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HIV-1 rational vaccine design: molecular details of b12–gp120 complex structure

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Pages 319-321 | Published online: 09 Jan 2014

References

  • Zhou T, Xu L, Dey B et al. Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature445(7129), 732–737 (2007).
  • Burton DR, Barbas CF 3rd, Persson MA et al. A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc. Natl Acad. Sci. USA88(22), 10134–10137 (1991).
  • Burton DR, Pyati J, Koduri R et al. Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. Science266(5187), 1024–1027 (1994).
  • Parren PW, Ditzel HJ, Gulizia RJ et al. Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site. AIDS9(6), F1–F6 (1995).
  • Posner MR, Cavacini LA, Emes CL et al. Neutralization of HIV-1 by F105, a human monoclonal antibody to the CD4 binding site of gp120. J. Acquir. Immune Defic. Syndr.6(1), 7–14 (1993).
  • Roben P, Moore JP, Thali M et al. Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1. J. Virol.68(8), 4821–4828 (1994).
  • Pantophlet R, Ollmann Saphire E, Poignard P et al. Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120. J. Virol.77(1), 642–658 (2003).
  • Burton DR, Stanfield RL, Wilson IA. Antibody vs. HIV in a clash of evolutionary titans. Proc. Natl Acad. Sci. USA102(42), 14943–14948 (2005).
  • Burton DR, Desrosiers RC, Doms RW et al. HIV vaccine design and the neutralizing antibody problem. Nat. Immunol.5(3), 233–236 (2004).
  • Douek DC, Kwong PD, Nabel GJ. The rational design of an AIDS vaccine. Cell124(4), 677–681 (2006).
  • Phogat S and Wyatt R. Rational modifications of HIV-1 envelope glycoproteins for immunogen design. Curr. Pharm. Des.13(2), 213–227 (2007).
  • Nishimura Y, Igarashi T, Haigwood NL et al. Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: implications for HIV-1 vaccine development. Proc. Natl Acad. Sci. USA100(25), 15131–15136 (2003).
  • Veazey RS, Shattock RJ, Pope M et al. Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120. Nat. Med.9(3), 343–346 (2003).
  • Mascola JR, Stiegler G, VanCott TC et al. Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nat. Med.6(2), 207–210 (2000).
  • Parren PW, Marx PA, Hessell AJ et al. Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro.J. Virol.75(17), 8340–8347 (2001).
  • Ofek G, Tang M, Sambor A et al. Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope. J. Virol.78(19), 10724–10737 (2004).
  • Cardoso RM, Brunel FM, Ferguson S et al. Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10. J. Mol. Biol.365(5), 1533–1544 (2007).
  • Cardoso RM, Zwick MB, Stanfield RL et al. Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. Immunity22(2), 163–173 (2005).
  • Calarese DA, Lee HK, Huang CY et al. Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. Proc. Natl Acad. Sci. USA102(38), 13372–13377 (2005).
  • Calarese DA, Scanlan CN, Zwick MB et al. Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science300(5628), 2065–2071 (2003).

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