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Perspective

Levonorgestrel-releasing intrauterine system: uses and controversies

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Pages 437-445 | Published online: 09 Jan 2014

References

  • Luukkainen T. Levonorgestrel-releasing intrauterine device. Ann. NY Acad. Sci.626, 43–49 (1991).
  • Luukkainen T. The levonorgestrel intrauterine system: therapeutic aspects. Steroids65(10–11), 699–702 (2000).
  • Faundes A, Alvarez F, Brache V, Tejada AS. The role of the levonorgestrel intrauterine device in the prevention and treatment of iron deficiency anemia during fertility regulation. Int. J. Gynaecol. Obstet.26(3), 429–433 (1988).
  • Odlind V. Long-term experience of a levonorgestrel-releasing intrauterine system. Eur. J. Contracept. Reprod. Health Care1(4), 319–323 (1996).
  • Hidalgo M, Bahamondes L, Perrotti M, Diaz J, Dantas-Monteiro C, Petta CA. Bleeding patterns and clinical performance of the levonorgestrel-releasing intrauterine system (Mirena) up to two years. Contraception65(2), 129–132 (2002).
  • Faúndes A, Alvarez F, Díaz J. A Latin American experience with levonorgestrel IUD. Ann. Med.25(2), 149–153 (1993).
  • Sivin I. Dose- and age-dependent ectopic pregnancy risks with intrauterine contraception. Obstet. Gynecol.78(2), 291–298 (1991).
  • Munuce MJ, Nascimento JAA, Rosano G, Faundes A, Bahamondes L. Doses of levonorgestrel comparable to that delivered by the levonorgestrel-releasing intrauterine system can modify the in vitro expression of zona binding sites of human spermatozoa. Contraception73(1), 97–101 (2006).
  • Sitruk-Ware R. Pharmacological profile of progestins. Maturitas47(4), 277–283 (2004).
  • Silverberg SG, Haukkamaa M, Arko H, Nilsson CG, Luukkainen T. Endometrial morphology during long-term use of levonorgestrel-releasing intrauterine devices. Int. J. Gynecol. Pathol.5(3), 235–241 (1986).
  • Guttinger A, Critchley HO. Endometrial effects of intrauterine levonorgestrel. Contrception75(6 Suppl.), S93–S98 (2007).
  • Peloggia A, Petta CA, Bahamondes L, Oliveira-Ribeiro M, Zhang J, Salamonsen L. Endometrial chemokines, uterine natural killer cells and mast cells in long-term users of the levonorgestrel-releasing intrauterine system. Hum. Reprod.21(5), 1129–1134 (2006).
  • Bahamondes L, Espejo-Arce X, Hidalgo MM, Hidalgo-Regina C, Teatin-Juliato C, Petta CA. A cross-sectional study of the forearm bone density of long-term users of levonorgestrel-releasing intrauterine system. Hum. Reprod.21(5), 1316–1319 (2006).
  • Bahamondes L, Hidalgo M, Petta CA, Diaz J, Espejo-Arce X, Monteiro-Dantas C. Enlarged ovarian follicles in users of a levonorgestrel-releasing intrauterine system and contraceptive implant. J. Reprod. Med.48(8), 637–640 (2003).
  • Inki P, Hurskainen R, Palo P et al. Comparison of ovarian cyst formation in women using the levonorgestrel-releasing intrauterine system vs. hysterectomy. Ultrasound Obstet. Gynecol.20(4), 381–385 (2002).
  • Rogovskaya S, Rivera R, Grimes DA et al. Effect of a levonorgestrel intrauterine system on women with Type 1 diabetes: a randomized trial. Obstet. Gynecol.105(4), 811–815 (2005).
  • Koh SC, Singh K. The effect of levonorgestrel-releasing intrauterine system use on menstrual blood loss and the hemostatic, fibrinolytic/inhibitor systems in women with menorrhagia. J. Thromb. Haemost.5(1), 133–138 (2007).
  • Graff-Iversen S, Tonstad S. Use of progestogen-only contraceptives/medications and lipid parameters in women age 40 to 42 years: results of a population-based cross-sectional Norwegian survey. Contraception66(1), 7–13 (2002).
  • Rönnerdag M, Odlind V. Health effects of long-term use of the intrauterine levonorgestrel-releasing system. A follow-up study over 12 years of continuous use. Acta Obstet. Gynecol. Scand.78(8), 716–721 (1999).
  • Yela DA, Monteiro IM, Bahamondes LG, Del Castillo S, Bahamondes MV, Fernandes A. Weight variation in users of the levonorgestrel-releasing intrauterine system, of the copper IUD and of medroxyprogesterone acetate in Brazil. Rev. Assoc. Med. Bras.52(1), 32–36 (2006).
  • Lessard T, Simons JA, Discacciati MG, Hidalgo M, Bahamondes L. Cytological evaluation and investigation of the vaginal flora of long-term users of the levonorgestrel-releasing intrauterine system (LNG-IUS). Contraception77(1), 30–33 (2008).
  • Misra JS, Engineer AD, Tandon P. Cervical cytology associated with levonorgestrel contraception. Acta Cytol.39(1), 45–49 (1995).
  • Toivonen J, Luukkainen T, Allonen H. Protective effect of intrauterine release of levonorgestrel on pelvic infection: three years’ comparative experience of levonorgestrel- and copper-releasing intrauterine devices. Obstet. Gynecol.77(2), 261–264 (1991).
  • Sivin I, Stern J, Coutinho E et al. Prolonged intrauterine contraception: a seven-year randomized study of the levonorgestrel 20 mcg/day (LNg 20) and the Copper T380 Ag IUDS. Contraception44(5), 473–480 (1991).
  • Baveja R, Bichille LK, Coyaji KJ et al. Randomized clinical trial with intrauterine devices (levonorgestrel intrauterine device (LNG), CuT 380Ag, CuT 220C and CuT 200B). A 36 -month study. Indian Council of Medical Research Task Force on IUD. Contraception39(1), 37–52 (1989).
  • Haukkamaa M, Stranden P, Jousimies-Somer H, Siitonen A. Bacterial flora of the cervix in women using different methods of contraception. Am. J. Obstet. Gynecol.154(3), 520–524 (1986).
  • Heikkilä M, Haukkamaa M, Luukkainen T. Levonorgestrel in milk and plasma of breast-feeding women with a levonorgestrel-releasing IUD. Contraception25(1), 41–49 (1982).
  • Heikkilä M, Luukkainen T. Duration of breast-feeding and development of children after insertion of a levonorgestrel-releasing intrauterine contraceptive device. Contraception25(3), 279–292 (1982).
  • Ortayli N, Bulut A, Sahin T, Sivin I. Immediate postabortal contraception with the levonorgestrel intrauterine device, Norplant, and traditional methods. Contraception63(6), 309–314 (2001).
  • Pakarinen P, Toivonen J, Luukkainen T. Randomized comparison of levonorgestrel- and copper-releasing intrauterine systems immediately after abortion, with 5 years’ follow-up. Contraception68(1), 31–34 (2003).
  • Pakarinen P, Toivonen J, Luukkainen T. Therapeutic use of the LNG IUS, and counseling. Semin. Reprod. Med.19(4), 365–372 (2001).
  • Luukkainen T, Allonen H, Haukkamaa M et al. Effective contraception with the levonorgestrel-releasing intrauterine device: 12-month report of a European multicenter study. Contraception36(2), 169–179 (1987).
  • Andersson K, Odlind V, Rybo G. Levonorgestrel-releasing and copper-releasing (Nova T) IUDs during five years of use: a randomized comparative trial. Contraception49(1), 56–72 (1994).
  • Backman T, Rauramo I, Huhtala S, Koskenvuo M. Pregnancy during the use of levonorgestrel intrauterine system. Am. J. Obstet. Gynecol.190(1), 50–54 (2004).
  • Peterson HB, Xia Z, Hughes JM, Wilcox LS, Tylor LR, Trussell J. The risk of pregnancy after tubal sterilization: findings from the U.S. Collaborative Review of Sterilization. Am. J. Obstet. Gynecol.174(4), 1161–1168 (1996).
  • Sivin I, Stern J. Health during prolonged use of levonorgestrel 20 micrograms/d and the copper TCu 380Ag intrauterine contraceptive devices: a multicenter study. International Committee for Contraception Research (ICCR). Fertil. Steril.61(1), 70–77 (1994).
  • Andersson K, Batar I, Rybo G. Return to fertility after removal of a levonorgestrel-releasing intrauterine device and Nova-T. Contraception46(6), 575–584 (1992).
  • Reid PC, Coker A, Coltart R. Assessment of menstrual blood loss using a pictorial chart: a validation study. Br. J. Obstet. Gynecol.107(3), 320–322 (2000).
  • Monteiro I, Bahamondes L, Diaz J, Perrotti M, Petta C. Therapeutic use of levonorgestrel-releasing intrauterine system in women with menorrhagia: a pilot study. Contraception65(5), 325–328 (2002).
  • Andersson JK, Rybo G. Levonorgestrel-releasing intrauterine device in the treatment of menorrhagia. Br. J. Obstet. Gynecol.97(8), 690–694 (1990).
  • Milsom I, Andersson K, Andersch B, Rybo G. A comparison of flurbiprofen, tranexamic acid, and a levonorgestrel-releasing intrauterine contraceptive device in the treatment of idiopathic menorrhagia. Am. J. Obstet. Gynecol.164(3), 879–883 (1991).
  • Irvine GA, Campbell-Brown MB, Lumsden MA, Heikkila A, Walker JJ, Cameron IT. Randomised comparative trial of the levonorgestrel intrauterine system and norethisterone for treatment of idiopathic menorrhagia. Br. J. Obstet. Gynecol.105(6), 592–598 (1998).
  • Reid PC, Virtanen-Kari S. Randomized comparative trial of the levonorgestrel intrauterine system and mefenamic acid for the treatment of idiopathic menorrhagia: a multiple analysis using total menstrual fluid loss, menstrual blood loss and pictorial blood loss assessment charts. Br. J. Obstet. Gynecol.112(8), 1121–1125 (2005).
  • Lähteenmäki P, Haukkamaa M, Puolakka J et al. Open randomised study of use of levonorgestrel releasing intrauterine system as alternative to hysterectomy. Br. Med. J.316(7138), 1122–1126 (1998).
  • Barrington JW, Arunkalaivanan AS, Abdel-Fattah M. Comparison between the levonorgestrel intrauterine system (LNG-IUS) and thermal balloon ablation in the treatment of menorrhagia. Eur. J. Obstet. Gynecol. Reprod. Biol.108(1), 72–74 (2003).
  • Busfield RA, Farquhar CM, Sowter MC et al. A randomised trial comparing the levonorgestrel intrauterine system and thermal balloon ablation for heavy menstrual bleeding. Br. J. Obstet. Gynecol.113(3), 257–263 (2006).
  • Brown PM, Farquhar CM, Lethaby A, Sadler LC, Johnson NP. Cost–effectiveness analysis of levonorgestrel intrauterine system and thermal balloon ablation for heavy menstrual bleeding. Br. J. Obstet. Gynecol.113(7), 797–803 (2006).
  • Istre O, Trolle B. Treatment of menorrhagia with the levonorgestrel intrauterine system versus endometrial resection. Fertil. Steril.76(2), 304–309 (2001).
  • Hurskainen R, Teperi J, Rissanen P et al. Quality of life and cost–effectiveness of levonorgestrel-releasing intrauterine system versus hysterectomy for treatment of menorrhagia: a randomised trial. Lancet357(9252), 273–277 (2001).
  • Hurskainen R, Teperi J, Rissanen P et al. Clinical outcomes and costs with the levonorgestrel-releasing intrauterine system or hysterectomy for treatment of menorrhagia: randomized trial 5-year follow-up. JAMA291(12), 1456–1463 (2004).
  • Sitruk-Ware R, Inki P. The levonorgestrel intrauterine system: long-term contraception and therapeutic effects. Women Health1(2), 171–182 (2005).
  • Sitruk-Ware R. The levonorgestrel intrauterine system for use in peri- and postmenopausal women. Contraception75(Suppl. 1), S155–S160 (2007).
  • Riphagen FE. Intrauterine application of progestins in hormone replacement therapy: a review. Climacteric3(3), 199–211 (2000).
  • Suhonen S, Holmström T, Lähteenmäki P. Three-year follow-up of the use of a levonorgestrel-releasing intrauterine system in hormone replacement therapy. Acta Obstet. Gynecol. Scand.76(2), 145–150 (1997).
  • Andersson K, Rybo G, Mattsson LO, Stadberg E. Intrauterine release of levonorgestrel – a new way of adding progestogen in hormone replacement therapy. Obstet. Gynecol.79(6), 963–967 (1992).
  • Raudaskoski TH, Lahti EI, Kauppila AJ, Apaja-Sarkkinen MA, Laatikainen TJ. Transdermal estrogen with a levonorgestrel-releasing intrauterine device for climacteric complaints: clinical and endometrial responses. Am. J. Obstet. Gynecol.172(1 Pt 1), 114–119 (1995).
  • Suhonen S, Allonen H, Lähteenmäki P. Sustained-release estradiol implants and a levonorgestrel-releasing intrauterine device in hormone replacement therapy. Am. J. Obstet. Gynecol.172(2 Pt 1), 562–567 (1995).
  • Varila E, Wahlstrom T, Rauramo I. A 5-year follow-up study on the use of a levonorgestrel intrauterine system in women receiving hormone replacement therapy. Fertil. Steril.76(5), 769–773 (2001).
  • Suvanto-Luukkonen E, Kauppila A. The slevonorgestrel intrauterine system in menopausal hormone replacement therapy: five-year experience. Fertil. Steril.72(1), 161–163 (1999).
  • Hampton NR, Rees MC, Lowe DG, Rauramo I, Barlow D, Guillebaud J. Levonorgestrel intrauterine system (LNG-IUS) with conjugated oral equine estrogen: a successful regimen for HRT in perimenopausal women. Hum. Reprod.20(9), 2653–2660 (2005).
  • Blumenfeld Z, Boulman N, Leiba R, Siegler E, Shachar S, Linn R, Levy Y. High C-reactive protein levels are associated with oral hormonal menopausal therapy but not with intrauterine levonorgestrel and transdermal estradiol. Scand. J. Clin. Lab. Invest.67(3), 257–263 (2007).
  • Prentice A, Deary AJ, Goldbeck-Wood S, Farquhar C, Smith SK. Gonadotrophin-releasing hormone analogues for pain associated with endometriosis. Cochrane Database Syst. Rev.2, CD000346 (2000).
  • Fedele L, Berlanda N. Emerging drugs for endometriosis. Expert Opin. Emerg. Drugs9(1), 167–177 (2004).
  • Vercellini P, Aimi G, Panazza S, De Giorgi O, Pesole A, Crosignani PG. A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study. Fertil. Steril.72(3), 505–508 (1999).
  • Vercellini P, Frontino G, De Giorgi O, Aimi G, Zaina B, Crosignani PG. Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study. Fertil. Steril.80(2), 305–309 (2003).
  • Fedele L, Bianchi S, Zanconato G, Portuese A, Raffaelli R. Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis. Fertil. Steril.75(3), 485–488 (2001).
  • Petta CA, Ferriani RA, Abrão MS et al. Randomized clinical trial of a levonorgestrel-releasing intrauterine system and a depot GnRH analogue for the treatment of chronic pelvic pain in women with endometriosis. Hum. Reprod.20(7), 1993–1998 (2005).
  • Lockhat FB, Emembolu JO, Konje JC. The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the disease. Hum. Reprod.19(1), 179–184 (2004).
  • Lockhat FB, Emembolu JO, Konje JC. The efficacy, side effects and continuation rates in women with symptomatic endometriosis undergoing treatment with an intra-uterine administered progestogen (levonorgestrel): a 3 year follow-up. Hum. Reprod.20(3), 789–793 (2005).
  • Bragheto AM, Caserta N, Bahamondes L, Petta CA. Effectiveness of the levonorgestrel-releasing intrauterine system in the treatment of adenomyosis diagnosed and monitored by magnetic resonance imaging. Contraception76(3), 195–199 (2007).
  • Scarselli G, Tantini C, Colafranceschi M et al. Levo-norgestrel-nova-T and precancerous lesions of the endometrium. Eur. J. Gynaecol. Oncol.9(4), 284–286 (1988).
  • Montz FJ, Bristow RE, Bovicelli A, Tomacruz R, Kurman RJ. Intrauterine progesterone treatment of early endometrial cancer. Am. J. Obstet. Gynecol.186(4), 651–657 (2002).
  • Bahamondes L, Ribeiro-Huguet P, de Andrade KC, Leon-Martins O, Petta CA. Levonorgestrel-releasing intrauterine system (Mirena) as a therapy for endometrial hyperplasia and carcinoma. Acta Obstet. Gynecol. Scand.82(6), 580–582 (2003).
  • Giannopoulos T, Butler-Manuel S, Tailor A. Levonorgestrel-releasing intrauterine system (LNG-IUS) as a therapy for endometrial carcinoma. Gynecol. Oncol.95(3), 762–764 (2004).
  • Dhar KK, NeedhiRajan T, Koslowski M, Woolas RP. Is levonorgestrel intrauterine system effective for treatment of early endometrial cancer? Report of four cases and review of the literature. Gynecol. Oncol.97(3), 924–927 (2005).
  • Vereide AB, Arnes M, Straume B, Maltau JM, Ørbo A. Nuclear morphometric changes and therapy monitoring in patients with endometrial hyperplasia: a study comparing effects of intrauterine levonorgestrel and systemic medroxyprogesterone. Gynecol. Oncol.91(3), 526–533 (2003).
  • Gardner FJ, Konje JC, Abrams KR et al. Endometrial protection from tamoxifen-stimulated changes by a levonorgestrel-releasing intrauterine system: a randomized controlled trial. Lancet356(9243), 1711–1717 (2000).
  • Chan SS, Tam WH, Yeo W et al. A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women. Br. J. Obstet. Gynecol.114(12), 1510–1515 (2007).
  • Rodeghiero F, Castaman G, Dini E. Epidemiological investigation of the prevalence of von Willebrand’s disease. Blood69(2), 454–459 (1987).
  • Foster PA. The reproductive health of women with von Willebrand disease unresponsive to DDAVP; results of an international survey. Thromb. Haemost.74(2), 784–790 (1995).
  • Kingman CE, Kadir RA, Lee CA, Economides DL. The use of levonorgestrel-releasing intrauterine system for treatment of menorrhagia in women with inherited bleeding disorders. Br. J. Obstet. Gynecol.111(12), 1425–1428 (2004).
  • Lukes AS, Reardon B, Arepally G. Use of the levonorgestrel-releasing intrauterine system in women with hemostatic disorders. Fertil. Steril. (2007) (Epub ahead of print).
  • Schaedel ZE, Dolan G, Powell M. The use of the levonorgestrel-releasing intrauterine system in the management of menorrhagia in women with hemostatic disorders. Am. J. Obstet. Gynecol.193(4), 1361–1363 (2005).
  • Pisoni CN, Cuadrado MJ, Khamashta MA, Hunt BJ. Treatment of menorrhagia associated with oral anticoagulation: efficacy and safety of the levonorgestrel releasing intrauterine device (Mirena coil). Lupus15(12), 877–880 (2006).
  • da Silveira Rossi A, Fonsechi-Carvasan GA, Makuch MY, Amaral E, Bahamondes L. Factors associated with reproductive options in HIV-infected women. Contraception71(1), 45–50 (2005).
  • Heikinheimo O, Lehtovirta P, Suni J, Paavonen J. The levonorgestrel-releasing intrauterine system (LNG-IUS) in HIV-infected women – effects on bleeding patterns, ovarian function and genital shedding of HIV. Hum. Reprod.21(11), 2857–2861 (2006).
  • Mercorio F, De Simone R, Di Spiezio Sardo A et al. The effect of levonorgestrel-releasing intrauterine device in the treatment of myoma-related menorrhagia. Contraception67(4), 277–280 (2003).
  • Grigorieva V, Chen-Mok M, Tarasova M, Mikhailov A. Use of a levonorgestrel-releasing intrauterine system to treat bleeding related to uterine leiomyomas. Fertil. Steril.79(5), 1194–1198 (2003).
  • Soysal S, Soysal M. The efficacy of levonorgestrel-releasing intrauterine device in selected cases of myoma-related menorrhagia: a prospective controlled trial. Gynecol. Obstet. Invest.59(1), 29–35 (2005).
  • Magalhães J, Aldrighi JM, de Lima GR. Uterine volume and menstrual patterns in users of the levonorgestrel-releasing intrauterine system with idiopathic menorrhagia or menorrhagia due to leiomyomas. Contraception75(3), 193–198 (2007).
  • Mattinson A, Mansour D. Female sterilization: is it what women really want or are alternative contraceptive methods acceptable? J. Fam. Plann. Reprod. Health Care32(3), 181–183 (2006).
  • Mansour D. Copper IUD and LNG IUS compared with tubal occlusion. Contraception75(6 Suppl.), S144–S151 (2007).
  • Reid PC, Mukri F. Trends in number of hysterectomies performed in England for menorrhagia: examination of health episode statistics, 1989 to 2002–3. Br. Med. J.330(7497), 938–939 (2005).
  • Raudaskoski T, Tapanainen J, Tomas E et al. Intrauterine 10 µg and 20 µg levonorgestrel systems in postmenopausal women receiving oral oestrogen replacement therapy: clinical, endometrial and metabolic response. Br. J. Obstet. Gynecol.109(2), 136–144 (2002).
  • Pakarinen P. Luukkainen T. Five years’ experience with a small intracervical/intrauterine levonorgestrel-releasing device. Contraception72(5), 342–345 (2005).
  • Rossouw JE, Anderson GL, Prentice RL et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA288(3), 321–333 (2002).
  • Banks E, Reeves G, Beral V et al. Impact of use of hormone replacement therapy on false positive recall in the NHS breast screening programme: results from the Million Women Study. Br. Med. J.328(7451), 1291–1292 (2004).
  • Backman T, Rauramo I, Jaakkola K et al. Use of the levonorgestrel-releasing intrauterine system and breast cancer. Obstet. Gynecol.106(4), 813–817 (2005).
  • Kaunitz A. Progestin-releasing intrauterine systems and leiomyoma. Contraception75(Suppl. 1), S130–S133 (2007).

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