Late-onset sepsis in preterm infants: update on strategies for therapy and prevention

References

• Lawn JE, Wilczynska-Ketende K, Cousens SN. Estimating the causes of 4 million neonatal deaths in the year 2000. Int J Epidemiol 2006;35(3):706-18
   PubMed Web of Science ®Google Scholar
• Stoll BJ. Infections of the neonatal infant. In: Behrman RE, Kliegman RM, Jenson HB, Editors Nelson Textbook of Pediatrics. 17th Edition. Saunders; Philadelphia: 2004a. 623-40
   Google Scholar
• Stoll BJ, Hansen N. Infections in VLBW infants: studies from the NICHD Neonatal Research Network. Semin Perinatol 2003;27(4):293-301
   PubMed Web of Science ®Google Scholar
• Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002;110(2 Pt 1):285-91
   PubMed Web of Science ®Google Scholar
• Vergnano S, Menson E, Kennea N, et al. Neonatal infections in England: the NeonIN surveillance network. Arch Dis Child Fetal Neonatal Ed 2011;96(1):F9-F14
   PubMed Web of Science ®Google Scholar
• Adams-Chapman I, Stoll BJ. Neonatal infection and long-term neurodevelopmental outcome in the preterm infant. Curr Opin Infect Dis 2006;19(3):290-7
   PubMed Web of Science ®Google Scholar
• Stoll BJ, Hansen NI, Adams-Chapman I, et al. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA 2004;292(19):2357-65
   PubMed Web of Science ®Google Scholar
• Kellogg JA, Ferrentino FL, Goodstein MH, et al. Frequency of low level bacteremia in infants from birth to two months of age. Pediatr Infect Dis J 1997;16(4):381-5
   PubMed Web of Science ®Google Scholar
• Schelonka RL, Chai MK, Yoder BA, et al. Volume of blood required to detect common neonatal pathogens. J Pediatr 1996;129(2):275-8
   PubMed Web of Science ®Google Scholar
• Ng PC. Diagnostic markers of infection in neonates. Arch Dis Child Fetal Neonatal Ed 2004;89(3):F229-35
   PubMed Web of Science ®Google Scholar
• Lacaze-Masmonteil T, Rosychuk RJ, Robinson JL. Value of a single C-reactive protein measurement at 18 h of age. Arch Dis Child Fetal Neonatal Ed 2014;99(1):F76-9
   PubMed Web of Science ®Google Scholar
• Sugitharini V, Prema A, Berla Thangam E. Inflammatory mediators of systemic inflammation in neonatal sepsis. Inflamm Res 2013;62(12):1025-34
   PubMed Web of Science ®Google Scholar
• Lee SM, Eun HS, Namgung R, et al. Usefulness of the delta neutrophil index for assessing neonatal sepsis. Acta Paediatrica 2013;102(1):e13-16
   PubMed Web of Science ®Google Scholar
• Mussap M. Laboratory medicine in neonatal sepsis and inflammation. J Matern Fetal Neonatal Med 2012;25(Suppl 4):32-4
   PubMedGoogle Scholar
• Koksal N, Harmanci R, Cetinkaya M, Hacimustafaoglu M. Role of procalcitonin and CRP in diagnosis and follow-up of neonatal sepsis. Turk J Pediatr 2007;49(1):21-9
   PubMed Web of Science ®Google Scholar
• Da Silva O, Ohlsson A, Kenyon C. Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review. Pediatr Infect Dis J 1995;14(5):362-6
   PubMed Web of Science ®Google Scholar
• Wasunna A, Whitelaw A, Gallimore R, et al. C-reactive protein and bacterial infection in preterm infants. Eur J Pediatr 1990;149(6):424-7
   PubMed Web of Science ®Google Scholar
• Kawamura M, Nishida H. The usefulness of serial C-reactive protein measurement in managing neonatal infection. Acta Paediatr 1995;84(1):10-13
   PubMed Web of Science ®Google Scholar
• Franz AR, Steinbach G, Kron M, Pohlandt F. Reduction of unnecessary antibiotic therapy in newborn infants using interleukin-8 and C-reactive protein as markers of bacterial infections. Pediatrics 1999;104(3 Pt 1):447-53
   PubMed Web of Science ®Google Scholar
• Dollner H, Vatten L, Austgulen R. Early diagnostic markers for neonatal sepsis: comparing C-reactive protein, interleukin-6, soluble tumour necrosis factor receptors and soluble adhesion molecules. J Clin Epidemiol 2001;54(12):1251-7
   PubMed Web of Science ®Google Scholar
• Pourcyrous M, Bada HS, Korones SB, et al. Significance of serial C-reactive protein responses in neonatal infection and other disorders. Pediatrics 1993;92(3):431-5
   PubMed Web of Science ®Google Scholar
• Ronnestad A, Abrahamsen TG, Gaustad P, Finne PH. C-reactive protein (CRP) response patterns in neonatal septicaemia. APMIS 1999;107(6):593-600
   PubMed Web of Science ®Google Scholar
• Arkader R, Troster EJ, Lopes MR, et al. Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome. Arch Dis Child 2006;91(2):117-20
   PubMed Web of Science ®Google Scholar
• Vazzalwar R, Pina-Rodrigues E, Puppala BL, et al. Procalcitonin as a screening test for late-onset sepsis in preterm very low birth weight infants. J Perinatol 2005;25(6):397-402
   PubMedGoogle Scholar
• Montagna MT, Coretti C, Rella A, et al. The role of procalcitonin in neonatal intensive care unit patients with candidemia. Folia Microbiol (Praha) 2013;58(1):27-31
   PubMed Web of Science ®Google Scholar
• Pacifico L, Osborn JF, Natale F, et al. Procalcitonin in pediatrics. Adv Clin Chem 2013;59:203-63
   PubMed Web of Science ®Google Scholar
• Gerdes JS. Clinicopathologic approach to the diagnosis of neonatal sepsis. Clin Perinatol 1991;18(2):361-81
   PubMed Web of Science ®Google Scholar
• Streimish I, Bizzarro M, Northrup V, et al. Neutrophil CD64 with hematologic criteria for diagnosis of neonatal sepsis. Am J Perinatol 2014;31(1):21-30
   PubMed Web of Science ®Google Scholar
• Elawady S, Botros SK, Sorour AE, et al. Neutrophil CD64 as a diagnostic marker of sepsis in neonates. J Investig Med 2014;62(3):644-9
   PubMed Web of Science ®Google Scholar
• Pammi M, Flores A, Leeflang M, Versalovic J. Molecular assays in the diagnosis of neonatal sepsis: a systematic review and meta-analysis. Pediatrics 2011;128(4):e973-85
   PubMed Web of Science ®Google Scholar
• Verboon-Maciolek MA, Krediet TG, Gerards LJ, et al. Clinical and epidemiologic characteristics of viral infections in a neonatal intensive care unit during a 12-year period. Pediatr Infect Dis J 2005;24(10):901-4
   PubMed Web of Science ®Google Scholar
• Pammi M, Holland L, Butler G, et al. Candida parapsilosis is a Significant Neonatal Pathogen: A Systematic Review and Meta-Analysis. Pediatr Infect Dis J 2013;32(5):e206-16
   PubMed Web of Science ®Google Scholar
• Viscardi RM. Ureaplasma species: role in neonatal morbidities and outcomes. Arch Dis Child Fetal Neonatal Ed 2014;99(1):F87-92
   PubMed Web of Science ®Google Scholar
• Karlowicz MG, Buescher ES, Surka AE. Fulminant late-onset sepsis in a neonatal intensive care unit, 1988-1997, and the impact of avoiding empiric vancomycin therapy. Pediatrics 2000;106(6):1387-90
   PubMed Web of Science ®Google Scholar
• Carcillo JA. A synopsis of 2007 ACCM clinical practice parameters for hemodynamic support of term newborn and infant septic shock. Early Hum Dev 2014;90(Suppl 1):S45-7
   PubMedGoogle Scholar
• Wynn JL, Wong HR. Pathophysiology and treatment of septic shock in neonates. Clin Perinatol 2010;37(2):439-79
   PubMed Web of Science ®Google Scholar
• Carcillo JA, Fields AI. Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock. Crit Care Med 2002;30(6):1365-78
   PubMed Web of Science ®Google Scholar
• Finer NN. Surfactant use for neonatal lung injury: beyond respiratory distress syndrome. Paediatr Respir Rev 2004;5(Suppl A):S289-97
   PubMedGoogle Scholar
• Recommendations for neonatal surfactant therapy. Paediatr Child Health 2005;10(2):109-16
   PubMedGoogle Scholar
• Kissoon N, Orr RA, Carcillo JA. Updated American College of Critical Care Medicine--pediatric advanced life support guidelines for management of pediatric and neonatal septic shock: relevance to the emergency care clinician. Pediatr Emerg Care 2010;26(11):867-9
   PubMed Web of Science ®Google Scholar
• Biban P, Gaffuri M. Vasopressin and terlipressin in neonates and children with refractory septic shock. Curr Drug Metab 2013;14(2):186-92
   PubMed Web of Science ®Google Scholar
• Caresta E, Papoff P, Benedetti Valentini S, et al. What’s new in the treatment of neonatal shock. J Matern Fetal Neonatal Med 2011;24(Suppl 1):17-19
   PubMedGoogle Scholar
• Shivanna B, Rios D, Rossano J, et al. Vasopressin and its analogues for the treatment of refractory hypotension in neonates. Cochrane Database Syst Rev 2013;3; CD009171
   PubMedGoogle Scholar
• Gupta A. Hospital-acquired infections in the neonatal intensive care unit--Klebsiella pneumoniae. Semin Perinatol 2002;26(5):340-5
   PubMed Web of Science ®Google Scholar
• Schaeffer EM. Re: extended-spectrum beta-lactamase-producing Gram-negative pathogens in community-acquired urinary tract infections: an increasing challenge for antimicrobial therapy. J Urol 2012;188(3):831-2
   PubMed Web of Science ®Google Scholar
• Gupta A, Ampofo K, Rubenstein D, Saiman L. Extended spectrum beta lactamase-producing Klebsiella pneumoniae infections: a review of the literature. J Perinatol 2003;23(6):439-43
   PubMedGoogle Scholar
• Jain A, Roy I, Gupta MK, et al. Prevalence of extended-spectrum beta-lactamase-producing Gram-negative bacteria in septicaemic neonates in a tertiary care hospital. J Med Microbiol 2003;52(Pt 5):421-5
   PubMed Web of Science ®Google Scholar
• Pessoa-Silva CL, Meurer Moreira B, Camara Almeida V, et al. Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit: risk factors for infection and colonization. J Hosp Infect 2003;53(3):198-206
   PubMed Web of Science ®Google Scholar
• Capparelli E, Hochwald C, Rasmussen M, et al. Population pharmacokinetics of cefepime in the neonate. Antimicrob Agents Chemother 2005;49(7):2760-6
   PubMed Web of Science ®Google Scholar
• Jones RN, Sader HS, Fritsche TR, Pottumarthy S. Comparisons of parenteral broad-spectrum cephalosporins tested against bacterial isolates from pediatric patients: report from the SENTRY Antimicrobial Surveillance Program (1998-2004. Diagn Microbiol Infect Dis 2007;57(1):109-16
   PubMed Web of Science ®Google Scholar
• Edwards JR. Meropenem: a microbiological overview. J Antimicrob Chemother 1995;36(Suppl A):1-17
   PubMed Web of Science ®Google Scholar
• Nicolau DP. Carbapenems: a potent class of antibiotics. Expert Opin Pharmacother 2008;9(1):23-37
   PubMed Web of Science ®Google Scholar
• Zhanel GG, Wiebe R, Dilay L, et al. Comparative review of the carbapenems. Drugs 2007;67(7):1027-52
   PubMed Web of Science ®Google Scholar
• Pediatrics AAo, editor. American Academy of Pediatrics, Elk Grove Village, IL, USA, 2012
   Google Scholar
• Muscato JJ, Wilbur DW, Stout JJ, Fahrlender RA. An evaluation of the susceptibility patterns of Gram-negative organisms isolated in cancer centres with aminoglycoside usage. J Antimicrob Chemother 1991;27(Suppl C):1-7
   PubMedGoogle Scholar
• Arciola CR, Campoccia D, Gamberini S, et al. Antibiotic resistance in exopolysaccharide-forming Staphylococcus epidermidis clinical isolates from orthopaedic implant infections. Biomaterials 2005;26(33):6530-5
   PubMed Web of Science ®Google Scholar
• Pediatrics AAo. Tables of antibacterial drug dosages Pickering L. editor. Report of the Committee on Infectious Diseases. American Academy of Pediatrics; Elk Grove Village, IL: 2003; 700
   Google Scholar
• Greenhow TL, Hung YY, Herz AM. Changing epidemiology of bacteremia in infants aged 1 week to 3 months. Pediatrics 2012;129(3):e590-6
   PubMed Web of Science ®Google Scholar
• Bradley JS, Wassel RT, Lee L, Nambiar S. Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events. Pediatrics 2009;123(4):e609-13
   PubMed Web of Science ®Google Scholar
• Chu A, Hageman JR, Schreiber M, Alexander K. Antimicrobial therapy and late onset sepsis. NeoReviews 2012;13(2):e94-e100
   Google Scholar
• Kimberlin DW, Leake JAD, Palumbo PE, et al. Antimicrobial therapy of newborns. In: Bradley JS, Nelson JD, Kimberlin DW, et al. editors. Nelson’s Pediatric Antimicrobial Therapy. American Academy of Pediatrics, Elk Grove Village, IL; 2012. 17-35
   Google Scholar
• Kaiser JR, Cassat JE, Lewno MJ. Should antibiotics be discontinued at 48 hours for negative late-onset sepsis evaluations in the neonatal intensive care unit? J Perinatol 2002;22(6):445-7
   PubMedGoogle Scholar
• Guerti K, Devos H, Ieven MM, Mahieu LM. Time to positivity of neonatal blood cultures: fast and furious? J Med Microbiol 2011;60(Pt 4):446-53
   PubMed Web of Science ®Google Scholar
• Gerdes JS. Diagnosis and management of bacterial infections in the neonate. Pediatr Clin North Am 2004;51(4):939-59. viii-ix
   PubMed Web of Science ®Google Scholar
• Cohen-Wolkowiez M, Benjamin DKJr, Capparelli E. Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. Curr Opin Pediatr 2009;21(2):177-81
   PubMed Web of Science ®Google Scholar
• Ohlsson A, Lacy JB. Intravenous immunoglobulin for suspected or proven infection in neonates. Cochrane Database Syst Rev 2013;7:CD001239
   PubMedGoogle Scholar
• Brocklehurst P, Farrell B, King A, et al. Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med 2011;365(13):1201-11
   PubMed Web of Science ®Google Scholar
• Weisman LE. Antibody for the prevention of neonatal nosocomial staphylococcal infection: a review of the literature. Arch Pediatr 2007;14(Suppl 1):S31-4
   PubMedGoogle Scholar
• Weisman LE, Thackray HM, Steinhorn RH, et al. A randomized study of a monoclonal antibody (pagibaximab) to prevent staphylococcal sepsis. Pediatrics 2011;128(2):271-9
   PubMed Web of Science ®Google Scholar
• Pammi M, Brocklehurst P. Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropenia. Cochrane Database Syst Rev 2011;10:CD003956
   Google Scholar
• Bo L, Wang F, Zhu J, et al. Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis. Crit Care 2011;15(1):R58
   PubMed Web of Science ®Google Scholar
• Carr R, Brocklehurst P, Dore CJ, Modi N. Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial. Lancet 2009;373(9659):226-33
   PubMed Web of Science ®Google Scholar
• Marlow N, Morris T, Brocklehurst P, et al. A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: outcomes at 2 years. Archives of disease in childhood. Fetal and neonatal edition 2013;98(1):F46-53
   PubMed Web of Science ®Google Scholar
• Pammi M, Haque KN. Pentoxifylline for treatment of sepsis and necrotizing enterocolitis in neonates. Cochrane Database Syst Rev 2015; In Press
   Web of Science ®Google Scholar
• Polin RA, Denson S, Brady MT. Strategies for prevention of health care-associated infections in the NICU. Pediatrics 2012;129(4):e1085-93
   PubMed Web of Science ®Google Scholar
• Janota J, Sebkova S, Visnovska M, et al. Hand hygiene with alcohol hand rub and gloves reduces the incidence of late onset sepsis in preterm neonates. Acta paediatrica Oslo, Norway : 1992 2014:103(10):1053-6
   Google Scholar
• Pittet D, Allegranzi B, Boyce J. The World Health Organization Guidelines on Hand Hygiene in Health Care and their consensus recommendations. Infect Control Hosp Epidemiol 2009;30(7):611-22
   PubMed Web of Science ®Google Scholar
• Boyce JM, Pittet D. Guideline for hand hygiene in health-care settings. recommendations of the healthcare infection control practices advisory committee and the HIPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Am J Infect Control 2002;30(8):S1-46
   PubMed Web of Science ®Google Scholar
• Edel E, Houston S, Kennedy V, LaRocco M. Impact of a 5-minute scrub on the microbial flora found on artificial, polished, or natural fingernails of operating room personnel. Nurs Res 1998;47(1):54-9
   PubMed Web of Science ®Google Scholar
• McNeil SA, Foster CL, Hedderwick SA, Kauffman CA. Effect of hand cleansing with antimicrobial soap or alcohol-based gel on microbial colonization of artificial fingernails worn by health care workers. Clin Infect Dis 2001;32(3):367-72
   PubMed Web of Science ®Google Scholar
• Moolenaar RL, Crutcher JM, San Joaquin VH, et al. A prolonged outbreak of Pseudomonas aeruginosa in a neonatal intensive care unit: did staff fingernails play a role in disease transmission? Infect Control Hosp Epidemiol 2000;21(2):80-5
   PubMed Web of Science ®Google Scholar
• Hewlett AL, Rupp ME. New developments in the prevention of intravascular catheter associated infections. Infect Dis Clin North Am 2012;26(1):1-11
   PubMed Web of Science ®Google Scholar
• Mermel LA. Prevention of central venous catheter-related infections: what works other than impregnated or coated catheters? J Hosp Infect 2007;65(Suppl 2)):30-3
   PubMedGoogle Scholar
• O’Grady N P, Alexander M, Dellinger EP, et al. Guidelines for the prevention of intravascular catheter-related infections. Am J Infect Control 2002;30(8):476-89
   PubMed Web of Science ®Google Scholar
• Raad I, Hanna H, Maki D. Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis 2007;7(10):645-57
   PubMed Web of Science ®Google Scholar
• Benjamin DKJr, Miller W, Garges H, et al. Bacteremia, central catheters, and neonates: when to pull the line. Pediatrics 2001;107(6):1272-6
   PubMed Web of Science ®Google Scholar
• Nazemi KJ, Buescher ES, Kelly REJr, Karlowicz MG. Central venous catheter removal versus in situ treatment in neonates with enterobacteriaceae bacteremia. Pediatrics 2003;111(3):e269-74
   PubMed Web of Science ®Google Scholar
• Karlowicz MG, Furigay PJ, Croitoru DP, Buescher ES. Central venous catheter removal versus in situ treatment in neonates with coagulase-negative staphylococcal bacteremia. Pediatr Infect Dis J 2002;21(1):22-7
   PubMed Web of Science ®Google Scholar
• Milstone AM, Reich NG, Advani S, et al. Catheter dwell time and CLABSIs in neonates with PICCs: a multicenter cohort study. Pediatrics 2013;132(6):e1609-15
   PubMed Web of Science ®Google Scholar
• Aly H, Herson V, Duncan A, et al. Is bloodstream infection preventable among premature infants? A tale of two cities. Pediatrics 2005;115(6):1513-18
   PubMed Web of Science ®Google Scholar
• Kuppala VS, Meinzen-Derr J, Morrow AL, Schibler KR. Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. J Pediatr 2011;159(5):720-5
   PubMed Web of Science ®Google Scholar
• Tsai MH, Chu SM, Hsu JF, et al. Risk factors and outcomes for multidrug-resistant Gram-negative bacteremia in the NICU. Pediatrics 2014;133(2):e322-9
   PubMed Web of Science ®Google Scholar
• Adams-Chapman I, Stoll BJ. Prevention of nosocomial infections in the neonatal intensive care unit. Curr Opin Pediatr 2002;14(2):157-64
   PubMed Web of Science ®Google Scholar
• Schelonka RL, Scruggs S, Nichols K, et al. Sustained reductions in neonatal nosocomial infection rates following a comprehensive infection control intervention. J Perinatol 2006;26(3):176-9
   PubMed Web of Science ®Google Scholar
• Shahheidari M, Homer C. Impact of the design of neonatal intensive care units on neonates, staff, and families: a systematic literature review. J Perinat Neonatal Nurs 2012;26(3):260-6. quiz 267-268
   PubMed Web of Science ®Google Scholar
• Stevens DC, Helseth CC, Thompson PA, et al. A comprehensive comparison of open-bay and single-family-room neonatal intensive care units at Sanford Children’s Hospital. Herd 2012;5(4):23-39
   PubMedGoogle Scholar
• Pammi M, Abrams SA. Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev 2011;10:CD007137
   Google Scholar
• Manzoni P, Rinaldi M, Cattani S, et al. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial. JAMA 2009;302(13):1421-8
   PubMed Web of Science ®Google Scholar
• Pammi M, Abrams SA. Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev 2015; In press
   Web of Science ®Google Scholar
• Lactoferrin immunoprophylaxis for very preterm infants. Archives of disease in childhood. Fetal and neonatal edition 2013;98(1):F2-4
   PubMed Web of Science ®Google Scholar
• Jacobs SE, Tobin JM, Opie GF, et al. Probiotic effects on late-onset sepsis in very preterm infants: a randomized controlled trial. Pediatrics 2013;132(6):1055-62
   PubMed Web of Science ®Google Scholar
• AlFaleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Evid Based Child Health 2014;9(3):584-671
   PubMedGoogle Scholar
• Stoll BJ, Hansen NI, Higgins RD, et al. Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of Gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003. Pediatr Infect Dis J 2005;24(7):635-9
   PubMed Web of Science ®Google Scholar
• Gordon A, Isaacs D. Late onset neonatal Gram-negative bacillary infection in Australia and New Zealand: 1992-2002. Pediatr Infect Dis J 2006;25(1):25-9
   PubMed Web of Science ®Google Scholar
• Levit O, Bhandari V, Li FY, et al. Clinical and laboratory factors that predict death in very low birth weight infants presenting with late-onset sepsis. Pediatr Infect Dis J 2014;33(2):143-6
   PubMed Web of Science ®Google Scholar
• Khoury J, Jones M, Grim A, et al. Eradication of methicillin-resistant Staphylococcus aureus from a neonatal intensive care unit by active surveillance and aggressive infection control measures. Infect Control Hosp Epidemiol 2005;26(7):616-21
   PubMed Web of Science ®Google Scholar
• Heinrich N, Mueller A, Bartmann P, et al. Successful management of an MRSA outbreak in a neonatal intensive care unit. Eur J Clin Microbiol Infect Dis 2011;30(7):909-13
   PubMed Web of Science ®Google Scholar
• Popoola VO, Budd A, Wittig SM, et al. Methicillin-resistant Staphylococcus aureus transmission and infections in a neonatal intensive care unit despite active surveillance cultures and decolonization: challenges for infection prevention. Infect Control Hosp Epidemiol 2014;35(4):412-18
   PubMed Web of Science ®Google Scholar
• You JH, Chan CY, Wong MY, Ip M. Active surveillance and decolonization of methicillin-resistant Staphylococcus aureus on admission to neonatal intensive care units in Hong Kong: a cost-effectiveness analysis. Infect Control Hosp Epidemiol 2012;33(10):1024-30
   PubMed Web of Science ®Google Scholar
• Milstone AM, Song X, Coffin S, Elward A. Identification and eradication of methicillin-resistant Staphylococcus aureus colonization in the neonatal intensive care unit: results of a national survey. Infect Control Hosp Epidemiol 2010;31(7):766-8
   PubMed Web of Science ®Google Scholar
• Nelson MU, Bizzarro MJ, Dembry LM, et al. One size does not fit all: why universal decolonization strategies to prevent methicillin-resistant Staphylococcus aureus colonization and infection in adult intensive care units may be inappropriate for neonatal intensive care units. J Perinatol 2014;34(9):653-5
   PubMed Web of Science ®Google Scholar
• Stone PW, Gupta A, Loughrey M, et al. Attributable costs and length of stay of an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae outbreak in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2003;24(8):601-6
   PubMed Web of Science ®Google Scholar
• Strunk T, Inder T, Wang X, et al. Infection-induced inflammation and cerebral injury in preterm infants. Lancet Infect Dis 2014;14(8):751-62
   PubMed Web of Science ®Google Scholar
• Adams-Chapman I, Bann CM, Das A, et al. Neurodevelopmental outcome of extremely low birth weight infants with Candida infection. J Pediatrics 2013;163(4):961-7. e963
   PubMed Web of Science ®Google Scholar
• Mitha A, Foix-L’Helias L, Arnaud C, et al. Neonatal infection and 5-year neurodevelopmental outcome of very preterm infants. Pediatrics 2013;132(2):e372-80
   PubMed Web of Science ®Google Scholar
• Alshaikh B, Yusuf K, Sauve R. Neurodevelopmental outcomes of very low birth weight infants with neonatal sepsis: systematic review and meta-analysis. J Perinatol 2013;33(7):558-64
   PubMed Web of Science ®Google Scholar
• Adams-Chapman I. Long-term impact of infection on the preterm neonate. Semin Perinatol 2012;36(6):462-70
   PubMed Web of Science ®Google Scholar
• O’Grady NP, Alexander M, Burns LA, et al. Summary of recommendations: guidelines for the Prevention of Intravascular Catheter-related Infections. Clin Infect Dis 2011;52(9):1087-99
   PubMed Web of Science ®Google Scholar
• Patel AL, Trivedi S, Bhandari NP, et al. Reducing necrotizing enterocolitis in very low birth weight infants using quality-improvement methods. J Perinato 2014;34(11):850-7
   PubMed Web of Science ®Google Scholar
• Pammi M, Adams KA, Weisman L. Infection in the neonate. In: Gardner SL, Carter BS, Enzman-Hines M, Hernandez JA, editors. Merenstein & Gardner’s Handbook of Neonatal Intensive Care. Mosby; St. Louis, Missouri: 2010. pp 553-80
   Google Scholar
• Haque KN, Pammi M. Pentoxifylline for treatment of sepsis and necrotizing enterocolitis in neonates. Cochrane Database Syst Rev 2011;10:CD004205
   Google Scholar
• Carr R, Modi N, Dore C. G-CSF and GM-CSF for treating or preventing neonatal infections. Cochrane Database Syst Rev 2003;3:CD003066
   Google Scholar
• Ohlsson A, Lacy JB. Intravenous immunoglobulin for preventing infection in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2013;7:CD000361
   PubMedGoogle Scholar