117
Views
19
CrossRef citations to date
0
Altmetric
Special Report

Tumor M2 pyruvate kinase: a tumor marker and its clinical application in gastrointestinal malignancy

&
Pages 579-585 | Published online: 09 Jan 2014

References

  • Eigenbrodt E, Reinacher M, Scheefers Borchel U, Scheefers H, Friis RR. Double role of pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. In: Critical Reviews in Oncogenesis. Perucho M (Ed.). CRC Press, FL, USA, 91–115 (1992).
  • Staal GEJ, Rijksen G. Pyruvate kinase in selected human tumors. In: Biochemical and Molecular Aspects of Selected Cancers. Pretlow TG, Pretlow TP (Eds). Academic Press, CA, USA, 313–337 (1991).
  • Mazurek S, Hugo F, Boschek CB, Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin. Cancer Biol.15, 300–308 (2005).
  • Paus E, Myklebust AT. Expression and interconversion of neuron-specific enolase in patient sera and extracts from small-cell lung cancer. Tumour Biol.17, 271–280 (1996).
  • Mazurek S, Eigenbrodt E, Failing K, Steinberg P. Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells. J. Cell Physiol.181, 136–146 (1999).
  • Eigenbrodt E, Glossmann H. Glycolysis – one of the keys to cancer? Trends Pharmacol. Sci1, 240–245 (1980).
  • Mazurek S, Boschek CB, Eigenbrodt E. The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy. J. Bioenerg. Biomembr.29, 315–330 (1997).
  • Eigenbrodt E, Mazurek S, Friis RR. Double role of pyruvate kinase type M2 in the regulation of phosphometabolite pools. In: Cell Growth and Oncogenesis. Bannasch P, Kanduc D, Papa S, Tager JM (Eds). Birkhäuser Verlag, Basel, Germany 15–30 (1998).
  • Oremek GM, Gerstmeier F, Sauer-Eppel H et al. Pre-analytical problems in the measurement or tumor type pyruvate kinase (Tumor M2-PK). Anticancer Res.23, 1127–1130 (2003).
  • Oremek GM, Muller R, Sapoutzis N et al. Pyruvate kinase type tumor M2 plasma levels in patients with rheumatic diseases. Anticancer Res.23, 1131–1134 (2003).
  • Oremek GM, Rutner F, Sapoutzis N et al. Tumor marker pyruvate kinase type tumor M2 in patients suffering from diabetic nephropathy. Anticancer Res.23, 1155–1158 (2003).
  • McDowell G, Gupta S, Dellerba M et al. Plasma concentrations of tumour dimeric pyruvate kinase are increased in patients with chronic cardiac failure. Ann. Clin. Biochem.41, 491–493 (2004).
  • Hardt PD, Ngoumou BK, Rupp J et al. Tumor M2-pyruvate kinase: a promising tumor marker in the diagnosis of gastro-intestinal cancer. Anticancer Res.20, 4965–4968 (2000).
  • Ventrucci M, Cipolla A, Racchine C et al. Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer. Dig. Dis. Sci.49, 1149–1155 (2004).
  • Oehler R, Weingartmann G, Manhart N et al. Polytrauma induces increased expression of pyruvate kinase in neutrophils. Blood95, 1086–1092 (2000).
  • Oremek GM, Eigenbrodt E, Radle J et al. Value of the serum level of the tumor marker TUM2-PK in pancreatic cancer. Anticancer Res.17, 3031–3033 (1997).
  • Cerwenka H, Aigner R, Bacher H et al. TUM2-PK (pyruvate type tumor M2), CA19-9 and CEA in patients with benign, malignant and metastasizing pancreatic lesions. Anticancer Res.19, 849–852 (1999).
  • Kumar Y, Gurusamy K, Pamecha V, Davidson BR. Tumor M2-pyruvate kinase as tumor marker in exocrine pancreatic cancer a meta-analysis. Pancreas35(2), 114–119 (2007).
  • Schulze G. The tumor marker Tumor M2-PK: an application in the diagnosis of gastrointestinal cancer. Anticancer Res.20, 4961–4964 (2000).
  • Schneider J, Schulze G. Comparison of tumor M2-pyruvate kinase (Tumor M2-PK), carcinoembryogenic antigen (CEA), carbohydrate antigens CA19-9 and CA72-4 in the diagnosis of gastrointestinal cancer. Anticancer Res.23, 5089–5094 (2003).
  • Kim CW, Kim JI, Park SH et al. Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer. Korean J. Gastroenterol.42, 387–393 (2003).
  • Zhang B, Chen JY, Chen DD et al. Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls. World J. Gastroenterol.10, 1643–1646 (2004).
  • Kumar Y, Tapuria N, Kirmani N, Davidson BR. Tumor M2-pyruvate kinase: a gastrointestinal cancer marker. Eur. J. Gastroenetrol. Hepatol.19(3), 265–276 (2007).
  • Lamerz R. SCCA (sqamous cell carcinoma antigen). In: Labor und Diagnose. Thomas L (Ed.). TH-Books Verlagsgesellschaft mbH, Frankfurt, Germany 1351–1355 (2005).
  • Lamerz R. CA 19-9, GICA (gastrointestinal cancer antigen). In: Labor und Diagnose. Thomas L (Ed.). TH-Books Verlagsgesellschaft mbH, Frankfurt, Germany 1302–1305 (2005).
  • Lamerz R. CA 72-4 (TAG-72). In: Labor und Diagnose. Thomas L (Ed.). TH-Books Verlagsgesellschaft mbH, Frankfurt, Germany 1310–1313 (2005).
  • Goonetilleke KS, Mason JM, Siriwardana P, King NK, France MW, Siriwardena AK. Diagnostic and prognostic value of plasma tumor M2 pyruvate kinase in periampullary cancer: evidence for a novel biological marker of adverse prognosis. Pancreas34(3), 318–324 (2007).
  • Pinedo R, Faroq R, Davidson BR. Tumour M2-PK: comparative study of the value of tumour markers in the diagnosis of colorectal liver metastasis. Gut54(2), A29 (2005).
  • Schneider J, Bitterlich N, Schulze G. Improved sensitivity in the diagnosis of gastro-intestinal tumors by fuzzy logic based tumor marker profiles including the Tumor M2-PK. Anticancer Res.25, 1507–1516 (2005).
  • Guittet L, Bouvier V, Mariotte N et al. Comparison of a Guaiac based and an immunochemical faecal occult blood test in screening for colorectal cancer in a general average risk population. Gut56, 210–214 (2007).
  • Hardt PD, Toepler M, Ngoumou B et al. Measurement of fecal pyruvate kinase type M2 (Tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls. Anticancer Res.23, 851–854 (2003).
  • Hardt PD, Mazurek S, Toepler M et al. Faecal tumor M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer. Br. J. Cancer91, 980–984 (2004).
  • Naumann M, Schaum B, Oremek GM et al. Pyruvatkinase typ M2 (M2-PK) im stuhl – ein valider screeningparameter für kolorektale neoplasien? Dtsch. Med. Wochenschr.129, 1806–1807 (2004).
  • Vogel T, Driemel C, Hauser A et al. Vergleich verschiedener stuhltests zur detektion von neoplasien des kolon. Dtsch. Med. Wochenschr.130, 872–877 (2005).
  • Koss K, Maxton D, Jankowski J. The potential use of fecal dimeric M2 pyruvate kinase (tumour M2PK) in screening for colorectal cancer. Gut54(Suppl. 2), A20 (2005).
  • Tonus C, Neupert G, Sellinger M. Colorectal cancer screening by non-invasive metabolic biomarker fecal Tumor M2-PK. World J. Gastroenterol.12, 7007–7011 (2006).
  • Shastri YM, Naumann M, Oremek GM et al. Prospective multicenter evaluation of fecal tumor pyruvate kinase type M2 (M2-PK) as a screening biomarker for colorectal neoplasia. Int. J. Cancer119, 2651–2656 (2006).
  • Mulder SA, van Leerdam ME, van Vuuren AJ et al. Pyruvate kinase isoenzyme type M2 and immunochemical fecal occult blood test: performance in screening for colorectal cancer. Eur. J. Gastroenterol. Hepatol.19(10), 878–882 (2007).
  • Haug U, Rothenbacher D, Wente MN, Seiler CM, Stegmaier C, Brenner H. Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients. Br. J. Cancer96(9), 1329–1334 (2007).
  • Koss K, Maxton D, Jankowski JA. Faecal dimeric M2 pyruvate kinase in colorectal cancer and polyps correlates with tumour staging and surgical intervention. Colorectal Dis.10(3), 244–248 (2008).
  • Alquist DA, McGill DB, Schwartz S, Taylor WF, Owen RA. Fecal blood levels in health and disease. N. Engl. J. Med.312, 1422–1428 (1985).
  • Towler BP, Irwig L, Glasziou P, Weller D, Kewenter J. Screening for colorectal cancer using the faecal occult blood test, Hemoccult. Cochrane Database Syst. Rev.2, CD001216 (1998).
  • Macrae FA, St John DJ. Relationship between patterns of bleeding and Haemoccult sensitivity in patients with colorectal cancers or adenomas. Gastroenterology82, 891–898 (1982).
  • Mandel JS, Bond JH, Church TR et al. Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N. Engl. J. Med.328, 1365–1371 (1993).
  • Mandel JS, Church TR, Ederer F, Bond JH. Colorectal cancer mortality: effectiveness of biennial screening for fecal occult blood. J. Natl Cancer Inst.91, 434–437 (1999).
  • Kronborg O, Fenger C, Olsen J, Jorgensen OD, Sondergaard O. Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet348, 1467–1471 (1996).
  • Jorgensen OD, Kronborg O, Fenger C. A randomised study of screening for colorectal cancer using faecal occult blood testing: results after 13 years and seven biennial screening rounds. Gut50, 29–32 (2002).
  • Hardcastle JD, Chamberlain JO, Robinson MH et al. Randomised controlled trial of faecal occult- blood screening for colorectal cancer. Lancet348, 1472–1477 (1996).
  • Mandel JS, Church TR, Bond JH et al. The effect of fecal occult-blood screening on the incidence of colorectal cancer. N. Engl. J. Med.343, 1603–1607 (2000).
  • Davies RJ, Miller R, Coleman N. Colorectal cancer screening: prospects for molecular stool analysis? Nat. Rev. Cancer5(3), 199–209 (2005).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.