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Review

Progress in the development of genetic immunization

Pages 1395-1404 | Published online: 09 Jan 2014

References

  • Cohen SN, Chang AC, Boyer HW, Helling B. Construction of biologically functional bacterial plasmids in vitro. Proc. Natl Acad. Sci. USA70(11), 3240–3244 (1973).
  • Crea R, Kraszewski A, Hirose T, Itakura K. Chemical synthesis of genes for human insulin. Proc. Natl Acad. Sci. USA75(12), 5765–5769 (1978).
  • Jonczyk A, Keefer LM, Naithani VK, Gattner HG, De Meyts P, Zahn H. Preparation and biological properties of human insulin. Hoppe Seylers Z. Physiol. Chem.362(5), 557–561 (1981).
  • Keefer LM, Piron MA, De Meyts P. Human insulin prepared by recombinant DNA techniques and native human insulin interact identically with insulin receptors. Proc. Natl Acad. Sci. USA78(3), 1391–1395 (1981).
  • Smith KA, Nelson PN, Warren P, Astley SJ, Murray PG, Greenman J. Demystified…recombinant antibodies. J. Clin. Pathol.57(9), 912–917 (2004).
  • Gill P, Jeffreys AJ, Werrett DJ. Forensic application of DNA ‘fingerprints’. Nature318(6046), 577–579 (1985).
  • Panicali D, Paoletti E. Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus. Proc. Natl Acad. Sci. USA79(16), 4927–4931 (1982).
  • Panicali D, Davis SW, Weinberg RL, Paoletti E. Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin. Proc. Natl Acad. Sci. USA80(17), 5364–5368 (1983).
  • McAleer WJ, Buynak EB, Maigetter RZ, Wampler DE, Miller WJ, Hilleman MR. Human hepatitis B vaccine from recombinant yeast. Nature307(5947), 178–180 (1984).
  • McAleer WJ, Markus HZ, Wampler DE et al. Vaccine against human hepatitis B virus prepared from antigen derived from human hepatoma cells in culture. Proc. Soc. Exp. Biol. Med.175(3), 314–319 (1984).
  • McKee AS, Munks MW, Marrack P. How do adjuvants work? Important considerations for new generation adjuvants. Immunity27(5), 687–690 (2007).
  • Grandi G. Antibacterial vaccine design using genomics and proteomics. Trends Biotechnol.19(5), 181–188 (2001).
  • Ward JI, Cherry JD, Chang S-J et al. Efficacy of an acellular pertussis vaccine among adolescents and adults. N. Engl. J. Med.353(15), 1555–1563 (2005).
  • Steere AC, Sikand VK, Meurice F et al. Vaccination against lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein a with adjuvant. N. Engl. J. Med.339(4), 209–215 (1998).
  • Tang DC, DeVit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature356(6365), 152–154 (1992).
  • Lu S, Wang S, Grimes-Serrano JM. Current progress of DNA vaccine studies in humans. Expert Rev. Vaccines7(2), 175–191 (2008).
  • Horner AA, Datta SK, Takabayashi K et al. Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites. J. Immunol.167(3), 1584–1591 (2001).
  • Barfoed AM, Blixenkrone-Moller M, Jensen MH, Botner A, Kamstrup S. DNA vaccination of pigs with open reading frame 1–7 of PRRS virus. Vaccine22(27–28), 3628–3641 (2004).
  • Donnelly J, Berry K, Ulmer JB. Technical and regulatory hurdles for DNA vaccines. Int. J. Parasitol.33(5–6), 457 (2003).
  • Babiuk LA, Babiuk SL, Loehr BI, van Drunnen Littel-van den H. Nucleic acid vaccines: research tool or commercial reality. Vet. Immunol. Immunopathol.76(1–2), 1–23 (2000).
  • Barry MA, Lai WC, Johnston SA. Protection against mycoplasma infection using expression-library immunization. Nature377(6550), 632–635 (1995).
  • Forde GM. Rapid-response vaccines: does DNA offer a solution? Nat. Biotech.23(9), 1059 (2005).
  • Jones WE. What’s news. J. Equine Vet. Sci.24(1), 9–13 (2004).
  • Corbeil S, Kurath G, Lapatra SE. Fish DNA vaccine against infectious hematopoietic necrosis virus: efficacy of various routes of immunisation. Fish Shellfish Immunol.10(8), 711–723 (2000).
  • Powell K. DNA vaccines – back in the saddle again? Nat. Biotechnol.22(7), 799–801 (2004).
  • Donnelly JJ, Ulmer JB, Liu MA. DNA vaccines. Dev. Biol. Stand.95, 43–53 (1998).
  • Fernandez-Borges N, Brun A, Whitton JL et al. DNA vaccination can break immunological tolerance to prp in wild-type mice and attenuates prion disease after intracerebral challenge. J. Virol.80(20), 9970–9976 (2006).
  • Manickan E, Yu Z, Rouse BT. DNA immunization of neonates induces immunity despite the presence of maternal antibody. J. Clin. Invest.100(9), 2371–2375 (1997).
  • Hassett DE, Zhang J, Slifka M, Whitton JL. Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization. J. Virol.74(6), 2620–2627 (2000).
  • Li BW, Rush A, Zhang SR, Curtis KC, Weil GJ. Antibody responses to Brugia malayi antigens induced by DNA vaccination. Filaria J.3(1), 1 (2004).
  • Grifantini R, Finco O, Bartolini E et al. Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid. Eur. J. Immunol.28(4), 1225–1232 (1998).
  • Wizemann TM, Heinrichs JH, Adamou JE et al. Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection. Infect. Immun.69(3), 1593–1598 (2001).
  • Piedrafita D, Xu DM, Hunter D, Harrison RA, Liew FY. Protective immune responses induced by vaccination with an expression genomic library of Leishmania major. J. Immunol.163(3), 1467–1472 (1999).
  • Manoutcharian K, Terrazas LI, Gevorkian G, Govezensky T. Protection against murine cysticercosis using cDNA expression library immunization. Immunol. Lett.62(3), 131–136 (1998).
  • Brayton KA, Vogel SW, Allsopp BA. Expression library immunization to identify protective antigens from Cowdria ruminantium. Ann. NY Acad. Sci.849, 369–371 (1998).
  • Alberti E, Acosta A, Sarmiento ME et al. Specific cellular and humoral immune response in BALB/c mice immunised with an expression genomic library of Trypanosoma cruzi. Vaccine16(6), 608–612 (1998).
  • Stemke-Hale K, Kaltenboeck B, DeGraves FJ et al. Screening the whole genome of a pathogen in vivo for individual protective antigens. Vaccine23(23), 3016–3025 (2005).
  • Mwau M, Cebere I, Sutton J et al. A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans. J. Gen. Virol.85(Pt 4), 911–919 (2004).
  • MacGregor RR, Boyer JD, Ugen KE et al. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response. J. Infect. Dis.178(1), 92–100 (1998).
  • Wang R, Doolan DL, Le TP et al. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science282(5388), 476–480 (1998).
  • Borgne SL, Michel ML, Camugli S, Corre B, Le Grand R, Riviere Y. Expansion of HBV-specific memory CTL primed by dual HIV/HBV genetic immunization during SHIV primary infection in rhesus macaques. Vaccine19(17–19), 2485–2495 (2001).
  • Locher CP, Sykes KF, Blackbourn DJ, Johnston SA. Immune responses in baboons vaccinated with HIV-2 genetic expression libraries. J. Med. Primatol.31(6), 323–329 (2002).
  • Sullivan NJ, Sanchez A, Rollin PE, Yang ZY, Nabel GJ. Development of a preventive vaccine for Ebola virus infection in primates. Nature408(6812), 605–609 (2000).
  • Ugen KE, Nyland SB, Boyer JD et al. DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans. Vaccine16(19), 1818–1821 (1998).
  • Calarota S, Bratt G, Nordlund S et al. Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients. Lancet351(9112), 1320–1325 (1998).
  • Kumar S, Villinger F, Oakley M et al. A DNA vaccine encoding the 42 kDa C-terminus of merozoite surface protein 1 of Plasmodium falciparum induces antibody, interferon-γ and cytotoxic T cell responses in rhesus monkeys: immuno-stimulatory effects of granulocyte macrophage-colony stimulating factor. Immunol. Lett.81(1), 13–24 (2002).
  • Bhardwaj D, Hora B, Singh N et al. Immunogenicity and protective efficacy of three DNA vaccines encoding pre-erythrocytic- and erythrocytic-stage antigens of Plasmodium cynomolgi in rhesus monkeys. FEMS Immunol. Med. Microbiol.34(1), 33–43 (2002).
  • Satkauskas S, Bureau MF, Mahfoudi A, Mir LM. Slow accumulation of plasmid in muscle cells: supporting evidence for a mechanism of DNA uptake by receptor-mediated endocytosis. Mol. Ther.4(4), 317–323 (2001).
  • Cox GJ, Zamb TJ, Babiuk LA. Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA. J. Virol.67(9), 5664–5667 (1993).
  • Armaleo D, Ye GN, Klein TM, Shark KB, Sanford JC, Johnston SA. Biolistic nuclear transformation of Saccharomyces cerevisiae and other fungi. Curr. Genet.17(2), 97–103 (1990).
  • Tree JA, Bembridge G, Hou S et al. An assessment of different DNA delivery systems for protection against respiratory syncytial virus infection in the murine model: gene gun delivery induces IgG in the lung. Vaccine22(19), 2438–2443 (2004).
  • Haynes JR. Particle-mediated DNA vaccine delivery to the skin. Expert Opin. Biol. Ther.4(6), 889–900 (2004).
  • Hayes SC, World MJ. Adverse reactions to anthrax immunisation in a military field hospital. J. R. Army Med. Corps.146(3), 191–195 (2000).
  • Hooper JW, Custer DM, Thompson E, Schmaljohn CS. DNA vaccination with the Hantaan virus M gene protects hamsters against three of four HFRS hantaviruses and elicits a high-titer neutralizing antibody response in rhesus monkeys. J. Virol.75(18), 8469–8477 (2001).
  • Fuller DH, Corb MM, Barnett S, Steimer K, Haynes JR. Enhancement of immunodeficiency virus-specific immune responses in DNA-immunized rhesus macaques. Vaccine15(8), 924 (1997).
  • Horton H, Vogel TU, Carter DK et al. Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239. J. Virol.76(14), 7187–7202 (2002).
  • Fuller DH, Simpson L, Cole KS et al. Gene gun-based nucleic acid immunization alone or in combination with recombinant vaccinia vectors suppresses virus burden in rhesus macaques challenged with a heterologous SIV. Immunol. Cell. Biol.75(4), 389–396 (1997).
  • Drape RJ, Macklin MD, Barr LJ, Jones S, Haynes JR, Dean HJ. Epidermal DNA vaccine for influenza is immunogenic in humans. Vaccine24(21), 4475–4481 (2006).
  • Chen D, Zuleger C, Chu Q, Maa Y-F, Osorio J, Payne LG. Epidermal power immunizations with a recombinant HIV gp120 targets Lagerhans cells and induces enhanced immune responses. AIDS Res. Hum. Retroviruses18(10), 715–722 (2002).
  • Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl Acad. Sci. USA90(24), 11478–11482 (1993).
  • Bennett AM, Phillpotts RJ, Perkins SD, Jacobs SC, Williamson ED. Gene gun mediated vaccination is superior to manual delivery for immunisation with DNA vaccines expressing protective antigens from Yersinia pestis or Venezuelan equine encephalitis virus. Vaccine18(7–8), 588–596 (1999).
  • Glenn GM, Kenney RT, Ellingsworth LR, Frech SA, Hammond SA, Zoeteweij JP. Transcutaneous immunization and immunostimulant strategies: capitalizing on the immunocompetence of the skin. Expert Rev. Vaccines2(2), 253–267 (2003).
  • Somiari S, Glasspool-Malone J, Drabick JJ et al. Theory and in vivo application of electroporative gene delivery. Mol. Ther.2(3), 178–187 (2000).
  • Donnelly JJ, Ulmer JB, Shiver JW, Liu MA. DNA vaccines. Annu. Rev. Immunol.15, 617–648 (1997).
  • Gronevik E, Mathiesen I, Lomo T. Early events of electroporation-mediated intramuscular DNA vaccination potentiate Th1-directed immune responses. J. Gene. Med.7(9), 1246–1254 (2005).
  • Widera G, Austin M, Rabussay D et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J. Immunol.164(9), 4635–4640 (2000).
  • Luckay A, Sidhu MK, Kjeken R et al. Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques. J. Virol.81(10), 5257–5269 (2007).
  • Porgador A, Irvine KR, Iwasaki A, Barber BH, Restifo NP, Germain RN. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J. Exp. Med.188(6), 1075–1082 (1998).
  • He Y, Zhang J, Donahue C, Falo LD Jr. Skin-derived dendritic cells induce potent CD8+ T cell immunity in recombinant lentivector-mediated genetic immunization. Immunity24(5), 643–656 (2006).
  • Timares L, Takashima A, Johnston SA. Quantitative analysis of the immunopotency of genetically transfected dendritic cells. Proc. Natl Acad. Sci. USA95(22), 13147–13152 (1998).
  • Klinman DM, Sechler JM, Conover J, Gu M, Rosenberg AS. Contribution of cells at the site of DNA vaccination to the generation of antigen-specific immunity and memory. J. Immunol.160(5), 2388–2392 (1998).
  • Nchinda G, Kuroiwa J, Oks M et al. The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells. J. Clin. Invest.118(4), 1427–1436 (2008).
  • Barry MA, Johnston SA. Biological features of genetic immunization. Vaccine15(8), 788–791. (1997).
  • Ivory C, Chadee K. DNA vaccines: designing strategies against parasitic infections. Genet. Vaccines Ther.2(1), 17 (2004).
  • Brandler P, Saikh KU, Heath D, Friedlander A, Ulrich RG. Weak anamnestic responses of inbred mice to Yersinia F1 genetic vaccine are overcome by boosting with F1 polypeptide while outbred mice remain nonresponsive. J. Immunol.161(8), 4195–4200 (1998).
  • Bennett AM, Lescott T, Phillpotts RJ, Mackett M, Titball RW. Recombinant vaccinia viruses protect against Clostridium perfringens α-toxin. Viral Immunol.12(2), 97–105 (1999).
  • Grosfeld H, Cohen S, Bino T et al. Effective protective immunity to Yersinia pestis infection conferred by DNA vaccine coding for derivatives of the F1 capsular antigen. Infect. Immun.71(1), 374–383 (2003).
  • Williamson ED, Bennett AM, Perkins SD, Beedham RJ, Miller J, Baillie LW. Co-immunisation with a plasmid DNA cocktail primes mice against anthrax and plague. Vaccine20(23–24), 2933–2941 (2002).
  • Garmory HS, Freeman D, Brown KA, Titball RW. Protection against plague afforded by immunisation with DNA vaccines optimised for expression of the Yersinia pestis V antigen. Vaccine22(8), 947–957 (2004).
  • Pashine A, Valiante NM, Ulmer JB. Targeting the innate immune response with improved vaccine adjuvants. Nat. Med.11(4 Suppl.), S63–68 (2005).
  • Williman J, Lockhart E, Slobbe L, Buchan G, Baird M. The use of Th1 cytokines, IL-12 and IL-23, to modulate the immune response raised to a DNA vaccine delivered by gene gun. Vaccine24(21), 4471–4474 (2006).
  • Barouch DH, Letvin NL, Seder RA. The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responses. Immunol. Rev.202(1), 266–274 (2004).
  • Khan CM, Villarreal-Ramos B, Pierce RJ et al. Construction, expression, and immunogenicity of multiple tandem copies of the Schistosoma mansoni peptide 115–131 of the P28 glutathione S-transferase expressed as C-terminal fusions to tetanus toxin fragment C in a live aro-attenuated vaccine strain of Salmonella. J. Immunol.153(12), 5634–5642 (1994).
  • Arrington J, Braun RP, Dong L et al. Plasmid vectors encoding cholera toxin or the heat-labile enterotoxin from Escherichia coli are strong adjuvants for DNA vaccines. J. Virol.76(9), 4536–4546 (2002).
  • Ballard JD, Collier RJ, Starnbach MN. Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo. Proc. Natl Acad. Sci. USA93(22), 12531–12534 (1996).
  • Carbonetti NH, Irish TJ, Chen CH et al. Intracellular delivery of a cytolytic T-lymphocyte epitope peptide by pertussis toxin to major histocompatibility complex class I without involvement of the cytosolic class I antigen processing pathway. Infect. Immun.67(2), 602–607 (1999).
  • Garmory HS, Brown KA, Titball RW. DNA vaccines: improving expression of antigens. Genet. Vaccines Ther.1(1), 2 (2003).
  • Xiang Z, Ertl HC. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity2(2), 129–135 (1995).
  • Harcourt JL, Brown MP, Anderson LJ, Tripp RA. CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c mice. Vaccine21(21–22), 2964–2979 (2003).
  • Jiang C, Magee DM, Cox RA. Coadministration of interleukin 12 expression vector with antigen 2 cDNA enhances induction of protective immunity against Coccidioides immitis. Infect. Immun.67(11), 5848–5853 (1999).
  • Sasaki S, Amara RR, Yeow WS, Pitha PM, Robinson HL. Regulation of DNA-raised immune responses by cotransfected interferon regulatory factors. J. Virol.76(13), 6652–6659 (2002).
  • Takashima A, Morita A. Dendritic cells in genetic immunization. J. Leukoc. Biol.66(2), 350–356 (1999).
  • Moore KW, de Waal Malefyt R, Coffman RL, O’Garra A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol.19, 683–765 (2001).
  • Barouch DH, Santra S, Schmitz JE et al. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science290(5491), 486–492 (2000).
  • Morita A, Ariizumi K, Ritter R 3rd et al. Development of a Langerhans cell-targeted gene therapy format using a dendritic cell-specific promoter. Gene Ther.8(22), 1729–1737 (2001).
  • Timares L, Safer KM, Qu B, Takashima A, Johnston SA. Drug-inducible, dendritic cell-based genetic immunization. J. Immunol.170(11), 5483–5490 (2003).
  • Xiong W, Goverdhana S, Sciascia SA et al. Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses. J. Virol.80(1), 27–37 (2006).
  • Krueger C, Danke C, Pfleiderer K et al. A gene regulation system with four distinct expression levels. J. Gene Med.8(8), 1037–1047 (2006).
  • Fleischmann RD, Adams MD, White O et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science269(5223), 496–512 (1995).
  • Venter JC, Adams MD, Myers EW et al. The sequence of the human genome. Science291(5507), 1304–1351 (2001).
  • Medini D, Serruto D, Parkhill J et al. Microbiology in the post-genomic era. Nat. Rev. Microbiol.6(6), 419–430 (2008).
  • Rappuoli R. Reverse vaccinology. Curr. Opin Microbiol.3(5), 445–450 (2000).
  • Pizza M, Scarlato V, Masignani V et al. Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.[comment]. Science287(5459), 1816–1820 (2000).
  • Montigiani S, Falugi F, Scarselli M et al. Genomic approach for analysis of surface proteins in Chlamydia pneumoniae. Infecti. Immun.70(1), 368–379 (2002).
  • Grifantini R, Bartolini E, Muzzi A et al. Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays. Nat. Biotechnol.20(9), 914–921 (2002).
  • Sykes KF, Lewis MG, Squires B, Johnston SA. Evaluation of SIV library vaccines with genetic cytokines in a macaque challenge. Vaccine20(17–18), 2382–2395 (2002).
  • Stemke-Hale K, Kaltenboeck B, DeGraves FJ et al. Screening the whole genome of a pathogen in vivo for individual protective antigens. Vaccine23(23), 3016 (2005).
  • Sykes KF, Johnston SA. Linear expression elements: a rapid, in vivo, method to screen for gene functions. Nat. Biotechnol.17(4), 355–359 (1999).
  • Li D, Borovkov A, Vaglenov A et al. Mouse model of respiratory Chlamydia pneumoniae infection for a genomic screen of subunit vaccine candidates. Vaccine24(15), 2917–2927 (2006).
  • Chambers RS, Johnston SA. High-level generation of polyclonal antibodies by genetic immunization. Nat. Biotechnol.21(9), 1088–1092 (2003).
  • Kaufmann SHE. Novel Vaccine Strategies. Wiley-VCH, Weinheim, Germany (2004).
  • Bellier B, Dalba C, Clerc B et al. DNA vaccines encoding retrovirus-based virus-like particles induce efficient immune responses without adjuvant. Vaccine24(14), 2643–2655 (2006).
  • Svarovsky S, Borovkov A, Sykes K. Cationic gold microparticles for biolistic delivery of nucleic acids. Biotechniques (2008) (In press).

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