against CCl4-induced toxicity: action mechanism and structure-activity relationship. Planta Med 2002;68:407-11
  • Handa SS, Sharma A. Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Indian J Med Res 1990;92:276-83
  • Handa SS, Sharma A. Hepatoprotective activity of andrographolide against galactosamine & paracetamol intoxication in rats. Indian J Med Res 1990;92:284-92
  • Mukherjee PK. Evaluation of Indian traditional medicine. Drug Inf J 2001;35:623-31
  • Mukherjee PK, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol 2006;106:1-28
  • Ghosh A, Sil PC. Protection of Acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-kappaB pathway: role of a novel plant protein. Chem Biol Interact 2009;177(2):96-106
  • Sarkar K, Ghosh A, Kinter M, et al. Purification and characterization of a 43 kD hepatoprotective protein from the herb Cajanus indicus L. Protein J 2006;25(6):411-21
  • Bhattacharjee R, Sil PC. Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem Toxicol 2007;45(5):817-26
  • Sarkar MK, Kinter M, Mazumder B, Sil PC. Purification and characterization of a novel antioxidant protein molecule from Phyllanthus niruri. Food Chem 2009;114(4):1405-12

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.