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Review

Recent advances in the understanding of infectious mononucleosis: are prospects improved for treatment or control?

Pages 1039-1049 | Published online: 10 Jan 2014

References

  • Epstein M, Achong B, Barr Y. Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet15, 702–703 (1964).
  • Young LS, Rickinson AB. Epstein–Barr virus: 40 years on. Nat. Rev. Cancer4(10), 757–768 (2004).
  • Rapp CE, Hewetson JF. Infectious mononucleosis and the Epstein–Barr virus. Am. J. Dis. Child132(1), 78–86 (1978).
  • Macsween KF, Crawford DH. Epstein–Barr virus – recent advances. Lancet Infect. Dis.3(3), 131–140 (2003).
  • Williams H, Crawford DH. Epstein–Barr virus: the impact of scientific advances on clinical practice. Blood107(3), 862–869 (2006).
  • Nye FJ. Social class and infectious mononucleosis. J. Hyg. (Lond.)71(1), 145–149 (1973).
  • Schuster V, Kreth HW. Epstein–Barr virus infection and associated diseases in children. I. Pathogenesis, epidemiology and clinical aspects. Eur. J. Pediatr.151(10), 718–725 (1992).
  • Auwaerter PG. Infectious mononucleosis in middle age (clinical conference). JAMA281(5), 454–459 (1999).
  • Crawford DH, Swerdlow AJ, Higgins C et al. Sexual history and Epstein–Barr virus infection. J. Infect. Dis.186(6), 731–736 (2002).
  • Crawford DH, Macsween KF, Higgins CD et al. A cohort study among university students: identification of risk factors for Epstein–Barr virus seroconversion and infectious mononucleosis. Clin. Infect. Dis.43(3), 276–282 (2006).
  • Thomas R, Macsween KF, McAulay K et al. Evidence of shared Epstein–Barr viral isolates between sexual partners, and low level EBV in genital secretions. J. Med. Virol.78(9), 1204–1209 (2006).
  • Morris MC, Edmunds WJ. The changing epidemiology of infectious mononucleosis? J. Infect.45(2), 107–109 (2002).
  • Tattevin P, Le Tulzo Y, Minjolle S et al. Increasing incidence of severe Epstein–Barr virus-related infectious mononucleosis: Surveillance study. J. Clin. Microbiol.44(5), 1873–1874 (2006).
  • Takeuchi K, Tanaka-Taya K, Kazuyama Y et al. Prevalence of Epstein–Barr virus in Japan: trends and future prediction. Pathol. Int.56(3), 112–116 (2006).
  • Sitki-Green DL, Edwards RH, Covington MM, Raab-Traub N. Biology of Epstein–Barr virus during infectious mononucleosis. J. Infect. Dis.189(3), 483–492 (2004).
  • Puchhammer-Stockl E, Gorzer I. Cytomegalovirus and Epstein–Barr virus subtypes – the search for clinical significance. J. Clin. Virol.36(4), 239–248 (2006).
  • Thorley-Lawson DA, Mann KP. Early events in Epstein–Barr virus infection provide a model for B cell activation. J. Exp. Med.162(1), 45–59 (1985).
  • Pattengale PK, Smith RW, Perlin E. Atypical lymphocytes in acute infectious mononucleosis. Identification by multiple T and B lymphocyte markers. N. Engl. J. Med.291(22), 1145–1148 (1974).
  • Callan MF, Steven N, Krausa P et al. Large clonal expansions of CD8+ T cells in acute infectious mononucleosis. Nat. Med.2(8), 906–911 (1996).
  • Silins SL, Sherritt MA, Silleri JM et al. Asymptomatic primary Epstein–Barr virus infection occurs in the absence of blood T-cell repertoire perturbations despite high levels of systemic viral load. Blood98(13), 3739–3744 (2001).
  • Balfour HH Jr, Holman CJ, Hokanson KM et al. A prospective clinical study of Epstein–Barr virus and host interactions during acute infectious mononucleosis. J. Infect. Dis.192(9), 1505–1512 (2005).
  • Williams H, Macsween K, McAulay K et al. Analysis of immune activation and clinical events in acute infectious mononucleosis. J. Infect Dis.190(1), 63–71 (2004).
  • Precopio ML, Sullivan JL, Willard C, Somasundaran M, Luzuriaga K. Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infection. J. Immunol.170(5), 2590–2598 (2003).
  • Williams H, McAulay K, Macsween KF et al. The immune response to primary EBV infection: a role for natural killer cells. Br. J. Haematol.129(2), 266–274 (2005).
  • Corsi MM, Ruscica M, Passoni D, Scarmozzino MG, Gulletta E. High Th1-type cytokine serum levels in patients with infectious mononucleosis. Acta Virol.48(4), 263–266 (2004).
  • Helminen M, Lahdenpohja N, Hurme M. Polymorphism of the interleukin-10 gene is associated with susceptibility to Epstein–Barr virus infection. J. Infect. Dis.180(2), 496–499 (1999).
  • Clute SC, Watkin LB, Cornberg M et al. Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein–Barr virus-associated infectious mononucleosis. J. Clin. Invest.115(12), 3602–3612 (2005).
  • Tsurumi T, Fujita M, Kudoh A. Latent and lytic Epstein–Barr virus replication strategies. Rev. Med. Virol.15(1), 3–15 (2005).
  • Fafi-Kremer S, Morand P, Brion JP et al. Long-term shedding of infectious Epstein–Barr virus after infectious mononucleosis. J. Infect. Dis.191(6), 985–989 (2005).
  • Hochberg D, Souza T, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Acute infection with Epstein–Barr virus targets and overwhelms the peripheral memory B-cell compartment with resting, latently infected cells. J. Virol.78(10), 5194–5204 (2004).
  • Schooley RT. Epstein–Barr virus (infectious mononucleosis). In: Principles and Practice of Infectious Diseases, 4th Edition. Mandell GL, Bennett JE, Dolin R (Eds), Churchill Livingston Inc., New York, NY, USA, 1364–1377 (1995).
  • Straus SE, Cohen JI, Tosato G, Meier J. NIH conference. Epstein–Barr virus infections: biology, pathogenesis, and management. Ann. Intern. Med.118(1), 45–58 (1993).
  • Generalfeatures of infectious mononucleosis (roundtable discussion). In: Infectious Mononucleosis: Proceedings of Symposium. Glade PR (Ed.), JB Lippincott, New York, NY, USA, 1–18 (1973).
  • Auwaerter PG. Infectious mononucleosis: return to play. Clin. Sports Med.23(3), 485–497 (2004).
  • Murray BJ. Medical complications of infectious mononucleosis. Am. Fam. Physician30(5), 195–199 (1984).
  • Imashuku S. Clinical features and treatment strategies of Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis. Crit. Rev. Oncol. Hematol.44(3), 259–272 (2002).
  • Jenson HB. Acute complications of Epstein–Barr virus infectious mononucleosis. Curr. Opin. Pediatr.12(3), 263–268 (2000).
  • Connelly KP, DeWitt LD. Neurologic complications of infectious mononucleosis. Pediatr. Neurol.10(3), 181–184 (1994).
  • Andersson J. Clinical and immunological considerations in Epstein–Barr virus-associated diseases. Scand. J. Infect. Dis.100(Suppl.), 72–82 (1996).
  • Cohen JI. Benign and malignant Epstein–Barr virus-associated B-cell lymphoproliferative diseases. Semin. Hematol.40(2), 116–123 (2003).
  • Markin RS. Manifestations of Epstein–Barr virus-associated disorders in liver. Liver14(1), 1–13 (1994).
  • Linde A. Diagnosis of Epstein–Barr virus-related diseases. Scand. J. Infect. Dis.100(Suppl.), 83–88 (1996).
  • Hess RD. Routine Epstein-Barr virus diagnostics from the laboratory perspective: still challenging after 35 years. J. Clin. Microbiol.42(8), 3381–3387 (2004).
  • Gartner BC, Hess RD, Bandt D et al. Evaluation of four commercially available Epstein–Barr virus enzyme immunoassays with an immunofluorescence assay as the reference method. Clin. Diagn. Lab. Immunol.10(1), 78–82 (2003).
  • Pitetti RD, Laus S, Wadowsky RM. Clinical evaluation of a quantitative real time polymerase chain reaction assay for diagnosis of primary Epstein–Barr virus infection in children. Pediatr. Infect. Dis. J.22(8), 736–739 (2003).
  • Candy B, Chalder T, Cleare AJ, Wessely S, Hotopf M. What advice do patients with infectious mononucleosis report being given by their general practitioner? J. Psychosom. Res.58(5), 435–437 (2005).
  • Dalrymple W. Infectious mononucleosis. 2. Relation of bed rest and activity to prognosis. Postgrad. Med.35, 345–349 (1964).
  • Candy B, Chalder T, Cleare AJ, Wessely S, White PD, Hotopf M. Recovery from infectious mononucleosis: a case for more than symptomatic therapy? A systematic review. Br. J. Gen. Pract.52(483), 844–851 (2002).
  • Thompson SK, Doerr TD, Hengerer AS. Infectious mononucleosis and corticosteroids: management practices and outcomes. Arch. Otolaryngol. Head Neck Surg.131(10), 900–904 (2005).
  • Disney FA. Corticosteroids for infectious mononucleosis. Pediatr. Infect. Dis. J.7(11), 820–821 (1988).
  • Collins M, Fleisher G, Kreisberg J, Fager S. Role of steroids in the treatment of infectious mononucleosis in the ambulatory college student. J. Am. Coll. Health33(3), 101–105 (1984).
  • Tynell E, Aurelius E, Brandell A et al. Acyclovir and prednisolone treatment of acute infectious mononucleosis: a multicenter, double-blind, placebo-controlled study. J. Infect. Dis.174, 324–331 (1996).
  • Brandfonbrener A, Epstein A, Wu S, Phair J. Corticosteroid therapy in Epstein–Barr virus infection. Effect on lymphocyte class, subset, and response to early antigen. Arch. Intern. Med.146(2), 337–339 (1986).
  • Andersson J, Ernberg I. Management of Epstein–Barr virus infections. Am. J. Med.85(2A), 107–115 (1988).
  • Roy M, Bailey B, Amre DK, Girodias JB, Bussieres JF, Gaudreault P. Dexamethasone for the treatment of sore throat in children with suspected infectious mononucleosis: a randomized, double-blind, placebo-controlled, clinical trial. Arch. Pediatr. Adolesc. Med.158(3), 250–254 (2004).
  • Peter J, Ray CG. Infectious mononucleosis. Pediatr. Rev.19(8), 276–279 (1998).
  • Portman M, Ingall D, Westenfelder G, Yogev R. Peritonsillar abscess complicating infectious mononucleosis.J. Pediatr.104(5), 742–744 (1984).
  • Fleisher GR, Collins M, Fager S. Humoral immune response in infectious mononucleosis. Late emergence of anti-EA(R) and the effects of corticosteroid therapy. J. Adolesc. Health Care6(6), 424–428 (1985).
  • Colby BM, Shaw JE, Elion GB, Pagano JS. Effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on Epstein–Barr virus DNA replication. J. Virol.34(2), 560–568 (1980).
  • Datta AK, Colby BM, Shaw JE, Pagano JS. Acyclovir inhibition of Epstein–Barr virus replication. Proc. Natl. Acad. Sci. USA77(9), 5163–5166 (1980).
  • Miller CS, Avdiushko SA, Kryscio RJ, Danaher RJ, Jacob RJ. Effect of prophylactic valacyclovir on the presence of human herpesvirus DNA in saliva of healthy individuals after dental treatment. J. Clin. Microbiol.43(5), 2173–2180 (2005).
  • Simon MW, Deeter RG, Shahan BS. The effect of valacyclovir and prednisolone in reducing symptoms of EBV illness in children: a double-blind, placebo-controlled study. Int. Pediatr.18, 164–169 (2003).
  • Torre D, Tambini R. Acyclovir for treatment of infectious mononucleosis: a meta-analysis. Scand. J. Infect. Dis.31(6), 543–547 (1999).
  • Alrabiah FA, Sacks SL. New antiherpesvirus agents. Their targets and therapeutic potential. Drugs52(1), 17–32 (1996).
  • Goldani LZ. Treatment of severe infectious mononucleosis with famciclovir. J. Infect.44(2), 92–93 (2002).
  • Diez R, Diaz C, Frauca E et al. Valganciclovir in EBV infection after pediatric liver transplantation. Paper presented at World Transplant Congress, Boston, MA (2006).
  • Simon MW, Fish DN, Deeter RG. Pharmacokinetics and safety of valaciclovir in children with Epstein–Barr virus illness. Drugs RD3(6), 365–373 (2002).
  • Darenkov IA, Marcarelli MA, Basadonna GP et al. Reduced incidence of Epstein–Barr virus-associated posttransplant lymphoproliferative disorder using preemptive antiviral therapy. Transplantation64(6), 848–852 (1997).
  • Garamendi I, Montejo M, Cancelo L et al. Encephalitis caused by Epstein–Barr virus in a renal transplant recipient. Clin. Infect. Dis.34(2), 287–288 (2002).
  • Dellemijn PL, Brandenburg A, Niesters HG, van den Bent MJ, Rothbarth PH, Vlasveld LT. Successful treatment with ganciclovir of presumed Epstein–Barr meningo-encephalitis following bone marrow transplant. Bone Marrow Transplant.16(2), 311–312 (1995).
  • Adams LA, Deboer B, Jeffrey G, Marley R, Garas G. Ganciclovir and the treatment of Epstein–Barr virus hepatitis. J. Gastroenterol. Hepatol.21(11), 1758–1760 (2006).
  • Meerbach A, Holy A, Wutzler P, De Clercq E, Neyts J. Inhibitory effects of novel nucleoside and nucleotide analogues on Epstein–Barr virus replication. Antivir. Chem. Chemother.9(3), 275–282 (1998).
  • Friedrichs C, Neyts J, Gaspar G, De Clercq E, Wutzler P. Evaluation of antiviral activity against human herpesvirus 8 (HHV-8) and Epstein–Barr virus (EBV) by a quantitative real-time PCR assay. Antiviral Res.62(3), 121–123 (2004).
  • Williams-Aziz SL, Hartline CB, Harden EA et al. Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro. Antimicrob. Agents Chemother.49(9), 3724–3733 (2005).
  • Gershburg E, Hong K, Pagano JS. Effects of maribavir and selected indolocarbazoles on Epstein–Barr virus protein kinase BGLF4 and on viral lytic replication. Antimicrob. Agents Chemother.48(5), 1900–1903 (2004).
  • Gershburg E, Pagano JS. Epstein–Barr virus infections: prospects for treatment. J. Antimicrob. Chemother.56(2), 277–281 (2005).
  • Hartline CB, Harden EA, Williams-Aziz SL, Kushner NL, Brideau RJ, Kern ER. Inhibition of herpesvirus replication by a series of 4-oxo-dihydroquinolines with viral polymerase activity. Antiviral Res.65(2), 97–105 (2005).
  • Pagano JS, Blaser M, Buendia MA et al. Infectious agents and cancer: criteria for a causal relation. Semin. Cancer Biol.14(6), 453–471 (2004).
  • Krilov LR, Fisher M, Friedman SB, Reitman D, Mandel FS. Course and outcome of chronic fatigue in children and adolescents. Pediatrics102(2 Pt 1), 360–366 (1998).
  • Petersen I, Thomas JM, Hamilton WT, White PD. Risk and predictors of fatigue after infectious mononucleosis in a large primary-care cohort. QJM99(1), 49–55 (2006).
  • Bennett BK, Hickie IB, Vollmer-Conna US et al. The relationship between fatigue, psychological and immunological variables in acute infectious illness. Aust. NZJ Psychiatry32(2), 180–186 (1998).
  • White PD, Thomas JM, Kangro HO et al. Predictions and associations of fatigue syndromes and mood disorders that occur after infectious mononucleosis. Lancet358(9297), 1946–1954 (2001).
  • Vernon SD, Whistler T, Cameron B, Hickie IB, Reeves WC, Lloyd A. Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virus. BMC Infect. Dis.6, 15 (2006).
  • Vernon SD, Nicholson A, Rajeevan M et al. Correlation of psycho-neuroendocrine-immune (PNI) gene expression with symptoms of acute infectious mononucleosis. Brain Res.1068(1), 1–6 (2006).
  • Katz BZ. Update on chronic fatigue syndrome and Epstein–Barr virus. Pediatr. Ann.31(11), 741–744 (2002).
  • Vernon SD, Whistler T, Aslakson E, Rajeevan M, Reeves WC. Challenges for molecular profiling of chronic fatigue syndrome. Pharmacogenomics7(2), 211–218 (2006).
  • Okano M, Kawa K, Kimura H et al. Proposed guidelines for diagnosing chronic active Epstein–Barr virus infection. Am. J. Hematol.80(1), 64–69 (2005).
  • Kimura H. Pathogenesis of chronic active Epstein–Barr virus infection: is this an infectious disease, lymphoproliferative disorder, or immunodeficiency? Rev. Med. Virol.16(4), 251–261 (2006).
  • Hjalgrim H, Askling J, Rostgaard K et al. Characteristics of Hodgkin's lymphoma after infectious mononucleosis. N. Engl. J. Med.349(14), 1324–1332 (2003).
  • Chang ET, Zheng T, Weir EG et al. Childhood social environment and Hodgkin’s lymphoma: new findings from a population-based case–control study. Cancer Epidemiol. Biomarkers Prev.13(8), 1361–1370 (2004).
  • Meyer RM, Ambinder RF, Stroobants S. Hodgkin’s lymphoma: evolving concepts with implications for practice. Hematology (Am. Soc. Hematol. Educ. Program), 184–202 (2004).
  • Glaser SL, Keegan TH, Clarke CA et al. Exposure to childhood infections and risk of Epstein–Barr virus – defined Hodgkin’s lymphoma in women. Int. J. Cancer115(4), 599–605 (2005).
  • Tao Q, Young LS, Woodman CB, Murray PG. Epstein–Barr virus (EBV) and its associated human cancers – genetics, epigenetics, pathobiology and novel therapeutics. Front Biosci.11, 2672–2713 (2006).
  • Sauce D, Larsen M, Curnow SJ et al. EBV-associated mononucleosis leads to long-term global deficit in T cell responsiveness to IL-15. Blood108(1), 8–11 (2006).
  • Alpdogan O, van den Brink MR. IL-7 and IL-15: therapeutic cytokines for immunodeficiency. Trends Immunol.26(1), 56–64 (2005).
  • Kulwichit W, Edwards RH, Davenport EM, Baskar JF, Godfrey V, Raab-Traub N. Expression of the Epstein–Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice. Proc. Natl Acad. Sci. USA95(20), 11963–11968 (1998).
  • Portis T, Dyck P, Longnecker R. Epstein–Barr virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma. Blood102(12), 4166–4178 (2003).
  • Ascherio A, Munger KL, Lennette ET et al. Epstein–Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA286(24), 3083–3088 (2001).
  • Levin LI, Munger KL, Rubertone MV et al. Temporal relationship between elevation of Epstein–Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis. JAMA293(20), 2496–2500 (2005).
  • Thacker EL, Mirzaei F, Ascherio A. Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. Ann. Neurol.59(3), 499–503 (2006).
  • McClain MT, Poole BD, Bruner BF, Kaufman KM, Harley JB, James JA. An altered immune response to Epstein–Barr nuclear antigen 1 in pediatric systemic lupus erythematosus. Arthritis Rheum.54(1), 360–368 (2006).
  • Poole BD, Scofield RH, Harley JB, James JA. Epstein–Barr virus and molecular mimicry in systemic lupus erythematosus. Autoimmunity39(1), 63–70 (2006).
  • Woodberry T, Suscovich TJ, Henry LM et al. Differential targeting and shifts in the immunodominance of Epstein–Barr virus-specific CD8 and CD4 T cell responses during acute and persistent infection. J. Infect. Dis.192(9), 1513–1524 (2005).
  • Khanna R, Moss DJ, Burrows SR. Vaccine strategies against Epstein–Barr virus-associated diseases: lessons from studies on cytotoxic T-cell-mediated immune regulation. Immunol. Rev.170, 49–64 (1999).
  • Shope TC. Prevention of Epstein–Barr virus (EBV)-induced infection in cotton-topped marmosets by human serum containing EBV neutralizing activity. IARC Sci. Publ.1975(11 Pt 2), 153–159.
  • Pither RJ, Zhang CX, Shiels C, Tarlton J, Finerty S, Morgan AJ. Mapping of B-cell epitopes on the polypeptide chain of the Epstein–Barr virus major envelope glycoprotein and candidate vaccine molecule gp340. J. Virol.66(2), 1246–1251 (1992).
  • Gu SY, Huang TM, Ruan L et al. First EBV vaccine trial in humans using recombinant vaccinia virus expressing the major membrane antigen. Dev. Biol. Stand.84, 171–177 (1995).
  • Emini EA, Schleif WA, Silberklang M, Lehman D, Ellis RW. Vero cell-expressed Epstein–Barr virus (EBV) gp350/220 protects marmosets from EBV challenge. J. Med. Virol.27(2), 120–123 (1989).
  • Finerty S, Mackett M, Arrand JR, Watkins PE, Tarlton J, Morgan AJ. Immunization of cottontop tamarins and rabbits with a candidate vaccine against the Epstein–Barr virus based on the major viral envelope glycoprotein gp340 and alum. Vaccine12(13), 1180–1184 (1994).
  • Denis M, Haumont H, Bolen A. Vaccination against Epstein–Barr virus (EBV): report of Phase II studies using recombinant viral glycoprotein gp350 in healthy adults. Paper presented at the 11th Biennial Conference of the International Association for Research on Epstein–Barr virus and Associated Diseases, September, Regensburg, Germany (2004).
  • Ponsonby AL, van der Mei I, Dwyer T et al. Exposure to infant siblings during early life and risk of multiple sclerosis. JAMA293(4), 463–469 (2005).
  • Grulich AE, Vajdic CM, Kaldor JM et al. Birth order, atopy, and risk of non-Hodgkin lymphoma. J. Natl Cancer Inst.97(8), 587–594 (2005).
  • Andersson J. An overview of Epstein–Barr virus: from discovery to future directions for treatment and prevention. Herpes7(3), 76–82 (2000).

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