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Drug Profile

Imatinib mesylate for the treatment of chronic myeloid leukemia

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Pages 853-864 | Published online: 10 Jan 2014

References

  • Sawyers CL. Chronic myeloid leukemia. N. Engl. J. Med.340(17), 1330–1340 (1999).
  • Rowley JD. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature243(5405), 290–293 (1973).
  • Bartram CR, de Klein A, Hagemeijer A et al. Translocation of c-Abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature306, 277–280 (1983).
  • Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science247(4946), 1079–1082 (1990).
  • Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science247(4944), 824–830 (1990).
  • Garcia-Manero G, Faderl S, O’Brien S. Chronic myelogenous leukemia: a review and update of therapeutic strategies. Cancer98, 427–456 (2003).
  • Hehlmann R, Heimpel H, Hasford J et al. Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group. Blood82(2), 398–407 (1993).
  • Talpaz M, Kantarjian H, Kurzrock R, Trujillo JM, Gutterman JU. Interferon-a produces sustained cytogenetic responses in chronic myelogenous leukemia. Philadelphia chromosome-positive patients. Ann. Intern. Med.114(7), 532–538 (1991).
  • Hehlmann R, Heimpel H, Hasford J et al. Randomized comparison of interferon-a with busulfan and hydroxyurea in chronic myelogenous leukemia. The German CML Study Group. Blood84(12), 4064–4077 (1994).
  • Interferon α-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. The Italian Cooperative Study Group on Chronic Myeloid Leukemia. N. Engl. J. Med.330(12), 820–825 (1994).
  • Guilhot F, Chastang C, Michallet M et al. Interferon α-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia. French Chronic Myeloid Leukemia Study Group. N. Engl. J. Med.337(4), 223–229 (1997).
  • Baccarani M, Rosti G, de Vivo A et al. A randomized study of interferon-α versus interferon-α and low-dose arabinosyl cytosine in chronic myeloid leukemia. Blood99(5), 1527–1535 (2002).
  • Garcia-Manero G, Talpaz M, Giles FJ et al. Treatment of Philadelphia chromosome-positive chronic myelogenous leukemia with weekly polyethylene glycol formulation of interferon-α-2b and low-dose cytosine arabinoside. Cancer97(12), 3010–3016 (2003).
  • Kantarjian HM, Smith TL, O’Brien S, Beran M, Pierce S, Talpaz M. Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-a therapy. The Leukemia Service. Ann. Intern. Med.122(4), 254–261 (1995).
  • Bonifazi F, de Vivo A, Rosti G et al. Chronic myeloid leukemia and interferon-α: a study of complete cytogenetic responders. Blood98(10), 3074–3081 (2001).
  • Gratwohl A, Brand R, Apperley J et al. Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results. An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Haematologica91(4), 513–521 (2006).
  • Nagar B, Bornmann WG, Pellicena P et al. Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res.62(15), 4236–4243 (2002).
  • Schindler T, Bornmann W, Pellicena P, Miller WT, Clarkson B, Kuriyan J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science289(5486), 1938–1942 (2000).
  • Cowan-Jacob SW, Guez V, Fendrich G et al. Imatinib (STI571) resistance in chronic myelogenous leukemia: molecular basis of the underlying mechanisms and potential strategies for treatment. Mini Rev. Med. Chem.4(3), 285–299 (2004).
  • Shah NP, Nicoll JM, Nagar B et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell2(2), 117–125 (2002).
  • Druker BJ, Tamura S, Buchdunger E et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med.2(5), 561–566 (1996).
  • Gambacorti-Passerini C, le Coutre P, Mologni L et al. Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis. Blood Cells Mol. Dis.23(3), 380–394 (1997).
  • Deininger MW, Goldman JM, Lydon N, Melo JV. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood90(9), 3691–3698 (1997).
  • Cohen MH, Williams G, Johnson JR et al. Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin. Cancer Res.8(5), 935–942 (2002).
  • Druker BJ, Talpaz M, Resta DJ et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med.344(14), 1031–1037 (2001).
  • Peng B, Lloyd P, Schran H. Clinical pharmacokinetics of imatinib. Clin. Pharmacokinet.44(9), 879–894 (2005).
  • O’Brien SG, Guilhot F, Larson RA et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med.348(11), 994–1004 (2003).
  • Hahn EA, Glendenning GA, Sorensen MV et al. Quality of life in patients with newly diagnosed chronic phase chronic myeloid leukemia on imatinib versus interferon a plus low-dose cytarabine: results from the IRIS Study. J. Clin. Oncol.21(11), 2138–2146 (2003).
  • Druker BJ, Guilhot F, O’Brien SG et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med.355(23), 2408–2417 (2006).
  • Hochhaus A, Druker B, Larson RA, O’Brien SG, Gathmann I, Guilhot F. IRIS 6-year follow-up: sustained survival and declining annual rate of transformation in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib. 2007 ASH Annual Meeting (2007).
  • Gorre ME, Mohammed M, Ellwood K et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science293(5531), 876–880 (2001).
  • Hochhaus A, Kreil S, Corbin AS et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia16(11), 2190–2196 (2002).
  • von Bubnoff N, Schneller F, Peschel C, Duyster J. BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. Lancet359, 487–491 (2002).
  • Branford S, Rudzki Z, Walsh S et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood99(9), 3472–3475 (2002).
  • Soverini S, Martinelli G, Rosti G et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J. Clin. Oncol.23(18), 4100–4109 (2005).
  • Soverini S, Colarossi S, Gnani A et al. Contribution of ABL Kinase Domain Mutations to Imatinib Resistance in Different Subsets of Philadelphia-Positive Patients: By the GIMEMA Working Party on Chronic Myeloid Leukemia. Clin. Cancer Res.12(24), 7374–7379 (2006).
  • Kantarjian H, Talpaz M, O’Brien S et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia. Blood103(8), 2873–2878 (2004).
  • Castagnetti F, Amabile M, Palandri F et al. Imatinib high dose (800 mg) in intermediate sokal risk patients CML in chronic phase: results of a Phase II trial of the GIMEMA CML working party. Haematologica92(Suppl. 2), 205 (2007). (Abstract 0550)
  • Baccarani M, Castagnetti F, Porkka K et al. A prospective study of imatinib 400 mg vs 800 mg frontline in high risk Ph+ chronic myeloid leukemia (CML) patients. 2007 ASH Annual Meeting (2007).
  • Pye SM, Cortes J, Ault P et al. The effects of imatinib on pregnancy outcome. Blood (2008) (Epub ahead of print).
  • Reckmann AH, Fischer T, Peng B. Effect of food on STI571 (Glivec®) pharmacokinetics and bioavailability. Proc. Am. Soc. Clin. Oncol.20, 1223 (2002). (Abstract).
  • Deininger MW, O’Brien SG, Ford JM, Druker BJ. Practical management of patients with chronic myeloid leukemia receiving imatinib. J. Clin. Oncol.21(8), 1637–1647 (2003).
  • Hensley ML, Ford JM. Imatinib treatment: specific issues related to safety, fertility, and pregnancy. Semin. Hematol.40(2 Suppl. 2), 21–25 (2003).
  • Lindahl P, Johansson BR, Leveen P, Betsholz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science277, 242–245 (1997).
  • Hsiao LT, Chung HM, Lin JT et al. Stevens-Johnson syndrome after treatment with STI571: a case report. Br. J. Haematol.117(3), 620–622 (2002).
  • Etienne G, Cony-Makhoul P, Mahon FX. Imatinib mesylate and gray hair. N. Engl. J. Med.347(6), 446 (2002).
  • Kerkela R, Grazette L, Yacobi R et al. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat. Med.12(8), 908–916 (2006).
  • Rosti G, Martinelli G, Baccarani M. In reply to ‘Cardiotoxicity of the cancer therapeutic agent imatinib mesylate’. Nat. Med.13(1), 15–16 (2007).
  • Hatfield A, Owen S, Pilot PR. In reply to ‘Cardiotoxicity of the cancer therapeutic agent imatinib mesylate’. Nat. Med.13(1), 13, 15–16 (2007).
  • Gambacorti-Passerini C, Tornaghi L, Franceschino A, Piazza R, Corneo G, Pogliani E. In reply to ‘Cardiotoxicity of the cancer therapeutic agent imatinib mesylate’. Nat. Med.13(1), 13–16 (2007).
  • Atallah E, Kantarjian H, Cortes J. In reply to ‘Cardiotoxicity of the cancer therapeutic agent imatinib mesylate’. Nat. Med.13(1), 14–16 (2007).
  • Atallah E, Durand JB, Kantarjian H, Cortes J. Congestive heart failure is a rare event in patients receiving imatinib therapy. Blood110(4), 1233–1237 (2007).
  • Lloyd-Jones DM, Larson MG, Leip EP et al. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation106(24), 3068–3072 (2002).
  • Talpaz M, Silver RT, Druker BJ et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a Phase II study. Blood99(6), 1928–1937 (2002).
  • Sawyers CL, Hochhaus A, Feldman E et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a Phase II study. Blood99(10), 3530–3539 (2002).
  • Petzer AL, Eaves CJ, Lansdorp PM, Ponchio L, Barnett MJ, Eaves AC. Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia. Blood88(6), 2162–2171 (1996).
  • Branford S, Seymour JF, Grigg A et al. BCR-ABL messenger RNA levels continue to decline in patients with chronic phase chronic myeloid leukemia treated with imatinib for more than 5 years and approximately half of all first-line treated patients have stable undetectable BCR-ABL using strict sensitivity criteria. Clin. Cancer Res.13(23), 7080–7085 (2007).
  • Rousselot P, Huguet F, Rea D et al. Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years. Blood109(1), 58–60 (2007).
  • La Rosee P, Corbin AS, Stoffregen EP, Deininger MW, Druker BJ. Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571). Cancer Res.62(24), 7149–7153 (2002).
  • Wisniewski D, Lambek CL, Liu C et al. Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Cancer Res.62(15), 4244–4255 (2002).
  • Golas JM, Arndt K, Etienne C et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res.63(2), 375–381 (2003).
  • von Bubnoff N, Veach DR, Miller WT et al. Inhibition of wild-type and mutant Bcr-Abl by pyrido-pyrimidine-type small molecule kinase inhibitors. Cancer Res.63(19), 6395–6404 (2003).
  • Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science305(5682), 399–401 (2004).
  • O’Hare T, Pollock R, Stoffregen EP et al. Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. Blood104(8), 2532–2539 (2004).
  • Golemovic M, Verstovsek S, Giles F et al. AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia. Clin. Cancer Res.11(13), 4941–4947 (2005).
  • O’Hare T, Walters DK, Stoffregen EP et al.In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res.65(11), 4500–4505 (2005).
  • Kimura S, Naito H, Segawa H et al. NS-187, a potent and selective dual Bcr–Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia. Blood106(12), 3948–3954 (2005).
  • Wolff NC, Veach DR, Tong WP, Bornmann WG, Clarkson B, Ilaria RL Jr. PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemia. Blood105(10), 3995–4003 (2005).
  • Gumireddy K, Baker SJ, Cosenza SC et al. A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance. Proc. Natl Acad. Sci. USA102(6), 1992–1997 (2005).
  • Naito H, Kimura S, Nakaya Y et al.In vivo antiproliferative effect of NS-187, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor, on leukemic cells harbouring Abl kinase domain mutations. Leuk. Res.30(11), 1443–1446 (2006).
  • Puttini M, Coluccia AM, Boschelli F et al.In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells. Cancer Res.66(23), 11314–11322 (2006).
  • Cortes J, Rousselot P, Kim DW et al. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood109(8), 3207–3213 (2007).
  • Talpaz M, Shah NP, Kantarjian H et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N. Engl. J. Med.354(24), 2531–2541 (2006).
  • Hochhaus A, Kantarjian HM, Baccarani M et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic phase chronic myeloid leukemia after failure of imatinib therapy. Blood109(6), 2303–2309 (2007).
  • Guilhot F, Apperley J, Kim DW et al. Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase. Blood109(10), 4143–4150 (2007).
  • Kantarjian H, Giles F, Wunderle L et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N. Engl. J. Med.354(24), 2542–2551 (2006).
  • Gambacorti-Passerini C, Gasser M, Ahmed S, Assouline S, Scapozza L. Abl inhibitor BMS354825 binding mode in Abelson kinase revealed by molecular docking studies. Leukemia19(7), 1267–1269 (2005).
  • O’Hare T, Walters DK, Deininger MW, Druker BJ. AMN107: tightening the grip of imatinib. Cancer Cell7(2), 117–119 (2005).
  • Druker BJ, Sawyers CL, Kantarjian H et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med.344(14), 1038–1042 (2001).
  • Kantarjian HM, Talpaz M, O’Brien S et al. Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-α: follow-up results. Clin. Cancer Res.8(7), 2177–2187 (2002).
  • Ottmann OG, Druker BJ, Sawyers CL et al. A Phase II study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood100(6), 1965–1971 (2002).

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