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Microscopy-based quantitative analysis of lung structure: application in diagnosis

, MD &
Pages 319-331 | Published online: 21 Jun 2011

Bibliography

  • Gundersen H. The smooth fractionator. J Microsc 2002;207(Pt 3):191-210
  • Gardi JE, Nyengaard JR, Gundersen HJ. The proportionator: unbiased stereological estimation using biased automatic image analysis and non-uniform probability proportional to size sampling. Comput Biol Med 2008;38(3):313-28
  • Gundersen HJ, Bendtsen T, Korbo L, Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 1988;5(5):379-94
  • Gundersen HJ, Jensen E. Stereological estimation of the volume-weighted mean volume of arbitrary particles observed on random sections. J Microsc 1985;138(Pt 2):127-42
  • Gundersen HJ. The nucleator. J Microsc 1988;151(Pt 1):3-21
  • Knudsen L, Weibel ER, Gundersen HJ, Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach. J Appl Physiol 2010;108(2):412-21
  • Gundersen HJ, Bagger P, Bendtsen T, The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988;96(10):857-81
  • de Groot DM, Hartgring S, van de Horst L, 2D and 3D assessment of neuropathology in rat brain after prenatal exposure to methylazoxymethanol, a model for developmental neurotoxicty. Reprod Toxicol 2005;20(3):417-32
  • Boyce JT, Boyce RW, Gundersen HJ. Choice of morphometric methods and consequences in the regulatory environment. Toxicol Pathol 2010;38(7):1128-33
  • Hsia CC, Hyde DM, Ochs M, Weibel ER. An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 2010181(4):394-418
  • Saper CB. Any way you cut it: a new journal policy for the use of unbiased counting methods. J Comp Neurol 1996;364(1):5
  • Madsen KM. The art of counting. J Am Soc Nephrol 1999;10(5):1124-5
  • Mendis-Handagama SM, Ewing LL. Sources of error in the estimation of Leydig cell numbers in control and atrophied mammalian testes. J Microsc 1990;159(Pt 1):73-82
  • Mayhew TM, Gundersen HJ. ‘If you assume, you can make an ass out of u and me’: a decade of the disector for stereological counting of particles in 3D space. J Anat 1996;188 (Pt 1):1-15
  • Ochs M. A brief update on lung stereology. J Microsc 2006;222(Pt 3):188-200
  • Weibel ER, Hsia CC, Ochs M. How much is there really? Why stereology is essential in lung morphometry. J Appl Physiol 2007;102(1):459-67
  • Sterio DC. The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 1984;134(Pt 2):127-36
  • Boyce R, Dorph-Petersen KA, Lyck L, Gundersen HJ. Design-based stereology: introduction to basic concepts and practical approaches for estimation of cell number. Toxicol Pathol 2010;38(7):1011-25
  • Nyengaard JR, Gundersen HJ. The isector: a simple and direct method for generating isotropic, uniform random sections from small specimens. J Microsc 1992;165:427-31
  • Mattfeldt T, Mall G, Gharehbaghi H, Moller P. Estimation of surface area and length with the orientator. J Microsc 1990;159(Pt 3):301-17
  • Bjugn R, Gundersen HJ. Estimate of the total number of neurons and glial and endothelial cells in the rat spinal cord by means of the optical disector. J Comp Neurol 1993;328(3):406-14
  • Ochs M, Nyengaard JR, Jung A, The number of alveoli in the human lung. Am J Respir Crit Care Med 2004;169(1):120-4
  • Hyde DM, Tyler N, Putney L, Total number and mean size of alveoli in mammalian lung estimated using fractionator sampling and unbiased estimates of the Euler characteristic of alveolar openings. Anat Rec A Discov Mol Cell Evol Biol 2004;277(1):216-26
  • Braendgaard H, Gundersen HJ. The impact of recent stereological advances on quantitative studies of the nervous system. J Neurosci Methods 1986;18(1-2):39-78
  • Gundersen HJ, Jensen E. The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987;147(Pt 3):229-63
  • Gundersen HJ, Jensen E, Kieu K, Nielsen J. The efficiency of systematic sampling in stereology–reconsidered. J Microsc 1999;193(Pt 3):199-211
  • Cruz-Orive LM, Weibel ER. Recent stereological methods for cell biology: a brief survey. Am J Physiol 1990;258(4 Pt 1):L148-56
  • Gundersen HJ, Osterby R. Optimizing sampling efficiency of stereological studies in biology: or ‘do more less well!’. J Microsc 1981;121(Pt 1):65-73
  • Hogg JC, McDonough JE, Sanchez PG, Micro-computed tomography measurements of peripheral lung pathology in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009;6(6):546-9
  • Fehrenbach H, Wahlers T, Ochs M, Ultrastructural pathology of the alveolar type II pneumocytes of human donor lungs. Electron microscopy, stereology, and microanalysis. Virchows Arch 1998;432(3):229-39
  • Regamey N, Ochs M, Hilliard TN, Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2008;177(8):837-43
  • Brain JD, Gehr P, Kavet RI. Airway macrophages. The importance of the fixation method. Am Rev Respir Dis 1984;129(5):823-6
  • Bachofen H, Ammann A, Wangensteen D, Weibel E. Perfusion fixation of lungs for structure-function analysis: credits and limitations. J Appl Physiol 1982;53(2):528-33
  • Gil J, Weibel ER. Extracellular lining of bronchioles after perfusion-fixation of rat lungs for electron microscopy. Anat Rec 1971;169(2):185-99
  • Gil J, Bachofen H, Gehr P, Weibel ER. Alveolar volume-surface area relation in air- and saline-filled lungs fixed by vascular perfusion. J Appl Physiol 1979;47(5):990-1001
  • Bachofen H, Schurch S, Urbinelli M, Weibel E. Relations among alveolar surface tension, surface area, volume, and recoil pressure. J Appl Physiol 1987;62(5):1878-87
  • Mercer RR, Laco JM, Crapo JD. Three-dimensional reconstruction of alveoli in the rat lung for pressure-volume relationships. J Appl Physiol 1987;62(4):1480-7
  • Michel RP, Cruz-Orive LM. Application of the Cavalieri principle and vertical sections method to lung: estimation of volume and pleural surface area. J Microsc 1988;150(Pt 2):117-36
  • Scherle W. A simple method for volumetry of organs in quantitative stereology. Mikroskopie 1970;26(1):57-60
  • Dorph-Petersen K, Nyengaard JR, Gundersen HJ. Tissue shrinkage and unbiased stereological estimation of particle number and size. J Microsc 2001;204(Pt 3):232-46
  • Knust J, Ochs M, Gundersen HJ, Nyengaard JR. Stereological estimates of alveolar number and size and capillary length and surface area in mice lungs. Anat Rec (Hoboken) 2009;292(1):113-22
  • Gerrits PO, Horobin RW, Stokroos I. The effects of glycol methacrylate as a dehydrating agent on the dimensional changes of liver tissue. J Microsc 1992;165(Pt 2):273-80
  • Thurlbeck WM, Muller NL. Emphysema: definition, imaging, and quantification. AJR Am J Roentgenol 1994;163(5):1017-25
  • Morris DG, Huang X, Kaminski N, Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature 2003;422(6928):169-73
  • Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 1997;277(5334):2002-4
  • Shapiro SD. Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease. Eur Respir J 2007;29(2):375-8
  • Fehrenbach H. Animal models of pulmonary emphysema: a stereologist's perspective. Eur Respir Rev 2006;15:136-47
  • Ochs M, Knudsen L, Allen L, GM-CSF mediates alveolar epithelial type II cell changes, but not emphysema-like pathology, in SP-D-deficient mice. Am J Physiol Lung Cell Mol Physiol 2004;287(6):L1333-41
  • Knudsen L, Ochs M, Mackay R, Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice. Respir Res 2007;8:70
  • Knudsen L, Wucherpfennig K, Mackay R, A recombinant fragment of human surfactant protein D lacking the short collagen-like stalk fails to correct morphological alterations in lungs of SP-D deficient mice. Anat Rec (Hoboken) 2009;292(2):183-9
  • Hawgood S, Ochs M, Jung A, Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema. Am J Physiol Lung Cell Mol Physiol 2002;283(5):L1002-10
  • Thurlbeck WM. Internal surface area and other measurements in emphysema. Thorax 1967;22(6):483-96
  • Thurlbeck WM. The internal surface area of nonemphysematous lungs. Am Rev Respir Dis 1967;95(5):765-73
  • Jung A, Allen L, Nyengaard JR, Design-based stereological analysis of the lung parenchymal architecture and alveolar type II cells in surfactant protein A and D double deficient mice. Anat Rec A Discov Mol Cell Evol Biol 2005;286(2):885-90
  • Gundersen HJ, Jensen EB. Stereological estimation of the volume-weighted mean volume of arbitrary particles observed on random sections. J Microsc 1985;138(Pt 2):127-42
  • Fehrenbach A, Ochs M, Wittwer T, Stereological estimation of the volume weighted mean volumes of alveoli and acinar pathways in the rat lung to characterise alterations after ischaemia/reperfusion. J Anat 1999;194(Pt 1):127-35
  • Ley B, Collard HR, King TE Jr. Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2011;183(4):431-40
  • Enomoto N, Suda T, Kato M, Quantitative analysis of fibroblastic foci in usual interstitial pneumonia. Chest 2006;130(1):22-9
  • Weibel ER, Knight B. A morphometric study on the thickness of the pulmonary air-blood barrier. J Cell Biol 1964;21:367-96
  • Ochs M, Nenadic I, Fehrenbach A, Ultrastructural alterations in intraalveolar surfactant subtypes after experimental ischemia and reperfusion. Am J Respir Crit Care Med 1999;160(2):718-24
  • Ochs M, Fehrenbach H, Nenadic I, Preservation of intraalveolar surfactant in a rat lung ischaemia/reperfusion injury model. Eur Respir J 2000;15(3):526-31
  • Fehrenbach H, Schepelmann D, Albes J, Pulmonary ischemia/reperfusion injury: a quantitative study of structure and function in isolated heart-lungs of the rat. Anat Rec 1999;255(1):84-9
  • Muhlfeld C, Becker L, Bussinger C, Exogenous surfactant in ischemia/reperfusion: effects on endogenous surfactant pools. J Heart Lung Transplant 2010;29(3):327-34
  • Muhlfeld C, Muller K, Pallesen L, Impact of preservation solution on the extent of blood-air barrier damage and edema formation in experimental lung transplantation. Anat Rec (Hoboken) 2007;290(5):491-500
  • Muhlfeld C, Schaefer I, Becker L, Pre-ischaemic exogenous surfactant reduces pulmonary injury in rat ischaemia/reperfusion. Eur Respir J 2009;33(3):625-33
  • Gundersen HJ. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc 1986;143(Pt 1):3-45
  • Nielsen K, Colstrup H, Nilsson T, Gundersen HJ. Stereological estimates of nuclear volume correlated with histopathological grading and prognosis of bladder tumour. Virchows Arch B Cell Pathol Incl Mol Pathol 1986;52(1):41-54
  • Nielsen K. Stereological estimates of nuclear volume in normal mucosa and carcinoma in situ of the human urinary bladder. Virchows Arch B Cell Pathol Incl Mol Pathol 1988;55(4):233-6
  • Sorensen FB. Objective histopathologic grading of cutaneous malignant melanomas by stereologic estimation of nuclear volume. Prediction of survival and disease-free period. Cancer 1989;63(9):1784-98
  • Sorensen FB. Stereological estimation of nuclear volume in benign melanocytic lesions and cutaneous malignant melanomas. Am J Dermatopathol 1989;11(6):517-27
  • Tschanz SA, Burri PH, Weibel ER. A simple tool for stereological assessment of digital images: the STEPanizer. J Microsc 2011; In press
  • Osmanagic E, Sukstanskii AL, Quirk JD, Quantitative assessment of lung microstructure in healthy mice using an MR-based 3He lung morphometry technique. J Appl Physiol 2010;109(6):1592-9
  • Vanhecke D, Studer D, Ochs M. Stereology meets electron tomography: towards quantitative 3D electron microscopy. J Struct Biol 2007;159(3):443-50

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