A role for B lymphocytes in anti-infective prion therapies?

References

• Prusiner SB. Biology and genetics of prion diseases. Annu. Rev. Microbiol.48, 655–686 (1994).
   PubMed Web of Science ®Google Scholar
• Wells GA, Wilesmith JW. The neuropathology and epidemiology of bovine spongiform encephalopathy. Brain Pathol.5(1), 91–103 (1995).
   PubMed Web of Science ®Google Scholar
• Laplanche JL. [Molecular basis of familial and sporadic forms of human prion diseases]. Transfus. Clin. Biol.1(5), 345–353 (1994).
   PubMedGoogle Scholar
• Prusiner SB, Hsiao KK. Human prion diseases. Ann. Neurol.35(4), 385–395 (1994).
   PubMed Web of Science ®Google Scholar
• Brown P, Preece M, Brandel JP et al. Iatrogenic Creutzfeldt–Jakob disease at the millennium. Neurology55(8), 1075–1081 (2000).
   PubMed Web of Science ®Google Scholar
• McGowan JP. Scrapie in sheep. Scott. J. Agric.5, 365–375 (1922).
   Google Scholar
• Williams ES, Young S. Chronic wasting disease of captive mule deer: a spongiform encephalopathy. J. Wildl. Dis.16, 89–98 (1980).
   PubMed Web of Science ®Google Scholar
• Wells GAH, Scott AC, Johnson CT et al. A novel progressive spongiform encephalopathy in cattle. Vet. Rec. Oct.31, 419–420 (1987).
   Google Scholar
• Gajdusek DC, Gibbs CJ Jr, Alpers MP. Experimental transmission of a kuru-like syndrome to chimpanzees. Nature209(5025), 794–796 (1966).
   PubMed Web of Science ®Google Scholar
• Lampert PW, Gajdusek DC, Gibbs CJ Jr. Subacute spongiform virus encephalopathies. Scrapie, kuru and Creutzfeldt–Jakob disease: a review. Am. J. Pathol.68(3), 626–652 (1972).
   PubMed Web of Science ®Google Scholar
• Gibbs CJ Jr, Gajdusek DC. Transmission of scrapie to the cynomolgus monkey (Macaca fascicularis). Nature236(5341), 73–74 (1972).
   PubMedGoogle Scholar
• Wopfner F, Weidenhofer G, Schneider R et al. Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein. J. Mol. Biol.289(5), 1163–1178 (1999).
   PubMed Web of Science ®Google Scholar
• Windl O, Dempster M, Estibeiro P, Lathe R. A candidate marsupial PrP gene reveals two domains conserved in mammalian PrP proteins. Gene159, 181–186 (1995).
   PubMed Web of Science ®Google Scholar
• Harris DA, Lele P, Snider WD. Localization of the mRNA for a chicken prion protein by in situ hybridization. Proc. Natl Acad. Sci. USA90(9), 4309–4313 (1993).
   PubMed Web of Science ®Google Scholar
• Manson J, West JD, Thomson V, McBride P, Kaufman MH, Hope J. The prion protein gene: a role in mouse embryogenesis? Development115(1), 117–122 (1992).
   PubMed Web of Science ®Google Scholar
• Dodelet VC, Cashman NR. Prion protein expression in human leukocyte differentiation. Blood91(5), 1556–1561 (1998).
   PubMed Web of Science ®Google Scholar
• Pan KM, Baldwin M, Nguyen J et al. Conversion of α-helices into β-sheets features in the formation of the scrapie prion proteins. Proc. Natl Acad. Sci. USA90(23), 10962–10966 (1993).
   PubMed Web of Science ®Google Scholar
• Safar J, Roller PP, Gajdusek DC, Gibbs CJ Jr. Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein. J. Biol. Chem.268(27), 20276–20284 (1993).
   PubMed Web of Science ®Google Scholar
• Taraboulos A, Rogers M, Borchelt DR et al. Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation. Proc. Natl Acad. Sci. USA87(21), 8262–8266 (1990).
   PubMed Web of Science ®Google Scholar
• Caughey B, Raymond GJ, Ernst D, Race RE. N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state. J. Virol.65(12), 6597–6603 (1991).
   PubMed Web of Science ®Google Scholar
• Borchelt DR, Taraboulos A, Prusiner SB. Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J. Biol. Chem.267(23), 16188–16199 (1992).
   PubMed Web of Science ®Google Scholar
• Taraboulos A, Scott M, Semenov A, Avrahami D, Laszlo L, Prusiner SB. Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J. Cell. Biol.129(1), 121–132 (1995).
   PubMed Web of Science ®Google Scholar
• Kaneko K, Vey M, Scott M, Pilkuhn S, Cohen FE, Prusiner SB. COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform. Proc. Natl Acad. Sci. USA94(6), 2333–2338 (1997).
   PubMed Web of Science ®Google Scholar
• Baron GS, Wehrly K, Dorward DW, Chesebro B, Caughey B. Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrPSc) into contiguous membranes. EMBO J.21(5), 1031–1040 (2002).
   PubMed Web of Science ®Google Scholar
• Laszlo L, Lowe J, Self T et al. Lysosomes as key organelles in the pathogenesis of prion encephalopathies. J. Pathol.166(4), 333–341 (1992).
   PubMedGoogle Scholar
• Mayer RJ, Landon M, Laszlo L, Lennox G, Lowe J. Protein processing in lysosomes: the new therapeutic target in neurodegenerative disease. Lancet340(8812), 156–159 (1992).
   PubMedGoogle Scholar
• Taraboulos A, Raeber AJ, Borchelt DR, Serban D, Prusiner SB. Synthesis and trafficking of prion proteins in cultured cells. Mol. Biol. Cell.3(8), 851–863 (1992).
   PubMed Web of Science ®Google Scholar
• Arnold JE, Tipler C, Laszlo L, Hope J, Landon M, Mayer RJ. The abnormal isoform of the prion protein accumulates in late-endosome-like organelles in scrapie-infected mouse brain. J. Pathol.176(4), 403–411 (1995).
   PubMedGoogle Scholar
• Gajdusek DC. Hypothesis: interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the central nervous system. N. Engl. J. Med.312, 714–719 (1985).
   PubMed Web of Science ®Google Scholar
• Bueler H, Aguzzi A, Sailer A et al. Mice devoid of PrP are resistant to scrapie. Cell73(7), 1339–1347 (1993).
   PubMed Web of Science ®Google Scholar
• Prusiner SB, Groth D, Serban A et al. Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies. Proc. Natl Acad. Sci. USA90(22), 10608–10612 (1993).
   PubMed Web of Science ®Google Scholar
• Chesebro B, Race R, Kercher L. Scrapie pathogenesis in brain and retina: effects of prion protein expression in neurons and astrocytes. J. Neurovirol.11(5), 476–480 (2005).
   PubMed Web of Science ®Google Scholar
• Mallucci G, Dickinson A, Linehan J, Klohn PC, Brandner S, Collinge J. Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis. Science302(5646), 871–874 (2003).
   PubMed Web of Science ®Google Scholar
• Baldauf E, Beekes M, Diringer H. Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord. J. Gen. Virol.78(Pt 5), 1187–1197 (1997).
   PubMedGoogle Scholar
• Kimberlin RH, Walker CA. Incubation periods in six models of intraperitoneally injected scrapie depend mainly on the dynamics of agent replication within the nervous system and not the lymphoreticular system. J. Gen. Virol.69(Pt 12), 2953–2960 (1988).
   PubMed Web of Science ®Google Scholar
• Lasmezas CI, Deslys JP, Demaimay R, Adjou KT, Hauw JJ, Dormont D. Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy. J. Gen. Virol.77(Pt 7), 1601–1609 (1996).
   PubMed Web of Science ®Google Scholar
• Blattler T, Brandner S, Raeber AJ et al. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature389(6646), 69–73 (1997).
   PubMed Web of Science ®Google Scholar
• Mabbott NA, Young J, McConnell I, Bruce ME. Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility. J. Virol.77(12), 6845–6854 (2003).
   PubMed Web of Science ®Google Scholar
• Glatzel M, Brandner S, Klein MA, Horstmann S, Aguzzi A. Prions – role of the peripheral nervous system. Virus Res.82(1–2), 53 (2002).
   PubMedGoogle Scholar
• Kimberlin RH, Walker CA. Pathogenesis of mouse scrapie: dynamics of agent replication in spleen, spinal cord and brain after infection by different routes. J. Comp. Pathol.89(4), 551–562 (1979).
   PubMed Web of Science ®Google Scholar
• Farquhar CF, Dornan J, Somerville RA, Tunstall AM, Hope J. Effect of Sinc genotype, agent isolate and route of infection on the accumulation of protease-resistant PrP in non-central nervous system tissues during the development of murine scrapie. J. Gen. Virol.75(Pt 3), 495–504 (1994).
   PubMedGoogle Scholar
• Brown KL, Stewart K, Ritchie DL et al. Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells. Nat. Med.5(11), 1308–1312 (1999).
   PubMed Web of Science ®Google Scholar
• Beekes M, McBride PA. Early accumulation of pathological PrP in the enteric nervous system and gut-associated lymphoid tissue of hamsters orally infected with scrapie. Neurosci. Lett.278(3), 181–184 (2000).
   PubMed Web of Science ®Google Scholar
• Heggebo R, Press CM, Gunnes G et al. Distribution of prion protein in the ileal Peyer’s patch of scrapie-free lambs and lambs naturally and experimentally exposed to the scrapie agent. J. Gen. Virol.81(Pt 9), 2327–2337 (2000).
   PubMedGoogle Scholar
• Heggebo R, Gonzalez L, Press CM, Gunnes G, Espenes A, Jeffrey M. Disease-associated PrP in the enteric nervous system of scrapie-affected Suffolk sheep. J. Gen. Virol.84(Pt 5), 1327–1338 (2003).
   PubMed Web of Science ®Google Scholar
• Mabbott NA, Mackay F, Minns F, Bruce ME. Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie. Nat. Med.6(7), 719–720 (2000).
   PubMed Web of Science ®Google Scholar
• Peden AH, Ritchie DL, Head MW, Ironside JW. Detection and localization of PrPSc in the skeletal muscle of patients with variant, iatrogenic, and sporadic forms of Creutzfeldt–Jakob disease. Am. J. Pathol.168(3), 927–935 (2006).
   PubMed Web of Science ®Google Scholar
• Hill AF, Butterworth RJ, Joiner S et al. Investigation of variant Creutzfeldt–Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet353(9148), 183–189 (1999).
   PubMed Web of Science ®Google Scholar
• Somerville RA, Birkett CR, Farquhar CF et al. Immunodetection of PrPSc in spleens of some scrapie-infected sheep but not BSE-infected cows. J. Gen. Virol.78(Pt 9), 2389–2396 (1997).
   PubMedGoogle Scholar
• Glatzel M, Abela E, Maissen M, Aguzzi A. Extraneural pathologic prion protein in sporadic Creutzfeldt–Jakob disease. N. Engl. J. Med.349(19), 1812–1820 (2003).
   PubMed Web of Science ®Google Scholar
• Hilton DA, Fathers E, Edwards P, Ironside JW, Zajicek J. Prion immunoreactivity in appendix before clinical onset of variant Creutzfeldt–Jakob disease. Lancet352(9129), 703–704 (1998).
   PubMed Web of Science ®Google Scholar
• Bruce ME, McConnell I, Will RG, Ironside JW. Detection of variant Creutzfeldt–Jakob disease infectivity in extraneural tissues. Lancet358(9277), 208–209 (2001).
   PubMed Web of Science ®Google Scholar
• van Keulen LJ, Schreuder BE, Meloen RH, Mooij-Harkes G, Vromans ME, Langeveld JP. Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie. J. Clin. Microbiol.34(5), 1228–1231 (1996).
   PubMed Web of Science ®Google Scholar
• McBride PA, Eikelenboom P, Kraal G, Fraser H, Bruce ME. PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice. J. Pathol.168(4), 413–418 (1992).
   PubMed Web of Science ®Google Scholar
• Fraser H, Dickinson AG. Studies of the lymphoreticular system in the pathogenesis of scrapie: the role of spleen and thymus. J. Comp. Pathol.88(4), 563–573 (1978).
   PubMed Web of Science ®Google Scholar
• Klein MA, Frigg R, Raeber AJ et al.PrP expression in B lymphocytes is not required for prion neuroinvasion. Nat. Med.4(12), 1429–1433 (1998).
   PubMedGoogle Scholar
• Fraser H, Dickinson AG. The sequential development of the brain lesion of scrapie in three strains of mice. J. Comp. Pathol.78(3), 301–311 (1968).
   PubMed Web of Science ®Google Scholar
• Raeber AJ, Klein MA, Frigg R, Flechsig E, Aguzzi A, Weissmann C. PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice. EMBO J.18(10), 2702–2706 (1999).
   PubMed Web of Science ®Google Scholar
• Taylor DM, McConnell I, Fraser H. Scrapie infection can be established readily through skin scarification in immunocompetent but not immunodeficient mice. J. Gen. Virol.77(Pt 7), 1595–1599 (1996).
   PubMedGoogle Scholar
• Frigg R, Klein MA, Hegyi I, Zinkernagel RM, Aguzzi A. Scrapie pathogenesis in subclinically infected B-cell-deficient mice. J. Virol.73(11), 9584–9588 (1999).
   PubMedGoogle Scholar
• Kosco-Vilbois MH, Bonnefoy JY, Chvatchko Y. The physiology of murine germinal center reactions. Immunol. Rev.156, 127–136 (1997).
   PubMedGoogle Scholar
• Fraser H, Farquhar CF. Ionising radiation has no influence on scrapie incubation period in mice. Vet. Microbiol.13, 211–223 (1987).
   PubMed Web of Science ®Google Scholar
• Jeffrey M, McGovern G, Martin S, Goodsir CM, Brown KL. Cellular and sub-cellular localisation of PrP in the lymphoreticular system of mice and sheep. Arch. Virol. Suppl.(16), 23–38 (2000).
   Google Scholar
• Fourth case of transfusion-associated vCJD infection in the UK. Euro Surveill.12(1), E070118 (2007).
   Google Scholar
• Glatzel M, Aguzzi A. Peripheral pathogenesis of prion diseases. Microbes Infect.2(6), 613–619 (2000).
   PubMed Web of Science ®Google Scholar
• Race R, Oldstone M, Chesebro B. Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen. J. Virol.74(2), 828–833 (2000).
   PubMed Web of Science ®Google Scholar
• Shmakov AN, McLennan NF, McBride P et al. Cellular prion protein is expressed in the human enteric nervous system. Nat. Med.6(8), 840–841 (2000).
   PubMed Web of Science ®Google Scholar
• Kimberlin RH, Walker CA. The role of the spleen in the neuroinvasion of scrapie in mice. Virus Res.12(3), 201–211 (1989).
   PubMed Web of Science ®Google Scholar
• Kimberlin RH, Walker CA. Intraperitoneal infection with scrapie is established within minutes of injection and is non-specifically enhanced by a variety of different drugs. Arch. Virol.112(1–2), 103–114 (1990).
   PubMedGoogle Scholar
• McBride PA, Beekes M. Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie. Neurosci. Lett.265(2), 135–138 (1999).
   PubMed Web of Science ®Google Scholar
• Aguzzi A, Heppner FL, Heikenwalder M et al. Immune system and peripheral nerves in propagation of prions to CNS. Br. Med. Bull.66(1), 141–159 (2003).
   PubMed Web of Science ®Google Scholar
• Porter DD, Porter HG, Cox NA. Failure to demonstrate a humoral immune response to scrapie infection in mice. J. Immunol.111(5), 1407–1410 (1973).
   PubMed Web of Science ®Google Scholar
• Aguzzi A. Prions and the immune system: a journey through gut, spleen, and nerves. Adv. Immunol.81, 123–171 (2003).
   PubMed Web of Science ®Google Scholar
• Miller JF, Basten A. Mechanisms of tolerance to self. Curr. Opin. Immunol.8(6), 815–821 (1996).
   PubMed Web of Science ®Google Scholar
• Kascsak RJ, Rubenstein R, Merz PA et al. Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J. Virol.59(3), 676–683 (1986).
   PubMed Web of Science ®Google Scholar
• Kascsak RJ, Rubenstein R, Merz PA et al. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J. Virol.61(12), 3688–3693 (1987).
   PubMed Web of Science ®Google Scholar
• Krasemann S, Groschup M, Hunsmann G, Bodemer W. Induction of antibodies against human prion proteins (PrP) by DNA-mediated immunization of PrP0/0 mice. J. Immunol. Methods199(2), 109–118 (1996).
   PubMed Web of Science ®Google Scholar
• Rubenstein R, Kascsak RJ, Papini M et al. Immune surveillance and antigen conformation determines humoral immune response to the prion protein immunogen. J. Neurovirol.5(4), 401–413 (1999).
   PubMed Web of Science ®Google Scholar
• Betemps D, Baron T. Molecular specificities of antibodies against ovine and murine recombinant prion proteins. Biochem. Biophys. Res. Commun.281(1), 101–108 (2001).
   PubMedGoogle Scholar
• Gilch S, Wopfner F, Renner-Muller I et al. Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells. J. Biol. Chem.278(20), 18524–18531 (2003).
   PubMed Web of Science ®Google Scholar
• Bueler H, Fischer M, Lang Y et al. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature356, 577–582 (1992).
   PubMed Web of Science ®Google Scholar
• Takahashi H, Takahashi RH, Hasegawa H et al. Characterization of antibodies raised against bovine-PrP-peptides. J. Neurovirol.5(3), 300–307 (1999).
   PubMed Web of Science ®Google Scholar
• Tayebi M, Enever P, Sattar Z, Collinge J, Hawke S. Disease-associated prion protein elicits immunoglobulin M responses in vivo.Mol. Med.10(7–12), 104–111 (2004).
   PubMedGoogle Scholar
• Paramithiotis E, Pinard M, Lawton T et al. A prion protein epitope selective for the pathologically misfolded conformation. Nat. Med.9(7), 893–899 (2003).
   PubMed Web of Science ®Google Scholar
• Curin S, V, Bresjanac M, Popovic M et al. Monoclonal antibody against a peptide of human prion protein discriminates between Creutzfeldt–Jacob’s disease-affected and normal brain tissue. J. Biol. Chem.279(5), 3694–3698 (2004).
   PubMed Web of Science ®Google Scholar
• Korth C, Stierli B, Streit P et al. Prion (PrPSc)-specific epitope defined by a monoclonal antibody. Nature390(6655), 74–77 (1997).
   PubMed Web of Science ®Google Scholar
• Enari M, Flechsig E, Weissmann C. Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc. Natl Acad. Sci. USA98(16), 9295–9299 (2001).
   PubMed Web of Science ®Google Scholar
• Peretz D, Williamson RA, Kaneko K et al. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature412(6848), 739–743 (2001).
   PubMed Web of Science ®Google Scholar
• Heppner FL, Musahl C, Arrighi I et al. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science294(5540), 178–182 (2001).
   PubMed Web of Science ®Google Scholar
• Sigurdsson EM, Brown DR, Daniels M et al. Immunization delays the onset of prion disease in mice. Am. J. Pathol.161(1), 13–17 (2002).
   PubMed Web of Science ®Google Scholar
• Schwarz A, Kratke O, Burwinkel M et al. Immunisation with a synthetic prion protein-derived peptide prolongs survival times of mice orally exposed to the scrapie agent. Neurosci. Lett.350(3), 187–189 (2003).
   PubMed Web of Science ®Google Scholar
• White AR, Enever P, Tayebi M et al. Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature422(6927), 80–83 (2003).
   PubMed Web of Science ®Google Scholar
• Dodart JC, Bales KR, Paul SM. Immunotherapy for Alzheimer’s disease: will vaccination work? Trends Mol. Med.9(3), 85–87 (2003).
   PubMedGoogle Scholar
• Solforosi L, Criado JR, McGavern DB et al. Cross-linking cellular prion protein triggers neuronal apoptosis in vivo.Science303(5663), 1514–1516 (2004).
   PubMed Web of Science ®Google Scholar
• Gregoire S, Bergot AS, Feraudet C, Carnaud C, Aucouturier P, Rosset MB. The murine B cell repertoire is severely selected against endogenous cellular prion protein. J. Immunol.175(10), 6443–6449 (2005).
   PubMed Web of Science ®Google Scholar
• Peretz D, Williamson RA, Matsunaga Y et al. A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform. J. Mol. Biol.273, 614–622 (1997).
   PubMed Web of Science ®Google Scholar
• Beringue V, Mallinson G, Kaisar M et al. Regional heterogeneity of cellular prion protein isoforms in the mouse brain. Brain126(Pt 9), 2065–2073 (2003).
   PubMed Web of Science ®Google Scholar
• Montrasio F, Frigg R, Glatzel M et al. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science288(5469), 1257–1259 (2000).
   PubMed Web of Science ®Google Scholar
• Huang FP, Farquhar CF, Mabbott NA, Bruce ME, MacPherson GG. Migrating intestinal dendritic cells transport PrPSc from the gut. J. Gen. Virol.83(Pt 1), 267–271 (2002).
   PubMed Web of Science ®Google Scholar
• Booth DR, Sunde M, Bellotti V et al. Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis. Nature385(6619), 787–793 (1997).
   PubMed Web of Science ®Google Scholar
• Klein MA, Frigg R, Flechsig E et al. A crucial role for B cells in neuroinvasive scrapie. Nature390(6661), 687–690 (1997).
   PubMed Web of Science ®Google Scholar