Anti-allergic drug discovery in China for eczema: current methods and future strategies

Bibliography

• Leung AK, Hon KL, Robson WL. Atopic dermatitis. Adv Pediatr 2007;54:241-73
   PubMedGoogle Scholar
• Leung DY. Atopic dermatitis: the skin as a window into the pathogenesis of chronic allergic diseases. J Allergy Clin Immunol 1995;96(3):302-18
   PubMed Web of Science ®Google Scholar
• Leung AKC, Barber KA. Managing childhood atopic dermatitis. Adv Ther 2003;20(3):129-37
   PubMed Web of Science ®Google Scholar
• Leung DY, Jain N, Leo HL. New concepts in the pathogenesis of atopic dermatitis. Curr Opin Immunol 2003;15(6):634-8
   PubMed Web of Science ®Google Scholar
• Leung DY, Bieber T. Atopic dermatitis. Lancet 2003;361(9352):151-60
   PubMed Web of Science ®Google Scholar
• Leung DY, Boguniewicz M, Howell MD, et al. New insights into atopic dermatitis. J Clin Invest 2004;113(5):651-7
   PubMed Web of Science ®Google Scholar
• Sehra S, Tuana FM, Holbreich M, et al. Scratching the surface: towards understanding the pathogenesis of atopic dermatitis. Crit Rev Immunol 2008;28(1):15-43
   PubMed Web of Science ®Google Scholar
• Grillo M, Gassner L, Marshman G, et al. Pediatric atopic eczema: the impact of an educational intervention. Pediatr Dermatol 2006;23(5):428-36
   PubMed Web of Science ®Google Scholar
• Williams HC. Is the prevalence of atopic dermatitis increasing? Clin Exp Dermatolog 1992;17(6):385-91
   PubMed Web of Science ®Google Scholar
• Simpson EL, Hanifin JM. Atopic dermatitis. J Am Acad Dermatol 2005;53(1):115-28
   PubMed Web of Science ®Google Scholar
• Leung R, Wong G, Lau J, et al. Prevalence of asthma and allergy in Hong Kong schoolchildren: an ISAAC study. Eur Respir J 1997;10(2):354-60
   PubMed Web of Science ®Google Scholar
• Leung DY, Nicklas RA, Li JT, et al. Disease management of atopic dermatitis: an updated practice parameter. Joint Task Force on Practice Parameters. Ann Allergy Asthma Immunol 2004;93(3 Suppl 2):S1-21
   PubMed Web of Science ®Google Scholar
• Simpson EL. Atopic dermatitis: a review of topical treatment options. Curr Med Res Opin 2010;26(3):633-40
   PubMed Web of Science ®Google Scholar
• Shaw TE, Currie GP, Koudelka et al. Eczema prevalence in the United States: data from the 2003 National Survey of Children's Health. J Invest Dermatol 2011;131(1):67-73
   PubMed Web of Science ®Google Scholar
• Li F, Zhou Y, Li S, et al. Prevalence and risk factors of childhood allergic diseases in eight metropolitan cities in China: a multicenter study. BMC Public Health 2011;11:437
   PubMed Web of Science ®Google Scholar
• Bufford JD, Gern JE. The hygiene hypothesis revisited. Immunol Allergy Clin North Am 2005;25(2):247-vi
   PubMed Web of Science ®Google Scholar
• Flohr C, Yeo L. Atopic dermatitis and the hygiene hypothesis revisited. Curr Probl Dermatol 2011;41:1-34
   PubMedGoogle Scholar
• Hon KL, Lam MC, Leung TF, et al. Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with moderate-to-severe atopic dermatitis. Ann Acad Med Singapore 2005;34(10):602-5
   PubMed Web of Science ®Google Scholar
• Chamlin SL, Frieden IJ, Williams ML, Chren MM. Effects of atopic dermatitis on young American children and their families. Pediatrics 2004;114(3):607-11
   PubMed Web of Science ®Google Scholar
• Hon KL, Leung TF, Wong K, et al. Does age or gender influence quality of life in children with atopic dermatitis? Clin Exp Dermatolog 2008;33(6):705-9
   PubMed Web of Science ®Google Scholar
• Ben Gashir MA, Seed PT, Hay RJ. Are quality of family life and disease severity related in childhood atopic dermatitis? J the Eur Acad Dermatolog Venereol 2002;16(5):455-62
   Google Scholar
• Ben Gashir MA. Relationship between quality of life and disease severity in atopic dermatitis/eczema syndrome during childhood. Curr Opin Allergy Clin Immunol 2003;3(5):369-73
   PubMedGoogle Scholar
• Ben Gashir MA, Seed PT, Hay RJ. Quality of life and disease severity are correlated in children with atopic dermatitis. Br J Dermatolog 2004;150(2):284-90
   PubMed Web of Science ®Google Scholar
• Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980;2:44-7
   Google Scholar
• Williams HC, Burney PG, Pembroke AC, et al. The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation. Br J Dermatolog 1994;131(3):406-16
   PubMed Web of Science ®Google Scholar
• Williams HC, Burney PG, Strachan D, et al. The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. II. Observer variation of clinical diagnosis and signs of atopic dermatitis. Br J Dermatolog 1994;131(3):397-405
   PubMed Web of Science ®Google Scholar
• Williams HC, Burney PG, Hay RJ, et al. The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatolog 1994;131(3):383-96
   PubMed Web of Science ®Google Scholar
• Hon KL, Leung TF. Seromarkers in childhood atopic dermatitis. Expert Rev Dermatolog 2010;5(3):299-314
   Google Scholar
• Abramovits W. Atopic dermatitis. J Am Acad Dermatol 2005;53(1 Suppl 1):S86-93
   PubMed Web of Science ®Google Scholar
• Hon KL, Wang SS, Leung TF. The atopic march: from skin to the airways. Iran J Allergy Asthma Immunol 2012;11:73-7
   PubMed Web of Science ®Google Scholar
• Leung TF, Ma KC, Hon KL, et al. Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children. Pediatric Allergy Immunol 2003;14(4):296-301
   PubMed Web of Science ®Google Scholar
• Marenholz I, Nickel R, Ruschendorf F, et al. Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. J Allergy Clin Immunol 2006;118(4):866-71
   PubMed Web of Science ®Google Scholar
• Palmer CN, Irvine AD, Terron-Kwiatkowski A, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006;38(4):441-6
   PubMed Web of Science ®Google Scholar
• Sandilands A, Terron-Kwiatkowski A, Hull PR, et al. Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet 2007;39(5):650-4
   PubMed Web of Science ®Google Scholar
• Sandilands A, Smith FJ, Irvine AD, McLean WH. Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis. J Invest Dermatol 2007;127:1282-4
   PubMed Web of Science ®Google Scholar
• Ching G, Hon KL, Leung TF. Filaggrin null mutations in childhood atopic dermatitis among the Chinese. Int J Immunogenet 2009;36(4):251-4
   PubMed Web of Science ®Google Scholar
• Heimall J, Spergel JM. Filaggrin mutations and atopy: consequences for future therapeutics. Expert Rev Clin Immunol 2012;8(2):189-97
   PubMed Web of Science ®Google Scholar
• Enomoto H, Hirata K, Otsuka K, et al. Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case-control study. J Human Genet 2008;53(7):615-21
   PubMed Web of Science ®Google Scholar
• Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol 2005;6(4):328-40
   PubMed Web of Science ®Google Scholar
• Krakowski AC, Eichenfield LF, Dohil MA. Management of atopic dermatitis in the pediatric population. Pediatrics 2008;122(4):812-24
   PubMed Web of Science ®Google Scholar
• Thulin CD, Taylor JA, Walsh KA. Microheterogeneity of human filaggrin: analysis of a complex peptide mixture using mass spectrometry. Protein Sci 1996;5(6):1157-64
   PubMed Web of Science ®Google Scholar
• Bikle DD, Chang S, Crumrine D, et al. 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J Invest Dermatol 2004;122(4):984-92
   PubMed Web of Science ®Google Scholar
• O'Regan GM, Irvine AD. The role of filaggrin in the atopic diathesis. Clin Exp Allergy 2010;40(7):965-72
   PubMed Web of Science ®Google Scholar
• Rousseau M, Bedouet L, Lati E, et al. Restoration of stratum corneum with nacre lipids. Comp Biochem Physiol B Biochem Mol Biol 2006;145(1):1-9
   PubMed Web of Science ®Google Scholar
• Jungersted JM, Scheer H, Mempel M, et al. Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy 2010;65(7):911-18
   PubMed Web of Science ®Google Scholar
• Lin X, Tu C, Yang C. [Study on treatment of eczema by Chinese herbal medicine with anti-type IV allergic activity]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000;20(4):258-60
   PubMedGoogle Scholar
• Hon KL, Chan BC, Leung PC. Chinese herbal medicine research in eczema treatment. Chin Med 2011;6:17
   PubMed Web of Science ®Google Scholar
• Hon KL, Leung TF, Yau HC, et al. Paradoxical use of oral and topical steroids in steroid-phobic patients resorting to traditional Chinese medicines. World J Pediatr 2012;8(3):263-7
   PubMed Web of Science ®Google Scholar
• Zhang S, Zeng X, Wei J, et al. Analysis of trends and opportunities of anti-allergy patents in China from 1998 to 2008. Recent Pat Inflamm Allergy Drug Discov 2010;4(2):130-7
   PubMedGoogle Scholar
• Zhang EQ. Clinic of traditional Chinese medicine (II). Publishing House of Shanghai College of Traditional Chinese Medicine, Shanghai, China; 1990
   Google Scholar
• Huang TK. A handbook of the composition and pharmacology of common chinese drugs. Chinese Medicine and Technology Press; Beijing: 1998
   Google Scholar
• Xu XJ, Banerjee P, Rustin MH, Poulter LW. Modulation by Chinese herbal therapy of immune mechanisms in the skin of patients with atopic eczema. Br J Dermatolog 1997;136(1):54-9
   PubMed Web of Science ®Google Scholar
• Kim SH, Jun CD, Suk K, et al. Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicol Sci 2006;91(1):123-31
   PubMed Web of Science ®Google Scholar
• Vo TS, Ngo DH, Kim SK. Gallic acid-grafted chitooligosaccharides suppress antigen-induced allergic reactions in RBL-2H3 mast cells. Eur J Pharm Sci 2012;47(2):527-33
   PubMed Web of Science ®Google Scholar
• Deng H, Fang Y. Anti-inflammatory gallic Acid and wedelolactone are G protein-coupled receptor-35 agonists. Pharmacology 2012;89(3-4):211-19
   PubMed Web of Science ®Google Scholar
• Liu KY, Hu S, Chan BC, et al. Anti-inflammatory and anti-allergic activities of pentaherb formula, moutan cortex (danpi) and gallic Acid. Molecules 2013;18(3):2483-500
   PubMed Web of Science ®Google Scholar
• Kim SH, Kim SA, Park MK, et al. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha. Int Immunopharmacol 2004;4(2):279-87
   PubMed Web of Science ®Google Scholar
• Du Q, Feng GZ, Shen L, et al. Paeonol attenuates airway inflammation and hyperresponsiveness in a murine model of ovalbumin-induced asthma. Can J Physiol Pharmacol 2010;88(10):1010-16
   PubMed Web of Science ®Google Scholar
• Lee B, Shin YW, Bae EA, et al. Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol. Arch Pharm Res 2008;31(4):445-50
   PubMed Web of Science ®Google Scholar
• Meng S, Wang LS, Huang ZQ, et al. Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention. Clin Exp Pharmacol Physiol 2012;39(5):406-11
   PubMed Web of Science ®Google Scholar
• Hong MH, Kim JH, Bae H, et al. Atractylodes japonica Koidzumi inhibits the production of proinflammatory cytokines through inhibition of the NF-kappaB/IkappaB signal pathway in HMC-1 human mast cells. Arch Pharm Res 2010;33(6):843-51
   PubMed Web of Science ®Google Scholar
• Kim S, Kim Y, Kim JE, et al. Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Phytomedicine 2008;15(5):340-7
   PubMed Web of Science ®Google Scholar
• Ueda H, Yamazaki C, Yamazaki M. Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. Biol Pharm Bull 2002;25(9):1197-202
   PubMed Web of Science ®Google Scholar
• Theoharides TC, Kempuraj D, Iliopoulou BP. Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis. Adv Exp Med Biol 2007;601:423-30
   PubMed Web of Science ®Google Scholar
• Kempuraj D, Tagen M, Iliopoulou BP, et al. Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell-dependent stimulation of Jurkat T cells. Br J Pharmacol 2008;155(7):1076-84
   PubMed Web of Science ®Google Scholar
• Theoharides TC, Asadi S, Panagiotidou S. A case series of a luteolin formulation (NeuroProtek(R)) in children with autism spectrum disorders. Int J Immunopathol Pharmacol 2012;25(2):317-23
   PubMed Web of Science ®Google Scholar
• Seelinger G, Merfort I, Schempp CM. Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med 2008;74(14):1667-77
   PubMed Web of Science ®Google Scholar
• Oku H, Ogawa Y, Iwaoka E, Ishiguro K. Allergy-preventive effects of chlorogenic acid and iridoid derivatives from flower buds of Lonicera japonica. Biol Pharm Bull 2011;34(8):1330-3
   PubMed Web of Science ®Google Scholar
• Chagas-Paula DA, Oliveira RB, da Silva VC, et al. Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones. J Ethnopharmacol 2011;136(2):355-62
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang YH, Shi RB. [Studies on the chemical constituents in herb of Mentha haplocalyx]. Zhongguo Zhong Yao Za Zhi 2005;30(14):1086-8
   PubMedGoogle Scholar
• Lee MY, Lee JA, Seo CS, et al. Protective effects of Mentha haplocalyx ethanol extract (MH) in a mouse model of allergic asthma. Phytother Res 2011;25(6):863-9
   PubMed Web of Science ®Google Scholar
• Zhou Y, Ren Y, Ma Z, et al. Identification and quantification of the major volatile constituents in antidepressant active fraction of xiaoyaosan by gas chromatography-mass spectrometry. J Ethnopharmacol 2012;141(1):187-92
   PubMed Web of Science ®Google Scholar
• Kitano A, Saika S, Yamanaka O, et al. Emodin suppression of ocular surface inflammatory reaction. Invest Ophthalmol Vis Sci 2007;48(11):5013-22
   PubMed Web of Science ®Google Scholar
• Lu Y, Yang JH, Li X, et al. Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. Biochem Pharmacol 2011;82(11):1700-8
   PubMed Web of Science ®Google Scholar
• Jin JH, Ngoc TM, Bae K, et al. Inhibition of experimental atopic dermatitis by rhubarb (rhizomes of Rheum tanguticum) and 5-lipoxygenase inhibition of its major constituent, emodin. Phytother Res 2011;25(5):755-9
   PubMed Web of Science ®Google Scholar
• Wang W, Zhou Q, Liu L, Zou K. Anti-allergic activity of emodin on IgE-mediated activation in RBL-2H3 cells. Pharmacol Rep 2012;64(5):1216-22
   PubMed Web of Science ®Google Scholar
• Chu X, Wei M, Yang X, et al. Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma. Food Chem Toxicol 2012;50(7):2368-75
   PubMed Web of Science ®Google Scholar
• Li D, Zhang N, Cao Y, et al. Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-kappaB and MAPKs signal pathways. Eur J Pharmacol 2013;705(1-3):79-85
   PubMed Web of Science ®Google Scholar
• Lim H, Lee JH, Kim J, et al. Effects of the rhizomes of Atractylodes japonica and atractylenolide I on allergic response and experimental atopic dermatitis. Arch Pharm Res 2012;35(11):2007-12
   PubMed Web of Science ®Google Scholar
• Lenon GB, Li CG, Xue CC, et al. Inhibition of inducible nitric oxide production and iNOS protein expression in lipopolysaccharide-stimulated rat aorta and Raw 264.7 macrophages by ethanol extract of a Chinese herbal medicine formula (RCM-101) for allergic rhinitis. J Ethnopharmacol 2008;116(3):547-53
   PubMed Web of Science ®Google Scholar
• Shams K, Grindlay DJ, Williams HC. What's new in atopic eczema? An analysis of systematic reviews published in 2009-2010. Clin Exp Dermatol 2011;36(6):573-7
   PubMed Web of Science ®Google Scholar
• Luo W, Wu C. Fifty-six cases of stubborn eczema treated by oral administration and topical application of herbal medicine. J Tradit Chin Med 2001;21(4):259-60
   PubMedGoogle Scholar
• Salameh F, Perla D, Solomon M, et al. The effectiveness of combined Chinese herbal medicine and acupuncture in the treatment of atopic dermatitis. J Altern Complement Med 2008;14(8):1043-8
   PubMed Web of Science ®Google Scholar
• Hon KL, Lo W, Cheng WK, et al. Prospective self-controlled trial of the efficacy and tolerability of a herbal syrup for young children with eczema. J Dermatolog Treat 2012;23(2):116-21
   PubMed Web of Science ®Google Scholar
• Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993;186(1):23-31
   PubMed Web of Science ®Google Scholar
• Kunz B, Oranje AP, Labreze L, et al. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology 1997;195(1):10-19
   PubMed Web of Science ®Google Scholar
• Hon KL, Leung TF, Wong Y, et al. A pentaherbs capsule as a treatment option for atopic dermatitis in children: An open-labeled case series. Am J Chin Med 2004;32(6):941-50
   PubMed Web of Science ®Google Scholar
• Hon KL, Leung TF, Ng PC, et al. Efficacy and tolerability of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, double-blind, placebo-controlled study. Br J Dermatolog 2007;157(2):357-63
   PubMed Web of Science ®Google Scholar
• Hon KL, Kam WY, Lam MC, et al. CDLQI, SCORAD and NESS: are they Correlated? Qual Life Res 2006;15:1551-8
   PubMed Web of Science ®Google Scholar
• Latchman Y, Bungy GA, Atherton DJ, et al. Efficacy of traditional Chinese herbal therapy in vitro. A model system for atopic eczema: inhibition of CD23 expression on blood monocytes. Br J Dermatolog 1995;132(4):592-8
   PubMed Web of Science ®Google Scholar
• Leung TF, Wong KY, Wong CK, et al. In vitro and clinical immunomodulatory effects of a novel Pentaherbs concoction for atopic dermatitis. Br J Dermatolog 2008;158(6):1216-23
   PubMed Web of Science ®Google Scholar
• Chan BC, Hon KL, Leung PC, et al. Traditional Chinese medicine for atopic eczema: pentaHerbs formula suppresses inflammatory mediators release from mast cells. J Ethnopharmacol 2008;120(1):85-91
   PubMed Web of Science ®Google Scholar
• Boneberger S, Rupec RA, Ruzicka T. Complementary therapy for atopic dermatitis and other allergic skin diseases: facts and controversies. Clin Dermatolog 2010;28(1):57-61.
   PubMed Web of Science ®Google Scholar
• Fung AY, Look PC, Chong LY, et al. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. Int J Dermatol 1999;38(5):387-92
   PubMed Web of Science ®Google Scholar
• Johnston G, Bilbao R, Graham-Brown RA. The use of complementary medicine in children with atopic dermatitis in secondary care in Leicester. Br J Dermatolog 2003;149(3):566-71
   PubMed Web of Science ®Google Scholar
• Zhang W, Leonard T, Bath-Hextall F, et al. Chinese herbal medicine for atopic eczema. Cochrane Database Sys Rev 2005(2):CD002291
   Google Scholar
• Sheehan MP, Atherton DJ. A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema. Br J Dermatolog 1992;126(2):179-84
   PubMed Web of Science ®Google Scholar
• Sheehan MP, Atherton DJ. One-year follow up of children treated with Chinese medicinal herbs for atopic eczema. Br J Dermatolog 1994;130(4):488-93
   PubMed Web of Science ®Google Scholar
• Sheehan MP, Stevens H, Ostlere LS, et al. Follow-up of adult patients with atopic eczema treated with Chinese herbal therapy for 1 year. Clin Exp Dermatolog 1995;20(2):136-40
   PubMed Web of Science ®Google Scholar
• Available from: http://www.cmchk.org.hk/pcm/pdf/good_manu_e.pdf) [Accessed 9 Apri 2013]
   Google Scholar
• Hon KL, Lee VW, Leung TF, et al. Corticosteroids are not present in a traditional chinese medicine formulation for atopic dermatitis in children. Ann Acad Med Singapore 2006;35(11):759-5
   PubMed Web of Science ®Google Scholar
• Bai YP, Yang DQ, Wang YM. [Clinical study on treatment of acute eczema by Shuangfujin]. Zhongguo Zhong Xi Yi Jie He Za Zh 2007;27(1):72-5
   PubMedGoogle Scholar
• Kobayashi H. [Clinical evaluation of Hochuekkito in the treatment of atopic dermatitis: a multicenter, double-blind, randomized, placebo-controlled study]. [Japanese]. Nippon Yakurigaku Zasshi 2008;132(5):285-7
   PubMedGoogle Scholar
• Cheng HM, Chiang LC, Jan YM, et al. The efficacy and safety of a Chinese herbal product (Xiao-Feng-San) for the treatment of refractory atopic dermatitis: a randomized, double-blind, placebo-controlled trial. Int Arch Allergy Immunol 2011;155(2):141-8
   PubMed Web of Science ®Google Scholar
• Hon KL, Yong V, Leung TF. Research statistics in Atopic Eczema: what disease is this? Ital J Pediatr 2012;38(1):26
   PubMedGoogle Scholar
• Hon KL, Wong KY, Cheung LK, et al. Efficacy and problems associated with using a wet-wrap garment for children with severe atopic dermatitis. J Dermatolog Treat 2007;18(5):301-5
   PubMed Web of Science ®Google Scholar
• Cui M, Wang FJ, Shao ZQ, et al. Influence of DS of CMC on morphology and performance of magnetic microcapsules. Cellulose 2011;18(5):1265-71
   Web of Science ®Google Scholar
• Huang L, Sui W, Wang Y, Jiao Q. Preparation of chitosan/chondroitin sulfate complex microcapsules and application in controlled release of 5-fluorouracil. Carbohydr Polym 2010;80(1):168-73
   Web of Science ®Google Scholar
• Luca G, Basta G, Calafiore R, et al. Multifunctional microcapsules for pancreatic islet cell entrapment: design, preparation and in vitro characterization. Biomaterials 2003;24(18):3101-14
   PubMed Web of Science ®Google Scholar
• Yuen CWM, Yip J, Liu L, et al. Chitosan microcapsules loaded with either miconazole nitrate or clotrimazole, prepared via emulsion technique. Carbohydr Polym 2012;89(3):795-801
   PubMed Web of Science ®Google Scholar
• Goh CH, Heng PWS, Chan LW. Alginates as a useful natural polymer for microencapsulation and therapeutic applications. Carbohydr Polym 2012;88(1):1-12
   Web of Science ®Google Scholar
• Gombotz WR, Wee SF. Protein release from alginate matrices. Adv Drug Deliv Rev 2012;64(Suppl 0):194-205
   Google Scholar
• Gombotz WR, Wee S. Protein release from alginate matrices. Adv Drug Deliv Rev 1998;31(3):267-85
   PubMed Web of Science ®Google Scholar
• Takka S, Acarturk F. Calcium alginate microparticles for oral administration: I: effect of sodium alginate type on drug release and drug entrapment efficiency. J Microencapsul 1999;16(3):275-90
   PubMed Web of Science ®Google Scholar
• Hsieh WC, Chang CP, Gao YL. Controlled release properties of Chitosan encapsulated volatile Citronella Oil microcapsules by thermal treatments. Colloids Surf B Biointerfaces 2006;53(2):209-14
   PubMed Web of Science ®Google Scholar
• Mi FL, Sung HW, Shyu SS. Drug release from chitosanΓ€“alginate complex beads reinforced by a naturally occurring cross-linking agent. Carbohydr Polym 2002;48(1):61-72
   Web of Science ®Google Scholar
• Yu W, Song H, Zheng G, et al. Study on membrane characteristics of alginate/chitosan microcapsule with cell growth YU2011. J of Membrane Sci 2011;377(1-2):214-20
   Web of Science ®Google Scholar
• Li XY, Chen XG, Sun ZW, et al. Preparation of alginate/chitosan/carboxymethyl chitosan complex microcapsules and application in Lactobacillus casei ATCC 393 LI2011. Carbohydrate Polymers 2011;83(4):1479-85
   Web of Science ®Google Scholar
• Hui PC, Wang WY, Kan CW, et al. Preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan. Int J Biol Macromol 2013;55:32-8
   PubMed Web of Science ®Google Scholar
• Hon KL, Wong KY, Leung TF, et al. Comparison of skin hydration evaluation sites and correlations among skin hydration, transepidermal water loss, SCORAD index, nottingham eczema severity score, and quality of life in patients with atopic dermatitis. Am J Clin Dermatolog 2008;9(1):45-50
   PubMed Web of Science ®Google Scholar
• Hon KL, Ma KC, Wong Y, et al. A survey of traditional Chinese medicine use in children with atopic dermatitis attending a paediatric dermatology clinic. J Dermatol Treat 2005;16(3):154-7
   PubMed Web of Science ®Google Scholar
• Ernst E. Homeopathy for eczema: a systematic review of controlled clinical trials. Br J Dermatol 2012;166(6):1170-2
   Google Scholar
• Hon KL, Kam WY, Leung TF, et al. Steroid fears in children with eczema. Acta Paediatrica 2006;95(11):1451-5
   PubMed Web of Science ®Google Scholar