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Review

Evaluation and management of recurrent urinary tract infections in children: state of the art

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References

  • Alper BS, Curry SH. Urinary tract infection in children. Am Fam Physician 2005;72(12):2483-8
  • Shaikh N, Morone NE, Bost JE, Farrell MH. Prevalence of urinary tract infection in childhood: a meta-analysis. Pediatr Infect Dis J 2008;27(4):302-8
  • Chang SL, Shortliffe LD. Pediatric urinary tract infections. Pediatr Clin N Am 2006;53(3):379-400
  • Lebowitz RL, Olbing H, Parkkulainen KV, et al. International system of radiographic grading of vesicoureteric reflux. Pediatr Radiol 1985;15(2):105-9
  • Sillén U, Brandström P, Jodal U, et al. The Swedish Reflux Trial in Children: V. Bladder Dysfunction. J Urol 2010;184(1):298-304
  • Slabbaert K, Bogaert G. Vesicoureteral reflux (VUR) in children: where are we now? Arch Esp Urol 2012;65(4):450-8
  • Blumenthal I. Vesicoureteric reflux and urinary tract infection in children. Postgrad Med J 2006;82(963):31-5
  • Shaikh N, Ewing AL, Bhatnagar S, Hoberman A. Risk of renal scarring in children with a first UTI: a systematic review. Pediatrics 2010;126(6):1084-91
  • Montini G, Tullus K, Hewitt I. Febrile urinary tract infections in children. N Engl J Med 2011;365(3):239-50
  • Sedberry-Ross S, Pohl HG. Urinary tract infections in children. Curr Urol Rep 2008;9(2):165-71
  • Jantunen ME, Saxén H, Salo E, Siitonen A. Recurrent urinary tract infections in infancy: relapses or reinfections? J Infect Dis 2002;185(3):375-9
  • Mak RH, Kuo HJ. Pathogenesis of urinary tract infection: an update. Curr Opin Pediatr 2006;18(2):148-52
  • Salo J, Ikäheimo R, Tapiainen T, Uhari M. Childhood urinary tract infections as a cause of chronic kidney disease. Pediatrics 2011;128(5):840-7
  • Kari JA, Tullus K. Controversy in urinary tract infection management in children: a review of new data and subsequent changes in guidelines. J Trop Pediatr 2013;59(6):465-9
  • Montini G, Hewitt I. Urinary tract infections: to prophylaxis or not to prophylaxis? Pediatr Nephrol 2009;24(9):1605-9
  • National Collaborating Centre for Women’s and Children’s Health. Urinary tract infection in children: diagnosis, treatment and long-term management. National Institute for Health and Clinical Excellence (2007). Available from: www.nice.org.uk/guidance/cg54/resources/guidance-urinary-tract-infection-in-children-pdf [Last accessed 4 October 2014]
  • Riccabona M, Avni FE, Blickman JG, et al. Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract ultrasonography and voiding cystourethrography, Barcelona, Spain, June 2007. Pediatr Radiol 2008;38(2):138-45
  • American Urological Association Education and Research. Management and screening of primary vesicoureteral reflux in children: AUA guideline. American Urological Association (2010). Available from: www.auanet.org/common/pdf/education/clinical-guidance/Vesicoureteral-Reflux-a.pdf [Last accessed 4 October 2014]
  • Roberts KB. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics 2011;128(3):595-610
  • Tekgül S, Riedmiller H, Hoebeke P, et al. EAU guidelines on vesicoureteral reflux in children. Eur Urol 2012;62(3):534-42
  • The RIVUR Trial Investigators. Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med 2014;370(25):2367-76
  • Schmiemann G, Kniehl E, Gebhardt K, et al. The diagnosis of urinary tract infection: a systematic review. Dtsch Arztebl Int 2010;107(21):361-7
  • Zorc JJ, Kiddo DA, Shaw KN. Diagnosis and management of pediatric urinary tract infections. Clin Microbiol Rev 2005;18(2):417-22
  • Finnell SM, Carroll AE, Downs SM, et al. Diagnosis and management of an initial UTI in febrile infants and young children. Pediatrics 2011;128(3):e749-70
  • Williams GJ, Macaskill P, Chan SF, et al. Absolute and relative accuracy of rapid urine tests for urinary tract infection in children: a meta-analysis. Lancet Infect Dis 2010;10(4):240-50
  • Antwi S, Bates I, Baffoe-Bonnie B, Critchley J. Urine dipstick as a screening test for urinary test infection. Ann Trop Pediatr 2008;28(2):117-22
  • Mori R, Yonemoto N, Fitzgerald A, et al. Diagnostic performance of urine dipstick testing in children with suspected UTI: a systematic review of relationship with age and comparison with microscopy. Acta Pediatr 2010;99(4):581-4
  • Pryles CV, Atkin MD, Morse TS, Welch KJ. Comparative bacteriologic study of urine obtained from children by percutaneous suprapubic aspiration of the bladder and by catheter. Pediatrics 1959;24(6):983-91
  • Bonadio WA. Urine culturing technique in febrile infants. Pediatr Emerg Care 1987;3(2):75-8
  • American Academy of Pediatrics, Committee on Quality Improvement, Subcommittee on Urinary Tract Infection. Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. Pediatrics 1999;103(4):843-52
  • Hoberman A, Chao HP, Keller DM, et al. Prevalence of urinary tract infection in febrile infants. J Pediatr 1993;123(1):17-23
  • Shaikh N, Morone NE, Lopez J, et al. Does this child have a urinary tract infection? JAMA 2007;298(24):2895-904
  • Mantadakis E, Vouloumanou EK, Georgantzi GG, et al. Acute Tc-99m DMSA scan for identifying dilating vesicoureteral reflux in children: a meta-analysis. Pediatrics 2011;128(1):e1-e11
  • Westwood ME, Whiting PF, Cooper J, et al. Further investigation of confirmed urinary tract infection (UTI) in children under five years: a systematic review. BMC Pediatr 2005;5(1):2
  • Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Am J Med 2002;113(1A):14S-9S
  • Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med 2002;113(1):5-13
  • Günşar C, Kurutepe S, Alparslan OGU, et al. The effect of circumcision status on periurethral and glanular bacterial flora. Urol Int 2004;72(3):212-15
  • Raz R, Colodner R, Kunin CM. Who are you—Staphylococcus saprophyticus? Clin Infect Dis 2005;40(6):896-8
  • Nielubowicz GR, Mobley HL. Host–pathogen interactions in urinary tract infection. Nat Rev Urol 2010;7(8):430-41
  • Karoly E, Fekete A, Banki NF, et al. Heat shock protein 72 (HSPA1B) gene polymorphism and Toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children. Pediatr Res 2007;61(3):371-4
  • Javor J, Králinský K, Sádová E, et al. Association of interleukin-10 gene promoter polymorphisms with susceptibility to acute pyelonephritis in children. Folia Microbiol (Praha) 2014;59(4):307-13
  • Javor J, Bucova M, Cervenova O, et al. Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children. Int J Immunogenet 2012;39(4):338-45
  • Robino L, Scavone P, Araujo L, et al. Intracellular bacteria in the pathogenesis of Escherichia coli urinary tract infection in children. Clin Infect Dis 2014; In Press
  • Tapiainen T, Hanni AM, Salo J, et al. Escherichia coli biofilm formation and recurrences of urinary tract infections in children. Eur J Clin Microbiol Infect Dis 2014;33(1):111-15
  • Ladhani S, Grandsen W. Increasing antibiotic resistance among urinary tract isolates. Arch Dis Child 2003;88(5):444-5
  • Thaver D, Ali SA, Zaidi AKM. Antimicrobial resistance among neonatal pathogens in developing countries. Pediatr Infect Dis J 2009;28(1 Suppl):S19-21
  • Craig JC, Simpson JM, Williams GJ, et al. Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med 2009;361(18):1748-59
  • Cheng CH, Tsai MH, Huang YC, et al. Antibiotic resistance patterns of community-acquired urinary tract infections in children with vesicoureteral reflux receiving prophylactic antibiotic therapy. Pediatrics 2008;122(6):1212-17
  • Kõljalg S, Truusalu K, Vainumäe I, et al. Persistence of Escherichia coli clones and phenotypic and genotypic antibiotic resistance in recurrent urinary tract infections in childhood. J Clin Microbiol 2009;47(1):99-105
  • Strohmeier Y, Hodson EM, Willis NS, et al. Antibiotics for acute pyelonephritis in children. Cochrane Database Syst Rev 2014;7:CD003772
  • Montini G, Toffolo A, Zucchetta P, et al. Antibiotic treatment for pyelonephritis in children: multicenter randomised controlled non-inferiority trial. BMJ 2007;335(7616):386
  • Bouissou F, Munzer C, Decramer S, et al. Prospective, randomized trial comparing short and long intravenous antibiotic treatment of acute pyelonephritis in children: dimercaptosuccinic acid scintigraphic evaluation at 9 months. Pediatrics 2008;121(3):e553-60
  • Neuhaus TJ, Berger C, Buechner K, et al. Randomised trial of oral versus sequential intravenous/oral cephalosporins in children with pyelonephritis. Eur J Pediatr 2008;167(9):1037-47
  • Bocquet N, Alaoui AS, Jais JP, et al. Randomized trial of oral versus sequential IV/oral antibiotic for acute pyelonephritis in children. Pediatrics 2012;129(2):e269-75
  • Hoberman A, Wald ER, Hickey RW, et al. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics 1999;104(1):79-86
  • Moffatt M, Embree J, Grimm P, Law B. Short-course antibiotic therapy for urinary tract infections in children: a methodological review of the literature. Am J Dis Child 1988;142(1):57-61
  • Michael M, Hodson EM, Craig JC, et al. Short compared with standard duration of antibiotic treatment for urinary tract infection: a systematic review of randomised controlled trials. Arch Dis Child 2002;87(2):118-23
  • Noorbakhsh S, Lari AR, Masjedian F, et al. Comparison of intravenous aminoglycoside therapy with switch therapy to cefixime in urinary tract infections. Saudi Med J 2004;25(10):1513-15
  • Benador D, Neuhaus TJ, Papazyan JP, et al. Randomised controlled trial of three day versus 10 day intravenous antibiotics in acute pyelonephritis: effect on renal scarring. Arch Dis Child 2001;84(3):241-6
  • Prasad MM, Cheng EY. Radiographic evaluation of children with febrile urinary tract infection: bottom-up, top-down, or none of the above? Adv Urol 2012;2012:716739
  • American Academy of Pediatrics, Committee on Quality Improvement, Subcomittee on Urinary Tract Infection. Practice parameter: the diagnosis, treatment and evaluation of the initial urinary tract infection in febrile infants and young children. Pediatrics 1999;103(4):843-52
  • Ward VL. Patient dose reduction during voiding cystourethrography. Pediatr Radiol 2006;36(Suppl 2):168-72
  • González E, Papazyan JP, Girardin E. Impact on vesicoureteral reflux on the size of renal lesions after an episode of acute pyelonephritis. J Urol 2005;173(2):571-5
  • Orellana P, Baquedano P, Rangarajan V, et al. Relationship between acute pyelonephritis, renal scarring, and vesicoureteral reflux. Pediatr Nephrol 2004;19(10):1122-6
  • Craig JC, Irwig LM, Knight JF, Roy P. Does treatment of vesicoureteral reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy? Pediatrics 2000;105(6):1236-41
  • Peters C, Rushton HG. Vesicoureteral reflux associated renal damage: congenital reflux nephropathy and acquired renal scarring. J Urol 2010;184(1):265-73
  • Smith EA. Pyelonephritis, renal scarring, and reflux nephropathy: a pediatric urologist’s perspective. Pediatr Radiol 2008;38(Suppl 1):S76-82
  • Hoberman A, Charron M, Hickey RW, et al. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med 2003;348(3):195-202
  • Silva JMP, Diniz JSS, Marino VSP, et al. Clinical course of 735 children and adolescents with primary vesicoureteral reflux. Pediatr Nephrol 2006;21(7):981-8
  • Schwab Jr CW, Wu HY, Selman H, et al. Spontaneous resolution of vesicoureteral reflux: a 15-year perspective. J Urol 2002;168(6):2594-9
  • Lim R. Vesicoureteral reflux and urinary tract infection: evolving practices and current controversies in pediatric imaging. AJR Am J Roentgenol 2009;192(5):1197-208
  • Wiesel A, Queisser-Luft A, Clementi M, et al. Prenatal detection of congenital renal malformations by renal ultrasonographic examination: an analysis of 709,030 births in 12 European countries. Eur J Med Genet 2005;48(2):131-44
  • Lee RS, Cendron M, Kinnamon DD, Nguyen HT. Antenatal hydronephrosis as a predictor of postnatal outcome: a meta-analysis. Pediatrics 2006;118(2):586-93
  • Moorthy I, Joshi N, Cook JV, Warren M. Antenatal hydronephrosis: negative predictive value of normal postnatal ultrasound—a 5-year study. Clin Radiol 2003;58(12):964-70
  • Ismaili K, Avni FE, Hall M. Results of systematic voiding cystourethrography in infants with antenatally diagnosed renal pelvis dilation. J Pediatr 2002;141(1):21-4
  • Lee H, Soh BH, Hong CH, et al. The efficacy of ultrasound and dimercaptosuccinic acid scan in predicting vesicoureteral reflux in children below the age of 2 years with their first febrile urinary tract infection. Pediatr Nephrol 2009;24(10):2009-13
  • Muensterer OJ. Comprehensive ultrasound versus voiding cystourethrography in the diagnosis of vesicoureteral reflux. Eur J Pediatr 2002;161(8):435-7
  • Herz D, Merguerian P, McQuiston L, et al. 5-year prospective results of dimercapto-succinic acid imaging in children with febrile urinary tract infection: proof that the top-down approach works. J Urol 2010;184(4):1703-9
  • Austin JC, Hardy RD, Grose C. DMSA renal scans and the top-down approach to urinary tract infection. Pediatr Infect Dis J 2008;27(5):476-7
  • Bhatnagar V, Mitra DK, Agarwala S, et al. The role of DMSA scans in evaluation of the correlation between urinary tract infection, vesicoureteral reflux, and renal scarring. Pediatr Surg Int 2002;18(2-3):128-34
  • Thomas KE, Parnell-Parmley JE, Haidar S, et al. Assessment of radiation dose awareness among pediatricians. Pediatr Radiol 2006;36(8):823-32
  • Awais M, Rehman A, Zaman MU, Nadeem N. Recurrent urinary tract infections in young children: role of DMSA scintigraphy in detecting vesicoureteric reflux. Pediatr Radiol 2014; In Press
  • Quirino IG, Silva JMP, Diniz JS, et al. Combined use of late phase dimercapto-succinic acid renal scintigraphy and ultrasound as first line screening after urinary tract infection in children. J Urol 2011;185(1):258-63
  • Fouzas S, Krikelli E, Vassilakos P, et al. DMSA scan for revealing vesicoureteral reflux in young children with urinary tract infection. Pediatrics 2010;126(3):e513-19
  • Lee MD, Lin CC, Huang FY, et al. Screening young children with a first febrile urinary tract infection for high-grade vesicoureteral reflux with renal ultrasound scanning and technetium-99m-labeled dimercaptosuccinic acid scanning. J Pediatr 2009;154(6):797-802
  • Preda I, Jodal U, Sixt R, et al. Normal dimercaptosuccinic acid scintigraphy makes voiding cystourethrography unnecessary after urinary tract infection. J Pediatr 2007;151(6):581-4
  • Tseng MH, Lin WJ, Lo WT, et al. Does a normal DMSA obviate the performance of voiding cystourethrography in evaluation of young children after their first urinary tract infection? J Pediatr 2007;150(1):96-9
  • Hansson S, Dhamey M, Sigström O, et al. Dimercapto-succinic acid scintigraphy instead of voiding cystourethrography for infants with urinary tract infection. J Urol 2004;172(3):1071-4
  • Giordano M, Marzolla R, Puteo F, et al. Voiding urosonography as first step in the diagnosis of vesicoureteral reflux in children: a clinical experience. Pediatr Radiol 2007;37(7):674-7
  • Darge K. Voiding urosonography with ultrasound contrast agents for the diagnosis of vesicoureteric reflux in children. Pediatr Radiol 2008;38(1):40-53
  • Ascenti G, Zimbaro G, Mazziotti S, et al. Vesicoureteral reflux: comparison between urosonography and radionuclide cystography. Pediatr Nephrol 2003;18(8):768-71
  • Jones RA, Grattan-Smith JD, Little S. Pediatric magnetic resonance urography. J Magn Reson Imaging 2011;33(3):510-26
  • Takazakura R, Johnin K, Furukawa A, et al. Magnetic resonance voiding cystourethrography for vesicoureteral reflux. J Magn Reson Imaging 2007;25(1):170-4
  • Carvas F, Silva A, Nguyen HT. The genetics of primary, nonsyndromic vesicoureteral reflux. Curr Opin Urol 2010;20(4):336-42
  • Chertin B, Puri P. Familial vesicoureteral reflux. J Urol 2003;169(5):1804-8
  • Yoneda A, Cascio S, Oue T, et al. Risk factors for the development of renal parenchymal damage in familial vesicoureteral reflux. J Urol 2002;168(4 Suppl):1704-7
  • Ataei N, Madani A, Esfahani ST, et al. Screening for vesicoureteral reflux and renal scars in siblings of children with known reflux. Pediatr Nephrol 2004;19(10):1127-31
  • Giel DW, Noe HN, Williams MA. Ultrasound screening of asymptomatic siblings of children with vesicoureteral reflux: a long-term followup study. J Urol 2005;174(4):1602-5
  • Skoog SJ, Peters CA, Arant Jr BS, et al. Pediatric vesicoureteral reflux guidelines panel summary report: clinical practice guidelines for screening siblings of children with vesicoureteral reflux and neonates/infants with prenatal hydronephrosis. J Urol 2010;184(3):1145-51
  • Greenfield SP, Ng M, Wan J. Experience with vesicoureteral reflux in children: clinical characteristics. J Urol 1997;158(2):574-7
  • Bailey RR, Lynn KL, Robson RA. End-stage reflux nephropathy. Ren Fail 1994;16(1):27-35
  • Wheeler D, Vimalachandra D, Hodson EM, et al. Antibiotics and surgery for vesicoureteral reflux: a meta-analysis of randomised controlled trials. Arch Dis Child 2003;88(8):688-94
  • Hellerstein S. Long-term consequences of urinary tract infections. Curr Opin Pediatr 2000;12(2):125-8
  • Smellie JM, Prescod NP, Shaw PJ, et al. Childhood reflux and urinary infection: a follow-up of 10–41 years in 226 adults. Pediatr Nephrol 1998;12(9):727-36
  • Garin EH, Campos A, Homsy Y. Primary vesicoureteral reflux: review of current concepts. Pediatr Nephrol 1998;12(3):249-56
  • Maisonneuve P, Agodoa L, Gellert R, et al. Distribution of primary renal diseases leading to end-stage renal failure in the United States, Europe, and Australia/New Zealand: results from an international comparative study. Am J Kidney Dis 2000;35(1):157-65
  • Montini G, Rigon L, Zucchetta P, et al. Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial. Pediatrics 2008;122(5):1064-71
  • Roussey-Kesler G, Gadjos V, Idres N, et al. Antibiotic prophylaxis for the prevention of recurrent urinary tract infection in children with low grade vesicoureteral reflux: results from a prospective randomized study. J Urol 2008;179(2):674-9
  • Garin EH, Olavarria F, Nieto VG, et al. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics 2006;117(3):626-32
  • Brandström P, Esbjörner E, Herthelius M, et al. The Swedish Reflux Trial in Children: III. Urinary tract infection pattern. J Urol 2010;184(1):286-91
  • Williams G, Craig JC. Long-term antibiotics for preventing recurrent urinary tract infection in children. Cochrane Database Syst Rev 2011;3:CD001534
  • Dai B, Liu Y, Jia J, Mei C. Long-term antibiotics for the prevention of recurrent urinary tract infection in children: a systematic review and meta-analysis. Arch Dis Child 2010;95(7):499-508
  • Mori R, Fitzgerald A, Williams C, et al. Antibiotic prophylaxis for children at risk of developing urinary tract infection: a systematic review. Acta Paediatr 2009;98(11):1781-6
  • Williams GJ, Wei L, Lee A, Craig JC. Long-term antibiotics for preventing urinary tract infection in children. Cochrane Database Syst Rev 2006;3:CD001534
  • Conway PH, Cnaan A, Zaoutis T, et al. Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials. JAMA 2007;298(2):179-86
  • van der Veen EL, Schilder AGM, Timmers TK, et al. Effect of long-term trimethoprim/sulfamethoxazole treatment on resistance and integron prevalence in the intestinal flora: a randomized, double-blind, placebo-controlled trial in children. J Antimicrob Chemother 2009;63(5):1011-16
  • Craig JC, Williams GJ, Hodson EM. Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med 2014;371(11):1070-3
  • Ingelfinger JR, Stapleton FB. Antibiotic prophylaxis for vesicoureteral reflux—answers, yet questions. N Engl J Med 2014;370(25):2440-1
  • Sung J, Skoog S. Surgical management of vesicoureteral reflux in children. Pediatr Nephrol 2012;27(4):551-61
  • Dite Z, Kocvara R, Dvoracek J, et al. [Endoscopic and conservative treatment of vesicoureteric reflux]. Cas Lek Cesk 2007;146(10):817-21
  • Jodal U, Smellie JM, Lax H, Hoyer PF. Ten-year results of randomized treatment of children with severe vesicoureteral reflux. Final report of the International Reflux Study in Children. Pediatr Nephrol 2006;21(6):785-92
  • Weiss R, Duckett J, Spitzer A. Results of a randomized clinical trial of medical versus surgical management of infants and children with grades III and IV primary vesicoureteral reflux (United States). The International Reflux Study in Children. J Urol 1992;148(5 Pt 2):1667-73
  • Birmingham Reflux Study Group. Prospective trial of operative versus non-operative treatment of severe vesicoureteric reflux in children: five years’ observation. BMJ 1987;295(6592):237-41
  • Nagler EVT, Williams G, Hodson EM, Craig JC. Interventions for primary vesicoureteric reflux. Cochrane Database Syst Rev 2011;6:CD001532
  • Nevéus T, Brandström P, Linnér T, et al. Parental experiences and preferences regarding the treatment of vesicoureteral reflux. Scand J Urol Nephrol 2012;46(1):26-30
  • Elder JS. Vesicoureteral Reflux—Surgical Treatment. In: Pediatric Surgery. New York: Springer-Verlag Berlin Heidelberg; 2006. pp 499-514
  • Kasturi S, Sehgal SS, Christman MS, et al. Prospective long-term analysis of nerve-sparing extravesical robotic-assisted laparoscopic ureteral reimplantation. Urology 2012;79(3):680-3
  • Marchini GS, Hong YK, Minnillo BJ, et al. Robotic assisted laparoscopic ureteral reimplantation in children: case matched comparative study with open surgical approach. J Urol 2011;185(5):1870-5
  • Heidenreich A, Özgur E, Becker T, Haupt G. Surgical management of vesicoureteral reflux in pediatric patients. World J Urol 2004;22(2):96-106
  • DeFoor W, Minevich E, Reddy P, et al. Results of tapered ureteral reimplantation for primary megaureter: extravesical versus intravesical approach. J Urol 2004;172(4 Suppl):1640-3
  • Lashley DB, McAleer IM, Kaplan GW. Ipsilateral ureteroureterostomy for the treatment of vesicoureteral reflux or obstruction associated with complete ureteral duplication. J Urol 2001;165(2):552-4
  • Capozza N, Lais A, Nappo S, Caione P. The role of endoscopic treatment of vesicoureteral reflux: a 17-year experience. J Urol 2004;172(4 Suppl):1626-9
  • Garcia-Aparicio L, Rovira J, Blazques-Gomez E, et al. Randomized clinical trial comparing endoscopic treatment with dextranomer hyaluronic acid copolymer and Cohen’s ureteral reimplantation for vesicoureteral reflux: long-term results. J Pediatr Urol 2013;9(4):483-7
  • van Capelle JW, de Haan T, El Sayed W, Azmy A. The long-term outcome of the endoscopic subureteric implantation of polydimethylsiloxane for treating vesico-ureteric reflux in children: a retrospective analysis of the first 195 consecutive patients in two European centres. BJU Int 2004;94(9):1348-51
  • Herbst KW, Corbett ST, Lendvay TS, Caldamone AA. Recent trends in the surgical management of primary vesicoureteral reflux in the era of dextranomer/hyaluronic acid. J Urol 2014;191(5 Suppl):1628-33
  • Lavelle MT, Conlin MJ, Skoog SJ. Subureteral injection of Deflux for correction of reflux: analysis of factors predicting success. Urology 2005;65(3):564-7
  • Mevorach RA, Hulbert WC, Rabinowitz R, et al. Results of a 2-year multicenter trial of endoscopic treatment of vesicoureteral reflux with synthetic calcium hydroxyapatite. J Urol 2006;175(1):288-91
  • Elder JS, Diaz M, Caldamone AA, et al. Endoscopic therapy for vesicoureteral reflux: a meta-analysis. I. Reflux resolution and urinary tract infection. J Urol 2006;175(2):716-22
  • Arlen AM, Scherz HC, Kirsch AJ. Endoscopic injection techniques for vesicoureteral reflux. In: Pediatric Endourology Techniques. New York: Springer-Verlag Berlin Heidelberg; 2014. pp 207-16
  • Keating MA. Role of periureteral injections in children with vesicoureteral reflux. Curr Opin Urol 2005;15(6):369-73
  • Guay DR. Cranberry and urinary tract infections. Drugs 2009;69(7):775-807
  • Nowack R, Schmitt W. Cranberry juice for prophylaxis of urinary tract infections–Conclusions from clinical experience and research. Phytomedicine 2008;15(9):653-67
  • Hisano M, Bruschini H, Nicodemo AC, Srougi M. Cranberries and lower urinary tract infection prevention. Clin (Sao Paulo) 2012;67(6):661-8
  • Howell AB. Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Mol Nutr Food Res 2007;51(6):732-7
  • Howell AB, Reed JD, Krueger CG, et al. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry 2005;66(18):2281-91
  • Gupta K, Chou MY, Howell A, et al. Cranberry products inhibit adherence of p-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. J Urol 2007;177(6):2357-60
  • Huang Y, Nikolic D, Pendland S, et al. Effects of cranberry extracts and ursolic acid derivatives on P-fimbriated Escherichia coli, COX-2 activity, pro-inflammatory cytokine release and the NF-κβ transcriptional response in vitro. Pharm Biol 2009;47(1):18-25
  • Vasileiou I, Katsargyris A, Theocharis S, Giaginis C. Current clinical status on the preventive effects of cranberry consumption against urinary tract infections. Nutr Res 2013;33(8):595-607
  • Di Martino P, Agniel R, David K, et al. Reduction of Escherichia coli adherence to uroepithelial bladder cells after consumption of cranberry juice: a double-blind randomized placebo-controlled cross-over trial. World J Urol 2006;24(1):21-7
  • Foo LY, Lu Y, Howell AB, Vorsa N. The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro. Phytochemistry 2000;54(2):173-81
  • Howell AB, Foxman B. Cranberry juice and adhesion of antibiotic-resistant uropathogens. JAMA 2002;287(23):3082-3
  • Liu Y, Black MA, Caron L, Camesano TA. Role of cranberry juice on molecular-scale surface characteristics and adhesion behavior of Escherichia coli. Biotechnol Bioeng 2006;93(2):297-305
  • Raz R, Chazan B, Dan M. Cranberry juice and urinary tract infection. Clin Infect Dis 2004;38(10):1413-19
  • Deprez S, Brezillon C, Rabot S, et al. Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids. J Nutr 2000;130(11):2733-8
  • Valentova K, Stejskal D, Bednar P, et al. Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial. J Agric Food Chem 2007;55(8):3217-24
  • Reid G, Howard J, Gan BS. Can bacterial interference prevent infection? Trends Microbiol 2001;9(9):424-8
  • Mutlu H, Ekinci Z. Urinary tract infection prophylaxis in children with neurogenic bladder with cranberry capsules: randomized controlled trial. ISRN Pediatr 2012;2012:317280
  • Salo J, Uhari M, Helminen M, et al. Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trial. Clin Infect Dis 2012;54(3):340-6
  • Uberos J, Nogueras-Ocana M, Fernandez-Puentes V, et al. Cranberry syrup vs trimethoprim in the prophylaxis of recurrent urinary tract infections among children: a controlled trial. Open Access J Clin Trials 2012;4:31-8
  • Ferrara P, Romaniello L, Vitelli O, et al. Cranberry juice for the prevention of recurrent urinary tract infections: a randomized controlled trial in children. Scand J Urol Nephrol 2009;43(5):369-72
  • Stapleton AE. Cranberry-containing products are associated with a protective effect against urinary tract infections. Evid Based Med 2013;18(3):110-11
  • Wang CH, Fang CC, Chen NC, et al. Cranberry-containing products for prevention of urinary tract infections in susceptible populations. Arch Intern Med 2012;172(13):988-96
  • Lorenzo AJ, Braga LHP. Use of cranberry products does not appear to be associated with a significant reduction in incidence of recurrent urinary tract infections. Evid Based Med 2013;18(5):181-2
  • Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2012;10:CD001321
  • Huopalahti R, Järvenpää EP, Katina K. A novel solid-phase extraction-HPLC method for the analysis of anthocyanin and organic acid composition of Finnish cranberry. J Liq Chromatogr Relat Technol 2000;23(17):2695-701
  • Çelik H, Özgen M, Serçe S, Kaya C. Phytochemical accumulation and antioxidant capacity at four maturity stages of cranberry fruit. Sci Hortic 2008;117(4):345-8
  • Forney CF, Kalt W, Jordan MA, et al. Blueberry and cranberry fruit composition during development. J Berry Res 2012;2(3):169-77
  • Feldman AS, Bauer SB. Diagnosis and management of dysfunctional voiding. Curr Opin Pediatr 2006;18(2):139-47
  • Nevéus T, von Gontard A, Hoebeke P, et al. The standardization of terminology of lower urinary tract function in children and adolescents: report from the Standardisation Committee of the International Children’s Continence Society. J Urol 2006;176(1):314-24
  • Bacsu CD, Chan L, Tse V. Diagnosing detrusor sphincter dyssynergia in the neurological patient. BJU Int 2012;109(Suppl 3):31-4
  • de Paepe H, Renson C, van Laecke E, et al. Pelvic-floor therapy and toilet training in young children with dysfunctional voiding and obstipation. BJU Int 2000;85(7):889-93
  • Klijn AJ, Asselman M, Vijverberg MAW, et al. The diameter of the rectum on ultrasonography as a diagnostic tool for constipation in children with dysfunctional voiding. J Urol 2004;172(5 Pt 1):1986-8
  • Chung JM, Lee SD, Kang DI, et al. An epidemiologic study of voiding and bowel habits in Korean children: a nationwide multicenter study. Urology 2010;76(1):215-19
  • Chung JM, Lee SD, Kang DI, et al. Prevalence and associated factors of overactive bladder in Korean children 5-13 years old: a nationwide multicenter study. Urology 2009;73(1):63-7
  • Ballek NK, McKenna PH. Lower urinary tract dysfunction in childhood. Urol Clin North Am 2010;37(2):215-28
  • Burgers RE, Mugie SM, Chase J, et al. Management of functional constipation in children with lower urinary tract symptoms: report from the Standardization Committee of the International Children’s Continence Society. J Urol 2013;190(1):29-36
  • Chase JW, Homsy Y, Siggaard C, et al. Functional constipation in children. J Urol 2004;171(6 Pt 2):2641-3
  • Koff SA, Wagner TT, Jayanthi VR. The relationship among dysfunctional elimination syndromes, primary vesicoureteral reflux and urinary tract infections in children. J Urol 1998;160(3):1019-22
  • Amira PA, Dušan P, Gordana ML, et al. Bladder control training in girls with lower urinary tract dysfunction. Int Braz J Urol 2013;39(1):118-27
  • Zivkovic V, Lazovic M, Vlajkovic M, et al. Diaphragmatic breathing exercises and pelvic floor retraining in children with dysfunctional voiding. Eur J Phys Rehabil Med 2012;48(3):413-21
  • Kajbafzadeh AM, Sharifi-Rad L, Ghahestani SM, et al. Animated biofeedback: an ideal treatment for children with dysfunctional elimination syndrome. J Urol 2011;186(6):2379-85
  • Vesna Z, Milica L, Marina V, et al. Correlation between uroflowmetry parameters and treatment outcome in children with dysfunctional voiding. J Pediatr Urol 2010;6(4):396-402
  • Chrzan R, Klijn AJ, Vijverberg MAW, et al. Colonic washout enemas for persistent constipation in children with recurrent urinary tract infections based on dysfunctional voiding. Urology 2008;71(4):607-10
  • Kibar Y, Ors O, Demir E, et al. Results of biofeedback treatment on reflux resolution rates in children with dysfunctional voiding and vesicoureteral reflux. Urology 2007;70(3):563-6
  • Petronijevic V, Lazovic M, Vlajkovic M, et al. Botulinum toxin type A in combination with standard urotherapy for children with dysfunctional voiding. J Urol 2007;178(6):2599-603
  • Barroso Jr U, Lordêlo P, Lopes AA, et al. Nonpharmacological treatment of lower urinary tract dysfunction using biofeedback and transcutaneous electrical stimulation: a pilot study. BJU Int 2006;98(1):166-71
  • Humphreys MR, Vandersteen DR, Slezak JM, et al. Preliminary results of sacral neuromodulation in 23 children. J Urol 2006;176(5):2227-31
  • Khen-Dunlop N, Egroo AV, Bouteiller C, et al. Biofeedback therapy in the treatment of bladder overactivity, vesico-ureteral reflux and urinary tract infection. J Pediatr Urol 2006;2(5):424-9
  • Vasconcelos M, Lima E, Caiafa L, et al. Voiding dysfunction in children. Pelvic-floor exercises or biofeedback therapy: a randomized study. Pediatr Nephrol 2006;21(12):1858-64
  • Yagci S, Kibar Y, Akay O, et al. The effect of biofeedback treatment on voiding and urodynamic parameters in children with voiding dysfunction. J Urol 2005;174(5):1994-8
  • Desantis DJ, Leonard MP, Preston MA, et al. Effectiveness of biofeedback for dysfunctional elimination syndrome in pediatrics: a systematic review. J Pediatr Urol 2011;7(3):342-8
  • Fazeli MS, Lin Y, Nikoo N, et al. Biofeedback for non-neuropathic daytime voiding disorders in children: a systematic review and meta-analysis of randomized controlled trials. J Urol 2014; In Press
  • Zorc JJ, Levine DA, Platt SL, et al. Clinical and demographic factors associated with urinary tract infection in young febrile infants. Pediatrics 2005;116(3):644-8
  • Newman TB, Bernzweig JA, Takayama JI, et al. Urine testing and urinary tract infections in febrile infants seen in office settings: the Pediatric Research in Office Settings’ Febrile Infant Study. Arch Pediatr Adolesc Med 2002;156(1):44-54
  • Singh-Grewal D, Macdessi J, Craig J. Circumcision for the prevention of urinary tract infection in boys: a systematic review of randomised trials and observational studies. Arch Dis Child 2005;90(8):853-8
  • Weiss HA, Larke N, Halperin D, Schenker I. Complications of circumcision in male neonates, infants and children: a systematic review. BMC Urol 2010;10(1):2
  • Lim IS, Lee HS, Kim WY. The effect of lactic acid bacteria isolates on the urinary tract pathogens to infants in vitro. J Korean Med Sci 2009;24(Suppl 1):S57-62
  • Storm DW, Koff SA, Horvath Jr DJ, et al. In vitro analysis of the bactericidal activity of Escherichia coli Nissle 1917 against pediatric uropathogens. J Urol 2011;186(4 Suppl):1678-83
  • Lee SJ, Shim YH, Cho SJ, Lee JW. Probiotics prophylaxis in children with persistent primary vesicoureteral reflux. Pediatr Nephrol 2007;22(9):1315-20
  • Mohseni MJ, Aryan Z, Emamzadeh-Fard S, et al. Combination of probiotics and antibiotics in the prevention of recurrent urinary tract infection in children. Iran J Pediatr 2013;23(4):430-8
  • Roberts JA, Kaack MB, Baskin G, et al. Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein. J Urol 2004;171(4):1682-5
  • Langermann S, Ballou Jr RW. Vaccination utilizing the FimCH complex as a strategy to prevent Escherichia coli urinary tract infections. J Infect Dis 2001;183(Suppl 1):S84-6
  • Alteri CJ, Hagan EC, Sivick KE, et al. Mucosal immunization with iron receptor antigens protects against urinary tract infection. PLoS Pathog 2009;5(9):e1000586
  • Li X, Lockatell CV, Johnson DE, et al. Development of an intranasal vaccine to prevent urinary tract infection by Proteus mirabilis. Infect Immun 2004;72(1):66-75
  • Uehling DT, Hopkins WJ, Balish E, et al. Vaginal mucosal immunization for recurrent urinary tract infection: phase II clinical trial. J Urol 1997;157(6):2049-52
  • Bauer HW, Alloussi S, Egger G, et al. A long-term, multicenter, double-blind study of an Escherichia coli extract (OM-89) in female patients with recurrent urinary tract infections. Eur Urol 2005;47(4):542-8
  • Magasi P, Pánovics J, Illés A, Nagy M. Uro-Vaxom and the management of recurrent urinary tract infection in adults: a randomized multicenter double-blind trial. Eur Urol 1994;26:137-40
  • Tammen H. Immunobiotherapy with Uro-Vaxom® in recurrent urinary tract infection. Br J Urol 1990;65(1):6-9
  • Lorenzo-Gómez MF, Padilla-Fernández B, Garciá-Criado FJ, et al. Evaluation of a therapeutic vaccine for the prevention of recurrent urinary tract infections versus prophylactic treatment with antibiotics. Int Urogynecol J 2013;24(1):127-34
  • Kim KS, Kim JY, Jeong IG, et al. A prospective multi-center trial of Escherichia coli extract for the prophylactic treatment of patients with chronically recurrent cystitis. J Korean Med Sci 2010;25(3):435-9
  • Bauer HW, Rahlfs VW, Lauener PA, Blessmann GS. Prevention of recurrent urinary tract infections with immuno-active E. Coli fractions: a meta-analysis of five placebo-controlled double-blind studies. Int J Antimicrob Agents 2002;19(6):451-6
  • Naber KG, Cho YH, Matsumoto T, Schaeffer AJ. Immunoactive prophylaxis of recurrent urinary tract infections: a meta-analysis. Int J Antimicrob Agents 2009;33(2):111-19
  • Hoberman A, Chesney RW; RIVUR trial investigators. Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med 2014;371(11):1072-3
  • Pennesi M, Travan L, Peratoner L, et al. Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial. Pediatrics 2008;121(6):e1489-94

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