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Transcriptomics in cancer diagnostics: developments in technology, clinical research and commercialization

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References

  • Papers of special note have been highlighted as:
  • * of interest
  • ** of considerable interest
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** A detailed review focused on the role of gene expression profiling in lung cancer as a predictive and prognostic biomarker.

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**A review of the current state of the art of single-cell expression profiling.

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*A review summarizing the methodology, analytical and clinical validation of various prognosis/predictive tests for early breast cancer.

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*A study identifying potential biomarkers for metastatic breast cancer.

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*A comparison of the gene expression profile of typical and atypical lung carcinoids to find diagnostic markers.

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*A review of the 12-gene Recurrence Score assay for colon cancer patients.

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*An analysis of whether a transcriptomic profile can be reliably obtained from a single cell using commercially available technology.

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*A report validating the analytical performance of the Oncotype DX Prostate Cancer Assay using predefined acceptance criteria.

**An article arguing that the molecular diagnostics industry would benefit from increased FDA regulation.

** A report evaluating the cost effectiveness of recurrence score-guided treatment using 2 commercially available GEP tests, Oncotype DX and MammaPrint.

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*An article evaluating the boom of “-omics” fields of study.

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*This report discusses the feasibility of accurate, multiclass molecular cancer classification with suggestions for future clinical implementation of molecular cancer diagnostics.

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