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Drug Evaluations

Use of gevokizumab for the treatment of Behçet's disease

, PhD, , MBChB PhD FRCP & , MBChB MRCPI DMed
Pages 755-763 | Published online: 28 Aug 2013

Bibliography

  • Sakane T, Takeno M, Suzuki N, Inaba G. Behçet's disease. N Engl J Med 1999;341(17):1284-91
  • Ambrose NL, Haskard DO. Differential diagnosis and management of Behçet syndrome. Nat Rev Rheumatol 2013;9(2):79-89
  • Gul A. Behçet's disease as an autoinflammatory disorder. Curr Drug Targets Inflamm Allergy 2005;4(1):81-3
  • de Menthon M, Lavalley MP, Maldini C, et al. HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies. Arthritis Rheum 2009;61(10):1287-96
  • Gul A, Ohno S. HLA-B*51 and Behçet Disease. Ocul Immunol Inflamm 2012;20(1):37-43
  • Ohno S, Ohguchi M, Hirose S, et al. Close association of HLA-Bw51 with Behçet's disease. Arch Ophthalmol 1982;100(9):1455-8
  • Kirino Y, Bertsias G, Ishigatsubo Y, et al. Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet 2013;45(2):202-7
  • Mizuki N, Meguro A, Ota M, et al. Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. Nat Genet 2010;42(8):703-6
  • Remmers EF, Cosan F, Kirino Y, et al. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Nat Genet 2010;42(8):698-702
  • Khairallah M, Accorinti M, Muccioli C, et al. Epidemiology of Behçet disease. Ocul Immunol Inflamm 2012;20(5):324-35
  • Verity DH, Marr JE, Ohno S, et al. Behçet's disease, the Silk Road and HLA-B51: historical and geographical perspectives. Tissue Antigens 1999;54(3):213-20
  • Azizlerli G, Kose AA, Sarica R, et al. Prevalence of Behçet's disease in Istanbul. Turkey. Int J Dermatol 2003;42(10):803-6
  • Zhang ZL, He F, Shi YJ. Behçet's disease seen in China: analysis of 334 cases. Rheumatol Int 2013;33(3):645-8
  • Davatchi F, Shahram F, Chams-Davatchi C, et al. Behçet's disease in Iran: analysis of 6500 cases. Int J Rheum Dis 2010;13(4):367-73
  • Kaneko F, Nakamura K, Sato M, et al. Epidemiology of Behçet's disease in Asian countries and Japan. Adv Exp Med Biol 2003;528:25-9
  • Bang D, Lee JH, Lee ES, et al. Epidemiologic and clinical survey of Behçet's disease in Korea: the first multicenter study. J Korean Med Sci 2001;16(5):615-18
  • Calamia KT, Wilson FC, Icen M, et al. Epidemiology and clinical characteristics of Behçet's disease in the US: a population-based study. Arthritis Rheum 2009;61(5):600-4
  • Altenburg A, Papoutsis N, Orawa H, et al. [Epidemiology and clinical manifestations of Adamantiades-Behçet disease in Germany -- current pathogenetic concepts and therapeutic possibilities]. J Dtsch Dermatol Ges 2006;4(1):49-64; quiz 5-6
  • Criteria for diagnosis of Behçet's disease. International Study Group for Behçet's Disease. Lancet 1990;335(8697):1078-80
  • Yazici H, Fresko I, Yurdakul S. Behçet's syndrome: disease manifestations, management, and advances in treatment. Nat Clin Pract Rheumatol 2007;3(3):148-55
  • Davatchi F, Assaad-Khalil S, Calamia KT, et al. The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol 2013; [Epub ahead of print]
  • Deuter CM, Kotter I, Wallace GR, et al. Behçet's disease: ocular effects and treatment. Prog Retin Eye Res 2008;27(1):111-36
  • Kitaichi N, Miyazaki A, Iwata D, et al. Ocular features of Behçet's disease: an international collaborative study. Br J Ophthalmol 2007;91(12):1579-82
  • Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, et al. Uveitis in Behçet disease: an analysis of 880 patients. Am J Ophthalmol 2004;138(3):373-80
  • Hatemi G, Silman A, Bang D, et al. EULAR recommendations for the management of Behçet disease. Ann Rheum Dis 2008;67(12):1656-62
  • Hamuryudan V, Ozyazgan Y, Hizli N, et al. Azathioprine in Behçet's syndrome: effects on long-term prognosis. Arthritis Rheum 1997;40(4):769-74
  • Saadoun D, Wechsler B, Terrada C, et al. Azathioprine in severe uveitis of Behçet's disease. Arthritis Care Res (Hoboken) 2010;62(12):1733-8
  • Yazici H, Pazarli H, Barnes CG, et al. A controlled trial of azathioprine in Behçet's syndrome. N Engl J Med 1990;322(5):281-5
  • BenEzra D, Cohen E, Chajek T, et al. Evaluation of conventional therapy versus cyclosporine A in Behçet's syndrome. Transplant Proc 1988;20(3 Suppl 4):136-43
  • Binder AI, Graham EM, Sanders MD, et al. Cyclosporin A in the treatment of severe Behçet's uveitis. Br J Rheumatol 1987;26(4):285-91
  • Masuda K, Nakajima A, Urayama A, et al. Double-masked trial of cyclosporin versus colchicine and long-term open study of cyclosporin in Behçet's disease. Lancet 1989;1(8647):1093-6
  • Ozyazgan Y, Yurdakul S, Yazici H, et al. Low dose cyclosporin A versus pulsed cyclophosphamide in Behçet's syndrome: a single masked trial. Br J Ophthalmol 1992;76(4):241-3
  • Kotter I, Gunaydin I, Batra M, et al. CNS involvement occurs more frequently in patients with Behçet's disease under cyclosporin A (CSA) than under other medications--results of a retrospective analysis of 117 cases. Clin Rheumatol 2006;25(4):482-6
  • Alpsoy E, Durusoy C, Yilmaz E, et al. Interferon alfa-2a in the treatment of Behçet disease: a randomized placebo-controlled and double-blind study. Arch Dermatol 2002;138(4):467-71
  • Kotter I, Vonthein R, Zierhut M, et al. Differential efficacy of human recombinant interferon-alpha2a on ocular and extraocular manifestations of Behçet disease: results of an open 4-center trial. Semin Arthritis Rheum 2004;33(5):311-19
  • Onal S, Kazokoglu H, Koc A, et al. Long-term efficacy and safety of low-dose and dose-escalating interferon alfa-2a therapy in refractory Behçet uveitis. Arch Ophthalmol 2011;129(3):288-94
  • Sobaci G, Erdem U, Durukan AH, et al. Safety and effectiveness of interferon alpha-2a in treatment of patients with Behçet's uveitis refractory to conventional treatments. Ophthalmology 2010;117(7):1430-5
  • Sugita S, Kawazoe Y, Imai A, et al. Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease. Arthritis Res Ther 2012;14(3):R99
  • Arida A, Fragiadaki K, Giavri E, Sfikakis PP. Anti-TNF agents for Behçet's disease: analysis of published data on 369 patients. Semin Arthritis Rheum 2011;41(1):61-70
  • Benitah NR, Sobrin L, Papaliodis GN. The use of biologic agents in the treatment of ocular manifestations of Behçet's disease. Semin Ophthalmol 2011;26(4-5):295-303
  • Mesquida M, Molins B, Llorenc V, et al. Current and future treatments for Behçet's uveitis: road to remission. Int Ophthalmol 2013; [Epub ahead of print]
  • Al-Rayes H, Al-Swailem R, Al-Balawi M, et al. Safety and efficacy of infliximab therapy in active behcet's uveitis: an open-label trial. Rheumatol Int 2008;29(1):53-7
  • Tugal-Tutkun I, Mudun A, Urgancioglu M, et al. Efficacy of infliximab in the treatment of uveitis that is resistant to treatment with the combination of azathioprine, cyclosporine, and corticosteroids in Behçet's disease: an open-label trial. Arthritis Rheum 2005;52(8):2478-84
  • Okada AA, Goto H, Ohno S, Mochizuki M. Multicenter study of infliximab for refractory uveoretinitis in Behçet disease. Arch Ophthalmol 2012;130(5):592-8
  • Sugita S, Yamada Y, Kaneko S, et al. Induction of regulatory T cells by infliximab in Behçet's disease. Invest Ophth Vis Sci 2011;52(1):476-84
  • Bawazeer A, Raffa LH, Nizamuddin SH. Clinical experience with adalimumab in the treatment of ocular Behçet disease. Ocul Immunol Inflamm 2010;18(3):226-32
  • Mushtaq B, Saeed T, Situnayake RD, Murray PI. Adalimumab for sight-threatening uveitis in Behçet's disease. Eye (Lond) 2007;21(6):824-5
  • Perra D, Alba MA, Callejas JL, et al. Adalimumab for the treatment of Behçet's disease: experience in 19 patients. Rheumatology (Oxford) 2012;51(10):1825-31
  • Davatchi F, Shams H, Rezaipoor M, et al. Rituximab in intractable ocular lesions of Behçet's disease; randomized single-blind control study (pilot study). Int J Rheum Dis 2010;13(3):246-52
  • Sadreddini S, Noshad H, Molaeefard M, Noshad R. Treatment of retinal vasculitis in Behçet's disease with rituximab. Mod Rheumatol 2008;18(3):306-8
  • Hirano T, Ohguro N, Hohki S, et al. A case of Behçet's disease treated with a humanized anti-interleukin-6 receptor antibody. tocilizumab. Mod Rheumatol 2012;22(2):298-302
  • Dinarello CA, Simon A, van der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov 2012;11(8):633-52
  • Botsios C, Sfriso P, Furlan A, et al. Resistant Behçet disease responsive to anakinra. Ann Intern Med 2008;149(4):284-6
  • Cantarini L, Vitale A, Borri M, et al. Successful use of canakinumab in a patient with resistant Behçet's disease. Clin Exp Rheumatol 2012;30(3 Suppl 72):S115
  • Ugurlu S, Ucar D, Seyahi E, et al. Canakinumab in a patient with juvenile Behçet's syndrome with refractory eye disease. Ann Rheum Dis 2012;71(9):1589-91
  • Geiler J, McDermott MF. Gevokizumab, an anti-IL-1beta mAb for the potential treatment of type 1 and 2 diabetes, rheumatoid arthritis and cardiovascular disease. Curr Opin Mol Ther 2010;12(6):755-69
  • Owyang AM, Issafras H, Corbin J, et al. XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases. MAbs 2011;3(1):49-60
  • Gul A, Tugal-Tutkun I, Dinarello CA, et al. Interleukin-1beta-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behçet's disease: an open-label pilot study. Ann Rheum Dis 2012;71(4):563-6
  • Mege JL, Dilsen N, Sanguedolce V, et al. Overproduction of monocyte derived tumor necrosis factor alpha, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Behçet's disease. A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol 1993;20(9):1544-9
  • de Waal Malefyt R, Abrams J, Bennett B, et al. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174(5):1209-20
  • Fiorentino DF, Zlotnik A, Mosmann TR, et al. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991;147(11):3815-22
  • Blech M, Peter D, Fischer P, et al. One target-two different binding modes: structural insights into gevokizumab and canakinumab interactions to interleukin-1beta. J Mol Biol 2013;425(1):94-111
  • Roell MK, Issafras H, Bauer RJ, et al. Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity. J Biol Chem 2010;285(27):20607-14
  • Owyang AM, Maedler K, Gross L, et al. XOMA 052, an anti-IL-1{beta} monoclonal antibody, improves glucose control and {beta}-cell function in the diet-induced obesity mouse model. Endocrinology 2010;151(6):2515-27
  • Cavelti-Weder C, Babians-Brunner A, Keller C, et al. Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes. Diabetes Care 2012;35(8):1654-62
  • Donath MY, Weder C, Whitmore J, et al. XOMA 052, an anti-IL-10 antibody, in a double-blind, placebocontrolled, dose escalation study of the safety and pharmacokinetics in patients with type 2 diabetes mellitus - a new approach to therapy. Diabetologia 2008;51:S7-S
  • Lachmann HJ, Lowe P, Felix SD, et al. In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes. J Exp Med 2009;206(5):1029-36
  • Dinarello CA, Ikejima T, Warner SJ, et al. Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro. J Immunol 1987;139(6):1902-10

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